Personal information

selenium, selenocysteine, molecular biology, translation

Activities

Employment (2)

Rutgers Robert Wood Johnson Medical School Department of Biochemistry and Molecular Biology: Piscataway, NJ, US

2002-04-01 to present | Professor (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Paul R. Copeland

Cleveland Clinic: Cleveland, OH, US

1997-01-15 to 2002-02-28 | Postdoc (Cell Biology)
Employment
Source: Self-asserted source
Paul R. Copeland

Education and qualifications (2)

University of Virginia: Charlottesville, VA, US

1990-09-01 to 1996-12-31 | PhD (Bioloogy)
Education
Source: Self-asserted source
Paul R. Copeland

Loyola University Chicago: Chicago, IL, US

1986-09-01 to 1990-06-01 | B.S. (Biology)
Education
Source: Self-asserted source
Paul R. Copeland

Funding (2)

Development of a zebrafish model for selenoprotein synthesis and function

2016-04-01 to 2018-03-31 | Grant
National Institute of Child Health and Human Development (Bethesda, US)
GRANT_NUMBER: R21HD083616
Source: Self-asserted source
Paul R. Copeland via DimensionsWizard

Functional Analysis of SBP2 and Selenocysteine Incorporation

2006-01-06 to 2019-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: R01GM077073
Source: Self-asserted source
Paul R. Copeland via DimensionsWizard

Works (50 of 59)

Items per page:
Page 1 of 2

Selenoprotein synthesis is not induced by hepatotoxic drugs

2023-05-14 | Preprint
Contributors: Sumangala P. Shetty; Dongming He; Paul R. Copeland
Source: check_circle
Crossref

The selenoprotein P 3’ untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation

PLOS ONE
2022-07-29 | Journal article
Contributors: Sumangala P. Shetty; Hodaka Fujii; Nora T. Kiledjian; Paul R. Copeland
Source: check_circle
Crossref

Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon

Science
2022-06-17 | Journal article
Contributors: Tarek Hilal; Benjamin Y. Killam; Milica Grozdanović; Malgorzata Dobosz-Bartoszek; Justus Loerke; Jörg Bürger; Thorsten Mielke; Paul R. Copeland; Miljan Simonović; Christian M. T. Spahn
Source: check_circle
Crossref

The expression of essential selenoproteins during development requires SECIS-binding protein 2–like

Life Science Alliance
2022-05 | Journal article
Contributors: Nora T Kiledjian; Rushvi Shah; Michael B Vetick; Paul R Copeland
Source: check_circle
Crossref

Ribosome Fate during Decoding of UGA-Sec Codons

International Journal of Molecular Sciences
2021-12-08 | Journal article
Contributors: Paul R. Copeland; Michael T. Howard
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The expression of essential selenoproteins during zebrafish development requires SECIS binding protein 2-like

2021-11-02 | Other
Contributors: Nora T. Kiledjian; Rushvi Shah; Michael B. Vetick; Paul R. Copeland
Source: check_circle
Crossref

The Selenoprotein P 3’ untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation

2020-11-23 | Preprint
Contributors: Sumangala P. Shetty; Nora T. Kiledjian; Paul R. Copeland
Source: check_circle
Crossref

New Directions for Understanding the Codon Redefinition Required for Selenocysteine Incorporation

Biological Trace Element Research
2019-11-24 | Journal article
Contributors: Michael T. Howard; Paul R. Copeland
Source: check_circle
Crossref

Gained in translation: The power of digging deep into disease models

Journal of Biological Chemistry
2019-09 | Journal article
Contributors: Paul R. Copeland
Source: check_circle
Crossref

Processive incorporation of multiple selenocysteine residues is driven by a novel feature of the selenocysteine insertion sequence

Journal of Biological Chemistry
2018-12 | Journal article
Contributors: Sumangala P. Shetty; Ryan Sturts; Michael Vetick; Paul R. Copeland
Source: check_circle
Crossref

The Selenium Transport Protein, Selenoprotein P, Requires Coding Sequence Determinants to Promote Efficient Selenocysteine Incorporation

Journal of Molecular Biology
2018-09 | Journal article
Contributors: Sumangala P. Shetty; Paul R. Copeland
Source: check_circle
Crossref

Uptake and Utilization of Selenium from Selenoprotein P

Biological Trace Element Research
2017 | Journal article
EID:

2-s2.0-85019148184

Contributors: Shetty, S.; Marsicano, J.R.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier
grade
Preferred source (of 2)‎

The utilization of selenocysteine-tRNA[Ser]Sec isoforms is regulated in part at the level of translation in vitro

Translation
2017-01-02 | Journal article
Contributors: Bradley A. Carlson; Nirupama Gupta; Mark H. Pinkerton; Dolph L. Hatfield; Paul R. Copeland
Source: check_circle
Crossref

Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation

Nature Communications
2016 | Journal article
EID:

2-s2.0-84990836946

Contributors: Dobosz-Bartoszek, M.; Pinkerton, M.H.; Otwinowski, Z.; Chakravarthy, S.; Söll, D.; Copeland, P.R.; Simonovic, M.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Eukaryotic mechanisms of selenocysteine incorporation and its reconstitution in vitro

Selenium: Its Molecular Biology and Role in Human Health, Fourth Edition
2016 | Book
EID:

2-s2.0-85018555515

Contributors: Pinkerton, M.H.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Selenoprotein gene nomenclature

Journal of Biological Chemistry
2016 | Journal article
EID:

2-s2.0-84995487883

Contributors: Regina, B.-F.; Gladyshev, V.N.; Arnér, E.S.; Berry, M.J.; Bruford, E.A.; Burk, R.F.; Carlson, B.A.; Castellano, S.; Chavatte, L.; Conrad, M. et al.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

The selenocysteine-specific elongation factor contains unique sequences that are required for both nuclear export and selenocysteine incorporation

PLoS ONE
2016 | Journal article
EID:

2-s2.0-84993973231

Contributors: Dubey, A.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Selenocysteine incorporation: A trump card in the game of mRNA decay

Biochimie
2015 | Journal article
EID:

2-s2.0-84930374007

Contributors: Shetty, S.P.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Regulation of selenocysteine incorporation into the selenium transport protein, selenoprotein P

Journal of Biological Chemistry
2014 | Journal article
EID:

2-s2.0-84906991144

Contributors: Shetty, S.P.; Shah, R.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Structural asymmetry of the terminal catalytic complex in selenocysteine synthesis

Journal of Biological Chemistry
2014 | Journal article
EID:

2-s2.0-84908093596

Contributors: French, R.L.; Gupta, N.; Copeland, P.R.; Simonović, M.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Reconstitution of selenocysteine incorporation reveals intrinsic regulation by SECIS elements

Journal of Molecular Biology
2013 | Journal article
EID:

2-s2.0-84879550686

Contributors: Gupta, N.; Demong, L.W.; Banda, S.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

The molecular biology of selenocysteine

Biomolecular Concepts
2013 | Journal article
EID:

2-s2.0-84881487884

Contributors: Gonzalez-Flores, J.N.; Shetty, S.P.; Dubey, A.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Molecular mechanism of eukaryotic selenocysteine incorporation

Selenium: Its Molecular Biology and Role in Human Health
2012 | Book
EID:

2-s2.0-84949178945

Contributors: Howard, M.T.; Gonzales-Flores, J.N.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Selenocysteine Insertion Sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84858979115

Contributors: Caban, K.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

The selenocysteine-specific elongation factor contains a novel and multi-functional domain

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84869061553

Contributors: Gonzalez-Flores, J.N.; Gupta, N.; DeMong, L.W.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Selenocysteine Insertion Sequence Binding Protein 2L Is Implicated as a Novel Post-Transcriptional Regulator of Selenoprotein Expression

PLoS ONE
2012-04 | Journal article
Contributors: Jesse Donovan; Paul R. Copeland; Mick F. Tuite
Source: Self-asserted source
Paul R. Copeland via Crossref Metadata Search
grade
Preferred source (of 2)‎

A Ribosomal Perspective on the Mechanism of Selenocysteine Incorporation

Selenium
2011 | Other
Contributors: Kelvin Caban; Paul R. Copeland
Source: Self-asserted source
Paul R. Copeland via Crossref Metadata Search
grade
Preferred source (of 2)‎

Eukaryotic polyribosome profile analysis

Journal of Visualized Experiments
2010 | Journal article
EID:

2-s2.0-80355135315

Contributors: Esposito, A.M.; Mateyak, M.; He, D.; Lewis, M.; Sasikumar, A.N.; Hutton, J.; Copeland, P.R.; Kinzy, T.G.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Eukaryotic polyribosome profile analysis.

Journal of visualized experiments : JoVE
2010 | Journal article
EID:

2-s2.0-84873031061

Contributors: Esposito, A.M.; Mateyak, M.; He, D.; Lewis, M.; Sasikumar, A.N.; Hutton, J.; Copeland, P.R.; Kinzy, T.G.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

The efficiency of selenocysteine incorporation is regulated by translation initiation factors

Journal of Molecular Biology
2010 | Journal article
EID:

2-s2.0-77954386407

Contributors: Donovan, J.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Threading the needle: Getting selenocysteine into proteins

Antioxidants and Redox Signaling
2010 | Journal article
EID:

2-s2.0-77649258954

Contributors: Donovan, J.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins

BMC Evolutionary Biology
2009 | Journal article
EID:

2-s2.0-70349311830

Contributors: Donovan, J.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

A birth-to-death view of mRNA from the RNA recognition motif perspective

Biochemistry and Molecular Biology Education
2008 | Journal article
EID:

2-s2.0-38949104116

Contributors: Kinzy, T.G.; De Stefano, L.A.; Esposito, A.M.; Hurley, J.M.; Roy, R.; Valentin-Acevedo, A.J.; Changt, K.-H.; Davila, J.; Defren, J.M.; Donovan, J. et al.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

A novel protein domain induces high affinity selenocysteine insertion sequence binding and elongation factor recruitment

Journal of Biological Chemistry
2008 | Journal article
EID:

2-s2.0-58049219755

Contributors: Donovan, J.; Caban, K.; Ranaweera, R.; Gonzalez-Flores, J.N.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Analysis of Saccharomyces cerevisiae null allele strains identifies a larger role for DNA damage versus oxidative stress pathways in growth inhibition by selenium

Molecular Nutrition and Food Research
2008 | Journal article
EID:

2-s2.0-55949090607

Contributors: Seitomer, E.; Balar, B.; He, D.; Copeland, P.R.; Kinzy, T.G.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Genome-wide screen of Saccharomyces cerevisiae null allele strains identifies genes involved in selenomethionine resistance

Proceedings of the National Academy of Sciences of the United States of America
2008 | Journal article
EID:

2-s2.0-56649117606

Contributors: Bockhorn, J.; Balar, B.; He, D.; Seitomer, E.; Copeland, P.R.; Kinzy, T.G.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Erratum: Selenoprotein expression is regulated at multiple levels in prostate cells (Cell Research (2007) 16 DOI:10.1038/sj.cr.7310117)

Cell Research
2007 | Journal article
EID:

2-s2.0-33947322578

Contributors: Rebsch, C.M.; Penna, F.J.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Functional analysis of the interplay between translation termination, selenocysteine codon context, and selenocysteine insertion sequence-binding protein 2

Journal of Biological Chemistry
2007 | Journal article
EID:

2-s2.0-37549056258

Contributors: Gupta, M.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

The L7Ae RNA binding motif is a multifunctional domain required for the ribosome-dependent sec incorporation activity of Sec insertion sequence binding protein 2

Molecular and Cellular Biology
2007 | Journal article
EID:

2-s2.0-34548789601

Contributors: Caban, K.; Kinzy, S.A.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Selenoprotein expression is regulated at multiple levels in prostate cells

Cell Research
2006 | Journal article
EID:

2-s2.0-33845805582

Contributors: Rebsch, C.M.; Penna III, F.J.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Size matters: A view of selenocysteine incorporation from the ribosome

Cellular and Molecular Life Sciences
2006 | Journal article
EID:

2-s2.0-30744435823

Contributors: Caban, K.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Characterization of the SECIS binding protein 2 complex required for the co-translational insertion of selenocysteine in mammals

Nucleic Acids Research
2005 | Journal article
EID:

2-s2.0-25144465577

Contributors: Kinzy, S.A.; Caban, K.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Making sense of nonsense: The evolution of selenocysteine usage in proteins

Genome Biology
2005 | Journal article
EID:

2-s2.0-21044456214

Contributors: Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Efficiency of mammalian selenocysteine incorporation

Journal of Biological Chemistry
2004 | Journal article
EID:

2-s2.0-4444229875

Contributors: Mehta, A.; Rebsch, C.M.; Kinzyi, S.A.; Fletcher, J.E.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Mechanism and regulation of selenoprotein synthesis

Annual Review of Nutrition
2003 | Book
EID:

2-s2.0-0041317009

Contributors: Driscoll, D.M.; Copeland, P.R.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Regulation of gene expression by stop codon recoding: selenocysteine

Gene
2003-07 | Journal article
Contributors: Paul R. Copeland
Source: Self-asserted source
Paul R. Copeland via Crossref Metadata Search
grade
Preferred source (of 2)‎

Purification and analysis of selenocysteine insertion sequence-binding protein 2

Methods in Enzymology
2002 | Book
EID:

2-s2.0-0036123135

Contributors: Copeland, P.R.; Driscoll, D.M.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

Insight into mammalian selenocysteine insertion: Domain structure and ribosome binding properties of Sec insertion sequence binding protein 2

Molecular and Cellular Biology
2001 | Journal article
EID:

2-s2.0-0035131148

Contributors: Copeland, P.R.; Stepanik, V.A.; Driscoll, D.M.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier

RNA binding proteins and selenocysteine

BioFactors
2001 | Journal article
Contributors: Paul R. Copeland; Donna M. Driscoll
Source: Self-asserted source
Paul R. Copeland via Crossref Metadata Search

RNA binding proteins and selenocysteine

BioFactors
2001 | Journal article
EID:

2-s2.0-0034858064

Contributors: Copeland, P.R.; Driscoll, D.M.
Source: Self-asserted source
Paul R. Copeland via Scopus - Elsevier
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Page 1 of 2

Peer review (1 review for 1 publication/grant)

Review activity for Heliyon. (1)