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Scopus Author ID: 9735215400
Loop profile: 923520
Researcher Name Resolver ID: 1000010431892

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Employment (6)

Teikyo University: Tokyo, JP

2021-07-01 to present | Senior Assistant Professor (Faculty of Pharma-Science)
Employment
Source: Self-asserted source
Genta Ito

University of Tokyo: Tokyo, JP

2018-09-01 to 2021-06-30 | Project Lecturer (Graduate School of Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Genta Ito

University of Tokyo: Tokyo, JP

2016-07-16 to 2017-08-31 | Project Assistant Professor (Graduate School of Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Genta Ito

University of Dundee: Dundee, GB

2013-08-02 to 2016-06-30 | Postdoctoral Research Assistant (MRC Protein Phosphorylation and Ubiquitylation Unit)
Employment
Source: Self-asserted source
Genta Ito

University of Tokyo: Tokyo, JP

2008-04-01 to 2013-07-31 | Research Associate (Graduate School of Medicine)
Employment
Source: Self-asserted source
Genta Ito

University of Tokyo: Tokyo, JP

2006-04-01 to 2008-03-31 | Research Associate (Graduate School of Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Genta Ito

Education and qualifications (4)

Ministry of Health, Labour and Welfare: Tokyo, JP

2003-10-24 to present | Registered Pharmacist
Qualification
Source: Self-asserted source
Genta Ito

University of Tokyo: Tokyo, JP

2005-04-01 to 2010-03-31 | PhD (Graduate School of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Genta Ito

University of Tokyo: Tokyo, JP

2003-04-01 to 2005-03-31 | MSc (Graduate School of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Genta Ito

University of Tokyo: Tokyo, JP

1999-04-01 to 2003-03-31 | BSc (School of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Genta Ito

Works (32)

Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons

Translational Psychiatry
2024-10-23 | Journal article | Author
DOI: 10.1038/s41398-024-03167-5
Part of ISSN: 2158-3188
Contributors: Fumiaki Yoshida; Ryota Nagatomo; Shun Utsunomiya; Misaki Kimura; Shiyori Shun; Rena Kono; Yuma Kato; Yosuke Nao; Kazuma Maeda; Ryuta Koyama et al.
Source: Self-asserted source
Genta Ito

Effects of bound nucleotides on the secondary structure, thermal stability, and phosphorylation of Rab3A

Biochemical and Biophysical Research Communications
2024-09 | Journal article | Author
DOI: 10.1016/j.bbrc.2024.150199
Part of ISSN: 0006-291X
Contributors: Genta Ito; Taisuke Tomita; Naoko Utsunomiya-Tate
Source: Self-asserted source
Genta Ito

LRRK2-mediated phosphorylation and thermal stability of Rab12 are regulated by bound nucleotides

Biochemical and Biophysical Research Communications
2023-07 | Journal article | Author
DOI: 10.1016/j.bbrc.2023.05.048
Part of ISSN: 0006-291X
Contributors: Genta Ito; Taisuke Tomita; Naoko Utsunomiya-Tate
Source: Self-asserted source
Genta Ito

Overview of the Impact of Pathogenic LRRK2 Mutations in Parkinson’s Disease

Biomolecules
2023-05 | Journal article | Author
DOI: 10.3390/biom13050845
Contributors: Genta Ito; Naoko Utsunomiya-Tate
Source: check_circle
Multidisciplinary Digital Publishing Institute

Pathogenic <scp>LRRK2</scp> compromises the subcellular distribution of lysosomes in a <scp>Rab12‐RILPL1</scp>‐dependent manner

The FASEB Journal
2023-05 | Journal article | Author
DOI: 10.1096/fj.202200780rr
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Contributors: Kyohei Ito; Miho Araki; Yuta Katai; Yuki Nishimura; Sota Imotani; Haruki Inoue; Genta Ito; Taisuke Tomita
Source: Self-asserted source
Genta Ito

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

iScience
2023-04 | Journal article
DOI: 10.1016/j.isci.2023.106375
Part of ISSN: 2589-0042
Contributors: Akihiro Iguchi; Sho Takatori; Shingo Kimura; Hiroki Muneto; Kai Wang; Hayato Etani; Genta Ito; Haruaki Sato; Yukiko Hori; Junko Sasaki et al.
Source: Self-asserted source
Genta Ito

Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency

Biochemical and Biophysical Research Communications
2023-04 | Journal article | Author
DOI: 10.1016/j.bbrc.2023.02.073
Part of ISSN: 0006-291X
Contributors: Takuya Murata; Genta Ito; Naoko Utsunomiya-Tate
Source: Self-asserted source
Genta Ito

The atypical Rab GTPase associated with Parkinson’s disease, Rab29, is localized to membranes

Journal of Biological Chemistry
2022-09 | Journal article
DOI: 10.1016/j.jbc.2022.102499
Part of ISSN: 0021-9258
Contributors: Genta Ito
Source: Self-asserted source
Genta Ito

The Regulation of Rab GTPases by Phosphorylation

Biomolecules
2021-09 | Journal article | Author
DOI: 10.3390/biom11091340
Contributors: Lejia Xu; Yuki Nagai; Yotaro Kajihara; Genta Ito; Taisuke Tomita
Source: check_circle
Multidisciplinary Digital Publishing Institute

BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice

Human Molecular Genetics
2021-06-02 | Journal article
DOI: 10.1093/hmg/ddab146
Part of ISSN: 0964-6906
Part of ISSN: 1460-2083
Source: Self-asserted source
Genta Ito

Interrogating Parkinson’s disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

Biochemical Journal
2018 | Journal article
DOI: 10.1042/BCJ20170803
EID:

2-s2.0-85046120944

Part of ISBN:

14708728 02646021
Contributors: Fan, Y.; Howden, A.J.M.; Sarhan, A.R.; Lis, P.; Ito, G.; Martinez, T.N.; Brockmann, K.; Gasser, T.; Alessi, D.R.; Sammler, E.M.
Source: Self-asserted source
Genta Ito via Scopus - Elsevier

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
DOI: 10.1073/pnas.1812196115
EID:

2-s2.0-85054031920

Part of ISBN:

10916490 00278424
Contributors: Eguchi, T.; Kuwahara, T.; Sakurai, M.; Komori, T.; Fujimoto, T.; Ito, G.; Yoshimura, S.-I.; Harada, A.; Fukuda, M.; Koike, M. et al.
Source: Self-asserted source
Genta Ito via Scopus - Elsevier

Physiological and pathological functions of LRRK2: implications from substrate proteins.

Neuronal signaling
2018-10-10 | Journal article
DOI: 10.1042/ns20180005
PMID: 32714591
PMC: PMC7373236
Source: Self-asserted source
Genta Ito

Rab10 phosphorylation detection by LRRK2 activity using SDS-PAGE with a phosphate-binding tag

Journal of Visualized Experiments
2017 | Journal article
DOI: 10.3791/56688
EID:

2-s2.0-85037662009

Part of ISBN:

1940087X
Contributors: Ito, G.; Tomita, T.
Source: Self-asserted source
Genta Ito via Scopus - Elsevier

Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases

eLife
2016 | Journal article
DOI: 10.7554/eLife.12813.001
EID:

2-s2.0-84958567797
Contributors: Steger, M.; Tonelli, F.; Ito, G.; Davies, P.; Trost, M.; Vetter, M.; Wachter, S.; Lorentzen, E.; Duddy, G.; Wilson, S. et al.
Source: Self-asserted source
Genta Ito via Scopus - Elsevier

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

The Biochemical journal
2016-07 | Journal article
DOI: 10.1042/BCJ20160557
PMID: 27474410
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor

ACS Medicinal Chemistry Letters
2015 | Journal article
DOI: 10.1021/acsmedchemlett.5b00064
PMID: 26005538
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Structural characterization of LRRK2 inhibitors

Journal of Medicinal Chemistry
2015 | Journal article
DOI: 10.1021/jm5018779
PMID: 25897865
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Lack of Correlation between the Kinase Activity of LRRK2 Harboring Kinase-Modifying Mutations and Its Phosphorylation at Ser910, 935, and Ser955

PloS one
2014-05 | Journal article
DOI: 10.1371/journal.pone.0097988
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Differential Effects of Familial Parkinson Mutations in LRRK2 Revealed by a Systematic Analysis of Autophosphorylation.

Biochemistry
2013-08 | Journal article
DOI: 10.1021/bi400596m
PMID: 23924436
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Phosphorylation of alpha-synuclein at Ser129 reduces neuronal dysfunction by lowering its membrane-binding property in Caenorhabditis elegans

The Journal of Biological Chemistry
2012 | Journal article
DOI: 10.1074/jbc.M111.237131
PMID: 22232559
ISBN: 8135841361
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form.

The Biochemical journal
2012-03 | Journal article
DOI: 10.1042/BJ20111215
PMID: 22047502
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Identification of the autophosphorylation sites of LRRK2.

Biochemistry
2009-11 | Journal article
DOI: 10.1021/bi9011379
PMID: 19824698
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1

Neuroscience Letters
2008 | Journal article
DOI: 10.1016/j.neulet.2007.10.019
EID:

2-s2.0-37549029702
Contributors: Takatori, S.; Ito, G.; Iwatsubo, T.
Source: Self-asserted source
Genta Ito via Scopus - Elsevier

Leucine-rich repeat kinase 2 colocalizes with α-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies

Neurodegenerative Diseases
2008 | Journal article
DOI: 10.1159/000113708
EID:

2-s2.0-40449088676
Contributors: Perry, G.; Zhu, X.; Babar, A.K.; Siedlak, S.L.; Yang, Q.; Ito, G.; Iwatsubo, T.; Smith, M.A.; Chen, S.G.
Source: Self-asserted source
Genta Ito via Scopus - Elsevier

Lewy body pathology involves cutaneous nerves.

Journal of neuropathology and experimental neurology
2008 | Journal article
DOI: 10.1097/NEN.0b013e318186de48
PMID: 18800013
ISBN:

0022-3069 (Print)$\backslash$n0022-3069 (Linking)
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.

The Journal of neuroscience
2007-12 | Journal article
DOI: 10.1523/JNEUROSCI.4244-07.2007
PMID: 18045903
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

Analysis of the Adrenal Gland Is Useful for Evaluating Pathology of the Peripheral Autonomic Nervous System in Lewy Body Disease

Journal of Neuropathology and Experimental Neurology
2007-05 | Journal article
DOI: 10.1097/nen.0b013e3180517454
PMID: 17483692
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.

Biochemistry
2007-02 | Journal article
DOI: 10.1021/bi061960m
PMID: 17260967
Source: Self-asserted source
Genta Ito
grade
Preferred source (of 2)‎

LRRK2 in Parkinson's disease and dementia with Lewy bodies

Molecular Neurodegeneration
2006 | Journal article
DOI: 10.1186/1750-1326-1-17
EID:

2-s2.0-34248206600
Contributors: Zhu, X.; Babar, A.; Siedlak, S.L.; Yang, Q.; Ito, G.; Iwatsubo, T.; Smith, M.A.; Perry, G.; Chen, S.G.
Source: Self-asserted source
Genta Ito via Scopus - Elsevier

Roles of distinct cysteine residues in S-nitrosylation and dimerization of DJ-1

Biochemical and Biophysical Research Communications
2006 | Journal article
DOI: 10.1016/j.bbrc.2005.11.058
EID:

2-s2.0-28444433110
Contributors: Ito, G.; Ariga, H.; Nakagawa, Y.; Iwatsubo, T.
Source: Self-asserted source
Genta Ito via Scopus - Elsevier

Pathogenesis of Parkinson's disease: Implications from familial Parkinson's disease

Clinical Neurology
2005 | Journal article
EID:

2-s2.0-31544477143
Contributors: Iwatsubo, T.; Ito, G.; Takatori, S.; Hannno, Y.; Kuwahara, T.
Source: Self-asserted source
Genta Ito via Scopus - Elsevier

Peer review (25 reviews for 13 publications/grants)

Review activity for Biomolecules. (5)
Review activity for Cells. (5)
Review activity for Drug discovery today. (1)
Review activity for Expert opinion on therapeutic targets (1)
Review activity for International journal of molecular sciences. (2)
Review activity for iScience. (1)
Review activity for Life science alliance. (1)
Review activity for Molecular brain (1)
Review activity for Molecular neurodegeneration (2)
Review activity for NPJ Parkinson's disease. (3)
Review activity for Protein science. (1)
Review activity for Scientific reports. (1)
Review activity for Small GTPases. (1)
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