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Emails & domains

Verified email domains

Websites & social links

Lab Website

Keywords

Aspergillus fumigatus, Fungal pathogenesis, anti fungal drug susceptibility, hypoxia, reactive oxygen species, anti fungal drug development, filamentous fungi, fungal synthetic biology

Countries

United States

Activities

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Employment (5)

Dartmouth College Geisel School of Medicine: Hanover, NH, US

2019-07-01 to present | Professor (Microbiology and Immunology)
Employment
Source: Self-asserted source
Robert Cramer

Dartmouth College Geisel School of Medicine: Hanover, NH, US

2015-02-01 to 2019-06-30 | Associate Professor (Microbiology and Immunology)
Employment
Source: Self-asserted source
Robert Cramer

Dartmouth College Geisel School of Medicine: Hanover, NH, US

2012-08-01 to 2015-02-01 | Assistant Professor (Microbiology and Immunology)
Employment
Source: Self-asserted source
Robert Cramer

Montana State University Bozeman: Bozeman, MT, US

2007-07-01 to 2012-07-31 | Assistant Professor (Immunology and Infectious Diseases)
Employment
Source: Self-asserted source
Robert Cramer

Duke Medical Center: Durham, North Carolina, US

2004-06-22 to 2007-06-30 | Post-Doctoral Fellow (Molecular Genetics and Microbiology)
Employment
Source: Self-asserted source
Robert Cramer

Education and qualifications (3)

Colorado State University: Fort Collins, CO, US

2001-05-21 to 2004-06-01 | PhD (Bioagricultural Sciences and Pest Management)
Education
Source: Self-asserted source
Robert Cramer

Colorado State University: Fort Collins, CO, US

2000-01-01 to 2001-05-20 | MS (Soil and Crop Sciences)
Education
Source: Self-asserted source
Robert Cramer

Lawrence University: Appleton, WI, US

1995-09-20 to 1999-06-15 | BA Biology (Biology)
Education
Source: Self-asserted source
Robert Cramer

Professional activities (3)

Medical Mycological Society of the Americas: New Orleans, LA, US

Membership
Source: Self-asserted source
Robert Cramer

Genetics Society of America: Bethesda, MD, US

Membership
Source: Self-asserted source
Robert Cramer

American Society for Microbiology: Washington D.C., District of Columbia, US

Membership
Source: Self-asserted source
Robert Cramer

Funding (6)

Overcoming Emerging Aspergillus fumigatus Azole Resistance Via Protease Inhibition

2019-02-01 to 2021-01-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.8385240
GRANT_NUMBER: R21AI140878
Source: Self-asserted source
Robert Cramer via DimensionsWizard

Antifungal Immunity and the Mechanism of Fungal Programmed Cell Death

2019-01-22 to 2024-12-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.8384792
GRANT_NUMBER: R01AI139632
Source: Self-asserted source
Robert Cramer via DimensionsWizard

Evolution of Aspergillus fumigatus virulence

2017-09-25 to 2022-08-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.7072465
GRANT_NUMBER: R01AI130128
Source: Self-asserted source
Robert Cramer via DimensionsWizard

Fungal Bioenergetics and Microbial Pathogenesis Sufficiency

2014-07 to 2020-06 | Award
Burroughs Wellcome Fund (Raleigh, NC, US)
GRANT_NUMBER:

BWF1013522

Source: Self-asserted source
Robert Cramer

Hypoxia Adaptation and Fungal Virulence of Aspergillus fumigatus

2009-08-15 to 2019-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2458584
GRANT_NUMBER: R01AI081838
Source: Self-asserted source
Robert Cramer via DimensionsWizard

Center for Zoonotic and Emerging Infectious Diseases

2004-09-29 to 2014-06-30 | Grant
National Center for Advancing Translational Sciences (Rockville, US)
URL: https://app.dimensions.ai/details/grant/grant.2438476
GRANT_NUMBER: P20RR020185
Source: Self-asserted source
Robert Cramer via DimensionsWizard

Works (50 of 83)

Items per page:
Page 1 of 2

An Ssd1 Homolog Impacts Trehalose and Chitin Biosynthesis and Contributes to Virulence in Aspergillus fumigatus.

mSphere
2019-05-08 | Journal article
DOI: 10.1128/mSphere.00244-19
PMID: 31068436
PMC: PMC6506620
Source: Self-asserted source
Robert Cramer

Natamycin and voriconazole exhibit synergistic interactions with non-antifungal ophthalmic agents against Fusarium species ocular isolates.

Antimicrobial Agents and Chemotherapy
2019-04-22 | Journal article
DOI: 10.1128/aac.02505-18
PMID: 31010869
Source: Self-asserted source
Robert Cramer

Characterizing the Pathogenic, Genomic, and Chemical Traits of Aspergillus fischeri, a Close Relative of the Major Human Fungal Pathogen Aspergillus fumigatus.

mSphere
2019-02-20 | Journal article
DOI: 10.1128/mSphere.00018-19
PMID: 30787113
PMC: PMC6382966
Source: Self-asserted source
Robert Cramer

Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in Aspergillus fumigatus.

mBio
2018-12-11 | Journal article
DOI: 10.1128/mBio.01952-18
PMID: 30538182
PMC: PMC6299480
Source: Self-asserted source
Robert Cramer

Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung.

Cancer immunology, immunotherapy : CII
2018-08-23 | Journal article
DOI: 10.1007/s00262-018-2234-9
PMID: 30167860
Source: Self-asserted source
Robert Cramer

Response to Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death".

Science (New York, N.Y.)
2018-06-01 | Journal article
DOI: 10.1126/science.aas9457
PMID: 29930111
Source: Self-asserted source
Robert Cramer

Hyperbaric Oxygen Reduces Aspergillus fumigatus Proliferation In Vitro and Influences In Vivo Disease Outcomes.

Antimicrobial agents and chemotherapy
2018-02-23 | Journal article
DOI: 10.1128/AAC.01953-17
PMID: 29229641
PMC: PMC5826133
Source: Self-asserted source
Robert Cramer

Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses.

Diabetologia
2018-01-14 | Journal article
DOI: 10.1007/s00125-017-4526-6
PMID: 29333574
PMC: PMC6448980
Source: Self-asserted source
Robert Cramer

The effect of reducing agents on challenge of rainbow trout with Aeromonas salmonicida

Journal of fish diseases
2017 | Journal article
Source: Self-asserted source
Robert Cramer

Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi.

Molecular microbiology
2017-12-29 | Journal article
DOI: 10.1111/mmi.13887
PMID: 29197127
PMC: PMC5777862
Source: Self-asserted source
Robert Cramer

Modulation of Immune Signaling and Metabolism Highlights Host and Fungal Transcriptional Responses in Mouse Models of Invasive Pulmonary Aspergillosis.

Scientific reports
2017-12-06 | Journal article
DOI: 10.1038/s41598-017-17000-1
PMID: 29213115
PMC: PMC5719083
Source: Self-asserted source
Robert Cramer

Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death.

Science (New York, N.Y.)
2017-09-01 | Journal article
DOI: 10.1126/science.aan0365
PMID: 28883073
PMC: PMC5628051
Source: Self-asserted source
Robert Cramer

Sniffing out the hypoxia volatile metabolic signature of Aspergillus fumigatus.

Journal of breath research
2017-08-21 | Journal article
DOI: 10.1088/1752-7163/aa7b3e
PMID: 28825403
PMC: PMC5793853
Source: Self-asserted source
Robert Cramer

Aspergillus fumigatus Trehalose-Regulatory Subunit Homolog Moonlights To Mediate Cell Wall Homeostasis through Modulation of Chitin Synthase Activity.

mBio
2017-04-25 | Journal article
DOI: 10.1128/mBio.00056-17
PMID: 28442603
PMC: PMC5405227
Source: Self-asserted source
Robert Cramer

Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression.

PLoS pathogens
2017-04-19 | Journal article
DOI: 10.1371/journal.ppat.1006340
PMID: 28423062
PMC: PMC5411099
Source: Self-asserted source
Robert Cramer

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.

Microbiology and molecular biology reviews : MMBR
2017-03-15 | Journal article
DOI: 10.1128/MMBR.00053-16
PMID: 28298477
PMC: PMC5485801
Source: Self-asserted source
Robert Cramer

Regulation of Sterol Biosynthesis in the Human Fungal Pathogen Aspergillus fumigatus: Opportunities for Therapeutic Development.

Frontiers in microbiology
2017-02-01 | Journal article
DOI: 10.3389/fmicb.2017.00092
PMID: 28203225
PMC: PMC5285346
Source: Self-asserted source
Robert Cramer

7th Advances Against Aspergillosis: Basic, diagnostic, clinical and therapeutic studies.

Medical mycology
2017-01-01 | Journal article
DOI: 10.1093/mmy/myw134
PMID: 27994098
Source: Self-asserted source
Robert Cramer

Host-Derived Leukotriene B4 Is Critical for Resistance against Invasive Pulmonary Aspergillosis.

Frontiers in immunology
2017-01-01 | Journal article
DOI: 10.3389/fimmu.2017.01984
PMID: 29375586
PMC: PMC5768911
Source: Self-asserted source
Robert Cramer

Heterogeneity among isolates reveals that fitness in low oxygen correlates with Aspergillus fumigatus virulence

MBio
2016 | Journal article
Source: Self-asserted source
Robert Cramer

Aspergillus fumigatus virulence through the lens of transcription factors.

Medical mycology
2016-11-05 | Journal article
DOI: 10.1093/mmy/myw120
PMID: 27816905
PMC: PMC6388973
Source: Self-asserted source
Robert Cramer

Functional and Genomic Architecture of Borrelia burgdorferi-Induced Cytokine Responses in Humans.

Cell host & microbe
2016-11-03 | Journal article
DOI: 10.1016/j.chom.2016.10.006
PMID: 27818078
Source: Self-asserted source
Robert Cramer

Aspergillus fumigatus Photobiology Illuminates the Marked Heterogeneity between Isolates.

mBio
2016-09-20 | Journal article
DOI: 10.1128/mBio.01517-16
PMID: 27651362
PMC: PMC5030361
Source: Self-asserted source
Robert Cramer

New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches.

Cytokine
2016-05-30 | Journal article
DOI: 10.1016/j.cyto.2016.05.015
PMID: 27253487
PMC: PMC4904826
Source: Self-asserted source
Robert Cramer

Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans.

Genetics
2016-03-26 | Journal article
DOI: 10.1534/genetics.116.187872
PMID: 27017621
PMC: PMC4858783
Source: Self-asserted source
Robert Cramer

RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus.

mSphere
2016-03-02 | Journal article
DOI: 10.1128/mSphere.00035-16
PMID: 27303716
PMC: PMC4863583
Source: Self-asserted source
Robert Cramer

Role of Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Regulating Neutrophil Antifungal Activity and the Oxidative Burst During Respiratory Fungal Challenge.

The Journal of infectious diseases
2016-02-09 | Journal article
DOI: 10.1093/infdis/jiw054
PMID: 26908736
PMC: PMC4799674
Source: Self-asserted source
Robert Cramer

In vivo veritas: Aspergillus fumigatus proliferation and pathogenesis--conditionally speaking.

Virulence
2016-01-01 | Journal article
DOI: 10.1080/21505594.2015.1134074
PMID: 26695225
PMC: PMC4871685
Source: Self-asserted source
Robert Cramer

Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection

PLoS pathogens
2015 | Journal article
Source: Self-asserted source
Robert Cramer

Characterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic Fungus.

PLoS neglected tropical diseases
2015-12-10 | Journal article
DOI: 10.1371/journal.pntd.0004282
PMID: 26659387
PMC: PMC4686304
Source: Self-asserted source
Robert Cramer

IL-1α signaling is critical for leukocyte recruitment after pulmonary Aspergillus fumigatus challenge.

PLoS pathogens
2015-01-28 | Journal article
DOI: 10.1371/journal.ppat.1004625
PMID: 25629406
PMC: PMC4309569
Source: Self-asserted source
Robert Cramer

ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence.

PLoS pathogens
2014-11-06 | Journal article
DOI: 10.1371/journal.ppat.1004487
PMID: 25375670
PMC: PMC4223079
Source: Self-asserted source
Robert Cramer

Biofilms: five-star accommodations for the aerobically challenged.

Current biology : CB
2014-10-21 | Journal article
DOI: 10.1016/j.cub.2014.09.030
PMID: 25442846
Source: Self-asserted source
Robert Cramer

Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection.

PLoS pathogens
2014-09-25 | Journal article
DOI: 10.1371/journal.ppat.1004378
PMID: 25255025
PMC: PMC4177996
Source: Self-asserted source
Robert Cramer

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

Science (New York, N.Y.)
2014-09-01 | Journal article
DOI: 10.1126/science.1250684
PMID: 25258083
PMC: PMC4226238
Source: Self-asserted source
Robert Cramer

Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus.

Microbiology (Reading, England)
2014-08-08 | Journal article
DOI: 10.1099/mic.0.080440-0
PMID: 25107308
PMC: PMC4219106
Source: Self-asserted source
Robert Cramer

The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess.

The EMBO journal
2014-08-04 | Journal article
DOI: 10.15252/embj.201489468
PMID: 25092765
PMC: PMC4232046
Source: Self-asserted source
Robert Cramer

Large-scale transcriptional response to hypoxia in Aspergillus fumigatus observed using RNAseq identifies a novel hypoxia regulated ncRNA.

Mycopathologia
2014-07-05 | Journal article
DOI: 10.1007/s11046-014-9779-8
PMID: 24996522
PMC: PMC4239182
Source: Self-asserted source
Robert Cramer

Endoplasmic reticulum localized PerA is required for cell wall integrity, azole drug resistance, and virulence in Aspergillus fumigatus.

Molecular microbiology
2014-05-09 | Journal article
DOI: 10.1111/mmi.12626
PMID: 24779420
PMC: PMC4112376
Source: Self-asserted source
Robert Cramer

Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1

PLoS pathogens
2013 | Journal article
Source: Self-asserted source
Robert Cramer

Fungal cell wall dynamics and infection site microenvironments: signal integration and infection outcome

Current opinion in microbiology
2013 | Journal article
Source: Self-asserted source
Robert Cramer

Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation

Microbes and infection
2013 | Journal article
Source: Self-asserted source
Robert Cramer

Aspergillus fumigatus mitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis

Molecular microbiology
2012 | Journal article
Source: Self-asserted source
Robert Cramer

Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi

Frontiers in microbiology
2012 | Journal article
Source: Self-asserted source
Robert Cramer

Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus

Eukaryotic cell
2012 | Journal article
Source: Self-asserted source
Robert Cramer

Hypoxia and fungal pathogenesis: to air or not to air?

Eukaryotic cell
2012 | Journal article
Source: Self-asserted source
Robert Cramer

SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A)

Antimicrobial agents and chemotherapy
2012 | Journal article
Source: Self-asserted source
Robert Cramer

Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter

BMC genomics
2012 | Journal article
Source: Self-asserted source
Robert Cramer

Candida albicans induces arginine biosynthetic genes in response to host-derived reactive oxygen species.

Eukaryotic cell
2012-11-09 | Journal article
DOI: 10.1128/EC.00290-12
PMID: 23143683
PMC: PMC3535846
Source: Self-asserted source
Robert Cramer

HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus

PLoS pathogens
2011 | Journal article
Source: Self-asserted source
Robert Cramer
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