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single-cell and spatial genomics, machine-learning, autoimmunity, cancer biology
Spain

Biography

Elisabetta Mereu obtained a MSc degree in Mathematics at the University of Cagliari (Italy) in 2009. In 2015, she earned a PhD degree in Genetics at the Microcitemico Pediatric Hospital and University of Cagliari. During her PhD, she worked at the Institute of Genetics and Biomedical Research (IRGB, National Research Council - Cagliari, Italy) and at the University of California (UCSF) in the department of Neurology, where her research projects concerned the interrogation of genomic-scale datasets for the identification of genetic mutations and integration of regulatory information in the context of complex diseases susceptibility. In 2016, she started working as computational postdoc at the National Center for Genomic Analysis of Spain (CNAG-CRG, Barcelona). Her research focus is on the analysis and interpretation of data from individual cells to determine the cellular composition of tissues and track transcriptional dynamics in health and disease. She works in a wide range of projects in collaboration with national, international research groups and consortia, such as the Human Cell Atlas and the European Pancreas Cell Atlas ESPACE. She extensively worked on the systematic comparison of single-cell RNA-seq protocols in addition to being familiar with diverse single-cell technologies and their data integration. Her expertise includes the development of machine learning tools as well as other computational methods for the analysis of single-cell genomics data. During her postdoc, she published more than 10 articles, 4 of these as first author, in high-ranked scientific journals including Nature Biotechnology, Nature Aging, Cell reports and Genome Research. Her postdoctoral work was also recognized with a Juan de la Cierva Senior Postdoctoral Fellowship and, more recently with a Ramon y Cajal Fellowship. In 2021, she started as Junior Group Leader of the Cellular Systems Genomics Group at the Josep Carreras Institute in Barcelona.

Activities

Employment (6)

Josep Carreras Leukaemia Research Institute: Barcelona, ES

2021-01-01 to present | Group Leader (Ramon y Cajal Fellow 2021, Cellular Systems Genomics Group)
Employment
Source: Self-asserted source
Elisabetta Mereu

Centre Nacional d'Anàlisi Genòmica (CNAG-CRG): Barcelona, Catalunya, ES

2016-05-15 to 2020-12-31 | Postdoctoral Fellow (Single Cell Genomics Team)
Employment
Source: Self-asserted source
Elisabetta Mereu

Pediatric Hospital Microcitemico for the treatment of Thalassemias: Cagliari, Sardegna, IT

2012-03-01 to 2015-05-05 | PhD student (Statistical Genetics)
Employment
Source: Self-asserted source
Elisabetta Mereu

University of California, San Francisco (UCSF): San Francisco, California, US

2014-10-01 to 2015-04-01 | Visiting PhD student (Neurology Department)
Employment
Source: Self-asserted source
Elisabetta Mereu

Institute of Genetics and Biomedical Research, National Research Council: Cagliari, Sardegna, IT

2013-01-01 to 2014-09-30 | PhD Student (Statistical Genetics)
Employment
Source: Self-asserted source
Elisabetta Mereu

Institute of Populations Genetics, National Research Council: Sassari, Sardegna, IT

2011-04-01 to 2011-10-01 | Data Analyst
Employment
Source: Self-asserted source
Elisabetta Mereu

Education and qualifications (3)

Pediatric Hospital Microcitemico for the treatment of Thalassemias, University of Cagliari: Cagliari, Sardegna, IT: Cagliari, Sardegna, IT

2012-03-01 to 2015-05-05 | PhD Degree (Statistical Genetics)
Education
Source: Self-asserted source
Elisabetta Mereu

University of Cagliari: Cagliari, Sardegna, IT

2007-10-01 to 2009-09-28 | Master of Science Degree (Applied Mathematics)
Education
Source: Self-asserted source
Elisabetta Mereu

University of Cagliari: Cagliari, Sardegna, IT

2002-10-01 to 2007-04-27 | Bachelor's Degree (Mathematics)
Education
Source: Self-asserted source
Elisabetta Mereu

Professional activities (9)

Human Cell Atlas: San Francisco, US

Membership
Source: Self-asserted source
Elisabetta Mereu

ASEICA: Barcelona, ES

Membership
Source: Self-asserted source
Elisabetta Mereu

Ministerio de Ciencia e Innovación: Madrid, ES: Barcelona, ES

2023-01-01 | Ramon y Cajal Fellowship
Distinction
Source: Self-asserted source
Elisabetta Mereu

European Bioconductor meeting 2019: Brussels, BE

2019-12 to 2019-12 | Invited Speaker
Invited position
Source: Self-asserted source
Elisabetta Mereu

The Chan Zuckerberg Initiative: Toronto, CA

2019-08 to 2019-08 | Travel Grant (CZI Seed Networks kick off meeting, 2019)
Invited position
Source: Self-asserted source
Elisabetta Mereu

Ministerio de Ciencia e Innovación: Madrid, ES

2019 | Juan de la Cierva Incorporación Fellowship
Distinction
Source: Self-asserted source
Elisabetta Mereu

The Chan Zuckerberg Initiative: Aptos, CA, US

2018-04 to 2018-04 | Travel Grant (Collaborative Computational Tools for the Human Cell Atlas)
Invited position
Source: Self-asserted source
Elisabetta Mereu

Ascona Workshop 2017: Monte Verita, Ascona, CH

2017-05 | Conference Bursary Award (Statistical Challenges in single-cell biology)
Distinction
Source: Self-asserted source
Elisabetta Mereu

University of Cagliari: Cagliari, IT

2012 | PhD Fellowship (Medical Genetics)
Distinction
Source: Self-asserted source
Elisabetta Mereu

Works (21)

The Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions

Nature Communications
2025-01-16 | Journal article
Contributors: Ricardo Martins-Ferreira; Josep Calafell-Segura; Bárbara Leal; Javier Rodríguez-Ubreva; Elena Martínez-Saez; Elisabetta Mereu; Paulo Pinho E Costa; Ariadna Laguna; Esteban Ballestar
Source: check_circle
Crossref

Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B cell neoplasias

Cell Reports Medicine
2024-11 | Journal article
Part of ISSN: 2666-3791
Contributors: Mercedes Guerrero-Murillo; Aina Rill-Hinarejos; Juan L. Trincado; Alex Bataller; Valentín Ortiz-Maldonado; Daniel Benítez-Ribas; Marta Español-Rego; E Azucena González-Navarro; Nuria Martínez-Cibrián; Doménica Marchese et al.
Source: Self-asserted source
Elisabetta Mereu

Single-cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy

Cancer Research Communications
2024-02-12 | Journal article
Contributors: Ignacio Campillo-Marcos; Marta Casado-Pelaez; Veronica Davalos; Gerardo Ferrer; Caterina Mata; Elisabetta Mereu; Gael Roué; David Valcárcel; Antonieta Molero; Lurdes Zamora et al.
Source: check_circle
Crossref

The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions

2023-08-14 | Preprint
Contributors: Esteban Ballestar; Ricardo Martins-Ferreira; Josep Calafell-Segura; Bárbara Leal; Javier Rodríguez-Ubreva; Elisabetta Mereu; Paulo Pinho e Costa
Source: check_circle
Crossref

Targeting lymphoid-derived IL-17 signaling to delay skin aging

Nature Aging
2023-06-08 | Journal article
Contributors: Paloma Solá; Elisabetta Mereu; Júlia Bonjoch; Marta Casado-Peláez; Neus Prats; Mònica Aguilera; Oscar Reina; Enrique Blanco; Manel Esteller; Luciano Di Croce et al.
Source: check_circle
Crossref

Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin

Cell Reports
2023-05 | Journal article
Contributors: Claudia Garcia-Diaz; Anni Pöysti; Elisabetta Mereu; Melanie P. Clements; Lucy J. Brooks; Felipe Galvez-Cancino; Simon P. Castillo; Wenhao Tang; Gordon Beattie; Lilas Courtot et al.
Source: check_circle
Crossref

A single-cell tumor immune atlas for precision oncology

Genome Research
2021-10 | Journal article
Part of ISSN: 1088-9051
Part of ISSN: 1549-5469
Source: Self-asserted source
Elisabetta Mereu

Single-cell technologies and analyses in hematopoiesis and hematological malignancies

Experimental Hematology
2021-06 | Journal article
Part of ISSN: 0301-472X
Source: Self-asserted source
Elisabetta Mereu

SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes.

Nucleic acids research
2021-02-05 | Journal article
Source: Self-asserted source
Elisabetta Mereu

Improved Diagnosis of Rare Disease Patients through Systematic Detection of Runs of Homozygosity

The Journal of Molecular Diagnostics
2020-09 | Journal article
Part of ISSN: 1525-1578
Source: Self-asserted source
Elisabetta Mereu
grade
Preferred source (of 2)‎

Immune Cell Associations with Cancer Risk

iScience
2020-07 | Journal article
Part of ISSN: 2589-0042
Source: Self-asserted source
Elisabetta Mereu

Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer

Cell Stem Cell
2020-06 | Journal article
Part of ISSN: 1934-5909
Source: Self-asserted source
Elisabetta Mereu

Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects

Nature Biotechnology
2020-04-06 | Journal article
Source: Self-asserted source
Elisabetta Mereu

Robustness and applicability of functional genomics tools on scRNA-seq data

Genome Biology
2020-02-12 | Journal article
Source: Self-asserted source
Elisabetta Mereu

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm

Stem Cell Reports
2019-09 | Journal article
Part of ISSN: 2213-6711
Source: Self-asserted source
Elisabetta Mereu

bigSCale: an analytical framework for big-scale single-cell data

Genome Research
2018-06 | Journal article
Part of ISSN: 1088-9051
Part of ISSN: 1549-5469
Source: Self-asserted source
Elisabetta Mereu

Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC)

Annals of Oncology
2017 | Journal article
EID:

2-s2.0-85030527025

Contributors: Martinez-Marti, A.; Felip, E.; Matito, J.; Mereu, E.; Navarro, A.; Cedrés, S.; Pardo, N.; de Castro, A.M.; Remon, J.; Miquel, J.M. et al.
Source: Self-asserted source
Elisabetta Mereu via Scopus - Elsevier

Single-cell transcriptome conservation in cryopreserved cells and tissues

Genome Biology
2017 | Journal article
EID:

2-s2.0-85014353565

Contributors: Guillaumet-Adkins, A.; Rodríguez-Esteban, G.; Mereu, E.; Mendez-Lago, M.; Jaitin, D.A.; Villanueva, A.; Vidal, A.; Martinez-Marti, A.; Felip, E.; Vivancos, A. et al.
Source: Self-asserted source
Elisabetta Mereu via Scopus - Elsevier

TRIM28 and Interacting KRAB-ZNFs Control Self-Renewal of Human Pluripotent Stem Cells through Epigenetic Repression of Pro-differentiation Genes

Stem Cell Reports
2017-12 | Journal article
Part of ISSN: 2213-6711
Source: Self-asserted source
Elisabetta Mereu
grade
Preferred source (of 2)‎

A genetic score for the prediction of beta-thalassemia severity

Haematologica
2015 | Journal article
EID:

2-s2.0-84926314486

Contributors: Danjou, F.; Francavilla, M.; Anni, F.; Satta, S.; Demartis, F.-R.; Perseu, L.; Manca, M.; Sollaino, M.C.; Manunza, L.; Mereu, E. et al.
Source: Self-asserted source
Elisabetta Mereu via Scopus - Elsevier

Differences in the erythropoiesis-hepcidin-iron store axis between hemoglobin H disease and β-thalassemia intermedia

Haematologica
2015 | Journal article
EID:

2-s2.0-84928493089

Contributors: Origa, R.; Cazzola, M.; Mereu, E.; Danjou, F.; Barella, S.; Giagu, N.; Galanello, R.; Swinkels, D.W.
Source: Self-asserted source
Elisabetta Mereu via Scopus - Elsevier

Peer review (7 reviews for 5 publications/grants)

Review activity for Genome biology. (3)
Review activity for Life science alliance. (1)
Review activity for Nature (1)
Review activity for Nature biotechnology. (1)
Review activity for Nature communications (1)