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Loop profile: 1138036

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Employment (1)

University of Massachusetts Chan Medical School: Worcester, MA, US

2012-04-02 to present | Assistant Professor (Gene Therapy Center)
Employment
Source: Self-asserted source
Dan Wang

Education and qualifications (2)

University of Alabama at Birmingham: Birmingham, AL, US

2006-09-01 to 2012-03-31 | Ph.D. (Genetics)
Education
Source: Self-asserted source
Dan Wang

Fudan University: Shanghai, Shanghai, CN

2002-09-01 to 2006-07-01 | B.S. (Life Sciences)
Education
Source: Self-asserted source
Dan Wang

Professional activities (1)

American Society of Gene and Cell Therapy: Milwaukee, Wisconsin, US

2006-04-01 to present | Member
Membership
Source: Self-asserted source
Dan Wang

Works (42)

Gene therapy then and now: A look back at changes in the field over the past 25 years

Molecular Therapy
2025-02 | Journal article
DOI: 10.1016/j.ymthe.2025.02.040
Contributors: Dan Wang; Gregg Stevens; Terence R. Flotte
Source: check_circle
Crossref

BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease

Science Translational Medicine
2025-02-26 | Journal article | Author
DOI: 10.1126/scitranslmed.ads0539
Contributors: Qin Su; David Chuang; Erik G. Puffenberger; Ran He; Karlla Brigatti; Heather Gray-Edwards; Kevin Strauss; Zhong Jiang; Alisha Gruntman; Lingzhi Ren et al.
Source: check_circle
AAAS - Science

Systemic gene therapy corrects the neurological phenotype in a mouse model of NGLY1 deficiency

JCI Insight
2024-10-08 | Journal article
DOI: 10.1172/jci.insight.183189
Contributors: Ailing Du; Kun Yang; Xuntao Zhou; Lingzhi Ren; Nan Liu; Chen Zhou; Jialing Liang; Nan Yan; Guangping Gao; Dan Wang
Source: check_circle
Crossref

Non-canonical amino acid incorporation into AAV5 capsid enhances lung transduction in mice

Molecular Therapy - Methods & Clinical Development
2023-12 | Journal article
DOI: 10.1016/j.omtm.2023.101129
Contributors: Hao Chang; Ailing Du; Jun Jiang; Lingzhi Ren; Nan Liu; Xuntao Zhou; Jialing Liang; Guangping Gao; Dan Wang
Source: check_circle
Crossref

Rescue of GM3 synthase deficiency by spatially controlled, rAAV-mediated ST3GAL5 delivery

JCI Insight
2023-05-08 | Journal article
DOI: 10.1172/jci.insight.168688
Contributors: Huiya Yang; Robert H. Brown, Jr.; Dan Wang; Kevin A. Strauss; Guangping Gao
Source: check_circle
Crossref

An efficacious and safe rescue of GM3 synthase deficiency by spatially regulated rAAV-mediated ST3GAL5 delivery

2022-06-17 | Preprint
DOI: 10.21203/rs.3.rs-1731386/v1
Contributors: Huiya Yang; Robert Brown; Dan Wang; Kevin Strauss; Guangping Gao
Source: check_circle
Crossref

AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway

Molecular Therapy
2022-01 | Journal article
DOI: 10.1016/j.ymthe.2021.10.023
Contributors: Shun-Qing Liang; Christopher J. Walkey; Alexa E. Martinez; Qin Su; Mary E. Dickinson; Dan Wang; William R. Lagor; Jason D. Heaney; Guangping Gao; Wen Xue
Source: check_circle
Crossref

CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors

Cell
2020-04 | Journal article
DOI: 10.1016/j.cell.2020.03.023
Contributors: Dan Wang; Feng Zhang; Guangping Gao
Source: check_circle
Crossref

Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno‐Associated Virus

Advanced Science
2019-11 | Journal article
DOI: 10.1002/advs.201900440
Contributors: Dan Wang; Yuyu Niu; Lingzhi Ren; Yu Kang; Phillip W. L. Tai; Chenyang Si; Craig A. Mendonca; Hong Ma; Guangping Gao; Weizhi Ji
Source: check_circle
Crossref

Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis

Nature Communications
2019-07-04 | Journal article
DOI: 10.1038/s41467-019-10809-6
Contributors: Yeon-Suk Yang; Jun Xie; Dan Wang; Jung-Min Kim; Phillip W. L. Tai; Ellen Gravallese; Guangping Gao; Jae-Hyuck Shim
Source: check_circle
Crossref

Adeno-associated virus vector as a platform for gene therapy delivery

Nature Reviews Drug Discovery
2019-05 | Journal article
DOI: 10.1038/s41573-019-0012-9
Contributors: Dan Wang; Phillip W. L. Tai; Guangping Gao
Source: check_circle
Crossref

A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates

Molecular therapy. Methods & clinical development
2018 | Journal article
DOI: 10.1016/j.omtm.2018.03.004
Source: Self-asserted source
Dan Wang

Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

Molecular therapy. Methods & clinical development
2018 | Journal article
DOI: 10.1016/j.omtm.2018.09.003
Source: Self-asserted source
Dan Wang

Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice

Nature biotechnology
2018 | Journal article
DOI: 10.1038/nbt.4219
Source: Self-asserted source
Dan Wang
grade
Preferred source (of 2)‎

In Vivo Genome Editing Partially Restores Alpha1-Antitrypsin in a Murine Model of AAT Deficiency

Human gene therapy
2018 | Journal article
DOI: 10.1089/hum.2017.225
Source: Self-asserted source
Dan Wang

Intrathecal Adeno-Associated Virus Vector-mediated Gene Delivery for Adrenomyeloneuropathy

Human gene therapy
2018 | Journal article
DOI: 10.1089/hum.2018.079
Source: Self-asserted source
Dan Wang

Slow Infusion of Recombinant Adeno-Associated Viruses into the Mouse Cerebrospinal Fluid Space

Human gene therapy methods
2018 | Journal article
DOI: 10.1089/hgtb.2017.250
Source: Self-asserted source
Dan Wang

Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adeno-associated viruses

Nature communications
2018 | Journal article
DOI: 10.1038/s41467-017-02706-7
Source: Self-asserted source
Dan Wang
grade
Preferred source (of 2)‎

Taking a Hint from Structural Biology: To Better Understand AAV Transport across the BBB

Molecular therapy : the journal of the American Society of Gene Therapy
2018 | Journal article
DOI: 10.1016/j.ymthe.2018.01.005
Source: Self-asserted source
Dan Wang

AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
DOI: 10.1073/pnas.1620729114
Source: Self-asserted source
Dan Wang

Short DNA Hairpins Compromise Recombinant Adeno-Associated Virus Genome Homogeneity

Molecular therapy : the journal of the American Society of Gene Therapy
2017 | Journal article
DOI: 10.1016/j.ymthe.2017.03.028
Source: Self-asserted source
Dan Wang
grade
Preferred source (of 2)‎

Slow Intrathecal Injection of rAAVrh10 Enhances its Transduction of Spinal Cord and Therapeutic Efficacy in a Mutant SOD1 Model of ALS

Neuroscience
2017 | Journal article
DOI: 10.1016/j.neuroscience.2017.10.001
Source: Self-asserted source
Dan Wang

A Single Injection of Recombinant Adeno-Associated Virus into the Lumbar Cistern Delivers Transgene Expression Throughout the Whole Spinal Cord

Molecular neurobiology
2016 | Journal article
DOI: 10.1007/s12035-015-9223-1
Source: Self-asserted source
Dan Wang

Adeno-associated Virus Serotype Vectors Efficiently Transduce Normal Prostate Tissue and Prostate Cancer Cells

European urology
2016 | Journal article
DOI: 10.1016/j.eururo.2015.10.019
Source: Self-asserted source
Dan Wang
grade
Preferred source (of 2)‎

CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector

Molecular therapy. Nucleic acids
2016 | Journal article
DOI: 10.1038/mtna.2016.49
Source: Self-asserted source
Dan Wang

570. Transient Reconstitution of Cas9 Protein for Safer Gene Editing In Vivo - A Ferry Tale Starring rAAV Capsid

Molecular Therapy
2016-05 | Journal article
DOI: 10.1016/s1525-0016(16)33378-0
Part of ISSN: 1525-0016
Contributors: Dan Wang; Karen Tran; Blake Y. Wang; Guangchao Xu; Mengxin Li; Hong Ma; Ran He; Qin Su; Phillip D. Zamore; Guangping Gao
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

733. Somatically Repairing Compound Heterozygous Recessive Mutations by Chromosomal Cut-and-Paste for In Vivo Gene Therapy

Molecular Therapy
2016-05 | Journal article
DOI: 10.1016/s1525-0016(16)33541-9
Part of ISSN: 1525-0016
Contributors: Dan Wang; Haiwei Mou; Karen Tran; Jia Li; Blake Y. Wang; Dominic J. Gessler; Phillip WL Tai; Qin Su; Wen Xue; Guangping Gao
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
DOI: 10.1073/pnas.1510604112
Source: Self-asserted source
Dan Wang

Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

Human gene therapy
2015 | Journal article
DOI: 10.1089/hum.2015.087
Source: Self-asserted source
Dan Wang

Abstract AS25: An adeno-associated virus (AAV) 9 vector delivering modified human mullerian inhibiting substance (MIS) as a gene therapy for ovarian cancer

Clinical Cancer Research
2015-08 | Journal article
DOI: 10.1158/1557-3265.ovcasymp14-as25
Part of ISSN: 1078-0432
Contributors: David Pepin; Amanda Sosulski; Katherine Hendren; Li Hua Zhang; Fotini Nicolaou; Dan Wang; Guangping Gao; Patricia K Donahoe
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

The nonsense suppression drug PTC124 restored alpha-l-iduronidase activity and reduces glycosaminoglycan accumulation in MPS IH mice carrying the Idua-W402X mutation

Molecular Genetics and Metabolism
2015-02 | Journal article
DOI: 10.1016/j.ymgme.2014.12.026
Part of ISSN: 1096-7192
Contributors: David M. Bedwell; Dan Wang; Ellen M. Welch; Kim M. Keeling
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

State-of-the-art human gene therapy: part I. Gene delivery technologies

Discovery medicine
2014 | Journal article
Source: Self-asserted source
Dan Wang

State-of-the-art human gene therapy: part II. Gene therapy strategies and clinical applications

Discovery medicine
2014 | Journal article
Source: Self-asserted source
Dan Wang

The potential of adeno-associated viral vectors for gene delivery to muscle tissue

Expert opinion on drug delivery
2014 | Journal article
DOI: 10.1517/17425247.2014.871258
Source: Self-asserted source
Dan Wang

Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression

PLoS ONE
2013-04-10 | Journal article
DOI: 10.1371/journal.pone.0060478
Part of ISSN: 1932-6203
Contributors: Kim M. Keeling; Dan Wang; Yanying Dai; Srinivasan Murugesan; Balachandra Chenna; Jeremy Clark; Valery Belakhov; Jeyakumar Kandasamy; Sadanandan E. Velu; Timor Baasov et al.
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

Suppression of premature termination codons as a therapeutic approach

Critical Reviews in Biochemistry and Molecular Biology
2012-06-07 | Journal article
DOI: 10.3109/10409238.2012.694846
Part of ISSN: 1040-9238
Contributors: Kim M. Keeling; Dan Wang; Sara E. Conard; David M. Bedwell
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

Suppression of a Nonsense Mutation in a Mouse Model Of Hurler Syndrome

Molecular Genetics and Metabolism
2012-02 | Journal article
DOI: 10.1016/j.ymgme.2011.11.090
Part of ISSN: 1096-7192
Contributors: Kim Keeling; Dan Wang; Valery Belakhov; Jeyakumar Kandasamy; Timor Baasov; Su-Chen Li; Yu-Teh Li; Yanying Dai; Sandanandan Velu; David Bedwell et al.
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse

Molecular Genetics and Metabolism
2012-01 | Journal article
DOI: 10.1016/j.ymgme.2011.10.005
Part of ISSN: 1096-7192
Contributors: Dan Wang; Valery Belakhov; Jeyakumar Kandasamy; Timor Baasov; Su-Chen Li; Yu-Teh Li; David M. Bedwell; Kim M. Keeling
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

Corrigendum to “Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation” [Mol. Genet. Metab. 99 (2010) 62–71]

Molecular Genetics and Metabolism
2010-04 | Journal article
DOI: 10.1016/j.ymgme.2009.12.013
Part of ISSN: 1096-7192
Contributors: Dan Wang; Charu Shukla; Xiaoli Liu; Trenton R. Schoeb; Lorne A. Clarke; David M. Bedwell; Kim M. Keeling
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation

Molecular Genetics and Metabolism
2010-01 | Journal article
DOI: 10.1016/j.ymgme.2009.08.002
Part of ISSN: 1096-7192
Contributors: Dan Wang; Charu Shukla; Xiaoli Liu; Trenton R. Schoeb; Lorne A. Clarke; David M. Bedwell; Kim M. Keeling
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

12. Suppression of a nonsense mutation in a mouse model of Hurler syndrome

Molecular Genetics and Metabolism
2009-02 | Journal article
DOI: 10.1016/j.ymgme.2008.11.013
Part of ISSN: 1096-7192
Contributors: David Bedwell; Dan Wang; Charu Shukla; Xiaoli Liu; Shirley Yeh; Ellen Welch; Trenton Schoeb; Kim Keeling
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

146. Suppression of a Nonsense mutation in a mouse model of Hurler syndrome

Molecular Genetics and Metabolism
2009-02 | Journal article
DOI: 10.1016/j.ymgme.2008.11.147
Part of ISSN: 1096-7192
Contributors: Dan Wang; Charu Shukla; Xiaoli Liu; Shirley Yeh; Ellen Welch; Trenton Schoeb; David Bedwell; Kim Keeling
Source: Self-asserted source
Dan Wang via Crossref Metadata Search

Peer review (8 reviews for 6 publications/grants)

Review activity for Cell reports medicine. (1)
Review activity for Cell. (1)
Review activity for Communications biology. (1)
Review activity for Molecular therapy (3)
Review activity for Nature chemical biology. (1)
Review activity for Nature reviews. (1)
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