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ResearcherID: P-1766-2018

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Employment (1)

University of Padua: Padova, Veneto, IT

2019-11 to present | Post-doctoral fellow (Biology)
Employment
Source: Self-asserted source
Jonathan P Lambert

Education and qualifications (2)

Temple University: Philadelphia, PA, US

2014-09-01 to 2019-08-11 | Ph.D. in Biomedical Sciences (Center for Translational Medicine)
Education
Source: Self-asserted source
Jonathan P Lambert

Boston College: Chestnut Hill, MA, US

2007-09 to 2011-05 | B.S. in Biology
Education
Source: Self-asserted source
Jonathan P Lambert

Professional activities (2)

International Society for Heart Research: Durham, North Carolina, US

2020 to present | Regular
Membership
Source: Self-asserted source
Jonathan P Lambert

American Heart Association: Dallas, Texas, US

2015 to present | Regular
Membership
Source: Self-asserted source
Jonathan P Lambert

Funding (3)

MitoFORMSinHF- Mitochondrial cristae form, function, and organization dependent upon metabolic sources and implication in heart failure

2022-09 to 2024-08 | Grant
European Commission (Padova, IT)
URL: https://cordis.europa.eu/project/id/101027093
GRANT_NUMBER:

101027093
Source: Self-asserted source
Jonathan P Lambert

Determining the metabolic sensing capability of mitochondrial cristae

2021-02 to 2022-08 | Grant
European Molecular Biology Organization (Heidelberg, DE)
GRANT_NUMBER:

ALTF 366-2020
Source: Self-asserted source
Jonathan P Lambert

Defining the molecular function of MCUb and contribution to cardiac physiology

2017-01-01 to 2018-12-31 | Grant
American Heart Association (New York, US)
URL: https://app.dimensions.ai/details/grant/grant.100056944
GRANT_NUMBER:

17PRE33460423
Source: Self-asserted source
Jonathan P Lambert via DimensionsWizard

Works (20)

MCU gain-and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure

2023-04-18 | Preprint
DOI: 10.1101/2023.04.17.537222
Contributors: Joanne F. Garbincius; Timothy S. Luongo; Jonathan P. Lambert; Adam S. Mangold; Emma K. Murray; Alycia N. Hildebrand; Pooja Jadiya; John W. Elrod
Source: check_circle
Crossref

Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2020-02-25 | Journal article
DOI: 10.1096/fj.201902105r
PMID: 32100368
Source: Self-asserted source
Jonathan P Lambert

MCUB and mitochondrial calcium uptake – modeling, function, and therapeutic potential

Expert Opinion on Therapeutic Targets
2020-02-24 | Journal article
DOI: 10.1080/14728222.2020.1732926
Part of ISSN: 1472-8222
Part of ISSN: 1744-7631
Source: Self-asserted source
Jonathan P Lambert

MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.

Circulation
2019-09-19 | Journal article
DOI: 10.1161/circulationaha.118.037968
PMID: 31533452
Source: Self-asserted source
Jonathan P Lambert

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Nature Communications
2019-08-29 | Journal article
DOI: 10.1038/s41467-019-11813-6
Contributors: Pooja Jadiya; Devin W. Kolmetzky; Dhanendra Tomar; Antonio Di Meco; Alyssa A. Lombardi; Jonathan P. Lambert; Timothy S. Luongo; Marthe H. Ludtmann; Domenico Praticò; John W. Elrod
Source: check_circle
Crossref

Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart.

Cell reports
2018-09-01 | Journal article
DOI: 10.1016/j.celrep.2018.08.040
PMID: 30231993
PMC: PMC6226263
Source: Self-asserted source
Jonathan P Lambert

Exercise training provides cardioprotection by activating and coupling endothelial nitric oxide synthaseviaa β3-adrenergic receptor-AMP-activated protein kinase signaling pathway

Medical Gas Research
2017 | Journal article
DOI: 10.4103/2045-9912.202904
Part of ISSN: 2045-9912
Source: Self-asserted source
Jonathan P Lambert

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.

Nature
2017-04-26 | Journal article
DOI: 10.1038/nature22082
PMID: 28445457
PMC: PMC5731245
Source: Self-asserted source
Jonathan P Lambert

Dysregulation of PINCH signaling in mesial temporal epilepsy.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2016-11-09 | Journal article
DOI: 10.1016/j.jocn.2016.10.012
PMID: 27838154
PMC: PMC6492941
Source: Self-asserted source
Jonathan P Lambert

Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.

American journal of cardiovascular disease
2016-09-15 | Journal article
PMID: 27679746
PMC: PMC5030391
Source: Self-asserted source
Jonathan P Lambert

IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction.

Proceedings of the National Academy of Sciences of the United States of America
2016-06-06 | Journal article
DOI: 10.1073/pnas.1603127113
PMID: 27274047
PMC: PMC4922143
Source: Self-asserted source
Jonathan P Lambert

DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission.

Journal of molecular and cellular cardiology
2016-04-22 | Journal article
DOI: 10.1016/j.yjmcc.2016.04.008
PMID: 27108530
PMC: PMC5002379
Source: Self-asserted source
Jonathan P Lambert

Sodium Sulfide Attenuates Ischemic-Induced Heart Failure by Enhancing Proteasomal Function in an Nrf2-Dependent Manner.

Circulation. Heart failure
2016-04-01 | Journal article
DOI: 10.1161/CIRCHEARTFAILURE.115.002368
PMID: 27056879
PMC: PMC4826721
Source: Self-asserted source
Jonathan P Lambert

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.

Cell reports
2015-06-25 | Journal article
DOI: 10.1016/j.celrep.2015.06.017
PMID: 26119731
PMC: PMC4517182
Source: Self-asserted source
Jonathan P Lambert

Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress.

Nitric oxide : biology and chemistry
2015-01-06 | Journal article
DOI: 10.1016/j.niox.2014.12.013
PMID: 25575644
PMC: PMC4361249
Source: Self-asserted source
Jonathan P Lambert

Hydrogen sulfide provides cardioprotection against myocardial/ischemia reperfusion injury in the diabetic state through the activation of the RISK pathway.

Medical gas research
2014-12-12 | Journal article
DOI: 10.1186/s13618-014-0020-0
PMID: 25525500
PMC: PMC4269946
Source: Self-asserted source
Jonathan P Lambert

A proliferative burst during preadolescence establishes the final cardiomyocyte number.

Cell
2014-05-01 | Journal article
DOI: 10.1016/j.cell.2014.03.035
PMID: 24813607
PMC: PMC4078902
Source: Self-asserted source
Jonathan P Lambert

Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.

Journal of molecular and cellular cardiology
2013-08-17 | Journal article
DOI: 10.1016/j.yjmcc.2013.08.002
PMID: 23962643
PMC: PMC3800246
Source: Self-asserted source
Jonathan P Lambert

Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner.

American journal of physiology. Heart and circulatory physiology
2013-03-11 | Journal article
DOI: 10.1152/ajpheart.00796.2012
PMID: 23479260
PMC: PMC3652093
Source: Self-asserted source
Jonathan P Lambert

Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.

Arteriosclerosis, thrombosis, and vascular biology
2013-01-24 | Journal article
DOI: 10.1161/ATVBAHA.112.300484
PMID: 23349187
PMC: PMC3827725
Source: Self-asserted source
Jonathan P Lambert
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