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Drosophila, olfactory circuit, local interneuron, olfactory behavior, neural circuit modeling, neural development
Taiwan

Biography

Ya-Hui Chou joined Dr. Cheng-Ting Chien’s lab in the Institute of Molecular Biology at Academia Sinica in 1999 as a graduate student. She studied how planar cell polarity genes pattern the Drosophila eye and received her Ph.D. in 2003, with Chien-Tien Hsu Outstanding Graduate Dissertation Award. After one-year postdoctoral study in Dr. Chien’s lab, she joined Dr. Liqun Luo’s lab in the Department of Biology at Stanford University in 2004. In Luo lab, she used the Drosophila olfactory system as a model to study mechanisms of neural circuit wiring. Her work offers insights into how the cell body positions of peripheral olfactory receptor neurons are coordinated with central targets and how they achieve precise axon targeting. In addition, she and colleagues demonstrated olfactory local interneurons (LNs) are highly diverse and variable in their morphologies and electrophysiological properties, which serves as the groundwork for future LN research and the variability of neuronal circuits.

In 2011, she joined Institute of Cellular and Organismic Biology at Academia Sinica as an assistant Research Fellow. She is currently an Associate Research fellow in the same institute. Ya-Hui Chou’s lab has been focusing on olfactory local interneuron network to explore the neural circuit dynamics in cellular, circuit, and behavior levels. The fact that interneurons are highly diverse and variable makes studying interneuron morphological and synaptic dynamics, functions, and consequent behavior outputs very challenging. To make these questions addressable, her lab has built a fundamental map of LN development and versatile LN drivers to label and manipulate distinct types of LNs. They further addressed the neural dynamic and animal behavior through building a camera-model Drosophila treadmill system and a mathematic model of interneuron network variability.

Currently, her lab focuses on neural circuit dynamics through three approaches:
(1) establishing a full developmental map of distinct types of local interneurons and uncovering the underlying mechanisms orchestrating interneuron diversity; (2) exploring the dynamics of single LNs and associated local interneuron connectomes; (3) building behavior paradigms and mathematic models for studying the dynamics of local neural connectomes.

Ya-Hui Chou’s research has earned her several awards, including Career Development Award from Academia Sinica. She has served as an editorial board member of Journal of Neurogenetics since 2019.

Activities

Employment (8)

Academia Sinica: Taipei, TW

2019-04 to present | Associate Research Fellow (Institute of Cellular and Organismic Biology)
Employment
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

National Taiwan University: Taipei, TW

2015-08 to present | Assistant Professor (adjunction) (Genome and System Biology Degree Program)
Employment
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

National Defense Medical Center: Taipei, TW

2012-08 to present | Assistant professor (adjunction) (Graduate Institute of Life Sciences)
Employment
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Academia Sinica: Taipei, TW

2011-08 to present | member (Neuroscience Program in Academia Sinica)
Employment
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Academia Sinica: Taipei, TW

2011-08 to 2019-03 | Assistant Research Fellow (Institute of Cellular and Organismic Biology)
Employment
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Stanford University: Stanford, CA, US

2009-08 to 2011-08 | Basic Life Science Research Associate (Department of Biology)
Employment
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Stanford University: Stanford, CA, US

2004-08 to 2009-07 | Postdoctoral Fellow (Department of Biology)
Employment
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Academia Sinica: Taipei, TW

2003-08 to 2004-07 | Postdoctoral Fellow (Institute of Molecular Biology)
Employment
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Education and qualifications (1)

National Defense Medical Center/Academia Sinica: Taipei, TW

1998-08 to 2003-07 | Ph.D. (Graduate Institute of Life Sciences/Institute of Molecular Biology)
Education
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Works (17)

Drosophila as a Model to Explore Individuality

Neuromethods
2022 | Book chapter
Part of ISBN: 9781071623206
Part of ISBN: 9781071623213
Part of ISSN: 0893-2336
Part of ISSN: 1940-6045
Contributors: Kuo-Ting Tsai; Ya-Hui Chou
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Mating-driven variability in olfactory local interneuron wiring.

Science advances
2022-02-18 | Journal article
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Random Walk Revisited: Quantification and Comparative Analysis of Drosophila Walking Trajectories

iScience
2019-09-04 | Journal article
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Interneuron Diversity: Toward a Better Understanding of Interneuron Development In the Olfactory System

Journal of Experimental Neuroscience
2019-04-07 | Journal article
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Differential efficacy of genetically swapping GAL4

Journal of Neurogenetics
2019-04-02 | Journal article
Part of ISSN: 1563-5260
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit

Nature Communications
2018-06-08 | Journal article
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Circuit variability interacts with excitatory-inhibitory diversity of interneurons to regulate network encoding capacity

Scientific Reports
2018-05-23 | Journal article
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs

Nature Communications
2017-11-02 | Journal issue or edition
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli

PNAS
2017-07-18 | Journal article
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting

Neuron
2011-12-08 | Journal article
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps

Cell
2010-09-17 | Journal issue or edition
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe

Nature Neuroscience
2010-02-07 | Journal article
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions

Neuron
2007-01-18 | Journal issue or edition
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Scabrous controls ommatidial rotation in the Drosophila compound eye

Developmental Cell
2002-12 | Journal issue or edition
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Induction of p21(CIP1/Waf1) and activation of p34(cdc2) involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells

Experimental Cell Research
1999-04-10 | Journal article
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Differential effects of phorbol ester on growth and protein kinase C isoenzyme regulation in human hepatoma Hep3B cells

Biochemical Journal
1998-07-01 | Journal article
PMID: 9639562
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)

Cell cycle phase-dependent changes of localization and oligomerization states of nucleophosmin/B23.

Biochemical and Biophysical Research Communications
1995-12-05 | Journal article
PMID: 8526928
Source: Self-asserted source
Ya-Hui Chou (0000-0001-6552-8728)