Personal information

Medicinal Chemistry, Organic synthesis, Biological Chemistry, Cancer Epigenetics, Computer-aided Drug Design, Small molecule Drug Discovery, Chemical Biology
United Arab Emirates

Activities

Employment (3)

United Arab Emirates University: Al Ain, AE

2023-08-05 to present | Assistant Professor (Chemistry)
Employment
Source: Self-asserted source
Yasir S. Raouf

Dalriada Drug Discovery: Toronto, CA

2021-02-06 to 2023-07-01 | Team Lead (Medicinal Chemistry)
Employment
Source: Self-asserted source
Yasir S. Raouf

University of Toronto: Toronto, CA

2021-01-05 to 2023-06-01 | Sessional Instructor Assistant (Chemistry)
Employment
Source: Self-asserted source
Yasir S. Raouf

Education and qualifications (2)

University of Toronto: Toronto, CA

2016-09-05 to 2021-06-05 | Ph.D. Design and Development of Novel Histone Deacetylase Inhibitors for the Treatment of Blood Cancers (Chemistry)
Education
Source: Self-asserted source
Yasir S. Raouf

University of Toronto: Toronto, CA

2012-09-05 to 2016-06-04 | B.Sc. (hons.) (Life Sciences)
Education
Source: Self-asserted source
Yasir S. Raouf

Works (14)

Potential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer’s disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors

PLOS ONE
2025-01-30 | Journal article
Contributors: Fatima Zahra Guerguer; Hazem Elkady; Bouchra Rossafi; Oussama Abchir; Yasir S. Raouf; Dhabya Bakhit Albalushi; Abdelouahid Samadi; Samir Chtita
Source: check_circle
Crossref

Moroccan natural products for multitarget-based treatment of Alzheimer’s disease: A computational study

PLOS ONE
2025-01-16 | Journal article
Contributors: Fatima Zahra Guerguer; Prashant Singh; Amal Bouribab; El Mehdi Karim; Meriem Khedraoui; Fatiha Amegrissi; Yasir S. Raouf; Abdelouahid Samadi; Samir Chtita
Source: check_circle
Crossref

Slow-Binding and Covalent HDAC Inhibition: A New Paradigm?

JACS Au
2024-11-25 | Journal article
Contributors: Yasir S. Raouf; Carlos Moreno-Yruela
Source: check_circle
Crossref

Exploring Moroccan Medicinal Plants for Anticancer Therapy Development Through In Silico Studies

Pharmaceuticals
2024-11-13 | Journal article
Contributors: Amal Bouribab; El Mehdi Karim; Meriem Khedraoui; Oussama Abchir; Abdelkbir Errougui; Yasir S. Raouf; Abdelouahid Samadi; Samir Chtita
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Covalent Inhibitors: To Infinity and Beyond

Journal of Medicinal Chemistry
2024-07-11 | Journal article
Contributors: Yasir S. Raouf
Source: check_circle
Crossref

Discovery of YSR734: A Covalent HDAC Inhibitor with Cellular Activity in Acute Myeloid Leukemia and Duchenne Muscular Dystrophy

Journal of Medicinal Chemistry
2023-12-28 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Yasir S. Raouf; Abootaleb Sedighi; Mulu Geletu; Geordon Frere; Rebecca G. Allan; Nabanita Nawar; Elvin D. de Araujo; Patrick Gunning
Source: Self-asserted source
Yasir S. Raouf

Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma

Journal of Medicinal Chemistry
2022 | Journal article
EID:

2-s2.0-85124467698

Part of ISSN: 15204804 00222623
Contributors: Nawar, N.; Bukhari, S.; Adile, A.A.; Suk, Y.; Manaswiyoungkul, P.; Toutah, K.; Olaoye, O.O.; Raouf, Y.S.; Sedighi, A.; Garcha, H.K. et al.
Source: Self-asserted source
Yasir S. Raouf via Scopus - Elsevier

Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia

Journal of Medicinal Chemistry
2021 | Journal article
EID:

2-s2.0-85108653828

Part of ISSN: 15204804 00222623
Contributors: Toutah, K.; Nawar, N.; Timonen, S.; Sorger, H.; Raouf, Y.S.; Bukhari, S.; von Jan, J.; Ianevski, A.; Gawel, J.M.; Olaoye, O.O. et al.
Source: Self-asserted source
Yasir S. Raouf via Scopus - Elsevier

Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype

Journal of Medicinal Chemistry
2021 | Journal article
EID:

2-s2.0-85101593613

Part of ISSN: 15204804 00222623
Contributors: Olaoye, O.O.; Watson, P.R.; Nawar, N.; Geletu, M.; Sedighi, A.; Bukhari, S.; Raouf, Y.S.; Manaswiyoungkul, P.; Erdogan, F.; Abdeldayem, A. et al.
Source: Self-asserted source
Yasir S. Raouf via Scopus - Elsevier

Advances in covalent kinase inhibitors

Chemical Society Reviews
2020 | Journal article
EID:

2-s2.0-85084693408

Part of ISSN: 14604744 03060012
Contributors: Abdeldayem, A.; Raouf, Y.S.; Constantinescu, S.N.; Moriggl, R.; Gunning, P.T.
Source: Self-asserted source
Yasir S. Raouf via Scopus - Elsevier

Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting

Journal of Medicinal Chemistry
2020 | Journal article
EID:

2-s2.0-85089614792

Part of ISSN: 15204804 00222623
Contributors: Hassan, M.M.; Israelian, J.; Nawar, N.; Ganda, G.; Manaswiyoungkul, P.; Raouf, Y.S.; Armstrong, D.; Sedighi, A.; Olaoye, O.O.; Erdogan, F. et al.
Source: Self-asserted source
Yasir S. Raouf via Scopus - Elsevier

Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia

ACS Medicinal Chemistry Letters
2020 | Journal article
EID:

2-s2.0-85078467478

Part of ISSN: 19485875
Contributors: Shouksmith, A.E.; Gawel, J.M.; Nawar, N.; Sina, D.; Raouf, Y.S.; Bukhari, S.; He, L.; Johns, A.E.; Manaswiyoungkul, P.; Olaoye, O.O. et al.
Source: Self-asserted source
Yasir S. Raouf via Scopus - Elsevier

PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia

European Journal of Medicinal Chemistry
2020 | Journal article
EID:

2-s2.0-85087006799

Part of ISSN: 17683254 02235234
Contributors: Gawel, J.M.; Shouksmith, A.E.; Raouf, Y.S.; Nawar, N.; Toutah, K.; Bukhari, S.; Manaswiyoungkul, P.; Olaoye, O.O.; Israelian, J.; Radu, T.B. et al.
Source: Self-asserted source
Yasir S. Raouf via Scopus - Elsevier

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

Journal of Medicinal Chemistry
2019 | Journal article
EID:

2-s2.0-85062769820

Part of ISSN: 15204804 00222623
Contributors: Shouksmith, A.E.; Shah, F.; Grimard, M.L.; Gawel, J.M.; Raouf, Y.S.; Geletu, M.; Berger-Becvar, A.; De Araujo, E.D.; Luchman, H.A.; Heaton, W.L. et al.
Source: Self-asserted source
Yasir S. Raouf via Scopus - Elsevier