I have a B.A. in Biology from Boston University and a PhD in Cell and Developmental Biology from Harvard University. My undergraduate research focused on glucose transport in erythrocytes with Scott Peterson and my PhD on cell-cell adhesion in the immune system with Timothy A. Springer. I did post-doctoral training in the area of lysosome biogenesis with Stuart Kornfeld at Washington University. I started my independent career in the Department of Pathology and Immunology at Washington University School of Medicine. There, I led a collaborative team on the initial characterization of the immunological synapse. I was tenured at Washington University. I moved to NYU School of Medicine in 2001 and became a Professor in 2006. At NYU SOM we utilized intravital microscopy to further define the role of immunological synapses and guidance mechanisms in the immune system in vivo. We recently defined a novel compartment in the immunological synapse based on release of T cell receptor enriched micro vesicles into the center of the immunological synapse. I'm in the process of moving my lab to the Kennedy Institute of Rheumatology at the University of Oxford in the UK. Here we will focus on translation of the immunological synapse toward identification of cures for inflammatory diseases with support of the Wellcome Trust and the Kennedy Trust.