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ResearcherID: F-2202-2010

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Employment (7)

Kawasaki Medical School: Kurashiki, Okayama, JP

2016-10-01 to present | Professor (Department of Biochemistry)
Employment
Source: Self-asserted source
Akira Yamauchi

Kawasaki Medical School: Kurashiki , Okayama, JP

2010-04-01 to 2016-09-30 | Associate Professor (Biochemistry)
Employment
Source: Self-asserted source
Akira Yamauchi

University of Oxford Green Templeton College: Oxford, Oxfordshire, GB

2015-10-01 to 2016-02-28 | Kawasaki Fellow
Employment
Source: Self-asserted source
Akira Yamauchi

Effectorcell, Inc.: Meguro, Tokyo, JP

2003-10-01 to 2010-03-31 | Director (Research Divisin)
Employment
Source: Self-asserted source
Akira Yamauchi

University of Tokyo: Meguro, Tokyo, JP

2003-10-01 to 2007-03-31 | Assistant Professor (Research Center for Advanced Science and Technology)
Employment
Source: Self-asserted source
Akira Yamauchi

Indiana University: IN, IN, US

1999-10-01 to 2003-09-30 | Post Doctoral Fellow (Pediatrics/Cellular and Molecular Biology)
Employment
Source: Self-asserted source
Akira Yamauchi

The Second Tokyo National Hospital: Meguro, Tokyo, JP

1995-06-01 to 1997-03-31 | Doctor (Internal Medicine)
Employment
Source: Self-asserted source
Akira Yamauchi

Education and qualifications (2)

Nagasaki University Graduate School: Nagasaki, Nagasaki, JP

1997-04-01 to 2001-03-31 | Ph.D. (Medicine)
Education
Source: Self-asserted source
Akira Yamauchi

Nagasaki University: Nagasaki, Nagasaki, JP

1989-04-01 to 1995-03-31 | Bachelor (School of Medicine)
Education
Source: Self-asserted source
Akira Yamauchi

Funding (4)

Tumor control by squamous cell carcinoma-specific cancer-related gene DKK3

2016-04-01 to 2020-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://grants.uberresearch.com/501100001691/16K11470/Tumor-control-by-squamous-cell-carcinoma-specific-cancer-related-gene-DKK3
GRANT_NUMBER: 16K11470
Source: Self-asserted source
Akira Yamauchi via DimensionsWizard

Search of new metastasis and growth factor of pancreatic cancer in which the cell kinetic analysis as an indicator

Source: Self-asserted source
Akira Yamauchi via DimensionsWizard

Elucidating how cells migrating to chemoattractants determine the direction.

2012-04-01 to 2015-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://grants.uberresearch.com/501100001691/24591473/Elucidating-how-cells-migrating-to-chemoattractants-determine-the-direction
GRANT_NUMBER: 24591473
Source: Self-asserted source
Akira Yamauchi via DimensionsWizard

Discovery and development of new drugs migration control molecules of neutrophils, eosinophils using chemotaxis measuring device of new development

Source: Self-asserted source
Akira Yamauchi via DimensionsWizard

Works (42)

Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner

Biochemical and Biophysical Research Communications
2022-01 | Journal article
DOI: 10.1016/j.bbrc.2021.11.090
Contributors: Shuichiro Okamoto; Kei Miyano; Keisuke Kitakaze; Hitomi Kato; Akira Yamauchi; Mizuho Kajikawa; Momoe Itsumi; Chikage Kawai; Futoshi Kuribayashi
Source: check_circle
Crossref

The downregulation of NADPH oxidase Nox4 during hypoxia in hemangioendothelioma cells: a possible role of p22phox on Nox4 protein stability

Free Radical Research
2021-10-03 | Journal article
DOI: 10.1080/10715762.2021.2009116
Contributors: Kei Miyano; Shuichiro Okamoto; Akira Yamauchi; Chikage Kawai; Mizuho Kajikawa; Takuya Kiyohara; Momoe Itsumi; Masahiko Taura; Futoshi Kuribayashi
Source: check_circle
Crossref

The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells

Bioscience, Biotechnology, and Biochemistry
2020-11-01 | Journal article
DOI: 10.1080/09168451.2020.1801378
Contributors: Shuichiro Okamoto; Kei Miyano; Mizuho Kajikawa; Akira Yamauchi; Futoshi Kuribayashi
Source: check_circle
Crossref

Constitutive activity of NADPH oxidase 1 (Nox1) that promotes its own activity suppresses the colon epithelial cell migration

Free Radical Research
2020-09-01 | Journal article
DOI: 10.1080/10715762.2020.1823383
Contributors: Kei Miyano; Shuichiro Okamoto; Akira Yamauchi; Mizuho Kajikawa; Takuya Kiyohara; Masahiko Taura; Chikage Kawai; Futoshi Kuribayashi
Source: check_circle
Crossref

The NADPH oxidase NOX4 promotes the directed migration of endothelial cells by stabilizing vascular endothelial growth factor receptor 2 protein

Journal of Biological Chemistry
2020-08 | Journal article
DOI: 10.1074/jbc.RA120.014723
Contributors: Kei Miyano; Shuichiro Okamoto; Akira Yamauchi; Chikage Kawai; Mizuho Kajikawa; Takuya Kiyohara; Minoru Tamura; Masahiko Taura; Futoshi Kuribayashi
Source: check_circle
Crossref

Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice

Cellular and Molecular Gastroenterology and Hepatology
2019-09 | Journal article
DOI: 10.1016/j.jcmgh.2018.08.008
Contributors: Sohji Nishina; Akira Yamauchi; Takumi Kawaguchi; Kohei Kaku; Moritaka Goto; Kyo Sasaki; Yuichi Hara; Yasuyuki Tomiyama; Futoshi Kuribayashi; Takuji Torimura et al.
Source: check_circle
Crossref
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exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis

Int J Cancer
2018 | Journal article
DOI: 10.1002/ijc.31945
Contributors: Kinoshita, R.; Sato, H.; Yamauchi, A.; Takahashi, Y.; Inoue, Y.; Sumardika, I. W.; Chen, Y.; Tomonobu, N.; Araki, K.; Shien, K. et al.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91(phox) , phagocyte flavocytochrome b558 large subunit

Microbiol Immunol
2018 | Journal article
DOI: 10.1111/1348-0421.12584
Contributors: Kawai, C.; Yamauchi, A.; Kuribayashi, F.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis

Int J Cancer
2018 | Journal article
DOI: 10.1002/ijc.31982
Contributors: Kinoshita, R.; Sato, H.; Yamauchi, A.; Takahashi, Y.; Inoue, Y.; Sumardika, I. W.; Chen, Y.; Tomonobu, N.; Araki, K.; Shien, K. et al.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

β-1,3-Galactosyl-

Oncol Res
2018 | Journal article
DOI: 10.3727/096504017X15031557924123
Contributors: Sumardika, I. W.; Youyi, C.; Kondo, E.; Inoue, Y.; Ruma, I. M. W.; Murata, H.; Kinoshita, R.; Yamamoto, K. I.; Tomida, S.; Shien, K. et al.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Embigin Promotes Prostate Cancer Progression by S100A4-Dependent and-Independent Mechanisms

Cancers
2018-07-23 | Journal article
DOI: 10.3390/cancers10070239
Contributors: I Made Winarsa Ruma; Rie Kinoshita; Nahoko Tomonobu; Yusuke Inoue; Eisaku Kondo; Akira Yamauchi; Hiroki Sato; I Wayan Sumardika; Youyi Chen; Ken-Ichi Yamamoto et al.
Source: check_circle
Crossref
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Reactive oxygen species suppress the cellular chemotaxis

Cytokine
2017 | Journal article
WOSUID:

WOS:000414817600277
Contributors: Yamauchi, A.; Okamoto, S.; Kuribayashi, F.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device

BMC Cancer
2017-12 | Journal article
DOI: 10.1186/s12885-017-3218-4
Source: Self-asserted source
Akira Yamauchi
grade
Preferred source (of 2)‎

DKK3 Overexpression Increases Malignant Properties of Head and Neck Squamous Cell Carcinoma Cells.

Oncology Research
2017-05-04 | Journal article
DOI: 10.3727/096504017X14926874596386
Source: Self-asserted source
Akira Yamauchi

Dipeptidyl peptidase 4 ( DPP4) inhibitor enhances natural killer cell chemotaxis, improving tumor immunity against hepatocellular carcinoma

Hepatology
2016 | Journal article
WOSUID:

WOS:000385493801209
Contributors: Nishina, S.; Yamauchi, A.; Hara, Y.; Sasaki, K.; Hino, K.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells.

Cancer Microenvironment
2016-12 | Journal article
DOI: 10.1007/s12307-016-0185-2
Source: Self-asserted source
Akira Yamauchi

Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium.

J Biologycal Chemistry
2016-11-25 | Journal article
DOI: 10.1074/jbc.M116.736926
Source: Self-asserted source
Akira Yamauchi

MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding.

Clinical & Experimental Metastasis
2016-08 | Journal article
DOI: 10.1007/s10585-016-9801-2
Source: Self-asserted source
Akira Yamauchi

CD26 (DPP-4) as a molecular target for HCC treatment

Hepatology
2015 | Journal article
WOSUID:

WOS:000368375404182
Contributors: Nishina, S.; Yamauchi, A.; Hara, Y.; Hino, K.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Increase in Activated Treg in TIL in Lung Cancer and In Vitro Depletion of Treg by ADCC Using an Antihuman CCR4 mAb (KM2760)

Journal of Thoracic Oncology
2015 | Journal article
DOI: 10.1097/JTO.0000000000000364
WOSUID:

WOS:000346986500011
Contributors: Kurose, Koji; Ohue, Yoshihiro; Sato, Eiichi; Yamauchi, Akira; Eikawa, Shingo; Isobe, Midori; Nishio, Yumi; Uenaka, Akiko; Oka, Mikio; Nakayama, Eiichi
Source: Self-asserted source
Akira Yamauchi via ResearcherID

The new molecular target therapy of Hsp90 inhibition in esophageal squamous cell carcinoma

Cancer Research
2015 | Journal article
DOI: 10.1158/1538-7445.am2015-1757
WOSUID:

WOS:000371578503242
Contributors: Yamamura, M.; Nohno, T.; Yamauchi, A.; Katase, N.; Okawaki, M.; Sawaki, A.; Matsumoto, H.; Hirai, T.; Yamaguchi, Y.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients

Journal of Immunological Methods
2014-02 | Journal article
DOI: 10.1016/j.jim.2013.12.005
Contributors: Akira Yamauchi; Mikako Degawa-Yamauchi; Futoshi Kuribayashi; Shiro Kanegasaki; Tomoko Tsuchiya
Source: check_circle
Crossref
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Human skin melanocyte migration towards stromal cell-derived factor-1α demonstrated by optical real-time cell mobility assay: Modulation of their chemotactic ability by α-melanocyte-stimulating hormone

Experimental Dermatology
2013 | Journal article
DOI: 10.1111/exd.12232
EID:

2-s2.0-84884723803
Contributors: Yamauchi, A.; Hadjur, C.; Takahashi, T.; Suzuki, I.; Hirose, K.; Mahe, Y.F.
Source: Self-asserted source
Akira Yamauchi via Scopus - Elsevier

Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells

Journal of Immunological Methods
2013 | Journal article
DOI: 10.1016/j.jim.2013.04.007
Part of ISSN: 0022-1759
Contributors: Miyachi, M.; Oyanagi, E.; Uchida, M.; Yamauchi, A.; Yano, H.
Source: Self-asserted source
Akira Yamauchi via ResearcherID
grade
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A highly sensitive chemiluminescence assay for superoxide detection and chronic granulomatous disease diagnosis

Tropical Medicine and Health
2011 | Journal article
DOI: 10.2149/tmh.2011-08
EID:

2-s2.0-79959865020
Contributors: Yamazaki, T.; Kawai, C.; Yamauchi, A.; Kuribayashi, F.
Source: Self-asserted source
Akira Yamauchi via Scopus - Elsevier

Functions of the phagocyte NADPH oxidase and chronic granulomatous disease (CGD)

Neutrophils: Lifespan, Functions and Roles in Disease
2010 | Book
EID:

2-s2.0-84895248756
Contributors: Yamauchi, A.; Kuribayashi, F.
Source: Self-asserted source
Akira Yamauchi via Scopus - Elsevier

Role of CC Chemokine Receptor 2 in Bone Marrow Cells in the Recruitment of Macrophages into Obese Adipose Tissue

Journal of Biological Chemistry
2008 | Journal article
DOI: 10.1074/jbc.M804220200
Part of ISSN: 0021-9258
Contributors: Degawa-Yamauchi, M.; Hirata, Y.; Ito, A.; Kamei, Y.; Kanegasaki, S.; Kobayashi, Y.; Kouyama, R.; Kuziel, W. A.; Nitta, N.; Ogawa, Y. et al.
Source: Self-asserted source
Akira Yamauchi via ResearcherID
grade
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Quantitative analysis of eosinophil chemotaxis tracked using a novel optical device - TAXIScan

Journal of Immunological Methods
2007 | Journal article
DOI: 10.1016/j.jim.2006.12.010
Part of ISSN: 0022-1759
Contributors: Kanegasaki, S.; Nitta, N.; Tamatani, T.; Tsuchiya, T.; Yamauchi, A.
Source: Self-asserted source
Akira Yamauchi via ResearcherID
grade
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Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

Journal of Immunology
2007 | Journal article
EID:

2-s2.0-40049099471
Contributors: Li, Y.; Yan, J.; De, P.; Chang, H.-C.; Yamauchi, A.; Christopherson II, K.W.; Paranavitana, N.C.; Peng, X.; Kim, C.; Munugulavadla, V. et al.
Source: Self-asserted source
Akira Yamauchi via Scopus - Elsevier

Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo - Role of the C-terminal polybasic domain

Journal of Biological Chemistry
2005 | Journal article
DOI: 10.1074/jbc.M408820200
Part of ISSN: 0021-9258
Contributors: Atkinson, S. J.; Dinauer, M. C.; Knaus, U.; Marchal, C. C.; Molitoris, J.; Pech, N.; Towe, J.; Yamauchi, A.
Source: Self-asserted source
Akira Yamauchi via ResearcherID
grade
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Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways

Journal of Immunology
2005 | Journal article
EID:

2-s2.0-20144387139
Contributors: Carstanjen, D.; Yamauchi, A.; Koornneef, A.; Zang, H.; Filippi, M.-D.; Harris, C.; Towe, J.; Atkinson, S.; Zheng, Y.; Dinauer, M.C. et al.
Source: Self-asserted source
Akira Yamauchi via Scopus - Elsevier

C-terminal polybasic domain of Rac mediates isoform-specific regulation of chemotaxis and NADPH oxidase activity in murine neutrophils in vivo

Molecular Biology of the Cell
2004 | Journal article
Part of ISSN: 1059-1524
Contributors: Atkinson, S. J.; Dinauer, M. C.; Marchal, C.; Pech, N.; Towe, J.; Yamauchi, A.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles

Journal of Immunology
2004 | Journal article
EID:

2-s2.0-8444239999
Contributors: Yamauchi, A.; Kim, C.; Li, S.; Marchal, C.C.; Towe, J.; Atkinson, S.J.; Dinauer, M.C.
Source: Self-asserted source
Akira Yamauchi via Scopus - Elsevier

Loss of Rap1A results in altered NADPH oxidase activity and haptotaxis of mouse myeloid cells

Faseb Journal
2003 | Journal article
Part of ISSN: 0892-6638
Contributors: De, P.; Dinauer, M. C.; Durden, D. L.; Li, Y.; Quilliam, L.; Stone, J. C.; Yamauchi, A.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: Preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions

Journal of Immunology
2002 | Journal article
EID:

2-s2.0-0036839579
Contributors: Li, S.; Yamauchi, A.; Marchal, C.C.; Molitoris, J.K.; Quilliam, L.A.; Dinauer, M.C.
Source: Self-asserted source
Akira Yamauchi via Scopus - Elsevier

Rac2 controls neutrophil chemotaxis and superoxide by reorganization of the actin skeleton

Blood
2002 | Journal article
Part of ISSN: 0006-4971
Contributors: Atkinson, S.; Carstanjen, D.; Dinauer, M. C.; Harris, C. E.; Luo, Y. N.; Williams, D. A.; Yamauchi, A.; Yi, Z.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Rac2-null macrophages have defects in superoxide production and Fc gamma-R-mediated phagocytosis

Blood
2002 | Journal article
WOSUID:

ISI:000179184701773
Contributors: Yamauchi, A.; Li, S. J.; Marchal, C. C.; Dinauer, M. C.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

The polybasic motif of the RhoGTPase Rac2, located in the C-terminus domain, is responsible for the specific function of Rac2 in superoxide production but not Chemotaxis

Experimental Hematology
2002 | Journal article
WOSUID:

ISI:000176187000180
Contributors: Filippi, M.; Yamauchi, A.; Gu, Y.; Ayele, A.; Dinauer, M.; Williams, D.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Location of the epitope for 7D5, a monoclonal antibody raised against human flavocytochrome b<inf>558</inf>, to the extracellular peptide portion of primate gp91<sup>phox</sup>

Microbiology and Immunology
2001 | Journal article
EID:

2-s2.0-0035069299
Contributors: Yamauchi, A.; Yu, L.; Pötgens, A.J.G.; Kuribayashi, F.; Nunoi, H.; Kanegasaki, S.; Roos, D.; Malech, H.L.; Dinauer, M.C.; Nakamura, M.
Source: Self-asserted source
Akira Yamauchi via Scopus - Elsevier

Eosinophil-specific regulation of gp91(phox) gene expression by transcription factors GATA-1 and GATA-2

Journal of Biological Chemistry
2000 | Journal article
DOI: 10.1074/jbc.275.13.9425
Part of ISSN: 0021-9258
Contributors: Fujii, Y.; Hao, L. J.; Kumatori, A.; Nakamura, M.; Suzuki, S.; Yamamoto, M.; Yamauchi, A.; Yang, D.
Source: Self-asserted source
Akira Yamauchi via ResearcherID
grade
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Phorbol ester-potentiated liposomal transfection to monocytic PLB-985 cells

Journal of Biochemistry
2000 | Journal article
EID:

2-s2.0-0034531865
Contributors: Li Jun Hao; Yang, D.; Fujii, Y.; Yamauchi, A.; Suzuki, N.; Kikuchi, H.; Kaneda, Y.; Nakamura, M.
Source: Self-asserted source
Akira Yamauchi via Scopus - Elsevier

An X-linked variant chronic granulomatous disease due to failure in PU.1 binding

Molecular Immunology
1998 | Journal article
DOI: 10.1016/S0161-5890(98)90388-1
Part of ISSN: 0161-5890
Contributors: Fujii, Y.; Hao, L. J.; Kondoh, T.; Kumatori, A.; Kuribayashi, F.; Nakamura, M.; Suzuki, S.; Tsuji, Y.; Yamauchi, A.
Source: Self-asserted source
Akira Yamauchi via ResearcherID

Peer review (4 reviews for 3 publications/grants)

Review activity for Antioxidants. (1)
Review activity for Cancers. (2)
Review activity for International journal of molecular sciences. (1)
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