Since 2000 my research has focused on the role of the Vps10p-D receptor family in health and disease. Using transgenic animal models the Nykjaer group is studying sortilin receptors in cellular sorting/trafficking, trans-synaptic communication, and neuronal development and signaling.
My research activities are focused towards the functional characterization of a family of neuronal type-1 receptors denoted sortilins, comprising sortilin, SorLA, and SorCS-1, -2, and -3. Although expression predominates in neurons, receptors are also present in specialized cell types outside the nervous system. They bind a vast number of ligands spanning from neurotrophic factors, Alzheimer precursor protein (APP), and progranulin to lipoproteins, implying critical roles in regulation of neuronal survival, differentiation, and cholesterol metabolism. Indeed, a number of genetic association studies and gene targeting in mice have linked sortilin dysfunction with neurodegenerative disorders, ADHD, schizophrenia, bipolar disorder, hypercholesterolemia and diabetes.
Using transgenic mouse models and a broad repertoire of molecular, cellular and genetic tools it is the goal to unravel the function of the receptor family in health and disease and to evaluate their potential as drug targets.
* * * Publications - summary (28 September 2017):
109 peer-reviewed papers, 5 book chapters, and 13 patent applications.
Total citations: >8,720, Average: 75, h-index: 45
* Publications appearing in: Nature, Cell, PNAS, Nature Rev. Neurosci, Neuron, Nature Cell Biol, Cell Metab, EMBO J, Cell Reports and more.
* * * Awards/honors:
* 2013 Queensland Brain Institute Travel Award
* 2011 Danish Alzheimer Res. Found. Honorary Award
* 2002 Yde and Desiré’s Honorary Award
* 2000 Awarded the 5-year Hallas-Møller Stipend
* * * Referee:
Journals: Nature; Cell Metab; EMBO J; Eur J Neurosci, PNAS; Mol Cell Biol; J Cell Sci; J Neurosci; J Biol Chem; J Mol Biol; Plos One, and more.
* Foundations: Swedish Res. Council, Hong Kong Res. Council, Scottish Med. Res. Council, The Welcome Trust, The Alzheimer Found., Austrian Acad. of Sci., Alzheimer´s Association, and more.