Personal information

Belgium

Activities

Employment (7)

University of Turin: Turin, Piemonte, IT

2019-04-01 to present | Guest Full professor (Molecular Biotechnology Center)
Employment
Source: Self-asserted source
Massimiliano Mazzone

Katholieke Universiteit Leuven: Leuven, BE

2014-10-01 to present | Full Professor (Department of Oncology)
Employment
Source: Self-asserted source
Massimiliano Mazzone

Vlaams Instituut voor Biotechnologie: Leuven, BE

2009-10-01 to present | Group Leader (Center for Cancer Biology)
Employment
Source: Self-asserted source
Massimiliano Mazzone

Katholieke Universiteit Leuven: Leuven, BE

2009-10-01 to 2014-09-30 | Associate Professor (Department of Oncology)
Employment
Source: Self-asserted source
Massimiliano Mazzone

Vlaams Instituut voor Biotechnologie: Leuven, BE

2006-11-01 to 2009-09-01 | Postdoctoral Fellow (Vesalius Research Center)
Employment
Source: Self-asserted source
Massimiliano Mazzone

International University College of Turin: Turin, IT

2002-11-01 to 2006-10-30 | Ph.D student (IRCC School of Medicine)
Employment
Source: Self-asserted source
Massimiliano Mazzone

International University College of Turin: Turin, IT

1998-06-01 to 2002-07-01 | Undergraduate student (IRCC School of Medicine)
Employment
Source: Self-asserted source
Massimiliano Mazzone

Education and qualifications (3)

Vlaams Instituut voor Biotechnologie: Leuven, BE

2006-11-01 to 2009-01-02 | Postdoctoral Fellow (Vesalius Research Center)
Education
Source: Self-asserted source
Massimiliano Mazzone

International University College of Turin: Turin, IT

2002-11-01 to 2007-02-07 | Ph.D. in Cell Science and Technology (IRCC School of Medicine)
Education
Source: Self-asserted source
Massimiliano Mazzone

International University College of Turin: Turin, IT

1997-09-01 to 2002-07-01 | Master in Medical Biotechnology (School of Medicine)
Education
Source: Self-asserted source
Massimiliano Mazzone

Funding (27)

GLUD1 as a potential target in Cancer Therapy and Cachexia

2019-04 to 2024-03 | Grant
Associazione Italiana per la Ricerca sul Cancro (Milano, IT)
GRANT_NUMBER:

22228

Source: Self-asserted source
Massimiliano Mazzone

Exploring the role of PlexinA4 in cytotoxic T cells: insights for anti-tumor immune response & cancer immunotherapy

2019-01 to 2022-12 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G0A8219

Source: Self-asserted source
Massimiliano Mazzone

Harnessing the pyrimidine salvaging pathway to foster anti-tumor immunity and sensitize tumors to immune checkpoint blockade

2019-01 to 2022-12 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G0A7419N

Source: Self-asserted source
Massimiliano Mazzone

Harnessing tumor metabolism to overcome immunosuppression

2018-06 to 2023-05 | Grant
European Commission (Brussels, BE)
GRANT_NUMBER:

773208

Source: Self-asserted source
Massimiliano Mazzone

Validation and druggability development of macrophage-specific targets in the tumor microenvironment

2018-01 to 2021-12 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

ZL3C3602

Source: Self-asserted source
Massimiliano Mazzone

Targeting the metabolism-immune system connections in Cancer

2017-09 to 2020-09 | Grant
Horizon 2020 Framework Programme (Brussels, BE)
GRANT_NUMBER:

MSCA-ITN MetaCan

Source: Self-asserted source
Massimiliano Mazzone

Exploring the role of TRAIL pathway in the tumor stroma: implications for cancer progression and drug resistance

2017-01 to 2021-01 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G0D1617N

Source: Self-asserted source
Massimiliano Mazzone

Metabolism following fucntion or function following metabolism: a study of AMPK in tumor-associated macrophages

2017-01 to 2021-01 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G0D1717N

Source: Self-asserted source
Massimiliano Mazzone

A comparative clinical study of a stool-based versus a blood-based screening test for early detection of CRC

2016-11 to 2017-11 | Grant
European Commission (Brussels, BE)
Source: Self-asserted source
Massimiliano Mazzone

The impact of hypoxia on inflammation and tumorigeneiss in Ulcerative Colitis

2016-05 to 2019-05 | Grant
Eranet (Brussels, BE)
Source: Self-asserted source
Massimiliano Mazzone

PHD1 as potential candidate for drug resistance in colorectal cancer

2016-01 to 2018-06 | Grant
Vlaamse Liga Tegen Kanker (Brussels, BE)
GRANT_NUMBER:

419.052.173

Source: Self-asserted source
Massimiliano Mazzone

A monocyte signature for monitoring disease relapse and response to chemotherapy in colorectal cancer patients

2015-01 to 2019-01 | Grant
Stichting Tegen Kanker (Brussels, BE)
GRANT_NUMBER:

2014-186

Source: Self-asserted source
Massimiliano Mazzone

Exploring the metabolic pathways driving tumor-associated macrophage polarization and their influence on tumor progression

2015-01 to 2019-01 | Grant
Stichting Tegen Kanker (Brussels, BE)
GRANT_NUMBER:

2014-197

Source: Self-asserted source
Massimiliano Mazzone

Exploring the metabolic pathways driving tumor-associated macrophage polarization and their influence on tumor progression

2015-01 to 2019-01 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G066515N

Source: Self-asserted source
Massimiliano Mazzone

Podoplanin: the missing link between breast cancer and lymphatic?

2015-01 to 2019-01 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G087615N

Source: Self-asserted source
Massimiliano Mazzone

A monocyte signature for monitoring disease relapse in colorectal cancer patients

2014-09 to 2018-09 | Grant
Vlaamse Liga Tegen Kanker (Brussels, BE)
Source: Self-asserted source
Massimiliano Mazzone

Podoplanin: the missing link between macrophages and lymphatic metastasis in breast cancer?

2013-06-01 to 2016-05-31 | Grant
Worldwide Cancer Research (St Andrews, GB)
GRANT_NUMBER:

WCR-13-1031

Source: Self-asserted source
Massimiliano Mazzone via DimensionsWizard

Oxygen sensing in macrophages: implications for cancer and ischemia

2012-11-01 to 2017-10-31 | Grant
European Research Council (Saint-Josse-ten-Noode, BE)
GRANT_NUMBER: 308459
Source: Self-asserted source
Massimiliano Mazzone via DimensionsWizard

Unraveling new molecular pathways in the oxygen sensing machinery

2012-01 to 2016-01 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G068612N

Source: Self-asserted source
Massimiliano Mazzone

Peripheral blood monocytes as predictive biomarkers in colorectal cancer

2011-01 to 2015-01 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G079311N10

Source: Self-asserted source
Massimiliano Mazzone

Peripheral blood monocytes as predictive biomarkers in coloractal cancer

2010-12 to 2014-12 | Grant
Stichting Tegen Kanker (Brussels, BE)
GRANT_NUMBER:

2010-198

Source: Self-asserted source
Massimiliano Mazzone

Unraveling new molecular pathways in the oxygen sensing machinery

2010-12 to 2012-12 | Grant
Stichting Tegen Kanker (Brussels, BE)
GRANT_NUMBER:

2010-169

Source: Self-asserted source
Massimiliano Mazzone

Endothelial phalanx cells in therapeutic angiogenesis

2010-01 to 2014-01 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G072610N

Source: Self-asserted source
Massimiliano Mazzone

PHD2 oxygen sensor: novel and promising target for the optimizations of chemo and radiotherapy

2010-01 to 2014-01 | Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G071810N

Source: Self-asserted source
Massimiliano Mazzone

André Vanderstricht-Emile Carpentier Prize

Award
Vlaamse Liga Tegen Kanker (Brussels, BE)
Source: Self-asserted source
Massimiliano Mazzone

Inhibiting FIH as a potential anti-angiogenic treatment

Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

G083613N

Source: Self-asserted source
Massimiliano Mazzone

Mir-210 at the crossroad of M2 and M1 macrophage polarizations: relevance for spesis and cancer

Grant
Fonds Wetenschappelijk Onderzoek (Brussels, BE)
GRANT_NUMBER:

1501215N

Source: Self-asserted source
Massimiliano Mazzone

Works (50 of 134)

Items per page:
Page 1 of 3

Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function [version 2; peer review: 3 approved, 1 approved with reservations]

2024-09-02 | Journal article
Part of ISSN: 2398-502X
Funded by GRANT_NUMBER: 108717, 224637, 209220, 225778
Funded by GRANT_NUMBER: MR/K023845/1
Funded by GRANT_NUMBER:

MRNO2995X/1

Funded by GRANT_NUMBER: SGL024\1056
Contributors: Emily Watts; Joseph Willison; Simone Arienti; Pranvera Sadiku; Patricia Coelho; Manuel Sanchez-Garcia; Ailiang Zhang; Fiona Murphy; Rebecca Dickinson; Ananda Mirchandani et al.
Source: check_circle
Wellcome Open Research

From monocyte‐derived macrophages to resident macrophages—how metabolism leads their way in cancer

Molecular Oncology
2024-07 | Journal article
Contributors: Ummi Ammarah; Andreia Pereira‐Nunes; Marcello Delfini; Massimiliano Mazzone
Source: check_circle
Crossref

Data from PHD2 Constrains Antitumor CD8<sup>+</sup> T-cell Activity

2023-04-04 | Preprint
Contributors: Charlotte Bisilliat Donnet; Valérie Acolty; Abdulkader Azouz; Anaëlle Taquin; Coralie Henin; Sarah Trusso Cafarello; Sébastien Denanglaire; Massimiliano Mazzone; Guillaume Oldenhove; Oberdan Leo et al.
Source: check_circle
Crossref

Data from PHD2 Constrains Antitumor CD8<sup>+</sup> T-cell Activity

2023-04-04 | Preprint
Contributors: Charlotte Bisilliat Donnet; Valérie Acolty; Abdulkader Azouz; Anaëlle Taquin; Coralie Henin; Sarah Trusso Cafarello; Sébastien Denanglaire; Massimiliano Mazzone; Guillaume Oldenhove; Oberdan Leo et al.
Source: check_circle
Crossref

Figures S1-S6 from PHD2 Constrains Antitumor CD8<sup>+</sup> T-cell Activity

2023-04-04 | Preprint
Contributors: Charlotte Bisilliat Donnet; Valérie Acolty; Abdulkader Azouz; Anaëlle Taquin; Coralie Henin; Sarah Trusso Cafarello; Sébastien Denanglaire; Massimiliano Mazzone; Guillaume Oldenhove; Oberdan Leo et al.
Source: check_circle
Crossref

Figures S1-S6 from PHD2 Constrains Antitumor CD8<sup>+</sup> T-cell Activity

2023-04-04 | Preprint
Contributors: Charlotte Bisilliat Donnet; Valérie Acolty; Abdulkader Azouz; Anaëlle Taquin; Coralie Henin; Sarah Trusso Cafarello; Sébastien Denanglaire; Massimiliano Mazzone; Guillaume Oldenhove; Oberdan Leo et al.
Source: check_circle
Crossref

A collaborative synthetase

Nature Chemical Biology
2023-03 | Journal article
Contributors: Massimiliano Mazzone; Alessandra Castegna
Source: check_circle
Crossref

PHD2 Constrains Antitumor CD8+ T-cell Activity

Cancer Immunology Research
2023-03-01 | Journal article
Contributors: Charlotte Bisilliat Donnet; Valérie Acolty; Abdulkader Azouz; Anaëlle Taquin; Coralie Henin; Sarah Trusso Cafarello; Sébastien Denanglaire; Massimiliano Mazzone; Guillaume Oldenhove; Oberdan Leo et al.
Source: check_circle
Crossref

Candida albicansstimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection

2023-02-23 | Preprint
Contributors: Quynh T. Phan; Norma V. Solis; Max V. Cravener; Marc Swidergall; Jianfeng Lin; Manning Y. Huang; Hong Liu; Shakti Singh; Ashraf S. Ibrahim; Massimiliano Mazzone et al.
Source: check_circle
Crossref

Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development

Cancers
2020-11 | Journal article | Author
Contributors: Yannick De Vlaeminck; Stefano Bonelli; Robin Maximilian Awad; Maarten Dewilde; Sabrina Rizzolio; Quentin Lecocq; Evangelia Bolli; Ana Rita Santos; Damya Laoui; Steve Schoonooghe et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling

Circulation Research
2020-08-28 | Journal article
Contributors: Manuel Ehling; Ward Celus; Rosa Martín-Pérez; Roser Alba-Rovira; Sander Willox; Donatella Ponti; Maria C. Cid; Elizabeth A.V. Jones; Giusy Di Conza; Massimiliano Mazzone
Source: check_circle
Crossref

Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?

Frontiers in Oncology
2020-04-30 | Journal article
Part of ISSN: 2234-943X
Source: Self-asserted source
Massimiliano Mazzone

PoEMs edit breast cancer outcome

Aging
2020-02-26 | Journal article
Part of ISSN: 1945-4589
Source: Self-asserted source
Massimiliano Mazzone

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates.

Cancer cell
2020-01-01 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Caspase-8 modulates physiological and pathological angiogenesis during retina development.

The Journal of clinical investigation
2019-12-01 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer.

Cell metabolism
2019-08-22 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy.

Physiological reviews
2019-08-15 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Role and therapeutic potential of dietary ketone bodies in lymph vessel growth

Nature Metabolism
2019-07 | Journal article
Part of ISSN: 2522-5812
Source: Self-asserted source
Massimiliano Mazzone

Blood Vessel Proximity Shapes Cancer Cell Metabolism.

Cell metabolism
2019-07-01 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.

American journal of respiratory and critical care medicine
2019-07-01 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.

Cell reports
2019-07-01 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer.

Cancer research
2019-06-25 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells.

Cancer research
2019-02-18 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Tumor-associated macrophages: a short compendium.

Cellular and molecular life sciences : CMLS
2019-02-12 | Journal article
Source: Self-asserted source
Massimiliano Mazzone
grade
Preferred source (of 2)‎

Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling.

Science signaling
2019-02-05 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis.

Annual review of physiology
2019-02-01 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy.

Nature communications
2018-10-05 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Cell metabolism
2018-08-23 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.

Cell metabolism
2018-08-23 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Neutrophils enhance early Trypanosoma brucei infection onset.

Scientific reports
2018-07-25 | Journal article
Source: Self-asserted source
Massimiliano Mazzone
grade
Preferred source (of 2)‎

Inhibition of prolyl hydroxylase domain proteins selectively enhances venous thrombus neovascularisation.

Thrombosis research
2018-07-11 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer.

Seminars in cancer biology
2018-06-20 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Is There Merit for MET-Targeted Therapies in Gastroesophageal Cancer?

JAMA oncology
2018-01-01 | Journal article
Source: Self-asserted source
Massimiliano Mazzone
grade
Preferred source (of 2)‎

MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability

Molecular Cancer
2017-12 | Journal article
Part of ISSN: 1476-4598
Source: Self-asserted source
Massimiliano Mazzone

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.

EMBO molecular medicine
2017-12-01 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis.

Cell reports
2017-12-01 | Journal article
Source: Self-asserted source
Massimiliano Mazzone

Metabolism and TAM functions-it takes two to tango.

The FEBS journal
2017-11-08 | Journal article
Source: Self-asserted source
Massimiliano Mazzone
grade
Preferred source (of 2)‎

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis

Oncotarget
2017-11-07 | Journal article
Part of ISSN: 1949-2553
Source: Self-asserted source
Massimiliano Mazzone

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy

Immunity
2017-10 | Journal article
Part of ISSN: 1074-7613
Source: Self-asserted source
Massimiliano Mazzone

Retinoid X receptor suppresses a metastasis-promoting transcriptional program in myeloid cells via a ligand-insensitive mechanism

Proceedings of the National Academy of Sciences
2017-10-03 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Massimiliano Mazzone

YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis

Developmental Cell
2017-09 | Journal article
Part of ISSN: 1534-5807
Source: Self-asserted source
Massimiliano Mazzone

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Nature Immunology
2017-09 | Journal article
Part of ISSN: 1529-2908
Part of ISSN: 1529-2916
Source: Self-asserted source
Massimiliano Mazzone

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Cell Reports
2017-08 | Journal article
Part of ISSN: 2211-1247
Source: Self-asserted source
Massimiliano Mazzone

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium

The EMBO Journal
2017-08-15 | Journal article
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Source: Self-asserted source
Massimiliano Mazzone

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Journal of Clinical Investigation
2017-08-14 | Journal article
Part of ISSN: 0021-9738
Part of ISSN: 1558-8238
Source: Self-asserted source
Massimiliano Mazzone

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

Nature Communications
2017-04 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Massimiliano Mazzone

PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner

Cell Reports
2017-03 | Journal article
Part of ISSN: 2211-1247
Source: Self-asserted source
Massimiliano Mazzone

SLC 25A26 overexpression impairs cell function via mt DNA hypermethylation and rewiring of methyl metabolism

The FEBS Journal
2017-03 | Journal article
Part of ISSN: 1742-464X
Part of ISSN: 1742-4658
Source: Self-asserted source
Massimiliano Mazzone

Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells

Antioxidants & Redox Signaling
2017-03-10 | Journal article
Part of ISSN: 1523-0864
Part of ISSN: 1557-7716
Source: Self-asserted source
Massimiliano Mazzone

The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia

Cell Reports
2017-02 | Journal article
Part of ISSN: 2211-1247
Source: Self-asserted source
Massimiliano Mazzone
Items per page:
Page 1 of 3

Peer review (15 reviews for 8 publications/grants)

Review activity for Cell. (2)
Review activity for Nature cancer. (5)
Review activity for Nature cell biology (1)
Review activity for Nature chemical biology. (1)
Review activity for Nature communications (3)
Review activity for Nature metabolism. (1)
Review activity for Nature protocols (1)
Review activity for Science translational medicine. (1)