Personal information

Activities

Employment (8)

Université Laval Faculté de médecine: Quebec, QC, CA

1999-06 to present | Full Professor
Employment
Source: Self-asserted source
Sheng-Xiang Lin

Centre hospitalier de l'Université Laval: Québec, Quebec, CA

1989 to present | Senior Scientist (Laboratory of Molecular Endocrinology)
Employment
Source: Self-asserted source
Sheng-Xiang Lin

Université Laval Faculté de médecine: Quebec, QC, CA

1995 to 1999 | Associate Professor
Employment
Source: Self-asserted source
Sheng-Xiang Lin

Université Laval Faculté de médecine: Quebec, QC, CA

1993 to 1995 | Assistant Professor
Employment
Source: Self-asserted source
Sheng-Xiang Lin

Université Laval Faculté de médecine: Quebec, QC, CA

1990 to 1993 | Professeur subventionnel
Employment
Source: Self-asserted source
Sheng-Xiang Lin

Université Laval Faculté des sciences et de génie: Quebec, QC, CA

1988 to 1989 | Professeur invité (Department of Biochemistry)
Employment
Source: Self-asserted source
Sheng-Xiang Lin

Case Western Reserve University: Cleveland, OH, US

1987 to 1988 | Visiting Professor (Department of Biochemistry)
Employment
Source: Self-asserted source
Sheng-Xiang Lin

Institute of Biochemistry and Cell Biology: Shanghai, Shanghai, CN

1985 to 1987 | Associate Professor
Employment
Source: Self-asserted source
Sheng-Xiang Lin

Education and qualifications (3)

Institut de Biologie Moléculaire et Cellulaire: Strasbourg, Alsace, FR

1982 to 1984 | Doctorat d'État
Education
Source: Self-asserted source
Sheng-Xiang Lin

Institut de Biologie Moléculaire et Cellulaire: Strasbourg, Alsace, FR

1979 to 1982 | Ph. D
Education
Source: Self-asserted source
Sheng-Xiang Lin

Institute of Biochemistry and Cell Biology: Shanghai, Shanghai, CN

1978 to 1979 | M. Sc.
Education
Source: Self-asserted source
Sheng-Xiang Lin

Funding (26)

New antiviral agents against herpes simplex viruses

2010-04-01 to 2011-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.c5b957c2058650d5c80d3890e77b37f0

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Sulfatase and aromatase pathways for estradiol synthesis in human breast cancer cells, tissues and animal models: identifying a combinatory therapy

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Superoxide dismutase-1 abnormalities associated with sporadic ALS

2009-04-01 to 2012-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.ff42e16af577fdcad1c83930c16439c2

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Estrogenic 17beta-hydroxysteroid dehydrogenases contributing to breast cancer stimulation: 3D-structure, function and inhibition

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Antiviral drug resistance in herpesviruses

2008-04-01 to 2013-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.938d77694b86c5ac7bfd14a5dfa09083

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Consortium for operation of a protein crystallographic synchrotron beamline

2006-04-01 to 2009-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
GRANT_NUMBER: grant.393116
Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Consortium for the operation of a protein crystallographic synchrotron beamline

2006-04-01 to 2009-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.f8f48e7dd536a4bd11f7f3b64ffb5e7b

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Effects of fasting and high fat feeding on transcriptome of tissues involved in food intake and characterization of novel appetite and satiety signals

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Consortium for operation of a protein crystallographic synchrotron beamline

2004-04-01 to 2006-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.e706a8d3eff410a0069f09bb55b2c64c

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Consortium for operation of a protein crystallographic synchrotron beamline

2003-04-01 to 2006-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
GRANT_NUMBER: grant.295985
Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Human estrogenic and androgenic 17B-hydroxysteroid dehydrogenases: 3D-structures, enzyme mechanisms and contribution to the therapy of breast and prostate cancers

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Attempts to crystallize a large number of membrane proteins for structural proteomics using steroid enzymes as targets

2002-10-01 to 2004-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.c0330453a7ccc8f75faf105e7f5bc052

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Génomique fonctionnelle et maladies endocriniennes

2002-03-01 to 2009-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.60717d374b11bc5f1843b149f6adaec0

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Inhibiteurs des isoformes 1, 3 et 12 de la 17beta-HSD à double action (sélectifs et sans activité résiduelles sur ER et AR) pour contrôler les niveaux d'estrogènes et d'androgènes dans les tumeurs cancéreuses du sein et de la prostate

Consortium For Operation of a Protein Crystallographic Synchrotron Beam Line

1999-04-01 to 2004-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.fde6099e0887a0d8f7deadcd59012704

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Consortium for operation of a protein cystallographic synchrotron beam line

1999-04-01 to 2003-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
GRANT_NUMBER: grant.211961
Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Crystallization and structure determination of som e substrate complexes of 17B-HSD types 1 and 5

1999-04-01 to 2003-02-28 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.5a98fdd177fd01ab54cc82471e80c660

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Isothermal titration microcalorimeter for studies of protein-ligand interactions

1999-04-01 to 2000-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
GRANT_NUMBER: grant.155735
Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Consortium for operation of a protein crystallography synchrotron beamline

1998-04-01 to 1999-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
GRANT_NUMBER: grant.138238
Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Human estrogenic and androgenic 17B-hyfroxysteroid dehydrogenases: 3D-structures, enzyme mechanisms and contribution to the therapy of breast and prostate cancers

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Molecular biology of the 3beta-hydroxysteroid dehydrogenase/isomerase gene family

1996-10-01 to 2001-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.a16adcc9464505618cc4f707cd6783e8

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Regulation of dehydroepiandrosterone production in the human adrenals

1996-10-01 to 2001-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.86cad51d3e08a678b34b20e08e4c004a

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Comparative structure-function studies of glutamyl-trna synthetases (GluRS) from gram-negative and gram-positive eubacteria

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Structure of the three-dimensional structures of the key human steroid metabolizing enzymes: inhibitor search via molecular modelling

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Health and life sciences multiusers equipments

1993-04-01 to 1994-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
GRANT_NUMBER: grant.48670
Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Study of androgen and estrogen formation and metabolism in the human

1990-07-01 to 2006-09-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
GRANT_NUMBER:

grant.d8ea962b0313ce94e047b5e2bd34ce46

Source: Self-asserted source
Sheng-Xiang Lin via DimensionsWizard

Works (50 of 131)

Items per page:
Page 1 of 3

Deep Drug Discovery of Mac Domain of SARS-CoV-2 (WT) Spike Inhibitors: Using Experimental ACE2 Inhibition TR-FRET Assay, Screening, Molecular Dynamic Simulations and Free Energy Calculations

Bioengineering
2023-08 | Journal article | Author
Contributors: Saleem Iqbal; Sheng-Xiang Lin
Source: check_circle
Multidisciplinary Digital Publishing Institute

Search of Novel Small Molecule Inhibitors for the Main Protease of SARS-CoV-2

Viruses
2023-02 | Journal article | Author
Contributors: Wenfa Zhang; Sheng-Xiang Lin
Source: check_circle
Multidisciplinary Digital Publishing Institute

CRIF1-CDK2 Interface Inhibitors Enhance Taxol Inhibition of the Lethal Triple-Negative Breast Cancer

Cancers
2022-02 | Journal article | Author
Contributors: Xiaoye Sang; Nassira Belmessabih; Ruixuan Wang; Preyesh; Sheng-Xiang Lin
Source: check_circle
Multidisciplinary Digital Publishing Institute

17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation

Journal of Steroid Biochemistry and Molecular Biology
2017 | Journal article
EID:

2-s2.0-85019483812

Contributors: Xu, D.; Aka, J.A.; Wang, R.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1

Molecular and Cellular Endocrinology
2017 | Journal article
EID:

2-s2.0-84995504007

Contributors: Aka, J.A.; Calvo, E.-L.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78

Journal of Steroid Biochemistry and Molecular Biology
2017 | Journal article
EID:

2-s2.0-85021856298

Contributors: Wang, X.-Q.; Aka, J.A.; Li, T.; Xu, D.; Doillon, C.J.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

RNA-dependent RNA polymerase: Addressing Zika outbreak by a phylogeny-based drug target study

Chemical Biology and Drug Design
2017 | Journal article
EID:

2-s2.0-85026460254

Contributors: Stephen, P.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Substrate inhibition of 17β-HSD1 in living cells and regulation of 17β-HSD7 by 17β-HSD1 knockdown

Journal of Steroid Biochemistry and Molecular Biology
2017 | Journal article
EID:

2-s2.0-85020617771

Contributors: Han, H.; Thériault, J.-F.; Chen, G.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1)

Gene
2016 | Journal article
EID:

2-s2.0-84991573980

Contributors: He, W.; Gauri, M.; Li, T.; Wang, R.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Current physico-biochemistry in steroid research and status of structural biology for steroid-converting enzymes

Journal of Steroid Biochemistry and Molecular Biology
2016 | Journal article
EID:

2-s2.0-84975166140

Contributors: Lin, S.X.; Shi, R.; Hu, X.J.; Penning, T.M.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Genomic data on breast cancer transcript profile modulation by 17beta-hydroxysteroid dehydrogenase type 1 and 17-beta-estradiol

Data in Brief
2016 | Journal article
EID:

2-s2.0-85030562484

Contributors: Aka, J.A.; Calvo, E.-L.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Human 3α-hydroxysteroid dehydrogenase type 3: Structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth

Biochemical Journal
2016 | Journal article
EID:

2-s2.0-84975127212

Contributors: Zhang, B.; Hu, X.-J.; Wang, X.-Q.; Thériault, J.-F.; Zhu, D.-W.; Shang, P.; Labrie, F.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity

Journal of Steroid Biochemistry and Molecular Biology
2016 | Journal article
EID:

2-s2.0-84947558276

Contributors: Maltais, R.; Trottier, A.; Barbeau, X.; Lagüe, P.; Perreault, M.; Thériault, J.-F.; Lin, S.-X.; Poirier, D.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Interplay between catalysts and substrates for activity of class ib aminoacyl-trna synthetases and implications for pharmacology

Current Topics in Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-84962596002

Contributors: Stephen, P.; Lin, S.-X.; Giegé, R.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Mimicking postmenopausal steroid metabolism in breast cancer cell culture: Differences in response to DHEA or other steroids as hormone sources

Journal of Steroid Biochemistry and Molecular Biology
2016 | Journal article
EID:

2-s2.0-84939497711

Contributors: Xu, D.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Structural Insight into NS5 of Zika Virus Leading to the Discovery of MTase Inhibitors

Journal of the American Chemical Society
2016 | Journal article
EID:

2-s2.0-85006928702

Contributors: Stephen, P.; Baz, M.; Boivin, G.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

In vitro interactions between mammary fibroblasts (Hs 578Bst) and cancer epithelial cells (MCF-7) modulate aromatase, steroid sulfatase and 17β-hydroxysteroid dehydrogenases

Molecular and Cellular Endocrinology
2015 | Journal article
EID:

2-s2.0-84939256521

Contributors: Wang, X.; Sang, X.; Diorio, C.; Lin, S.-X.; Doillon, C.J.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells

Journal of Steroid Biochemistry and Molecular Biology
2015 | Journal article
EID:

2-s2.0-84925721092

Contributors: Zhang, C.-Y.; Wang, W.-Q.; Chen, J.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Synergistic control of sex hormones by 17β-HSD type 7: A novel target for estrogen-dependent breast cancer

Journal of Molecular Cell Biology
2015 | Journal article
EID:

2-s2.0-84975780447

Contributors: Wang, X.; Gérard, C.; Thériault, J.-F.; Poirier, D.; Doillon, C.J.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity

Journal of Steroid Biochemistry and Molecular Biology
2014 | Journal article
EID:

2-s2.0-84896858967

Contributors: Zhang, B.; Zhu, D.-W.; Hu, X.-J.; Zhou, M.; Shang, P.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: An integrated biological function and inhibition study

Current Topics in Medicinal Chemistry
2013 | Journal article
EID:

2-s2.0-84878785319

Contributors: Lin, S.; Poirier, D.; Adamski, J.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84884683230

Contributors: Shi, R.; Chen, Z.-Y.; Zhu, D.-W.; Li, C.; Shan, Y.; Xu, G.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Dendritic Cell Immunoreceptor Is a New Target for Anti-AIDS Drug Development: Identification of DCIR/HIV-1 Inhibitors

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84879948354

Contributors: Lambert, A.A.; Azzi, A.; Lin, S.-X.; Allaire, G.; St-Gelais, K.P.; Tremblay, M.J.; Gilbert, C.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Interaction of Androst-5-ene-3β,17β-diol and 5α-androstane- 3β,17β-diol with estrogen and androgen receptors: A combined binding and cell study

Journal of Steroid Biochemistry and Molecular Biology
2013 | Journal article
EID:

2-s2.0-84886717642

Contributors: Chen, J.; Wang, W.-Q.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration

Breast Cancer Research
2012 | Journal article
EID:

2-s2.0-84861993200

Contributors: Aka, J.A.; Zerradi, M.; Houle, F.; Huot, J.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Comparison of functional proteomic analyses of human breast cancer cell lines T47D and MCF7

PLoS ONE
2012 | Journal article
EID:

2-s2.0-84863128254

Contributors: Aka, J.A.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells

PLoS ONE
2012 | Journal article
EID:

2-s2.0-84855490420

Contributors: Zhang, C.-Y.; Chen, J.; Yin, D.-C.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Analysis and statistics of crystallisation success increase by composition modification of protein and precipitant mixing ratio

Protein and Peptide Letters
2011 | Journal article
EID:

2-s2.0-79960616681

Contributors: Zhang, C.-Y.; Mazumdar, M.; Zhu, D.-W.; Yin, D.-C.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet

Antimicrobial Agents and Chemotherapy
2011 | Journal article
EID:

2-s2.0-80051817678

Contributors: Gilbert, C.; Azzi, A.; Goyette, N.; Lin, S.-X.; Boivin, G.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Structure analysis of a new psychrophilic marine protease

PLoS ONE
2011 | Journal article
EID:

2-s2.0-82055184890

Contributors: Zhang, S.-C.; Sun, M.; Li, T.; Wang, Q.-H.; Hao, J.-H.; Han, Y.; Hu, X.-J.; Zhou, M.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

17β-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production

Molecular Endocrinology
2010 | Journal article
EID:

2-s2.0-77950421854

Contributors: Aka, J.A.; Mazumdar, M.; Chen, C.-Q.; Poirier, D.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Crystallization of the membrane-associated annexin B1: Ro y

Crystal Growth and Design
2010 | Journal article
EID:

2-s2.0-77953157962

Contributors: Ding, F.-X.; Xu, Y.-F.; Azzi, A.; Zhu, D.-W.; Rehse, P.; Chen, C.-Q.; Sun, S.-H.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Molecular therapy of breast cancer: Progress and future directions

Nature Reviews Endocrinology
2010 | Journal article
EID:

2-s2.0-77955923386

Contributors: Lin, S.-X.; Chen, J.; Mazumdar, M.; Poirier, D.; Wang, C.; Azzi, A.; Zhou, M.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity

Antiviral Therapy
2010 | Journal article
EID:

2-s2.0-77956803865

Contributors: Martin, M.; Azzi, A.; Lin, S.-X.; Boivin, G.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Binary and ternary crystal structure analyses of a novel inhibitor with 17β-HSD type 1: A lead compound for breast cancer therapy

Biochemical Journal
2009 | Journal article
EID:

2-s2.0-73149097897

Contributors: Mazumdar, M.; Fournier, D.; Zhu, D.-W.; Cadot, C.; Poirier, D.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Crystal structure of native cinnamomin isoform III and its comparison with other ribosome inactivating proteins

Proteins: Structure, Function and Bioinformatics
2009 | Journal article
EID:

2-s2.0-58949083855

Contributors: Azzi, A.; Wang, T.; Zhu, D.-W.; Zou, Y.-S.; Liu, W.-Y.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Reductive 17β-hydroxysteroid dehydrogenases in the sulfatase pathway: Critical in the cell proliferation of breast cancer

Molecular and Cellular Endocrinology
2009 | Journal article
EID:

2-s2.0-60249089307

Contributors: Aka, J.A.; Mazumdar, M.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

The ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation

Journal of Biological Chemistry
2009 | Journal article
EID:

2-s2.0-70350355110

Contributors: Bao, R.; Zhou, C.-Z.; Jiang, C.; Lin, S.-X.; Chi, C.-W.; Chen, Y.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

An extensive study of protein phase diagram modification: Increasing macromolecular crystallizability by temperature screening

Crystal Growth and Design
2008 | Journal article
EID:

2-s2.0-61549090269

Contributors: Lin, Y.-B.; Zhu, D.-W.; Wang, T.; Song, J.; Zou, Y.-S.; Zhang, Y.-L.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Cinnamomin: Separation, crystallization and preliminary X-ray diffraction study

Amino Acids
2008 | Journal article
EID:

2-s2.0-39049100378

Contributors: Wang, T.; Zou, Y.-S.; Zhu, D.-W.; Azzi, A.; Liu, W.-Y.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Design and synthesis of bisubstrate inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Overview and perspectives

European Journal of Medicinal Chemistry
2008 | Journal article
EID:

2-s2.0-54049116349

Contributors: Fournier, D.; Poirier, D.; Mazumdar, M.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Crystallization and preliminary X-ray diffraction analysis of E. coli arginyl-tRNA synthetase in complex form with a tRNA<sup>Arg</sup>

Amino Acids
2007 | Journal article
EID:

2-s2.0-34249107077

Contributors: Zhou, M.; Azzi, A.; Xia, X.; Wang, E.-D.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Crystallogenesis of steroid-converting enzymes and their complexes: Enzyme-ligand interaction studies and inhibitor design facilitated by complex structures

Crystal Growth and Design
2007 | Journal article
EID:

2-s2.0-36549012262

Contributors: Mazumdar, M.; Zhou, M.; Zhu, D.-W.; Azzi, A.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Good crystals, still a challenge for structural biology

Crystal Growth and Design
2007 | Journal article
EID:

2-s2.0-36549065737

Contributors: Lin, S.-X.; McPherson, A.; Giegé, R.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Progress in macromolecular crystallogenesis

Crystal Growth and Design
2007 | Journal article
EID:

2-s2.0-36549054722

Contributors: Lin, S.-X.; Giegé, R.; Bergfors, T.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Purification, refolding, crystallization and diffraction analysis of the native and selenomethionine-substituted rat epidymal-specific lipocalin

Crystal Growth and Design
2007 | Journal article
EID:

2-s2.0-36549062524

Contributors: Wang, T.; Zhu, D.-W.; Zou, Y.-S.; Azzi, A.; Shi, Y.; Jin, Y.-X.; Zhang, R.-G.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Structure function analysis of West Nile virus RNA dependent RNA polymerase: Molecular model and implications for drug design

Medicinal Chemistry
2007 | Journal article
EID:

2-s2.0-34648834203

Contributors: Azzi, A.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Structure-based inhibitor design for an enzyme that binds different steroids: A potent inhibitor for human type 5 17β-hydroxysteroid dehydrogenase

Journal of Biological Chemistry
2007 | Journal article
EID:

2-s2.0-34247218025

Contributors: Qiu, W.; Zhou, M.; Mazumdar, M.; Azzi, A.; Ghanmi, D.; Luu-The, V.; Labrie, F.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Attempts to rationalize protein crystallization using relative crystallizability

Journal of Structural Biology
2006 | Journal article
EID:

2-s2.0-33646696907

Contributors: Zhu, D.-W.; Garneau, A.; Mazumdar, M.; Zhou, M.; Xu, G.-J.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier

Estrone and estradiol C-16 derivatives as inhibitors of type 1 17β-hydroxysteroid dehydrogenase

Molecular and Cellular Endocrinology
2006 | Journal article
EID:

2-s2.0-33644887991

Contributors: Poirier, D.; Chang, H.-J.; Azzi, A.; Boivin, R.P.; Lin, S.-X.
Source: Self-asserted source
Sheng-Xiang Lin via Scopus - Elsevier
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Peer review (4 reviews for 2 publications/grants)

Review activity for The journal of physical chemistry letters. (2)
Review activity for The Journal of steroid biochemistry and molecular biology. (2)