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Education and qualifications (2)

Duke NUS Graduate Medical School: Singapore, SG

2019-08-19 to 2024-09-30 | PhD Candidate (IBM (Cancer and Stem Cell Biology))
Education
Source: Self-asserted source
JIAJUN YAP

National University of Singapore: Singapore, SG

2012-08-12 to 2016-07-15 | Bachelor Degree with Honors (Life Sciences (Biomedical Science))
Education
Source: Self-asserted source
JIAJUN YAP

Works (9)

Target Hyperactive ERK Signaling for Cancer Therapy

Handbook of Cancer and Immunology
2023 | Book chapter
Part of ISBN: 9783030809621
Part of ISBN: 9783030809621
Contributors: Yap Jiajun; Hu Jiancheng
Source: Self-asserted source
JIAJUN YAP

BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes

Molecular Cancer
2023-08-05 | Journal article
Part of ISSN: 1476-4598
Contributors: Jiajun Yap; Jimin Yuan; Wan Hwa Ng; Gao Bin Chen; Yuen Rong M. Sim; Kah Chun Goh; Joey Teo; Trixie Y. H. Lim; Shee Min Goay; Jia Hao Jackie Teo et al.
Source: Self-asserted source
JIAJUN YAP

Drug resistance in targeted cancer therapies with RAF inhibitors

Cancer Drug Resistance
2021 | Review
Contributors: Ufuk Degirmenci; Jiajun Yap; Yuen Rong M. Sim; Shiru Qin; Jiancheng Hu
Source: Self-asserted source
JIAJUN YAP

The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop

Science Advances
2021-06-11 | Journal article
Contributors: Jiajun Yap; R. N. V. Krishna Deepak; Zizi Tian; Wan Hwa Ng; Kah Chun Goh; Alicia Foo; Zi Heng Tee; Manju Payini Mohanam; Yuen Rong M. Sim; Ufuk Degirmenci et al.
Source: check_circle
Crossref

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

Journal of Hematology & Oncology
2020-12 | Review
Part of ISSN: 1756-8722
Source: Self-asserted source
JIAJUN YAP

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Journal of Visualized Experiments
2019-07-17 | Journal article
Part of ISSN: 1940-087X
Contributors: Jiajun Yap; Jimin Yuan; Zi Heng Tee; Xuchao Huang; Wan Hwa Ng; Jiancheng Hu
Source: Self-asserted source
JIAJUN YAP

The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants

Oncogene
2018-10 | Journal article
Part of ISSN: 0950-9232
Part of ISSN: 1476-5594
Contributors: Jimin Yuan; Wan Hwa Ng; Paula Y. P. Lam; Yu Wang; Hongping Xia; Jiajun Yap; Shou Ping Guan; Ann S. G. Lee; Mei Wang; Manuela Baccarini et al.
Source: Self-asserted source
JIAJUN YAP

Activating mutations in MEK1 enhance homodimerization and promote tumorigenesis

Science Signaling
2018-10-30 | Journal article
Part of ISSN: 1945-0877
Part of ISSN: 1937-9145
Contributors: Jimin Yuan; Wan Hwa Ng; Zizi Tian; Jiajun Yap; Manuela Baccarini; zhongzhou chen; Jiancheng Hu
Source: Self-asserted source
JIAJUN YAP

The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking phospho–Ser-621 in the C terminus of CRAF

Journal of Biological Chemistry
2018-09 | Journal article
Part of ISSN: 0021-9258
Contributors: Jimin Yuan; Wan Hwa Ng; Jiajun Yap; Brandon Chia; Xuchao Huang; Mei Wang; Jiancheng Hu
Source: Self-asserted source
JIAJUN YAP