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Neuroscience: MicroRNAs: Theranostic: Parkinson's Disease: Nose to brain delivery
We are trying to understand the α-synuclein dysregulation at post-transcriptional (miRNA’s) and post-translational levels (Phosphorylation), leading to its overexpression and transition to toxic oligomeric form in PD. A multidisciplinary approach is employed to investigate the cellular and molecular mechanism underlying the pathogenic degeneration of specific neuronal populations in the brain. In addition, the pharmacological screening of novel molecules isolated from plant sources or synthetic congeners, and targeted drug delivery systems for their neuroprotective and neuronal regeneration properties carried out using cellular and animal models.