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Loop profile: 1186906

Keywords

Immunoengineering, Biomedical Engineering, Nanomedicine

Biography

My PhD research mainly focused on developing novel drug conjugates for cancer theranostics. One of the representative research was published in ACS NANO, where a triad microbubble was engineered for ultrasound and fluorescence imaging-guided combined therapy for colon cancer.(This work was highlighted on the website of Chinese Ministry of Science and Technology) In 2019, I joined an Immunoengineering lab at PME at UChicago, I started to work on cancer immunotherapy such as CART cell therapy using advanced molecular imaging techniques. I also developed a new nanomedicine termed as Nanotraps to inhibit SARS-CoV2 viral infection since the pandemic in 2020. Currently, I am developing mRNA-based Omicron-specific nano vaccines and mRNA based CAR-T cell therapy for cancer and fibrosis disease.

Activities

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Employment (2)

Massachusetts Institute of Technology: Cambridge, US

2023-09-15 to present | Postdoctoral Associate (Koch Institute for Integrative Cancer Research)
Employment
Source: Self-asserted source
Min Chen

University of Chicago: Chicago, IL, US

2019-09-16 to present | Postdoctoral Researcher (Pritzker School of Molecular Engineering)
Employment
Source: Self-asserted source
Min Chen

Education and qualifications (1)

Peking University: Beijing, Beijing, CN

2014-09-01 to 2019-07-01 | PhD (Biomedical Engineering)
Education
Source: Self-asserted source
Min Chen

Works (21)

Multimodal probing of T-cell recognition with hexapod heterostructures

Nature Methods
2024 | Journal article
DOI: 10.1038/S41592-023-02165-7
WOSUID: WOS:001165959600004
Contributors: Huang, Xiaodan; Meng, Lingyuan; Cao, Guoshuai; Prominski, Aleksander; Hu, Yifei; Yang, Chuanwang; Chen, Min; Shi, Jiuyun; Gallagher, Charles; Cao, Thao et al.
Source: check_circle
Web of Science Researcher Profile Sync

Rapid, Sensitive, Label-Free Electrical Detection of SARS-CoV-2 in Nasal Swab Samples

ACS Applied Materials & Interfaces
2023-03-29 | Journal article
DOI: 10.1021/acsami.3c00331
Contributors: Hyun-June Jang; Wen Zhuang; Xiaoyu Sui; Byunghoon Ryu; Xiaodan Huang; Min Chen; Xiaolei Cai; Haihui Pu; Kathleen Beavis; Jun Huang et al.
Source: check_circle
Crossref

Remote Floating-Gate Field-Effect Transistor with 2-Dimensional Reduced Graphene Oxide Sensing Layer for Reliable Detection of SARS-CoV-2 Spike Proteins

ACS Applied Materials & Interfaces
2022-06-01 | Journal article
DOI: 10.1021/acsami.2c04969
Contributors: Hyun-June Jang; Xiaoyu Sui; Wen Zhuang; Xiaodan Huang; Min Chen; Xiaolei Cai; Yale Wang; Byunghoon Ryu; Haihui Pu; Nicholas Ankenbruck et al.
Source: check_circle
Crossref

Complementing Cancer Photodynamic Therapy with Ferroptosis through Iron Oxide Loaded Porphyrin-Grafted Lipid Nanoparticles

ACS Nano
2021-12-28 | Journal article
DOI: 10.1021/acsnano.1c08108
Part of ISSN: 1936-0851
Part of ISSN: 1936-086X
Source: Self-asserted source
Min Chen

Nanotraps for the containment and clearance of SARS-CoV-2

Matter
2021-06 | Journal article
DOI: 10.1016/j.matt.2021.04.005
Contributors: Min Chen; Jillian Rosenberg; Xiaolei Cai; Andy Chao Hsuan Lee; Jiuyun Shi; Mindy Nguyen; Thirushan Wignakumar; Vikranth Mirle; Arianna Joy Edobor; John Fung et al.
Source: check_circle
Crossref

Fibronectin-targeted dual-acting micelles for combination therapy of metastatic breast cancer

Signal Transduction and Targeted Therapy
2020-12 | Journal article
DOI: 10.1038/s41392-019-0104-3
Part of ISSN: 2059-3635
Source: Self-asserted source
Min Chen

Perfluorocarbon@Porphyrin Nanoparticles for Tumor Hypoxia Relief to Enhance Photodynamic Therapy against Liver Metastasis of Colon Cancer

ACS Nano
2020-09-11 | Journal article
DOI: 10.1021/acsnano.0c05617
Part of ISSN: 1936-0851
Part of ISSN: 1936-086X
Source: Self-asserted source
Min Chen

Ultrasound/Optical Dual‐Modality Imaging for Evaluation of Vulnerable Atherosclerotic Plaques with Osteopontin Targeted Nanoparticles

Macromolecular Bioscience
2020-02 | Journal article
DOI: 10.1002/mabi.201900279
Part of ISSN: 1616-5187
Part of ISSN: 1616-5195
Source: Self-asserted source
Min Chen

Manganese(iii)-chelated porphyrin microbubbles for enhanced ultrasound/MR bimodal tumor imaging through ultrasound-mediated micro-to-nano conversion

Nanoscale
2019 | Journal article
DOI: 10.1039/C9NR01373C
Contributors: Min Chen; Xiaolong Liang; Zhifei Dai
Source: check_circle
Crossref

Intraoperative Identification and Guidance of Breast Cancer Microfoci Using Ultrasound and Near-Infrared Fluorescence Dual-Modality Imaging

ACS Applied Bio Materials
2019-05-20 | Journal article
DOI: 10.1021/acsabm.9b00206
Part of ISSN: 2576-6422
Part of ISSN: 2576-6422
Source: Self-asserted source
Min Chen

Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy

Theranostics
2018 | Journal article
DOI: 10.7150/thno.23734
Part of ISSN: 1838-7640
Source: Self-asserted source
Min Chen

Polarization-based super-resolution imaging of surface-enhanced Raman scattering nanoparticles with orientational information

Nanoscale
2018 | Journal article
DOI: 10.1039/C8NR04808H
Contributors: Miaoyan Wang; Min Chen; Karl Zhanghao; Xu Zhang; Zhenli Jing; Juntao Gao; Michael Q. Zhang; Dayong Jin; Zhifei Dai; Peng Xi et al.
Source: check_circle
Crossref

Porphyrin-grafted Lipid Microbubbles for the Enhanced Efficacy of Photodynamic Therapy in Prostate Cancer through Ultrasound-controlled In Situ Accumulation

Theranostics
2018 | Journal article
DOI: 10.7150/thno.22469
Part of ISSN: 1838-7640
Source: Self-asserted source
Min Chen

Ultrasound-targeted photodynamic and gene dual therapy for effectively inhibiting triple negative breast cancer by cationic porphyrin lipid microbubbles loaded with HIF1α-siRNA

Nanoscale
2018 | Journal article
DOI: 10.1039/c8nr03074j
Part of ISSN: 2040-3364
Part of ISSN: 2040-3372
Source: Self-asserted source
Min Chen

Amphiphilic Drug Conjugates as Nanomedicines for Combined Cancer Therapy

Bioconjugate Chemistry
2018-12-19 | Journal article
DOI: 10.1021/acs.bioconjchem.8b00692
Part of ISSN: 1043-1802
Part of ISSN: 1520-4812
Source: Self-asserted source
Min Chen

Self-assembly of porphyrin-grafted lipid into nanoparticles encapsulating doxorubicin for synergistic chemo-photodynamic therapy and fluorescence imaging

Theranostics
2018-11-03 | Journal article
DOI: 10.7150/thno.27721
Part of ISSN: 1838-7640
Source: Self-asserted source
Min Chen

Loading Lovastatin into Camptothecin–Floxuridine Conjugate Nanocapsules for Enhancing Anti-metastatic Efficacy of Cocktail Chemotherapy on Triple-negative Breast Cancer

ACS Applied Materials & Interfaces
2018-09-05 | Journal article
DOI: 10.1021/acsami.8b11723
Part of ISSN: 1944-8244
Part of ISSN: 1944-8252
Source: Self-asserted source
Min Chen

Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer

Biomaterials
2018-08 | Journal article
DOI: 10.1016/j.biomaterials.2018.04.054
Part of ISSN: 0142-9612
Source: Self-asserted source
Min Chen

Ultrasound Triggered Conversion of Porphyrin/Camptothecin-Fluoroxyuridine Triad Microbubbles into Nanoparticles Overcomes Multidrug Resistance in Colorectal Cancer

ACS Nano
2018-06-14 | Journal article
Source: Self-asserted source
Min Chen

Anisotropy in Shape and Ligand-Conjugation of Hybrid Nanoparticulates Manipulates the Mode of Bio-Nano Interaction and Its Outcome

Advanced Functional Materials
2017-08 | Journal article
DOI: 10.1002/adfm.201700406
Part of ISSN: 1616-301X
Source: Self-asserted source
Min Chen

Bioinspired synthesis of fluorescent calcium carbonate/carbon dot hybrid composites

Dalton Transactions
2015 | Journal article
DOI: 10.1039/c5dt00837a
Part of ISSN: 1477-9226
Part of ISSN: 1477-9234
Source: Self-asserted source
Min Chen

Peer review (4 reviews for 3 publications/grants)

Review activity for ACS biomaterials science & engineering. (2)
Review activity for Journal of nanobiotechnology (1)
Review activity for Molecular pharmaceutics. (1)
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