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Systems Biology, Bioinformatics, Systems Medicine, Systems Theory, Mathematical Modelling, Biomedicine
Germany

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Employment (1)

University of Rostock: Rostock, Mecklenburg-Vorpommern, DE

2004 to present | Professor (Dept. of Systems Biology & Bioinformatics)
Employment
Source: Self-asserted source
Olaf Wolkenhauer

Works (50 of 165)

Items per page:
Page 1 of 4

The role of epigenetic modifications for the pathogenesis of Crohn's disease

Clinical Epigenetics
2021-12 | Journal article
Contributors: M. Hornschuh; E. Wirthgen; M. Wolfien; K. P. Singh; O. Wolkenhauer; J. Däbritz
Source: check_circle
Crossref

Network- and Enrichment-based Inference of Phenotypes and Targets from large-scale Disease Maps

2021-09-15 | Other
Contributors: Matti Hoch; Suchi Smita; Konstantin Cesnulevicius; David Lescheid; Myron Schultz; Olaf Wolkenhauer; Shailendra Gupta
Source: check_circle
Crossref

AMES: Automated evaluation of sarcomere structures in cardiomyocytes

2021-08-08 | Other
Contributors: Maximilian Hillemanns; Heiko Lemcke; Robert David; Thomas Martinetz; Markus Wolfien; Olaf Wolkenhauer
Source: check_circle
Crossref

Are all models wrong?

Computational and Systems Oncology
2021-03 | Journal article
Contributors: Heiko Enderling; Olaf Wolkenhauer
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Crossref

LoRAS: an oversampling approach for imbalanced datasets

Machine Learning
2021-02-12 | Journal article
Contributors: Saptarshi Bej; Narek Davtyan; Markus Wolfien; Mariam Nassar; Olaf Wolkenhauer
Source: check_circle
Crossref

Automated annotation of rare-cell types from single-cell RNA-sequencing data through synthetic oversampling

2021-01-21 | Preprint
Contributors: Saptarshi Bej; Anne-Marie Galow; Robert David; Markus Wolfien; Olaf Wolkenhauer
Source: check_circle
Crossref

Identification and Epidemiological Characterization of Non-obese Type 2 Diabetic Sub-populations in the NFHS-4 Study using an Unsupervised Machine Learning Approach

2020-09-22 | Other
Contributors: Saptarshi Bej; Jit Sarkar; Saikat Biswas; Pabitra Mitra; Partha Chakrabarti; Olaf Wolkenhauer
Source: check_circle
Crossref

The timing of contact restrictions and pro-active testing balances the socio-economic impact of a lockdown with the control of infections

2020-05-13 | Other
Contributors: Saptarshi Bej; Olaf Wolkenhauer
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Crossref

Omics integration analyses reveal the early evolution of malignancy in breast cancer

2020-04-11 | Preprint
Contributors: Shamim Sarhadi; Ali Salehzadeh-Yazdi; Mehdi Damaghi; Nosratallah Zarghami; Olaf Wolkenhauer; Hedayatollah Hosseini
Source: check_circle
Crossref

GEMtractor: Extracting Views into Genome-scale Metabolic Models

2019-10-02 | Other
Contributors: Martin Scharm; Olaf Wolkenhauer; Mahdi Jalili; Ali Salehzadeh-Yazdi
Source: check_circle
Crossref

Pathway maps enable straightforward yet customized and semi-automated yet insightful analyses of omics data

2018-09-24 | Other
Contributors: Steffen Möller; Israel Barrantes; Robert Jaster; Larissa Henze; Hugo Murua Escobar; Christian Junghanss; Oliver Hakenberg; Marc-André Weber; Bernd J. Krause; Olaf Wolkenhauer et al.
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Crossref

Quick tips for creating effective and impactful biological pathways using the Systems Biology Graphical Notation

PLOS Computational Biology
2018-02-15 | Journal article
Contributors: Vasundra Touré; Francis Ouellette; Nicolas Le Novère; Dagmar Waltemath; Olaf Wolkenhauer
Source: check_circle
Crossref

A systematic survey of centrality measures for protein-protein interaction networks

2017-06-13 | Preprint
Contributors: Minoo Ashtiani; Ali Salehzadeh-Yazdi; Zahra Razaghi-Moghadam; Holger Hennig; Olaf Wolkenhauer; Mehdi Mirzaie; Mohieddin Jafari
Source: check_circle
Crossref

Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice

2014 | Journal article
DOI:

10.1371/journal.pone.0094494

EID:

2-s2.0-84899560216

Contributors: Müller, S.; Kaiser, H.; Krüger, B.; Fitzner, B.; Lange, F.; Bock, C.N.; Nizze, H.; Ibrahim, S.M.; Fuellen, G.; Wolkenhauer, O. et al.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin

2014 | Journal article
DOI:

10.1002/path.4400

EID:

2-s2.0-84906532371

Contributors: Meier, C.; Spitschak, A.; Abshagen, K.; Gupta, S.; Mor, J.M.; Wolkenhauer, O.; Haier, J.; Vollmar, B.; Alla, V.; Pützer, B.M.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum-evidence from a mathematical model

2014 | Journal article
DOI:

10.1007/s00253-014-5987-x

EID:

2-s2.0-84906167897

Contributors: Millat, T.; Voigt, C.; Janssen, H.; Cooksley, C.M.; Winzer, K.; Minton, N.P.; Bahl, H.; Fischer, R.-J.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Cooperative gene regulation by microRNA pairs and their identification using a computational workflow

2014 | Journal article
DOI:

10.1093/nar/gku465

EID:

2-s2.0-84904016399

Contributors: Schmitz, U.; Lai, X.; Winter, F.; Wolkenhauer, O.; Vera, J.; Gupta, S.K.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Enabling multiscale modeling in systems medicine

2014 | Journal article
DOI:

10.1186/gm538

EID:

2-s2.0-84898808114

Contributors: Wolkenhauer, O.; Auffray, C.; Brass, O.; Clairambault, J.; Deutsch, A.; Drasdo, D.; Gervasio, F.; Preziosi, L.; Maini, P.; Marciniak-Czochra, A. et al.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Glucose de-repression by yeast AMP-activated protein kinase SNF1 is controlled via at least two independent steps

2014 | Journal article
DOI:

10.1111/febs.12753

EID:

2-s2.0-84897480343

Contributors: García-Salcedo, R.; Lubitz, T.; Beltran, G.; Elbing, K.; Tian, Y.; Frey, S.; Wolkenhauer, O.; Krantz, M.; Klipp, E.; Hohmann, S.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Hybrid modeling of the crosstalk between signaling and transcriptional networks using ordinary differential equations and multi-valued logic

2014 | Journal article
DOI:

10.1016/j.bbapap.2013.05.007

EID:

2-s2.0-84890126626

Contributors: Khan, F.M.; Schmitz, U.; Nikolov, S.; Engelmann, D.; Pützer, B.M.; Wolkenhauer, O.; Vera, J.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching

2014 | Journal article
DOI:

10.1111/acel.12226

EID:

2-s2.0-84904886674

Contributors: Moeller, M.; Hirose, M.; Mueller, S.; Roolf, C.; Baltrusch, S.; Ibrahim, S.; Junghanss, C.; Wolkenhauer, O.; Jaster, R.; Köhling, R. et al.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

The systems biology of mitochondrial fission and fusion and implications for disease and aging

2014 | Journal article
DOI:

10.1007/s10522-013-9474-z

EID:

2-s2.0-84893847881

Contributors: Chauhan, A.; Vera, J.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Tumors as chaotic attractors

2014 | Journal article
DOI:

10.1039/c3mb70331b

EID:

2-s2.0-84891383496

Contributors: Nikolov, S.; Wolkenhauer, O.; Vera, J.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Why model?

2014 | Journal article
DOI:

10.3389/fphys.2014.00021

EID:

2-s2.0-84893498674

Contributors: Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Pushing limits by embracing complexity

IET Systems Biology
2014-12 | Journal article
Contributors: Olaf Wolkenhauer
Source: check_circle
Crossref

A shift in the dominant phenotype governs the pH-induced metabolic switch of Clostridium acetobutylicumin phosphate-limited continuous cultures

2013 | Journal article
DOI:

10.1007/s00253-013-4860-7

EID:

2-s2.0-84879840909

Contributors: Millat, T.; Janssen, H.; Thorn, G.J.; King, J.R.; Bahl, H.; Fischer, R.-J.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

A systems' biology approach to study microrna-mediated gene regulatory networks

2013 | Journal article
DOI:

10.1155/2013/703849

EID:

2-s2.0-84890019107

Contributors: Lai, X.; Bhattacharya, A.; Schmitz, U.; Kunz, M.; Vera, J.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Analysing the impact of nucleo-cytoplasmic shuttling of β-catenin and its antagonists APC, Axin and GSK3 on Wnt/β-catenin signalling

2013 | Journal article
DOI:

10.1016/j.cellsig.2013.07.005

EID:

2-s2.0-84882636723

Contributors: Schmitz, Y.; Rateitschak, K.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Do simple models lead to generality in ecology?

2013 | Journal article
DOI:

10.1016/j.tree.2013.05.022

EID:

2-s2.0-84884351044

Contributors: Evans, M.R.; Grimm, V.; Johst, K.; Knuuttila, T.; de Langhe, R.; Lessells, C.M.; Merz, M.; O'Malley, M.A.; Orzack, S.H.; Weisberg, M. et al.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Improving the reuse of computational models through version control

2013 | Journal article
DOI:

10.1093/bioinformatics/btt018

EID:

2-s2.0-84875175386

Contributors: Waltemath, D.; Henkel, R.; Hälke, R.; Scharm, M.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Integrative modelling of pH-dependent enzyme activity and transcriptomic regulation of the acetone-butanol-ethanol fermentation of Clostridium acetobutylicum in continuous culture

2013 | Journal article
DOI:

10.1111/1751-7915.12033

EID:

2-s2.0-84879843202

Contributors: Millat, T.; Janssen, H.; Bahl, H.; Fischer, R.-J.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Kinetic modeling-based detection of genetic signatures that provide chemoresistance via the E2F1-p73/DNp73-miR-205 network

2013 | Journal article
DOI:

10.1158/0008-5472.CAN-12-4095

EID:

2-s2.0-84879088218

Contributors: Vera, J.; Schmitz, U.; Lai, X.; Engelmann, D.; Khan, F.M.; Wolkenhauer, O.; Pützer, B.M.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

MicroRNA-regulated networks: The Perfect Storm for classical molecular biology, the Ideal Scenario for systems biology

2013 | Book
DOI:

10.1007/978-94-007-5590-1-4

EID:

2-s2.0-84890124612

Contributors: Vera, J.; Lai, X.; Schmitz, U.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology.

2013 | Journal article
DOI:

10.1007/978-94-007-5590-1_4

EID:

2-s2.0-84878789629

Contributors: Vera, J.; Lai, X.; Schmitz, U.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Phosphoglycerate Mutases Function as Reverse Regulated Isoenzymes in Synechococcus elongatus PCC 7942

2013 | Journal article
DOI:

10.1371/journal.pone.0058281

EID:

2-s2.0-84874601568

Contributors: Jablonsky, J.; Hagemann, M.; Schwarz, D.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Preface

2013 | Book
DOI:

10.1007/978-94-007-5590-1

EID:

2-s2.0-84892949247

Contributors: Schmitz, U.; Wolkenhauer, O.; Vera, J.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma

2013 | Journal article
DOI:

10.1038/onc.2012.324

EID:

2-s2.0-84879687956

Contributors: Bhattacharya, A.; Schmitz, U.; Wolkenhauer, O.; Schönherr, M.; Raatz, Y.; Kunz, M.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Reverse Engineering of Biochemical Reaction Networks Using Co-evolution with Eng-Genes

2013 | Journal article
DOI:

10.1007/s12559-012-9159-y

EID:

2-s2.0-84874568936

Contributors: Gormley, P.; Li, K.; Wolkenhauer, O.; Irwin, G.W.; Du, D.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Simulations of stressosome activation emphasize allosteric interactions between RsbR and RsbT

2013 | Journal article
DOI:

10.1186/1752-0509-7-3

EID:

2-s2.0-84872150231

Contributors: Liebal, U.W.; Millat, T.; Marles-Wright, J.; Lewis, R.J.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Systems biology and pediatric research

2013 | Journal article
DOI:

10.1038/pr.2013.33

EID:

2-s2.0-84877326832

Contributors: Minoo, P.; Wolkenhauer, O.; Guttentag, S.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

The road from systems biology to systems medicine

2013 | Journal article
DOI:

10.1038/pr.2013.4

EID:

2-s2.0-84877329448

Contributors: Wolkenhauer, O.; Auffray, C.; Jaster, R.; Steinhoff, G.; Dammann, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

The role of theory and modeling in medical research

2013 | Journal article
DOI:

10.3389/fphys.2013.00377

EID:

2-s2.0-84891665549

Contributors: Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

The search for organizing principles as a cure against reductionism in systems medicine

2013 | Journal article
DOI:

10.1111/febs.12311

EID:

2-s2.0-84888295655

Contributors: Wolkenhauer, O.; Green, S.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Tracing organizing principles: learning from the history of systems biology.

2013 | Journal article
EID:

2-s2.0-84900410255

Contributors: Green, S.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Web resources for microRNA research

2013 | Book
DOI:

10.1007/978-94-007-5590-1-12

EID:

2-s2.0-84892910481

Contributors: Schmitz, U.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Web resources for microRNA research.

2013 | Journal article
DOI:

10.1007/978-94-007-5590-1_12

EID:

2-s2.0-84878789045

Contributors: Schmitz, U.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

A frequency-based gene selection method to identify robust biomarkers for radiation dose prediction

2012 | Journal article
DOI:

10.3109/09553002.2012.638358

EID:

2-s2.0-84857823582

Contributors: Boldt, S.; Knops, K.; Kriehuber, R.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Analysis of cell adhesion during early stages of colon cancer based on an extended multi-valued logic approach

2012 | Journal article
DOI:

10.1039/c2mb05277f

EID:

2-s2.0-84858013992

Contributors: Guebel, D.V.; Schmitz, U.; Wolkenhauer, O.; Vera, J.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs

2012 | Journal article
DOI:

10.1093/nar/gks657

EID:

2-s2.0-84867499417

Contributors: Lai, X.; Schmitz, U.; Gupta, S.K.; Bhattacharya, A.; Kunz, M.; Wolkenhauer, O.; Vera, J.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier

Diagrams as locality aids for explanation and model construction in cell biology

2012 | Journal article
DOI:

10.1007/s10539-012-9311-9

EID:

2-s2.0-84865409690

Contributors: Jones, N.; Wolkenhauer, O.
Source: Self-asserted source
Olaf Wolkenhauer via Scopus - Elsevier
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