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Drug Discovery, Cancer Research, Chemical Biology, Molecular Pharmacology, Natural Products
United States, Egypt

Activities

Employment (10)

Edward Via College of Osteopathic Medicine: Monroe, LA, US

2023 to present (Department of Biomedical Sciences)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Helwan University: Helwan, Cairo, EG

2022 to present | Associate Professor (Faculty of Pharmacy)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

The University of Louisiana Monroe: Monroe, LA, US

2022 to 2023 (College of Pharmacy)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Helwan University: Cairo, EG

2016 to 2022 | Assistant Professor (Faculty of Pharmacy)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Galala University: Suez, EG

2020 to 2021 | Adjunct Faculty (Faculty of Pharmacy)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Helwan University: Cairo, EG

2016 to 2020 | Assistant Manager (Projects Managing Unit)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Egyptian Russian University: Badr, Cairo, EG

2017 to 2019 | Adjunct Faculty (Faculty of Pharmacy)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Ahram Canadian University: 6th of October, Giza, EG

2017 to 2018 | Adjunct Faculty (Faculty of Pharmacy)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Helwan University: Cairo, EG

2008 to 2016 | Assistant Lecturer (Faculty of Pharmacy)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Helwan University: Cairo, EG

2005 to 2008 | Teaching Assistant ( Faculty of Pharmacy)
Employment
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Education and qualifications (3)

University of Louisiana at Monroe: Monroe, LA, US

2012 to 2016 | Doctor of Philosophy in Pharmacy (Natural Products/ Medicinal Chemistry)
Education
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Helwan University: Cairo, EG

2005 to 2008 | Master of Pharmaceutical Sciences
Education
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Helwan University: Cairo, EG

1999 to 2004 | Bachelor of Pharmaceutical Sciences
Education
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Works (30)

Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation

Marine Drugs
2023-03-28 | Journal article
Contributors: Khaldoun S. Abdelwahed; Abu Bakar Siddique; Hassan Y. Ebrahim; Mohammed H. Qusa; Ethar A. Mudhish; Ashkan H. Rad; Mourad Zerfaoui; Zakaria Y. Abd Elmageed; Khalid A. El Sayed
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Towards Developing Novel Prostate Cancer Recurrence Suppressors: Acute Toxicity of Pseurotin A, an Orally Active PCSK9 Axis-Targeting Small-Molecule in Swiss Albino Mice

Molecules
2023-02-02 | Journal article
Contributors: Oliver C. McGehee; Hassan Y. Ebrahim; Ashkan H. Rad; Khaldoun S. Abdelwahed; Ethar A. Mudhish; Judy A. King; Iman E. Helal; Sharon A. Meyer; Khalid A. El Sayed
Source: check_circle
Crossref

Melaleuca rugulosa (Link) Craven Tannins: Appraisal of anti-inflammatory, radical scavenging activities, and molecular modeling studies

Journal of Ethnopharmacology
2022-11 | Journal article
Contributors: Hassan Y. Ebrahim; Mohamed S. Mady; Hanaa B. Atya; Sahar A. Ali; Heba E. Elsayed; Fatma A. Moharram
Source: check_circle
Crossref

Oleocanthal Attenuates Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence by Targeting SMYD2

Cancers
2022-07-21 | Journal article
Contributors: Abu Bakar Siddique; Hassan Y. Ebrahim; Afsana Tajmim; Judy Ann King; Khaldoun S. Abdelwahed; Zakaria Y. Abd Elmageed; Khalid A. El Sayed
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Ethnopharmacological impact of Melaleuca rugulosa (Link) Craven leaves extract on liver inflammation

Journal of Ethnopharmacology
2022-06 | Journal article
Contributors: Heba E. Elsayed; Hassan Y. Ebrahim; Mohamed S. Mady; Mohamed A. Khattab; Elsayed K. El-Sayed; Fatma A. Moharram
Source: check_circle
Crossref

The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase

Nutrients
2022-04 | Journal article | Author
Contributors: Ethar Mudhish; Abu Bakar Siddique; Hassan Y. Ebrahim, PhD; Khaldoun S. Abdelwahed; Judy Ann King; Khalid El Sayed
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Growth Inhibition and Apoptotic Effect of Pine Extract and Abietic Acid on MCF-7 Breast Cancer Cells via Alteration of Multiple Gene Expressions Using In Vitro Approach

Molecules
2022-01-04 | Journal article
Contributors: Hesham Haffez; Shimaa Osman; Hassan Y. Ebrahim; Zeinab A. Hassan
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Synthesis, anticancer evaluation and molecular docking studies of new heterocycles linked to sulfonamide moiety as novel human topoisomerase types I and II poisons

Bioorganic Chemistry
2020 | Journal article
EID:

2-s2.0-85081964817

Part of ISBN:

10902120 00452068

Contributors: Halawa, A.H.; Elgammal, W.E.; Hassan, S.M.; Hassan, A.H.; Nassar, H.S.; Ebrahim, H.Y.; Mehany, A.B.M.; El-Agrody, A.M.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Scopus - Elsevier

(−)-Oleocanthal combined with lapatinib treatment synergized against HER-2 positive breast cancer in vitro and in vivo

Nutrients
2019 | Journal article
EID:

2-s2.0-85061864240

Contributors: Siddique, A.B.; Ebrahim, H.Y.; Akl, M.R.; Ayoub, N.M.; Goda, A.A.; Mohyeldin, M.M.; Nagumalli, S.K.; Hananeh, W.M.; Liu, Y.-Y.; Meyer, S.A. et al.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Scopus - Elsevier
grade
Preferred source (of 3)‎

Novel liquid-liquid extraction and self-emulsion methods for simplified isolation of extra-virgin olive oil phenolics with emphasis on (-)-oleocanthal and its oral anti-breast cancer activity

PLoS ONE
2019 | Journal article
EID:

2-s2.0-85064090780

Contributors: Siddique, A.B.; Ebrahim, H.; Mohyeldin, M.; Qusa, M.; Batarseh, Y.; Fayyad, A.; Tajmim, A.; Nazzal, S.; Kaddoumi, A.; El Sayed, K.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Scopus - Elsevier

Prodigiosins from a marine sponge-associated actinomycete attenuate HCl/ethanol-induced gastric lesion via antioxidant and anti-inflammatory mechanisms

PLoS ONE
2019 | Journal article
EID:

2-s2.0-85067365321

Contributors: Abdelfattah, M.S.; Elmallah, M.I.Y.; Ebrahim, H.Y.; Almeer, R.S.; Eltanany, R.M.A.; Abdel Moneim, A.E.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Scopus - Elsevier

Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors

International Journal of Molecular Sciences
2019-11-08 | Journal article
Contributors: Ahmed H. Halawa; Areej A. Eskandrani; Walid E. Elgammal; Saber M. Hassan; Ahmed H. Hassan; Hassan Y. Ebrahim; Ahmed B. M. Mehany; Ahmed M. El-Agrody; Rawda M. Okasha
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

13 <sup>1</sup> -Oxophorbine protopheophorbide A from Ziziphus lotus as a novel mesenchymal-epithelial transition factor receptor inhibitory lead for the control of breast tumor growth in vitro and in vivo

Molecular Carcinogenesis
2018 | Journal article
EID:

2-s2.0-85050948442

Contributors: Souid, S.; Elsayed, H.E.; Ebrahim, H.Y.; Mohyeldin, M.M.; Siddique, A.B.; Karoui, H.; El Sayed, K.A.; Essafi-Benkhadir, K.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Scopus - Elsevier

Rationally designed hecogenin thiosemicarbazone analogs as novel MEK inhibitors for the control of breast malignancies

Bioorganic and Medicinal Chemistry
2017 | Journal article
EID:

2-s2.0-85031747994

Contributors: Elsayed, H.E.; Ebrahim, H.Y.; Haggag, E.G.; Kamal, A.M.; El Sayed, K.A.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Scopus - Elsevier

Rutin as A Novel c-Met Inhibitory Lead for The Control of Triple Negative Breast Malignancies

Nutrition and Cancer
2017 | Journal article
EID:

2-s2.0-85032696121

Contributors: Elsayed, H.E.; Ebrahim, H.Y.; Mohyeldin, M.M.; Siddique, A.B.; Kamal, A.M.; Haggag, E.G.; El Sayed, K.A.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Scopus - Elsevier

The olive oil phenolic (-)-oleocanthal modulates estrogen receptor expression in luminal breast cancer in vitro and in vivo and synergizes with tamoxifen treatment

European Journal of Pharmacology
2017 | Journal article
EID:

2-s2.0-85020928848

Contributors: Ayoub, N.M.; Siddique, A.B.; Ebrahim, H.Y.; Mohyeldin, M.M.; El Sayed, K.A.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Scopus - Elsevier

The tobacco cembranoid (1S,2E,4S,7E,11E)-2,7,11-cembratriene-4,6-diol as a novel angiogenesis inhibitory lead for the control of breast malignancies

Bioorganic and Medicinal Chemistry
2017 | Journal article
EID:

2-s2.0-85020117961

Contributors: Hailat, M.M.; Ebrahim, H.Y.; Mohyeldin, M.M.; Goda, A.A.; Siddique, A.B.; El Sayed, K.A.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Scopus - Elsevier

Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies.

2017-02 | Journal article
Contributors: Ebrahim HY; Akl MR; Elsayed HE; Hill RA; El Sayed KA
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 2)‎

Olive oil-based oleocanthal and bioisosteres as c-Met inhibitors for the control of triple negative breast cancer

The 107th Annual Meeting of the American Association for Cancer Research
2016 | Conference abstract
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

(1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies.

2016-11 | Journal article
Contributors: Ebrahim HY; Mohyeldin MM; Hailat MM; El Sayed KA
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 2)‎

The oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitor.

2016-05 | Journal article
Contributors: Mohyeldin MM; Akl MR; Ebrahim HY; Dragoi AM; Dykes S; Cardelli JA; El Sayed KA
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 2)‎

Norstictic Acid Inhibits Breast Cancer Cell Proliferation, Migration, Invasion, and In Vivo Invasive Growth Through Targeting C-Met.

2016-04 | Journal article
Contributors: Ebrahim HY; Elsayed HE; Mohyeldin MM; Akl MR; Bhattacharjee J; Egbert S; El Sayed KA
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 2)‎

Discovery of Novel Antiangiogenic Marine Natural Product Scaffolds.

2016-03 | Journal article
Contributors: Ebrahim HY; El Sayed KA
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 4)‎

The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion

Bioorganic & Medicinal Chemistry
2016-01 | Journal article
Contributors: Mohamed S. Mady; Mohamed M. Mohyeldin; Hassan Y. Ebrahim; Heba E. Elsayed; Wael E. Houssen; Eman G. Haggag; Randa F. Soliman; Khalid A. El Sayed
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

PEGylated γ-tocotrienol isomer of vitamin E: Synthesis, characterization, in vitro cytotoxicity, and oral bioavailability.

2015-10 | Journal article
Contributors: Abu-Fayyad A; Behery F; Sallam AA; Alqahtani S; Ebrahim H; El Sayed KA; Kaddoumi A; Sylvester PW; Carroll JL; Cardelli JA et al.
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 2)‎

Discovery, optimization, and pharmacophore modeling of oleanolic acid and analogues as breast cancer cell migration and invasion inhibitors through targeting Brk/Paxillin/Rac1 axis.

2015-02 | Journal article
Contributors: Elsayed HE; Akl MR; Ebrahim HY; Sallam AA; Haggag EG; Kamal AM; El Sayed KA
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 2)‎

Araguspongine C induces autophagic death in breast cancer cells through suppression of c-Met and HER2 receptor tyrosine kinase signaling.

2015-01 | Journal article
Contributors: Akl MR; Ayoub NM; Ebrahim HY; Mohyeldin MM; Orabi KY; Foudah AI; El Sayed KA
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 2)‎

3-O-[N-(p-fluorobenzenesulfonyl)-carbamoyl]-oleanolic acid, a semisynthetic analog of oleanolic acid, induces apoptosis in breast cancer cells.

2014-10 | Journal article
Contributors: Akl MR; Elsayed HE; Ebrahim HY; Haggag EG; Kamal AM; El Sayed KA
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 2)‎

The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling.

2014-04 | Journal article
Contributors: Akl MR; Foudah AI; Ebrahim HY; Meyer SA; El Sayed KA
Source: Self-asserted source
Hassan Y. Ebrahim, PhD via Europe PubMed Central
grade
Preferred source (of 2)‎

Olive oil-based oleocanthal and bioisosteres as c-Met inhibitors for the control of triple negative breast cancer

the 107th Annual Meeting of the American Association for Cancer Research
Conference abstract
Source: Self-asserted source
Hassan Y. Ebrahim, PhD

Peer review (36 reviews for 15 publications/grants)

Review activity for Antibiotics. (1)
Review activity for Biomolecules. (1)
Review activity for Chemistry & biodiversity. (4)
Review activity for Cosmetics. (1)
Review activity for Current issues in molecular biology. (1)
Review activity for International journal of molecular sciences. (2)
Review activity for Journal of ethnopharmacology. (11)
Review activity for Life. (1)
Review activity for Marine drugs. (3)
Review activity for Metabolites. (2)
Review activity for Molecules. (1)
Review activity for Nutraceuticals. (1)
Review activity for Pharmaceuticals. (4)
Review activity for Pharmaceutics. (1)
Review activity for PloS one. (2)