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University of Alberta: Edmonton, AB, CA

2008-10-03 to present | Professor (Pharmacy & Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Arno Siraki

Education and qualifications (1)

University of Toronto: Toronto, ON, CA

2001-01-01 to 2004-06-01 | PhD (Pharmacy)
Education
Source: Self-asserted source
Arno Siraki

Works (50 of 65)

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Page 1 of 2

The Interaction of Myeloperoxidase with the Industrial Contaminant 6-PPD: A Potential Pathway for Reactive Metabolites

Chemical Research in Toxicology
2024-10-21 | Journal article
DOI: 10.1021/acs.chemrestox.4c00265
Contributors: Steven Lockhart; Dinesh Babu; Newton H. Tran; Béla Reiz; Lusine Tonoyan; Arno G. Siraki
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Crossref

Application of electron paramagnetic resonance spectroscopy for determining the relative nanoenvironment fluidity of polymeric micelles

European Biophysics Journal
2024-05 | Journal article
DOI: 10.1007/s00249-024-01706-y
Contributors: Lusine Tonoyan; Sirazum Munira; Afsaneh Lavasanifar; Arno G. Siraki
Source: check_circle
Crossref

Comparing the oxidative functions of neutrophil myeloperoxidase and cytochrome P450 enzymes in drug metabolism

Chemico-Biological Interactions
2024-04 | Journal article
DOI: 10.1016/j.cbi.2024.110942
Contributors: Newton H. Tran; Farag E.S. Mosa; Khaled Barakat; Ayman O.S. El-Kadi; Randy Whittal; Arno G. Siraki
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Crossref

The oxidation of fenamic acid NSAIDs by neutrophil myeloperoxidase produces toxic reactive metabolites that induce leukemic cell death

Redox Biochemistry and Chemistry
2023-12 | Journal article
DOI: 10.1016/j.rbc.2023.100013
Contributors: Newton H. Tran; Dinesh Babu; Steven Lockhart; Andrew G. Morgan; Nadine Commandeur; Md Harunur Rashid; Béla Reiz; Lusine Tonoyan; Arno G. Siraki
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Crossref

Effect of Plasma-Activated Water Bubbles on <i>Fusarium graminearum</i>, Deoxynivalenol, and Germination of Naturally Infected Barley during Steeping.

Toxins
2023-02 | Journal article
DOI: 10.3390/toxins15020124
PMID: 36828438
PMC: PMC9967671
Contributors: Feizollahi E; Basu U; Fredua-Agyeman R; Jeganathan B; Tonoyan L; Strelkov SE; Vasanthan T; Siraki AG; Roopesh MS
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Heating of consumer cannabis oils can lead to free radical initiated degradation, causing CBD and THC depletion

Free Radical Biology and Medicine
2022-11 | Journal article
DOI: 10.1016/j.freeradbiomed.2022.09.005
Contributors: Lusine Tonoyan; Dinesh Babu; Bela Reiz; Tyson Le; Arno G. Siraki
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Crossref

Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to N-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite

Chemical Research in Toxicology
2022-06-20 | Journal article
DOI: 10.1021/acs.chemrestox.2c00008
Contributors: Md Harunur Rashid; Dinesh Babu; Newton Tran; Béla Reiz; Arno G. Siraki
Source: check_circle
Crossref

The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery

Redox Biology
2021-10 | Journal article
DOI: 10.1016/j.redox.2021.102109
Contributors: Arno G. Siraki
Source: check_circle
Crossref

β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models.

International journal of molecular sciences
2021-09 | Journal article
DOI: 10.3390/ijms221910550
PMID: 34638895
PMC: PMC8508804
Contributors: Dahham SS; Tabana Y; Asif M; Ahmed M; Babu D; Hassan LE; Ahamed MBK; Sandai D; Barakat K; Siraki A et al.
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants

Chemico-Biological Interactions
2021-08 | Journal article
DOI: 10.1016/j.cbi.2021.109574
Contributors: Md Harunur Rashid; Dinesh Babu; Arno G. Siraki
Source: check_circle
Crossref

Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations.

Expert opinion on therapeutic targets
2021-05 | Journal article
DOI: 10.1080/14728222.2021.1937123
PMID: 34056985
Contributors: Tabana Y; Moon TC; Siraki A; Elahi S; Barakat K
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Tackling Immune Targets for Breast Cancer: Beyond PD-1/PD-L1 Axis.

Frontiers in oncology
2021-03 | Journal article
DOI: 10.3389/fonc.2021.628138
PMID: 33747948
PMC: PMC7973280
Contributors: Tabana Y; Okoye IS; Siraki A; Elahi S; Barakat KH
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Treatment of a mixture of pharmaceuticals, herbicides and perfluorinated compounds by powdered activated carbon and ozone: Synergy, catalysis and insights into non-free OH contingent mechanisms.

The Science of the total environment
2021-03 | Journal article
DOI: 10.1016/j.scitotenv.2021.146138
PMID: 33689896
Contributors: Alameddine M; Siraki A; Tonoyan L; Gamal El-Din M
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action.

British journal of pharmacology
2019-11 | Journal article
DOI: 10.1111/bph.14867
PMID: 31517993
PMC: PMC6965675
Contributors: Khan SR; Manialawy Y; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.

Scientific reports
2019-08 | Journal article
DOI: 10.1038/s41598-019-48826-6
PMID: 31455818
PMC: PMC6712002
Contributors: Ganesan A; Ahmed M; Okoye I; Arutyunova E; Babu D; Turnbull WL; Kundu JK; Shields J; Agopsowicz KC; Xu L et al.
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Introduction to the special issue from the 10th meeting of the Canadian Oxidative Stress Consortium.

Chemico-biological interactions
2019-08 | Journal article
DOI: 10.1016/j.cbi.2019.108800
PMID: 31449778
Contributors: Siraki AG; Babu D
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Myeloperoxidase-mediated oxidation of edaravone produces an apparent non-toxic free radical metabolite and modulates hydrogen peroxide-mediated cytotoxicity in HL-60 cells.

Free radical biology & medicine
2019-08 | Journal article
DOI: 10.1016/j.freeradbiomed.2019.08.021
PMID: 31445206
Contributors: Suh LYK; Babu D; Tonoyan L; Reiz B; Whittal R; Tabatabaei-Dakhili SA; Morgan AG; Velázquez-Martínez CA; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Caution for the routine use of phenol red - It is more than just a pH indicator.

Chemico-biological interactions
2019-07 | Journal article
DOI: 10.1016/j.cbi.2019.108739
PMID: 31288001
Contributors: Morgan A; Babu D; Reiz B; Whittal R; Suh LYK; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Eosinophil peroxidase oxidizes isoniazid to form the active metabolite against M. tuberculosis, isoniazid-NAD.

Chemico-biological interactions
2019-03 | Journal article
DOI: 10.1016/j.cbi.2019.03.019
PMID: 30922765
Contributors: Babu D; Morgan AG; Reiz B; Whittal RM; Almas S; Lacy P; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Isoniazid induces a monocytic-like phenotype in HL-60 cells.

Archives of biochemistry and biophysics
2019-01 | Journal article
DOI: 10.1016/j.abb.2019.01.004
PMID: 30682330
Contributors: Babu D; Khan SR; Srivastava N; Kyoung Suh LY; Morgan AG; Aljuhani N; Fahlman RP; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Reactive Oxygen Species Mediate Therapeutic Ultrasound-Induced, Mitogen-Activated Protein Kinase Activation in C28/I2 Chondrocytes.

Ultrasound in medicine & biology
2018-07 | Journal article
DOI: 10.1016/j.ultrasmedbio.2018.05.025
PMID: 30037475
Contributors: Kaur H; Siraki AG; Sharma M; UludaÄŸ H; Dederich DN; Flood P; El-Bialy T
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy.

Scientific reports
2018-02 | Journal article
DOI: 10.1038/s41598-018-20613-9
PMID: 29426916
PMC: PMC5807528
Contributors: Maayah ZH; Levasseur J; Siva Piragasam R; Abdelhamid G; Dyck JRB; Fahlman RP; Siraki AG; El-Kadi AOS
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Characterization of Mechanisms of Glutathione Conjugation with Halobenzoquinones in Solution and HepG2 Cells.

Environmental science & technology
2018-02 | Journal article
DOI: 10.1021/acs.est.7b05945
PMID: 29420883
Contributors: Wang W; Qian Y; Li J; Aljuhani N; Siraki AG; Le XC; Li XF
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation.

Cardiovascular research
2017-12 | Journal article
DOI: 10.1093/cvr/cvx179
PMID: 29016749
PMC: PMC5852541
Contributors: Radziwon-Balicka A; Lesyk G; Back V; Fong T; Loredo-Calderon EL; Dong B; El-Sikhry H; El-Sherbeni AA; El-Kadi A; Ogg S et al.
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Role of Reactive Oxygen Species during Low-Intensity Pulsed Ultrasound Application in MC-3 T3 E1 Pre-osteoblast Cell Culture.

Ultrasound in medicine & biology
2017-08 | Journal article
DOI: 10.1016/j.ultrasmedbio.2017.07.002
PMID: 28807447
Contributors: Kaur H; Siraki AG; UludaÄŸ H; Dederich DN; Flood P; El-Bialy T
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity.

Toxicology letters
2017-07 | Journal article
DOI: 10.1016/j.toxlet.2017.07.894
PMID: 28754375
Contributors: Morgan AGM; Babu D; Michail K; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol.

Molecular and cellular biochemistry
2017-03 | Journal article
DOI: 10.1007/s11010-017-2943-y
PMID: 28251434
Contributors: Maayah ZH; Althurwi HN; El-Sherbeni AA; Abdelhamid G; Siraki AG; El-Kadi AO
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Screening of genotoxicity and mutagenicity in extractable organics from oil sands process-affected water.

Environmental toxicology and chemistry
2016-12 | Journal article
DOI: 10.1002/etc.3670
PMID: 27800635
Contributors: Zetouni NC; Siraki AG; Weinfeld M; Pereira ADS; Martin JW
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.

Biochemical pharmacology
2016-02 | Journal article
DOI: 10.1016/j.bcp.2016.02.003
PMID: 26867495
Contributors: Khan SR; Morgan AG; Michail K; Srivastava N; Whittal RM; Aljuhani N; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog.

Bioorganic & medicinal chemistry letters
2016-01 | Journal article
DOI: 10.1016/j.bmcl.2016.01.069
PMID: 26850006
Contributors: Aldawsari FS; Aguiar RP; Wiirzler LA; Aguayo-Ortiz R; Aljuhani N; Cuman RK; Medina-Franco JL; Siraki AG; Velázquez-Martínez CA
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Global protein expression dataset acquired during isoniazid-induced cytoprotection against H2O2 challenge in HL-60 cells.

Data in brief
2016-01 | Journal article
DOI: 10.1016/j.dib.2016.01.035
PMID: 26937455
PMC: PMC4749934
Contributors: Khan SR; Baghdasarian A; Fahlman RP; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Cytoprotective effect of isoniazid against H2O2 derived injury in HL-60 cells.

Chemico-biological interactions
2015-11 | Journal article
DOI: 10.1016/j.cbi.2015.11.026
PMID: 26658028
Contributors: Khan SR; Aljuhani N; Morgan AG; Baghdasarian A; Fahlman RP; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Phenylbutazone Oxidation via Cu,Zn-SOD Peroxidase Activity: An EPR Study.

Chemical research in toxicology
2015-07 | Journal article
DOI: 10.1021/acs.chemrestox.5b00152
PMID: 26090772
Contributors: Aljuhani N; Whittal RM; Khan SR; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: Role of myeloperoxidase and arylamine free radicals.

Chemico-biological interactions
2015-06 | Journal article
DOI: 10.1016/j.cbi.2015.06.020
PMID: 26102013
Contributors: Khan SR; Baghdasarian A; Nagar PH; Fahlman R; Jurasz P; Michail K; Aljuhani N; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Current status and future prospects of toxicogenomics in drug discovery.

Drug discovery today
2013-11 | Journal article
DOI: 10.1016/j.drudis.2013.11.001
PMID: 24216320
Contributors: Khan SR; Baghdasarian A; Fahlman RP; Michail K; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Scavenging of free-radical metabolites of aniline xenobiotics and drugs by amino acid derivatives: toxicological implications of radical-transfer reactions.

Chemical research in toxicology
2013-11 | Journal article
DOI: 10.1021/tx4002463
PMID: 24191655
Contributors: Michail K; Baghdasarian A; Narwaley M; Aljuhani N; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

The effect of bicarbonate on menadione-induced redox cycling and cytotoxicity: potential involvement of the carbonate radical.

Canadian journal of physiology and pharmacology
2013-07 | Journal article
DOI: 10.1139/cjpp-2012-0254
PMID: 24144048
Contributors: Aljuhani N; Michail K; Karapetyan Z; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

The interaction of diamines and polyamines with the peroxidase-catalyzed metabolism of aromatic amines: a potential mechanism for the modulation of aniline toxicity.

Canadian journal of physiology and pharmacology
2012-12 | Journal article
DOI: 10.1139/cjpp-2012-0253
PMID: 23537436
Contributors: Michail K; Aljuhani N; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism.

Journal of ethnopharmacology
2012-09 | Journal article
DOI: 10.1016/j.jep.2012.09.032
PMID: 23026305
Contributors: El Gendy MA; Ali BH; Michail K; Siraki AG; El-Kadi AO
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Post-trapping derivatization of radical-derived EPR-silent adducts: application to free radical detection by HPLC/UV in chemical, biochemical, and biological systems and comparison with EPR spectroscopy.

Analytical chemistry
2012-07 | Journal article
DOI: 10.1021/ac301142c
PMID: 22724922
Contributors: Michail K; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

4-Aminobenzoic acid hydrazide inhibition of microperoxidase-11: catalytic inhibition by reactive metabolites.

Archives of biochemistry and biophysics
2011-08 | Journal article
DOI: 10.1016/j.abb.2011.07.015
PMID: 21840294
Contributors: Arvadia P; Narwaley M; Whittal RM; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites.

Chemical research in toxicology
2011-06 | Journal article
DOI: 10.1021/tx200016h
PMID: 21671642
Contributors: Narwaley M; Michail K; Arvadia P; Siraki AG
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis.

Chemical research in toxicology
2010-05 | Journal article
DOI: 10.1021/tx900432d
PMID: 20199096
PMC: PMC3590803
Contributors: Siraki AG; Jiang J; Mason RP
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems.

Toxicology and applied pharmacology
2008-10 | Journal article
DOI: 10.1016/j.taap.2008.10.002
PMID: 18977373
PMC: PMC2703010
Contributors: Brimfield AA; Mancebo AM; Mason RP; Jiang JJ; Siraki AG; Novak MJ
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.

Chemical research in toxicology
2008-05 | Journal article
DOI: 10.1021/tx700415b
PMID: 18489081
PMC: PMC2766841
Contributors: Siraki AG; Deterding LJ; Bonini MG; Jiang J; Ehrenshaft M; Tomer KB; Mason RP
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.

Chemical research in toxicology
2007-06 | Journal article
DOI: 10.1021/tx6003562
PMID: 17602675
PMC: PMC2073000
Contributors: Siraki AG; Bonini MG; Jiang J; Ehrenshaft M; Mason RP
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Glutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity.

Free radical biology & medicine
2007-01 | Journal article
DOI: 10.1016/j.freeradbiomed.2006.12.026
PMID: 17349926
PMC: PMC1994934
Contributors: Bonini MG; Siraki AG; Bhattacharjee S; Mason RP
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes.

Free radical biology & medicine
2006-11 | Journal article
DOI: 10.1016/j.freeradbiomed.2006.11.019
PMID: 17275685
PMC: PMC1952183
Contributors: Bonini MG; Siraki AG; Atanassov BS; Mason RP
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

A conceptual framework for predicting the toxicity of reactive chemicals: modeling soft electrophilicity.

SAR and QSAR in environmental research
2006-08 | Journal article
DOI: 10.1080/10629360600884371
PMID: 16920662
Contributors: Schultz TW; Carlson RE; Cronin MT; Hermens JL; Johnson R; O'Brien PJ; Roberts DW; Siraki A; Wallace KB; Veith GD
Source: Self-asserted source
Arno Siraki via Europe PubMed Central

Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.

Critical reviews in toxicology
2005-08 | Journal article
DOI: 10.1080/10408440591002183
PMID: 16417045
Contributors: O'Brien PJ; Siraki AG; Shangari N
Source: Self-asserted source
Arno Siraki via Europe PubMed Central
Items per page:
Page 1 of 2

Peer review (32 reviews for 8 publications/grants)

Review activity for Antioxidants. (1)
Review activity for Chemical research in toxicology. (2)
Review activity for Chemico-biological interactions. (20)
Review activity for Environmental science & technology letters. (3)
Review activity for Enzyme and microbial technology. (2)
Review activity for Journal of controlled release. (1)
Review activity for Journal of medicinal chemistry. (1)
Review activity for Molecular pharmaceutics. (2)
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