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Uniwersytet Jagiellonski w Krakowie Collegium Medicum: Kraków, PL

2009-06-01 to present
Employment
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Barbara Mordyl

Works (45)

Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease

Angewandte Chemie
2025-02-03 | Journal article
Contributors: Dawid Panek; Anna Pasieka; Jakub Jończyk; Milena Gawlińska; Paula Zaręba; Agata Siwek; Małgorzata Wolak; Barbara Mordyl; Monika Głuch‐Lutwin; Gniewomir Latacz et al.
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Anti-diabetes and neuroprotection potential and primary safety studies of<i> Isatis</i><i> tinctoria</i> L. hydroalcoholic leaf extract

Fitoterapia
2024 | Journal article
Contributors: Nicosia, Noemi; Kwiecien, Inga; Bednarski, Marek; Gluch-Lutwin, Monika; Mordyl, Barbara; Mika, Kamil; Hambaryan, Rimma; Miller, Anthea; Alesci, Alessio; Lauriano, Eugenia R. et al.
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Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease-Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors

Molecules
2024 | Journal article
Contributors: Goral, Izabella; Wichur, Tomasz; Slugocka, Emilia; Godyn, Justyna; Szalaj, Natalia; Zareba, Paula; Gluch-Lutwin, Monika; Mordyl, Barbara; Panek, Dawid; Wieckowska, Anna
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Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties

European Journal of Medicinal Chemistry
2024 | Journal article
Contributors: Siwek, Agata; Marcinkowska, Monika; Gluch-Lutwin, Monika; Mordyl, Barbara; Wolak, Malgorzata; Jastrzebska-Wiesek, Magdalena; Wilczynska-Zawal, Natalia; Wyska, Elzbieta; Szafranska, Katarzyna; Karcz, Tadeusz et al.
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Exploring Novel GSK-3β Inhibitors for Anti-Neuroinflammatory and Neuroprotective Effects: Synthesis, Crystallography, Computational Analysis, and Biological Evaluation

ACS Chemical Neuroscience
2024 | Journal article
Contributors: Goral, Izabella; Wichur, Tomasz; Slugocka, Emilia; Grygier, Przemyslaw; Gluch-Lutwin, Monika; Mordyl, Barbara; Honkisz-Orzechowska, Ewelina; Szalaj, Natalia; Godyn, Justyna; Panek, Dawid et al.
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First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT<sub>6</sub> Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease

Journal of Medicinal Chemistry
2024 | Journal article
Contributors: Pyka, Patryk; Haberek, Wawrzyniec; Wiecek, Malgorzata; Szymanska, Ewa; Ali, Wesam; Cios, Agnieszka; Jastrzebska-Wiesek, Magdalena; Satala, Grzegorz; Podlewska, Sabina; Di Giacomo, Silvia et al.
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Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease

Angewandte Chemie International Edition
2024 | Journal article
Contributors: Panek, Dawid; Pasieka, Anna; Jonczyk, Jakub; Gawlinska, Milena; Zareba, Paula; Siwek, Agata; Wolak, Malgorzata; Mordyl, Barbara; Gluch-Lutwin, Monika; Latacz, Gniewomir et al.
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Preferential Synaptic Type of GABA-A Receptor Ligands Enhancing Neuronal Survival and Facilitating Functional Recovery After Ischemic Stroke

Journal of Medicinal Chemistry
2024 | Journal article
Contributors: Mordyl, Barbara; Fajkis-Zajaczkowska, Nikola; Szafranska, Katarzyna; Siwek, Agata; Gluch-Lutwin, Monika; Zmudzki, Pawel; Jonczyk, Jakub; Karcz, Tadeusz; Sloczynska, Karolina; Pekala, Elzbieta et al.
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2-(4-Fluorophenyl)-1H-benzo[d]imidazole as a Promising Template for the Development of Metabolically Robust, α1β2γ2GABA-A Receptor-Positive Allosteric Modulators

ACS Chemical Neuroscience
2023 | Journal article
Contributors: Marcinkowska, Monika; Fajkis-Zajaczkowska, Nikola; Szafranska, Katarzyna; Jonczyk, Jakub; Siwek, Agata; Mordyl, Barbara; Karcz, Tadeusz; Latacz, Gniewomir; Kolaczkowski, Marcin
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Hybrid molecules combining GABA-A and serotonin 5-HT6 receptors activity designed to tackle neuroinflammation associated with depression

European Journal of Medicinal Chemistry
2023 | Journal article
Contributors: Marcinkowska, Monika; Mordyl, Barbara; Fajkis-Zajaczkowska, Nikola; Siwek, Agata; Karcz, Tadeusz; Gawalska, Alicja; Bucki, Adam; Zmudzki, Pawel; Partyka, Anna; Jastrzebska-Wiesek, Magdalena et al.
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Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT<sub>6</sub>R agents

European Journal of Medicinal Chemistry
2023 | Journal article
Contributors: Sudol-Talaj, Sylwia; Kucwaj-Brysz, Katarzyna; Podlewska, Sabina; Kurczab, Rafal; Satala, Grzegorz; Mordyl, Barbara; Gluch-Lutwin, Monika; Wilczynska-Zawal, Natalia; Jastrzebska-Wiesek, Magdalena; Czarnota-Lydka, Kinga et al.
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Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT<sub>6</sub>R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease

European Journal of Medicinal Chemistry
2023 | Journal article
Contributors: Czarnota-Lydka, Kinga; Sudol-Talaj, Sylwia; Kucwaj-Brysz, Katarzyna; Kurczab, Rafal; Satala, Grzegorz; de Candia, Modesto; Samarelli, Francesco; Altomare, Cosimo Damiano; Carocci, Alessia; Barbarossa, Alexia et al.
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Xanthine-Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases

Biomolecules
2023 | Journal article
Contributors: Zaluski, Michal; Karcz, Tadeusz; Drabczynska, Anna; Vielmuth, Christin; Olejarz-Maciej, Agnieszka; Gluch-Lutwin, Monika; Mordyl, Barbara; Siwek, Agata; Satala, Grzegorz; Muller, Christa E. et al.
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Milk-Derived Carbon Quantum Dots: Study of Biological and Chemical Properties Provides Evidence of Toxicity

Molecules
2022 | Journal article
Contributors: Shabbir, Hasan; Wojtaszek, Konrad; Rutkowski, Bogdan; Csapo, Edit; Bednarski, Marek; Adamiec, Anita; Gluch-Lutwin, Monika; Mordyl, Barbara; Druciarek, Julia; Kotanska, Magdalena et al.
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Modulation of the MOP Receptor (μ Opioid Receptor) by Imidazo[1,2-<i>a</i>]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action

Molecules
2022 | Journal article
Contributors: Straszak, Dominik; Siwek, Agata; Gluch-Lutwin, Monika; Mordyl, Barbara; Kolaczkowski, Marcin; Pietrzak, Aldona; Rahnama-Hezavah, Mansur; Drop, Bartlomiej; Matosiuk, Dariusz
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V(III) and V(IV) Schiff base complexes as potential insulin-mimetic compounds - Comparison, characterization and biological activity

Polyhedron
2022 | Journal article
Contributors: Jasinska, Anna; Szklarzewicz, Janusz; Jurowska, Anna; Hodorowicz, Maciej; Kazek, Grzegorz; Mordyl, Barbara; Gluch-Lutwin, Monika
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An exit beyond the pharmacophore model for 5-HT6R agents - a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential

Bioorganic Chemistry
2022-04 | Journal article
Part of ISSN: 0045-2068
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Barbara Mordyl

Design, synthesis, and behavioral evaluation of dual-acting compounds as phosphodiesterase type 10A (PDE10A) inhibitors and serotonin ligands targeting neuropsychiatric symptoms in dementia

European Journal of Medicinal Chemistry
2022-04 | Journal article
Part of ISSN: 0223-5234
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Barbara Mordyl

Characterization and antidiabetic activity of salicylhydrazone Schiff base vanadium(IV) and (V) complexes

Transition Metal Chemistry
2021 | Journal article
Contributors: Szklarzewicz, Janusz; Jurowska, Anna; Hodorowicz, Maciej; Kazek, Grzegorz; Mordyl, Barbara; Menaszek, Elzbieta; Sapa, Jacek
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The Phenoxyalkyltriazine Antagonists for 5-HT<sub>6</sub> Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases

International Journal of Molecular Sciences
2021 | Journal article
Contributors: Sudol, Sylwia; Cios, Agnieszka; Jastrzebska-Wiesek, Magdalena; Honkisz-Orzechowska, Ewelina; Mordyl, Barbara; Wilczynska-Zawal, Natalia; Satala, Grzegorz; Kucwaj-Brysz, Katarzyna; Partyka, Anna; Latacz, Gniewomir et al.
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Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties

European Journal of Medicinal Chemistry
2021-12 | Journal article
Part of ISSN: 0223-5234
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Barbara Mordyl

Design and Synthesis of Novel Aminoalkanamides Targeting Neurodegeneration and Symptoms of Alzheimer’s Disease

Current Medicinal Chemistry
2021-09-17 | Journal article
Contributors: Agnieszka Jankowska; Grzegorz Satała; Gniewomir Latacz; Anna Partyka; Annamaria Lubelska; Krzysztof Pociecha; Artur Świerczek; Natalia Wilczyńska; Barbara Mordyl; Andrzej J. Bojarski et al.
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6-Acetyl-5-hydroxy-4,7-dimethylcoumarin derivatives: Design, synthesis, modeling studies, 5-HT 1A, 5-HT 2A and D 2 receptors affinity

Bioorganic Chemistry
2020 | Journal article
Contributors: Ostrowska, Kinga; Lesniak, Anna; Karczynska, Urszula; Jeleniewicz, Paulina; Gluch-Lutwin, Monika; Mordyl, Barbara; Siwek, Agata; Trzaskowski, Bartosz; Sacharczuk, Mariusz; Bujalska-Zadrozny, Magdalena
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Antidepressant-like activity and safety profile evaluation of 1<i>H</i>-imidazo[2,1-<i>f</i>]purine-2,4(3H,8H)-dione derivatives as 5-HT<sub>1A</sub>receptor partial agonists

Plos One
2020 | Journal article
Contributors: Partyka, Anna; Zagorska, Agnieszka; Kotanska, Magdalena; Walczak, Maria; Jastrzebska-Wiesek, Magdalena; Knutelska, Joanna; Bednarski, Marek; Gluch-Lutwin, Monika; Mordyl, Barbara; Janiszewska, Paulina et al.
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Chlorine substituents and linker topology as factors of 5-HT6R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo

European Journal of Medicinal Chemistry
2020 | Journal article
Contributors: Sudol, Sylwia; Kucwaj-Brysz, Katarzyna; Kurczab, Rafal; Wilczynska, Natalia; Jastrzebska-Wiesek, Magdalena; Satala, Grzegorz; Latacz, Gniewomir; Gluch-Lutwin, Monika; Mordyl, Barbara; Zeslawska, Ewa et al.
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Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione

International Journal of Molecular Sciences
2020 | Journal article
Contributors: Gora, Malgorzata; Czopek, Anna; Rapacz, Anna; Dziubina, Anna; Gluch-Lutwin, Monika; Mordyl, Barbara; Obniska, Jolanta
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Synthesis, coordination properties and biological activity of vanadium complexes with hydrazone Schiff base ligands

Polyhedron
2020 | Journal article
Contributors: Szklarzewicz, Janusz; Jurowska, Anna; Matoga, Dariusz; Kruczala, Krzysztof; Kazek, Grzegorz; Mordyl, Barbara; Sapa, Jacek; Papiez, Monika
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ANTINOCICEPTIVE AND ANTIPRURITIC EFFECTS OF THE HISTAMINE H-3 RECEPTOR ANTAGONIST (DL-76) IN ACUTE, INFLAMMATORY AND NEUROPATHIC PAIN AND HISTAMINE- DEPENDENT AND -INDEPENDENT ITCH

Inflammation Research
2019 | Journal article
Contributors: Mogilski, S.; Lazewska, D.; Kubacka, M.; Gluch-Lutwin, M.; Mordyl, B.; Filipek, B.; Kiec-Kononowicz, K.
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Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6

European Journal of Medicinal Chemistry
2019 | Journal article
Contributors: Ali, Wesam; Wiecek, Malgorzata; Lazewska, Dorota; Kurczab, Rafal; Jastrzebska-Wiesek, Magdalena; Satala, Grzegorz; Kucwaj-Brysz, Katarzyna; Lubelska, Annamaria; Gluch-Lutwin, Monika; Mordyl, Barbara et al.
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New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

Journal of Medicinal Chemistry
2019-11-14 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
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Barbara Mordyl

Evaluation of anticonvulsant and analgesic activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-l-yl)-propanamides and -butanamides

Epilepsy Research
2018 | Journal article
Contributors: Kaminski, Krzysztof; Abram, Michal; Filipek, Barbara; Mordyl, Barbara; Gluch-Lutwin, Monika; Rapacz, Anna
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Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate

International Journal of Medical Sciences
2017 | Journal article
Contributors: Plech, Tomasz; Tomczykowski, Adam; Jozwiak, Krzysztof; Pajak, Karolina; Nowak, Gabriel; Grybos, Anna; Gluch-Lutwin, Monika; Mordyl, Barbara; Karcz, Tadeusz; Siwek, Agata et al.
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Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity

Journal of Enzyme Inhibition and Medicinal Chemistry
2016 | Journal article
Contributors: Chlon-Rzepa, Grazyna; Bucki, Adam; Kolaczkowski, Marcin; Partyka, Anna; Jastrzebska-Wiesek, Magdalena; Satala, Grzegorz; Bojarski, Andrzej J.; Kalinowska-Tluscik, Justyna; Kazek, Grzegorz; Mordyl, Barbara et al.
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Design, synthesis, and biological evaluation of fluorinated imidazo [1,2-a]pyridine derivatives with potential antipsychotic activity

European Journal of Medicinal Chemistry
2016 | Journal article
Contributors: Bienkowski, Przemyslaw; Mierzejewski, Pawel; Samochowiec, Jerzy; Wesolowska, Anna; Pekala, Elibieta; Kubowicz, Paulina; Starowicz, Gabriela; Mordyl, Barbara; Karcz, Tadeusz; Siwek, Agata et al.
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HBK-7-A new xanthone derivative and a 5-HT<sub>1A</sub> receptor antagonist with antidepressant-like properties

Pharmacology, Biochemistry and Behavior
2016 | Journal article
Contributors: Pytka, Karolina; Kazek, Grzegorz; Siwek, Agata; Mordyl, Barbara; Gluch-Lutwin, Monika; Rapacz, Anna; Olczyk, Adrian; Galuszka, Adam; Waszkielewicz, Anna; Marona, Henryk et al.
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Pyrrolidin-2-one derivatives may reduce body weight in rats with diet-induced obesity

European Journal of Pharmacology
2016 | Journal article
Contributors: Dudek, Magdalena; Knutelska, Joanna; Bednarski, Marek; Nowinski, Leszek; Zygmunt, Malgorzata; Kazek, Grzegorz; Mordyl, Barbara; Gluch-Lutwin, Monika; Zareba, Paula; Kulig, Katarzyna et al.
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RECEPTOR AFFINITY AND PHOSPHODIESTERASES 4B AND 10A ACTIVITY OF OCTAHYDRO- AND 6,7-DIMETHOXY-3,4-DIHYDRO-ISOQUINOLIN-2(1H)-YL-ALKYL DERIVATIVES OF IMIDAZO- AND PYRIMIDINO[2,1-f]PURINES

Acta Poloniae Pharmaceutica
2016 | Journal article
Contributors: Zagorska, Agnieszka; Gryzlo, Beata; Satala, Grzegorz; Bojarski, Andrzej J.; Gluch-Lutwin, Monika; Mordyl, Barbara; Kazek, Grzegorz; Pawlowski, Maciej
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SALIVARY OXIDATIVE STATUS IN PATIENTS WITH ORAL LICHEN PLANUS

Journal of Physiology and Pharmacology
2016 | Journal article
Contributors: Chomyszyn-Gajewska, M.; Mordyl, B.; Gluch-Lutwin, M.; Kaczmarzyk, T.; Lipska, W.; Galecka-Wanatowicz, D.; Kesek, B.; Vyhouskaya, P.; Krzysciak, W.; Darczuk, D.
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A Comparison of the Anorectic Effect and Safety of the Alpha(2)-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity

Plos One
2015 | Journal article
Contributors: Dudek, Magdalena; Knutelska, Joanna; Bednarski, Marek; Nowinski, Leszek; Zygmunt, Malgorzata; Mordyl, Barbara; Gluch-Lutwin, Monika; Kazek, Grzegorz; Sapa, Jacek; Pytka, Karolina
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Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT<sub>1A</sub> and 5-HT<sub>7</sub> Antagonists in Animal Models

Plos One
2015 | Journal article
Contributors: Pytka, Karolina; Partyka, Anna; Jastrzebska-Wiesek, Magdalena; Siwek, Agata; Gluch-Lutwin, Monika; Mordyl, Barbara; Kazek, Grzegorz; Rapacz, Anna; Olczyk, Adrian; Galuszka, Adam et al.
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Structure-5-HT Receptor Affinity Relationship in a New Group of 7-Arylpiperazynylalkyl and 7-Tetrahydroisoquinolinylalkyl Derivatives of 8-Amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

Archiv der Pharmazie
2015 | Journal article
Contributors: Zmudzki, Pawel; Chlon-Rzepa, Grazyna; Bojarski, Andrzej J.; Zygmunt, Malgorzata; Kazek, Grzegorz; Mordyl, Barbara; Pawlowski, Maciej
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Assemblies of salen-type oxidovanadium(IV) complexes: substituent effects and in vitro protein tyrosine phosphatase inhibition

Dalton Transactions
2014 | Journal article
Contributors: Zabierowski, Piotr; Szklarzewicz, Janusz; Grybos, Ryszard; Modryl, Barbara; Nitek, Wojciech
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Influence of analgesic active 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one on the antioxidant status, glucose utilization and lipid accumulation in some in vitro and ex vivo assays

Toxicology Mechanisms and Methods
2014 | Journal article
Contributors: Salat, Kinga; Gluch-Lutwin, Monika; Nawiesniak, Barbara; Gawlik, Katarzyna; Pawlica-Gosiewska, Dorota; Witalis, Jadwiga; Kazek, Grzegorz; Filipek, Barbara; Librowski, Tadeusz; Wieckowski, Krzysztof et al.
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Evaluation of analgesic, antioxidant, cytotoxic and metabolic effects of pregabalin for the use in neuropathic pain

Neurological Research
2013 | Journal article
Contributors: Salat, Kinga; Librowski, Tadeusz; Nawiesniak, Barbara; Gluch-Lutwin, Monika
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Partial agonist efficacy of EMD386088, a 5-HT6 receptor ligand, in functional in vitro assays

Pharmacological Reports
2013 | Journal article
Contributors: Jastrzebska-Wiesek, Magdalena; Siwek, Agata; Kazek, Grzegorz; Nawiesniak, Barbara; Partyka, Anna; Marcinkowska, Monika; Kolaczkowski, Marcin; Wesolowska, Anna
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