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Scopus Author ID: 51261628300
ResearcherID: A-1613-2008
Loop profile: 5133

Keywords

Neuroscience, neurodegenerative diseases, insulin factors

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Employment (1)

Achucarro Basque Center for Neuroscience: Leioa, ES

2020-10-01 to present
Employment
Source: Self-asserted source
Ignacio Torres Aleman

Education and qualifications (1)

Cajal Institute: Madrid, Madrid, ES

Professor
Education
Source: Self-asserted source
Ignacio Torres Aleman

Works (50 of 175)

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Page 1 of 4

The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer’s Disease

International Journal of Molecular Sciences
2023-11-17 | Journal article
DOI: 10.3390/ijms242216440
Contributors: Jonathan A. Zegarra-Valdivia; Jaime Pignatelli; Angel Nuñez; Ignacio Torres Aleman
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The neurobiology of insulin-like growth factor I: From neuroprotection to modulation of brain states

Molecular Psychiatry
2023-08 | Journal article
DOI: 10.1038/s41380-023-02136-6
Contributors: A. Nuñez; J. Zegarra-Valdivia; D. Fernandez de Sevilla; J. Pignatelli; I. Torres Aleman
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Cognitive Deficits in Aging Related to Changes in Basal Forebrain Neuronal Activity

Cells
2023-05-25 | Journal article
DOI: 10.3390/cells12111477
Contributors: Irene Chaves-Coira; Nuria García-Magro; Jonathan Zegarra-Valdivia; Ignacio Torres-Alemán; Ángel Núñez
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Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology [version 3; peer review: 2 approved]

2022-12-20 | Journal article
DOI: 10.12688/f1000research.121901.3
Part of ISSN: 2046-1402
Funded by GRANT_NUMBER: 2017/14742-0, 2019/03368-5
Funded by GRANT_NUMBER: PB005
Funded by GRANT_NUMBER:

PIBA 2021_1_0033

Funded by GRANT_NUMBER: SAF2016-76462
Contributors: Jonathan Zegarra-Valdivia; Ana M. Fernandez; Laura Martinez-Rachadell; Raquel Herrero-Labrador; Jansen Fernandes; Ignacio Torres Aleman; Fernandes Jansen; Fernandes Jansen; Fernandes Jansen; Fernandes Jansen et al.
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Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

F1000Research
2022-11-30 | Journal article
DOI: 10.12688/f1000research.121901.2
Contributors: Jonathan Zegarra-Valdivia; Ana M. Fernandez; Laura Martinez-Rachadell; Raquel Herrero-Labrador; Jansen Fernandes; Ignacio Torres Aleman
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Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

F1000Research
2022-06-16 | Journal article
DOI: 10.12688/f1000research.121901.1
Contributors: Jonathan Zegarra-Valdivia; Ana M. Fernandez; Laura Martinez-Rachadell; Raquel Herrero-Labrador; Jansen Fernandes; Ignacio Torres Aleman
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Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons

Molecular Psychiatry
2022-04 | Journal article
DOI: 10.1038/s41380-022-01442-9
Contributors: M. Estrella Fernández de Sevilla; Jaime Pignatelli; Jonathan A. Zegarra-Valdivia; Pablo Mendez; Angel Nuñez; Ignacio Torres Alemán
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Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons

International Journal of Molecular Sciences
2022-04-23 | Journal article
DOI: 10.3390/ijms23094679
Contributors: Jaime Pignatelli; M. Estrella Fernandez de Sevilla; Jacob Sperber; Daniel Horrillo; Gema Medina-Gomez; Ignacio Torres Aleman
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Response Facilitation Induced by Insulin-like Growth Factor-I in the Primary Somatosensory Cortex of Mice Was Reduced in Aging

Cells
2022-02-17 | Journal article
DOI: 10.3390/cells11040717
Contributors: Nuria García-Magro; Jonathan A. Zegarra-Valdivia; Sara Troyas-Martinez; Ignacio Torres-Aleman; Angel Nuñez
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Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse

Frontiers in Aging Neuroscience
2021-09-01 | Journal article
DOI: 10.3389/fnagi.2021.682388
Part of ISSN: 1663-4365
Source: Self-asserted source
Ignacio Torres Aleman

INTEROCEPTIVE INFORMATION OF PHYSICAL VIGOR: OREXIN NEURONS GAUGE CIRCULATING IGF-I FOR MOTIVATIONAL MOTOR OUTPUT

2021-05-25 | Other
DOI: 10.1101/2021.05.25.445442
Contributors: Jonathan A. Zegarra-Valdivia; Jansen Fernandes; Julio Esparza; Kentaro Suda; Maria Estrella Fernandez de Sevilla; Sonia Díaz-Pacheco; Ignacio Torres Aleman
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Astrocytic IGF-IRs induce adenosine-mediated inhibitory down regulation and improve sensory discrimination

The Journal of Neuroscience
2021-04-28 | Journal article
DOI: 10.1523/jneurosci.0005-21.2021
Part of ISSN: 0270-6474
Part of ISSN: 1529-2401
Source: Self-asserted source
Ignacio Torres Aleman

INSULIN-LIKE GROWTH FACTOR I SENSITIZATION REJUVENATES SLEEP PATTERNS IN OLD MICE

2021-02-24 | Other
DOI: 10.1101/2021.02.23.432494
Contributors: Ignacio Torres Aleman; Jonathan A Zegarra-Valdivia; Jansen Fernandes; Angel Trueba-Saiz; Maria Estrella Fernandez de Sevilla; Jaime Pignatelli; Kentaro Suda; Laura Martinez Rachadell; Ana M Fernandez; Julio Esparza et al.
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Insulin-Like Growth Factor I Couples Metabolism With Circadian Activity Through Hypothalamic Orexin Neurons

2021-02-08 | Preprint
DOI: 10.1101/2021.02.07.429949
Contributors: J. Pignatelli; E. Fernandez de Sevilla; J. Sperber; J.D. Horrillo; G. Medina-Gomez; I. Torres Aleman
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Circulating Insulin-Like Growth Factor I is Involved in the Effect of High Fat Diet on Peripheral Amyloid β Clearance

International Journal of Molecular Sciences
2020-12-18 | Journal article
DOI: 10.3390/ijms21249675
Contributors: Raquel Herrero-Labrador; Angel Trueba-Saiz; Laura Martinez-Rachadell; Mᵃ Estrella Fernandez de Sevilla; Jonathan A. Zegarra-Valdivia; Jaime Pignatelli; Sonia Diaz-Pacheco; Ana M. Fernandez; Ignacio Torres Aleman
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Insulin-like growth factor I modulates sleep through hypothalamic orexin neurons.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2020-10-08 | Journal article
DOI: 10.1096/fj.202001281rr
PMID: 33070417
Source: Self-asserted source
Ignacio Torres Aleman

Insulin-Like Growth Factor I Modulates Sleep Through Hypothalamic Orexin Neurons

2020-03-21 | Preprint
DOI: 10.1101/2020.03.20.000000
Contributors: Jonathan A. Zegarra-Valdivia; Jaime Pignatelli; Maria Estrella Fernandez de Sevilla; Ana M. Fernandez; Victor Munive; Laura Martinez-Rachadell; Angel Nuñez; Ignacio Torres Aleman
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Insulin-Like Growth Factor I Modulates Vulnerability to Stress Through Orexin Neurons

2020-02-10 | Preprint
DOI: 10.1101/2020.02.10.941377
Contributors: ME Fernandez de Sevilla; J Pignatelli; P. Mendez; J Zegarra-Valdivia; I Torres Alemán
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The Insulin Receptor in Astrocytes is Involved in the Entrance of Circulating Insulin into the Brain

2019-07-31 | Other
DOI: 10.1101/720813
Contributors: Ana M. Fernandez; M. Navarrete; Jose Carlos Davila; Cristina Garcia-Caceres; Rocio Palenzuela; Samuel Ruiz de Martin Esteban; Ricardo Mostany; Matthias Tschöp; Antonia Gutierrez; Ignacio Torres Aleman
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Cell-specific expression of insulin/insulin-like growth factor-I receptor hybrids in the mouse brain

Growth Hormone & IGF Research
2019-04 | Journal article
DOI: 10.1016/j.ghir.2019.02.003
Contributors: L. Martinez-Rachadell; A. Aguilera; P. Perez-Domper; J. Pignatelli; A.M. Fernandez; I. Torres-Aleman
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Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice.

Aging
2019-01 | Journal article
PMID: 30636168
Source: Self-asserted source
Ignacio Torres Aleman

Serum Insulin-Like Growth Factor I Deficiency Associates to Alzheimer's Disease Co-Morbidities.

Journal of Alzheimer's disease : JAD
2019-01-01 | Journal article
DOI: 10.3233/jad-190241
PMID: 31156175
Source: Self-asserted source
Ignacio Torres Aleman

Insulin Peptides as Mediators of the Impact of Life Style in Alzheimer's disease.

Brain Plasticity
2018 | Journal article
PMID: 30564544
Source: Self-asserted source
Ignacio Torres Aleman

Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man

Translational Psychiatry
2018-08-01 | Journal article
DOI: 10.1038/s41398-018-0196-5
Contributors: A. Santi; M. Bot; A. Aleman; B. W. J. H. Penninx; I. Torres Aleman
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A Coordinated Action of Blood-Borne and Brain Insulin-Like Growth Factor I in the Response to Traumatic Brain Injury.

Cerebral cortex (New York, N.Y. : 1991)
2017 | Journal article
DOI: 10.1093/cercor/bhx106
WOSUID:

MEDLINE:28449086
Contributors: Santi, A; Genis, L; Torres Aleman, I
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID

A network of insulin peptides regulate glucose uptake by astrocytes: Potential new druggable targets for brain hypometabolism.

Neuropharmacology
2017 | Journal article
DOI: 10.1016/j.neuropharm.2017.08.034
WOSUID:

MEDLINE:28859884
Contributors: Fernandez, Ana M; Hernandez, Edwin; Guerrero-Gomez, David; Miranda-Vizuete, Antonio; Torres Aleman, Ignacio
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Circulating Insulin-Like Growth Factor I Regulates Its Receptor in the Brain of Male Mice

Endocrinology
2017 | Journal article
DOI: 10.1210/en.2016.1468
WOSUID:

WOS:000397101700016
Contributors: Trueba-Saiz, A.; Fernandez, A. M.; Nishijima, T.; Mecha, M.; Santi, A.; Munive, V.; Torres Aleman, I.
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

Diabetes
2017 | Journal article
DOI: 10.2337/db16-0861
WOSUID:

WOS:000390834300012
Contributors: Fernandez, Ana M.; Hernandez-Garzon, Edwin; Perez-Domper, Paloma; Perez-Alvarez, Alberto; Mederos, Sara; Matsui, Takashi; Santi, Andrea; Trueba-Saiz, Angel; Garcia-Guerra, Lucia; Pose-Utrilla, Julia et al.
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID

Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes

Diabetologia
2017 | Journal article
DOI: 10.1007/s00125-016-4164-4
WOSUID:

WOS:000394462100025
Contributors: Shima, Takeru; Matsui, Takashi; Jesmin, Subrina; Okamoto, Masahiro; Soya, Mariko; Inoue, Koshiro; Liu, Yu-Fan; Torres-Aleman, Ignacio; McEwen, Bruce S.; Soya, Hideaki
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Acute exercise does not modify brain activity and memory performance in APP/PS1 mice

PLOS ONE
2017-05-22 | Journal article
DOI: 10.1371/journal.pone.0178247
Contributors: Angelica Miki Stein; Sergio Pellis; Victor Munive; Ana M. Fernandez; Angel Nuñez; Ignacio Torres Aleman
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A role for astrocytes in cerebellar deficits in frataxin deficiency: Protection by insulin-like growth factor I

Molecular and Cellular Neuroscience
2017-04 | Journal article
DOI: 10.1016/j.mcn.2017.02.008
Contributors: C Franco; L Genis; JA Navarro; P Perez-Domper; AM Fernandez; S Schneuwly; I Torres Alemán
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A Concerted Action Of Estradiol And Insulin Like Growth Factor I Underlies Sex Differences In Mood Regulation By Exercise.

2016 | Journal article
DOI: 10.1038/srep25969
PMID: 27170462
PMC: PMC4864325
Contributors: Munive V; Santi A; Torres-Aleman I
Source: Self-asserted source
Ignacio Torres Aleman via Europe PubMed Central
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Astrocyte resilience to oxidative stress induced by insulin-like growth factor i (IGF-I) involves preserved AKT (protein kinase B) activity

Journal of Biological Chemistry
2016 | Journal article
DOI: 10.1074/jbc.M115.695478
EID:

2-s2.0-84957006670
Contributors: Dávila, D.; Fernández, S.; Torres-Alemán, I.
Source: Self-asserted source
Ignacio Torres Aleman via Scopus - Elsevier

Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation

Biochimica Et Biophysica Acta-Molecular Cell Research
2016 | Journal article
DOI: 10.1016/j.bbamcr.2016.07.002
WOSUID:

WOS:000385329900003
Contributors: Diez, Hector; Jose Benitez, Ma; Fernandez, Silvia; Torres-Aleman, Ignacio; Jose Garrido, Juan; Wandosell, Francisco
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Erratum: Astrocyte resilience to oxidative stress induced by insulin-like growth factor i (igf-i) involves preserved akt (protein kinase b) activity(Journal of Biological Chemistry (2016) 291 (120))

Journal of Biological Chemistry
2016 | Journal article
DOI: 10.1074/jbc.A115.695478
EID:

2-s2.0-84974578043
Contributors: Dávila, D.; Fernández, S.; Torres-Alemán, I.
Source: Self-asserted source
Ignacio Torres Aleman via Scopus - Elsevier

Exercise and cerebrovascular plasticity

New Horizons in Neurovascular Coupling: a Bridge Between Brain Circulation and Neural Plasticity
2016 | Book chapter
DOI: 10.1016/bs.pbr.2016.03.010
WOSUID:

WOS:000385737200012
Contributors: Nishijima, T.; Torres-Aleman, I.; Soya, H.
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Insulin-like peptides signaling in Alzheimer's disease: on the road to alternative therapeutics

Current Opinion in Behavioral Sciences
2016 | Journal article
DOI: 10.1016/j.cobeha.2015.11.013
WOSUID:

WOS:000395322600004
Contributors: Trueba-Saiz, Angel; Torres Aleman, Ignacio
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID

The insulin-like growth factor I receptor regulates glucose transport by astrocytes.

2016-11 | Journal article
DOI: 10.1002/glia.23035
PMID: 27462832
Contributors: Hernandez-Garzón E; Fernandez AM; Perez-Alvarez A; Genis L; Bascuñana P; Fernandez de la Rosa R; Delgado M; Angel Pozo M; Moreno E; McCormick PJ et al.
Source: Self-asserted source
Ignacio Torres Aleman via Europe PubMed Central
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Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability.

2016-08 | Journal article
DOI: 10.1016/j.cell.2016.07.028
PMID: 27518562
Contributors: García-Cáceres C; Quarta C; Varela L; Gao Y; Gruber T; Legutko B; Jastroch M; Johansson P; Ninkovic J; Yi CX et al.
Source: Self-asserted source
Ignacio Torres Aleman via Europe PubMed Central
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Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death.

2016-04 | Journal article
DOI: 10.3233/jad-160149
PMID: 27079728
Contributors: Fernandez AM; Hervas R; Dominguez-Fraile M; Garrido VN; Gomez-Gutierrez P; Vega M; Vitorica J; Perez JJ; Torres Aleman I
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Ignacio Torres Aleman via Europe PubMed Central
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A phosphatase-independent gain-of-function mutation in PTEN triggers aberrant cell growth in astrocytes through an autocrine IGF-1 loop

Oncogene
2014 | Journal article
DOI: 10.1038/onc.2013.376
WOSUID:

WOS:000340595700002
Contributors: Fernandez, S.; Genis, L.; Torres-Aleman, I.
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury.

F1000Research
2014 | Journal article
DOI: 10.12688/f1000research.3-28.v1
WOSUID:

MEDLINE:24715976
Contributors: Genis, Laura; Davila, David; Fernandez, Silvia; Pozo-Rodrigalvarez, Andrea; Martinez-Murillo, Ricardo; Torres-Aleman, Ignacio
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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IGF-1 in autosomal dominant cerebellar ataxia - open-label trial.

Cerebellum & ataxias
2014 | Journal article
DOI: 10.1186/s40673-014-0013-8
WOSUID:

MEDLINE:26331037
Contributors: Sanz-Gallego, Irene; Rodriguez-de-Rivera, Francisco J; Pulido, Irene; Torres-Aleman, Ignacio; Arpa, Javier
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID

IGF-1 in Friedreich's Ataxia - proof-of-concept trial.

Cerebellum & ataxias
2014 | Journal article
DOI: 10.1186/2053-8871-1-10
WOSUID:

MEDLINE:26331034
Contributors: Sanz-Gallego, Irene; Torres-Aleman, Ignacio; Arpa, Javier
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID

Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice

Behavioural Brain Research
2013 | Journal article
DOI: 10.1016/j.bbr.2013.02.009
WOSUID:

WOS:000317704800006
Contributors: Nishijima, Takeshi; Llorens-Martin, Maria; Sanchez Tejeda, Gonzalo; Inoue, Koshiro; Yamamura, Yuhei; Soya, Hideaki; Luis Trejo, Jose; Torres-Aleman, Ignacio
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice

Translational Psychiatry
2013 | Journal article
DOI: 10.1038/tp.2013.102
WOSUID:

WOS:000330127200004
Contributors: Trueba-Saiz, A.; Cavada, C.; Fernandez, A. M.; Leon, T.; Gonzalez, D. A.; Fortea Ormaechea, J.; Lleo, A.; Del Ser, T.; Nunez, A.; Torres-Aleman, I.
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency

Neuroscience Letters
2012 | Journal article
DOI: 10.1016/j.neulet.2011.12.048
WOSUID:

WOS:000301168300008
Contributors: Poirier, R.; Fernandez, A. M.; Torres-Aleman, I.; Metzger, F.
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Ignacio Torres Aleman via ResearcherID
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Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons

Molecular Neurodegeneration
2012 | Journal article
DOI: 10.1186/1750-1326-7-51
WOSUID:

WOS:000313888300001
Contributors: Franco, Carolina; Fernandez, Silvia; Torres-Aleman, Ignacio
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Insulin-Like Growth Factor-1 and Central Neurodegenerative Diseases

Endocrinology and Metabolism Clinics of North America
2012 | Journal article
DOI: 10.1016/j.ecl.2012.04.016
WOSUID:

WOS:000305861800012
Contributors: Torres Aleman, Ignacio
Source: Self-asserted source
Ignacio Torres Aleman via ResearcherID
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Reduced brain insulin-like growth factor I function during aging

Molecular and Cellular Neuroscience
2012 | Journal article
DOI: 10.1016/j.mcn.2011.07.008
WOSUID:

WOS:000299141600002
Contributors: Muller, Alexandre Pastoris; Fernandez, Ana M.; Haas, Clarissa; Zimmer, Eduardo; Portela, Luis Valmor; Torres-Aleman, Ignacio
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Ignacio Torres Aleman via ResearcherID
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Items per page:
Page 1 of 4

Peer review (8 reviews for 5 publications/grants)

Review activity for Acta neuropathologica communications. (1)
Review activity for Biochemistry and biophysics reports. (2)
Review activity for Journal of physiology and biochemistry. (1)
Review activity for Molecular neurobiology. (2)
Review activity for Nature neuroscience. (2)
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