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vitamin K

Activities

Employment (1)

University of North Carolina at Chapel Hill: Chapel Hill, NC, US

Research associate (Biology)
Employment
Source: Self-asserted source
Xuejie Chen

Education and qualifications (1)

Beijing Normal University: Beijing, Beijing, CN

PhD (Cell biology)
Education
Source: Self-asserted source
Xuejie Chen

Works (15)

Synthesis of new vitamin K derivatives with a ketone group at the C-1′ position of the side chain and their conversion to menaquinone-4

Journal of Molecular Structure
2023-03 | Journal article
Contributors: Natsuko Furukawa; Xuejie Chen; Satoshi Asano; Marina Matsumoto; Yuxin Wu; Kohei Murata; Atsuko Takeuchi; Chisato Tode; Taiki Homma; Ryohto Koharazawa et al.
Source: check_circle
Crossref

A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

Nature Communications
2023-02-14 | Journal article
Contributors: Da-Yun Jin; Xuejie Chen; Yizhou Liu; Craig M. Williams; Lars C. Pedersen; Darrel W. Stafford; Jian-Ke Tie
Source: check_circle
Crossref

Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K‐dependent carboxylation

The FEBS Journal
2022-05 | Journal article
Contributors: Xuejie Chen; Natsuko Furukawa; Da‐Yun Jin; Yizhou Liu; Darrel W. Stafford; Craig M. Williams; Yoshitomo Suhara; Jian‐Ke Tie
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Crossref

A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase

Journal of Thrombosis and Haemostasis
2021-03 | Journal article
Contributors: Xuejie Chen; Yizhou Liu; Natsuko Furukawa; Da‐Yun Jin; G. Paul Savage; Darrel W. Stafford; Yoshitomo Suhara; Craig M. Williams; Jian‐Ke Tie
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Crossref

γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins

Blood
2021-01-28 | Journal article
Contributors: Zhenyu Hao; Da-Yun Jin; Xuejie Chen; Leon J. Schurgers; Darrel W. Stafford; Jian-Ke Tie
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Crossref

A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

Blood
2020-08-13 | Journal article
Contributors: Xuejie Chen; Caihong Li; Da-Yun Jin; Brian Ingram; Zhenyu Hao; Xue Bai; Darrel W. Stafford; Keping Hu; Jian-Ke Tie
Source: check_circle
Crossref

Determining the necessity of phenyl ring π-character in warfarin.

Bioorganic & medicinal chemistry letters
2019-05-23 | Journal article
Contributors: Xuejie Chen; Xing H; Sevan Houston; Chen X; Jin DY; Savage GP; Jian-Ke Tie; Craig Williams
Source: Self-asserted source
Xuejie Chen

Cyclooctatetraene: A Bioactive Cubane Paradigm Complement.

Chemistry (Weinheim an der Bergstrasse, Germany)
2019-01-25 | Journal article
Contributors: Xuejie Chen; Xing H; Sevan Houston; Chen X; Ghassabian S; Tyler Fahrenhorst-Jones; Andy Kuo; Cody-Ellen Murray; Conn KA; Jaeschke KN et al.
Source: Self-asserted source
Xuejie Chen

Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu.

Blood
2018-08-08 | Journal article
Contributors: Xuejie Chen; Chen X; Jin DY; Stafford DW; Jian-Ke Tie
Source: Self-asserted source
Xuejie Chen

Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition.

Blood
2018-05-09 | Journal article
Contributors: Xuejie Chen; Wu S; Chen X; Jin DY; Stafford DW; Lee Pedersen; Jian-Ke Tie
Source: Self-asserted source
Xuejie Chen

Identification of Surface-Exposed Protein Radicals and A Substrate Oxidation Site in A-Class Dye-Decolorizing Peroxidase from Thermomonospora curvata.

ACS catalysis
2016-10-12 | Journal article
Contributors: Xuejie Chen; Shrestha R; Chen X; Ramyar KX; Hayati Z; Carlson EA; Bossmann SH; Song L; Geisbrecht BV; Li P
Source: Self-asserted source
Xuejie Chen

The Mechanism of Mycobacterium smegmatis PafA Self-Pupylation.

PloS one
2016-03-08 | Journal article
Contributors: Xuejie Chen; Chen X; Li C; Wang L; Liu Y; Li C; Junjie Zhang
Source: Self-asserted source
Xuejie Chen

Multiple lines of evidence on the genetic relatedness of the parthenogenetic and bisexual Haemaphysalis longicornis (Acari: Ixodidae).

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2013-12-06 | Journal article
Contributors: Xuejie Chen; Chen X; Xu S; Zhijun Yu; Guo L; Yang S; Liu L; Yang X; Liu J
Source: Self-asserted source
Xuejie Chen

Curcumin inhibits proliferation and induces apoptosis of human colorectal cancer cells by activating the mitochondria apoptotic pathway.

Phytotherapy research : PTR
2012-05-25 | Journal article
Contributors: Xuejie Chen; Guo LD; Chen XJ; yuhong hu; Zhijun Yu; Hui Wang; Liu JZ
Source: Self-asserted source
Xuejie Chen

Life cycle of Haemaphysalis doenitzi (Acari: Ixodidae) under laboratory conditions and its phylogeny based on mitochondrial 16S rDNA.

Experimental & applied acarology
2011-11-24 | Journal article
Contributors: Xuejie Chen; Chen X; Zhijun Yu; Guo L; Li L; Meng H; Wang D; Liu R; Liu J
Source: Self-asserted source
Xuejie Chen