Personal information

DNA damage, DNA repair, Mutagenesis
Japan

Activities

Employment (5)

Fukuoka University: Fukuoka, JP

2017-04-01 to present | Professor
Employment
Source: Self-asserted source
Isao Kuraoka

Osaka University: Toyonaka, JP

2008-04-01 to 2017-03-31 | Associate Professor
Employment
Source: Self-asserted source
Isao Kuraoka

National Hospital Organization Kyushu Cancer Center: Fukuoka, JP

2006-04-01 to 2008-03-31 | Principal investigator
Employment
Source: Self-asserted source
Isao Kuraoka

Osaka University: Suita, JP

2001-04-01 to 2006-03-31 | Assistant Professor
Employment
Source: Self-asserted source
Isao Kuraoka

London Research Institute Clare Hall Laboratories: South Mimms, Hertfordshire, GB

1996-09-01 to 2001-03-31 | Postdoctoral fellow
Employment
Source: Self-asserted source
Isao Kuraoka

Education and qualifications (1)

Osaka University: Suita, JP

1992-04-01 to 1996-03-31 | Ph.D
Education
Source: Self-asserted source
Isao Kuraoka

Funding (15)

転写と共役したDNA鎖切断修復機構の解明

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Mechanisms and functions of i-RNase activity

2014-04-01 to 2016-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: grant.26650006
Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Alternative DNA repair pathways of DNA damage induced by topoisomerase inhibitor

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Formulation of parameters for quantitative definition of the vitality of human cells and evaluation of their life-span

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Why are microsatellites unstable?

2010-01-01 to 2012-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: grant.22570010
Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Detection and analysis of DNA repair using chemically-synthesized DNA sensors

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Analysis of DNA damage avoidance systems by RNA polymerase II on transcription elongation

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Is microsatellite instability caused merely by defective DNA mismatch repair?

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Molecular mechanisms of the antineoplastic agents inhibiting DNA replication and their applications to cancer patient treatmen

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Molecular genetic analysis of cellular response to transcription-blocking DNA damage and its defective disorders

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Search for DNA repair factors binding to stalled-RNA polymerase II

2005-01-01 to 2006-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: grant.17510043
Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

DNA損傷におけるRNAポリメラーゼII伸長反応の生化学的解析

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

転写とヌクレオチド除去修復機構を共役する新規蛋白質複合体の解析

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Molecular genetics of human diseases with defect in transcription and DNA repair

Source: Self-asserted source
Isao Kuraoka via DimensionsWizard

Works (50 of 80)

Items per page:
Page 1 of 2

Structure-specific DNA endonuclease T7 endonuclease I cleaves DNA containing UV-induced DNA lesions

2024-02-28 | Other
Contributors: Kazuki Matsubara; Shouta Ueda; Junpei Yamamoto; Shigenori Iwai; Narumi Shioi; Arato Takedachi; Isao Kuraoka
Source: check_circle
Crossref

Acetaldehyde induces NER repairable mutagenic DNA lesions

Carcinogenesis
2022-02-11 | Journal article
Contributors: Yuina Sonohara; Reine Takatsuka; Chikahide Masutani; Shigenori Iwai; Isao Kuraoka
Source: check_circle
Crossref

Arabidopsis thaliana endonuclease V is a ribonuclease specific for inosine-containing single-stranded RNA

Open Biology
2021-10 | Journal article
Contributors: Megumi Endo; Jung In Kim; Narumi Aoki Shioi; Shigenori Iwai; Isao Kuraoka
Source: check_circle
Crossref

Effects of acetaldehyde-induced DNA lesions on DNA metabolism

Genes and Environment
2020-12 | Journal article
Contributors: Haruka Tsuruta; Yuina Sonohara; Kosuke Tohashi; Narumi Aoki Shioi; Shigenori Iwai; Isao Kuraoka
Source: check_circle
Crossref

Nucleotide excision repair genes shaping embryonic development

Open Biology
2019-10-31 | Journal article
Contributors: Sofia J. Araújo; Isao Kuraoka
Source: check_circle
Crossref

Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

Scientific Reports
2019-01-24 | Journal article
Contributors: Yuina Sonohara; Junpei Yamamoto; Kosuke Tohashi; Reine Takatsuka; Tomonari Matsuda; Shigenori Iwai; Isao Kuraoka
Source: check_circle
Crossref

Alternative excision repair of topoisomerase inhibitor-induced DNA damage

The Nucleus
2018-12 | Journal article
Contributors: Isao Kuraoka
Source: check_circle
Crossref

Oligo swapping method for in vitro DNA repair substrate containing a single DNA lesion at a specific site

Genes and Environment
2018-12 | Journal article
Contributors: Mika Yukutake; Mika Hayashida; Narumi Shioi Aoki; Isao Kuraoka
Source: check_circle
Crossref

Fluorescence detection of DNA mismatch repair in human cells

Scientific Reports
2018-08-15 | Journal article
Contributors: Shunsuke Ito; Miyako Shiraishi; Kazuki Tsuchihashi; Reine Takatsuka; Junpei Yamamoto; Isao Kuraoka; Shigenori Iwai
Source: check_circle
Crossref

An assay to detect DNA-damaging agents that induce nucleotide excision-repairable DNA lesions in living human cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis
2017 | Journal article
EID:

2-s2.0-85019613244

Contributors: Takatsuka, R.; Ito, S.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Facile preparation of a fluorescent probe to detect the cellular ability of nucleotide excision repair

Analytical Biochemistry
2017 | Journal article
EID:

2-s2.0-85016403380

Contributors: Tawarahara, H.; Kuraoka, I.; Iwai, S.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Chemical incorporation of chain-terminating nucleoside analogs as 3′-blocking DNA damage and their removal by human ERCC1-XPF endonuclease

Molecules
2016 | Journal article
EID:

2-s2.0-84976540642

Contributors: Yamamoto, J.; Takahata, C.; Kuraoka, I.; Hirota, K.; Iwai, S.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks

Carcinogenesis
2016 | Journal article
EID:

2-s2.0-84954350239

Contributors: Kametani, Y.; Takahata, C.; Narita, T.; Tanaka, K.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Inosine-specific ribonuclease activity of natural variants of human endonuclease V

FEBS Letters
2016 | Journal article
EID:

2-s2.0-84995576445

Contributors: Kim, J.I.; Tohashi, K.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

An in vitro method for detecting genetic toxicity based on inhibition of RNA synthesis by DNA lesions

Genes and Environment
2015 | Journal article
EID:

2-s2.0-84942599507

Contributors: Sonohara, Y.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression

Chemico-Biological Interactions
2015 | Journal article
EID:

2-s2.0-84946150233

Contributors: Barron, G.A.; Goua, M.; Kuraoka, I.; Bermano, G.; Iwai, S.; Kong Thoo Lin, P.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Diversity of endonuclease V: From DNA repair to RNA editing

Biomolecules
2015 | Journal article
EID:

2-s2.0-84964913729

Contributors: Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Epigenetic modifications in DNA could mimic oxidative DNA damage: A double-edged sword

DNA Repair
2015 | Journal article
EID:

2-s2.0-84938210275

Contributors: Ito, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex

Carcinogenesis
2015 | Journal article
EID:

2-s2.0-84938689917

Contributors: Takahata, C.; Masuda, Y.; Takedachi, A.; Tanaka, K.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability

Molecular Cell
2015 | Journal article
EID:

2-s2.0-84920408083

Contributors: Guervilly, J.-H.; Takedachi, A.; Naim, V.; Scaglione, S.; Chawhan, C.; Lovera, Y.; Despras, E.; Kuraoka, I.; Kannouche, P.; Rosselli, F. et al.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

An RNA synthesis inhibition assay for detecting toxic substances using click chemistry

Journal of Toxicological Sciences
2014 | Journal article
EID:

2-s2.0-84896441547

Contributors: Kametani, Y.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Fluorescence detection of cellular nucleotide excision repair of damaged DNA

Scientific Reports
2014 | Journal article
EID:

2-s2.0-84904015405

Contributors: Toga, T.; Kuraoka, I.; Watanabe, S.; Nakano, E.; Takeuchi, S.; Nishigori, C.; Sugasawa, K.; Iwai, S.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Frequencies of mutagenic translesion DNA synthesis over cisplatin-guanine intra-strand crosslinks in lacZ plasmids propagated in human cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis
2014 | Journal article
EID:

2-s2.0-84902210103

Contributors: Fujikawa, Y.; Kawanishi, M.; Kuraoka, I.; Yagi, T.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Guanine-5-carboxylcytosine base pairs mimic mismatches during DNA replication

Scientific Reports
2014 | Journal article
EID:

2-s2.0-84902153677

Contributors: Shibutani, T.; Ito, S.; Toda, M.; Kanao, R.; Collins, L.B.; Shibata, M.; Urabe, M.; Koseki, H.; Masuda, Y.; Swenberg, J.A. et al.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

A transfection reporter for the prevention of false-negative results in molecular beacon experiments

Analytical Biochemistry
2013 | Journal article
EID:

2-s2.0-84879489357

Contributors: Toga, T.; Kuraoka, I.; Yasui, A.; Iwai, S.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase: Implications for bypass RNA synthesis on oxidative DNA lesions

Mutagenesis
2013 | Journal article
EID:

2-s2.0-84871793703

Contributors: Nakanishi, N.; Fukuoh, A.; Kang, D.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Establishment of a human cell line stably overexpressing mouse Nip45 and characterization of Nip45 subcellular localization

Biochemical and Biophysical Research Communications
2013 | Journal article
EID:

2-s2.0-84872398137

Contributors: Hashiguchi, K.; Ozaki, M.; Kuraoka, I.; Saitoh, H.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Human endonuclease v is a ribonuclease specific for inosine-containing RNA

Nature Communications
2013 | Journal article
EID:

2-s2.0-84881412394

Contributors: Morita, Y.; Shibutani, T.; Nakanishi, N.; Nishikura, K.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Miscoding properties of 8-chloro-2′-deoxyguanosine, a hypochlorous acid-induced DNA adduct, catalysed by human DNA polymerases

Mutagenesis
2013 | Journal article
EID:

2-s2.0-84871747360

Contributors: Sassa, A.; Kamoshita, N.; Matsuda, T.; Ishii, Y.; Kuraoka, I.; Nohmi, T.; Ohta, T.; Honma, M.; Yasui, M.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Strand breakage of a (6-4) photoproduct-containing DNA at neutral pH and its repair by the ERCC1-XPF protein complex

Organic and Biomolecular Chemistry
2013 | Journal article
EID:

2-s2.0-84877660619

Contributors: Arichi, N.; Yamamoto, J.; Takahata, C.; Sano, E.; Masuda, Y.; Kuraoka, I.; Iwai, S.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

"Challenge to conquer cancer - New trends in mutation research" JEMS Open Symposium 2011

Genes and Environment
2012 | Journal article
EID:

2-s2.0-84865701069

Contributors: Nunoshiba, T.; Kuraoka, I.; Ibuki, Y.; Narumi, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Effects of 5′,8-cyclodeoxyadenosine triphosphates on DNA synthesis

Chemical Research in Toxicology
2012 | Journal article
EID:

2-s2.0-84871255024

Contributors: Kamakura, N.; Yamamoto, J.; Brooks, P.J.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84859965553

Contributors: Punchihewa, C.; Inoue, A.; Hishiki, A.; Fujikawa, Y.; Connelly, M.; Evison, B.; Shao, Y.; Heath, R.; Kuraoka, I.; Rodrigues, P. et al.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

When and where polymerases encounter DNA lesions

Genes and Environment
2012 | Journal article
EID:

2-s2.0-84865682803

Contributors: Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Xeroderma pigmentosum group F protein binds to Eg5 and is required for proper mitosis: Implications for XP-F and XFE

Genes to Cells
2012 | Journal article
EID:

2-s2.0-84863182810

Contributors: Tan, L.J.; Saijo, M.; Kuraoka, I.; Narita, T.; Takahata, C.; Iwai, S.; Tanaka, K.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

A method for detecting genetic toxicity using the rna synthesis response to dna damage

Journal of Toxicological Sciences
2011 | Journal article
EID:

2-s2.0-80053467320

Contributors: Morita, Y.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex

Genes to Cells
2011 | Journal article
EID:

2-s2.0-78650640724

Contributors: Horibata, K.; Saijo, M.; Bay, M.N.; Lan, L.; Kuraoka, I.; Brooks, P.J.; Honma, M.; Nohmi, T.; Yasui, A.; Tanaka, K.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

A non-isotopic assay uses bromouridine and RNA synthesis to detect DNA damage responses

Mutation Research - Genetic Toxicology and Environmental Mutagenesis
2010 | Journal article
EID:

2-s2.0-77952582649

Contributors: Hasegawa, M.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Characterization of a Y-family DNA polymerase eta from the eukaryotic thermophile Alvinella pompejana

Journal of Nucleic Acids
2010 | Journal article
EID:

2-s2.0-84869003216

Contributors: Kashiwagi, S.; Kuraoka, I.; Fujiwara, Y.; Hitomi, K.; Cheng, Q.J.; Fuss, J.O.; Shin, D.S.; Masutani, C.; Tainer, J.A.; Hanaoka, F. et al.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Fluorescent probes for the analysis of DNA strand scission in base excision repair.

Nucleic acids research
2010 | Journal article
EID:

2-s2.0-77952302415

Contributors: Matsumoto, N.; Toga, T.; Hayashi, R.; Sugasawa, K.; Katayanagi, K.; Ide, H.; Kuraoka, I.; Iwai, S.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

MMXD, a TFIIH-Independent XPD-MMS19 Protein Complex Involved in Chromosome Segregation

Molecular Cell
2010 | Journal article
EID:

2-s2.0-77956002171

Contributors: Ito, S.; Tan, L.J.; Andoh, D.; Narita, T.; Seki, M.; Hirano, Y.; Narita, K.; Kuraoka, I.; Hiraoka, Y.; Tanaka, K.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Polymerization by DNA polymerase η is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: Implications for cytotoxic effects in nucleotide excision repair-negative tumor cells

Carcinogenesis
2010 | Journal article
EID:

2-s2.0-77950872566

Contributors: Chijiwa, S.; Masutani, C.; Hanaoka, F.; Iwai, S.; Kuraoka, I.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Corrigendum to "Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non-small cell lung cancer patients with habitual smoking" [Mutat. Res. 677 (2009) 66-71] (DOI:10.1016/j.mrgentox.2009.05.008)

Mutation Research - Genetic Toxicology and Environmental Mutagenesis
2009 | Journal article
EID:

2-s2.0-70249144622

Contributors: Ohba, T.; Kometani, T.; Shoji, F.; Yano, T.; Yoshino, I.; Taguchi, K.; Kuraoka, I.; Oda, S.; Maehara, Y.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

DNA conformation-dependent activities of human mitochondrial RNA polymerase

Genes to Cells
2009 | Journal article
EID:

2-s2.0-68049107471

Contributors: Fukuoh, A.; Ohgaki, K.; Hatae, H.; Kuraoka, I.; Aoki, Y.; Uchiumi, T.; Jacobs, H.T.; Kang, D.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non-small cell lung cancer patients with habitual smoking

Mutation Research - Genetic Toxicology and Environmental Mutagenesis
2009 | Journal article
EID:

2-s2.0-67650021428

Contributors: Ohba, T.; Kometani, T.; Shoji, F.; Yano, T.; Ichiro, Y.; Taguchi, K.; Kuraoka, I.; Oda, S.; Maehara, Y.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Fluorescence detection of the endonuclease III reaction using modified oligonucleotides.

Nucleic acids symposium series (2004)
2009 | Journal article
EID:

2-s2.0-77952490939

Contributors: Matsumoto, N.; Hayashi, R.; Himoto, M.; Kuraoka, I.; Morita, S.; Hagiwara, F.; Katayanagi, K.; Ide, H.; Iwai, S.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair

Journal of Biological Chemistry
2008 | Journal article
EID:

2-s2.0-38149086154

Contributors: Kuraoka, I.; Ito, S.; Wada, T.; Hayashida, M.; Lee, L.; Saijo, M.; Nakatsu, Y.; Matsumoto, M.; Matsunaga, T.; Handa, H. et al.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

Molecular and Cellular Biology
2007 | Journal article
EID:

2-s2.0-35148894396

Contributors: Ikura, T.; Tashiro, S.; Kakino, A.; Shima, H.; Jacob, N.; Amunugama, R.; Yoder, K.; Izumi, S.; Kuraoka, I.; Tanaka, K. et al.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

DNA repair as a determinant of tumour chemosensitivity

Gan to kagaku ryoho. Cancer & chemotherapy
2007 | Journal article
EID:

2-s2.0-34047179506

Contributors: Oda, S.; Kuraoka, I.; Maehara, Y.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier

Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly

Chemical Research in Toxicology
2007 | Journal article
EID:

2-s2.0-34248571849

Contributors: Kawanishi, M.; Matsukawa, K.; Kuraoka, I.; Takamura-Enya, T.; Totsuka, Y.; Matsumoto, Y.; Watanabe, M.; Zou, Y.; Tanaka, K.; Sugimura, T. et al.
Source: Self-asserted source
Isao Kuraoka via Scopus - Elsevier
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