Personal information

chromatin, histone, epigenetics
Japan

Activities

Employment (4)

The Cancer Institute for JFCR: Ariake, Tokyo, JP

2017-04-01 to present | Staff Scientist (Division of Cancer Biology)
Employment
Source: Self-asserted source
Hiroaki Tachiwana

Waseda University: Shinjyuku, Tokyo, JP

2014-09-15 to 2017-03-31 | Research Associate (School of Advanced Science and Engineering)
Employment
Source: Self-asserted source
Hiroaki Tachiwana

Institut Curie: Paris, ÃŽle-de-France, FR

2012-06-01 to 2014-08-31 | Postdoctoral fellow (Research Unit ‘‘Nuclear Dynamics and Genome Plasticity’’ )
Employment
Source: Self-asserted source
Hiroaki Tachiwana

Waseda University: Shinjyuku, Tokyo, JP

2009-04-01 to 2012-05-31 | Research Associate (School of Advanced Science and Engineering)
Employment
Source: Self-asserted source
Hiroaki Tachiwana

Education and qualifications (1)

Waseda University: Shinjyuku, Tokyo, JP

2004-04-01 to 2009-03-15 | Ph.D. (Department of Science and Engineering)
Education
Source: Self-asserted source
Hiroaki Tachiwana

Funding (4)

Analysis of chromatin dynamics using permeabilized cells

Source: Self-asserted source
Hiroaki Tachiwana
grade
Preferred source (of 2)‎

Establishment of new approach to analyzing histone modifications without specific antibodies

Source: Self-asserted source
Hiroaki Tachiwana
grade
Preferred source (of 2)‎

Analyses of centromeric chromatin structure

2011-01-01 to 2012-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 23770008
Source: Self-asserted source
Hiroaki Tachiwana via DimensionsWizard

The structural analysis of centromere specific nucleosome

2009-01-01 to 2010-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 21870038
Source: Self-asserted source
Hiroaki Tachiwana via DimensionsWizard

Works (38)

Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.

Cell reports
2017-01 | Journal article
Contributors: Ueda J; Harada A; Urahama T; Machida S; Maehara K; Hada M; Makino Y; Nogami J; Horikoshi N; Osakabe A et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis.

Epigenetics & chromatin
2016 | Journal article
Contributors: Urahama T; Harada A; Maehara K; Horikoshi N; Sato K; Sato Y; Shiraishi K; Sugino N; Osakabe A; Tachiwana H et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity.

Molecular cell
2016-08 | Journal article
Contributors: Roulland Y; Ouararhni K; Naidenov M; Ramos L; Shuaib M; Syed SH; Lone IN; Boopathi R; Fontaine E; Papai G et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing.

Scientific reports
2016-04 | Journal article
Contributors: Kobayashi W; Takaku M; Machida S; Tachiwana H; Maehara K; Ohkawa Y; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer.

Biochemical and biophysical research communications
2016-02 | Journal article
Contributors: Horikoshi N; Tachiwana H; Kagawa W; Osakabe A; Matsumoto S; Iwai S; Sugasawa K; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome.

Scientific reports
2015 | Journal article
Contributors: Osakabe A; Tachiwana H; Kagawa W; Horikoshi N; Matsumoto S; Hasegawa M; Matsumoto N; Toga T; Yamamoto J; Hanaoka F et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Two arginine residues suppress the flexibility of nucleosomal DNA in the canonical nucleosome core.

PloS one
2015 | Journal article
Contributors: Kono H; Shirayama K; Arimura Y; Tachiwana H; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Stable complex formation of CENP-B with the CENP-A nucleosome.

Nucleic acids research
2015-05 | Journal article
Contributors: Fujita R; Otake K; Arimura Y; Horikoshi N; Miya Y; Shiga T; Osakabe A; Tachiwana H; Ohzeki J; Larionov V et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment.

Cell reports
2015-04 | Journal article
Contributors: Tachiwana H; Müller S; Blümer J; Klare K; Musacchio A; Almouzni G
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.

Biochemistry
2015-02 | Journal article
Contributors: Kato D; Osakabe A; Tachiwana H; Tanaka H; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

DNA binding properties of the actin-related protein Arp8 and its role in DNA repair.

PloS one
2014 | Journal article
Contributors: Osakabe A; Takahashi Y; Murakami H; Otawa K; Tachiwana H; Oma Y; Nishijima H; Shibahara KI; Kurumizaka H; Harata M
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.

Scientific reports
2014 | Journal article
Contributors: Machida S; Takaku M; Ikura M; Sun J; Suzuki H; Kobayashi W; Kinomura A; Osakabe A; Tachiwana H; Horikoshi Y et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Structure of human nucleosome containing the testis-specific histone variant TSH2B.

Acta crystallographica. Section F, Structural biology communications
2014-04 | Journal article
Contributors: Urahama T; Horikoshi N; Osakabe A; Tachiwana H; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX.

Molecular cell
2014-02 | Journal article
Contributors: Lacoste N; Woolfe A; Tachiwana H; Garea AV; Barth T; Cantaloube S; Kurumizaka H; Imhof A; Almouzni G
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

The centromeric nucleosome-like CENP-T-W-S-X complex induces positive supercoils into DNA.

Nucleic acids research
2014-02 | Journal article
Contributors: Takeuchi K; Nishino T; Mayanagi K; Horikoshi N; Osakabe A; Tachiwana H; Hori T; Kurumizaka H; Fukagawa T
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Contribution of histone N-terminal tails to the structure and stability of nucleosomes.

FEBS open bio
2013 | Journal article
Contributors: Iwasaki W; Miya Y; Horikoshi N; Osakabe A; Taguchi H; Tachiwana H; Shibata T; Kagawa W; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Structural basis of a nucleosome containing histone H2A.B/H2A.Bbd that transiently associates with reorganized chromatin.

Scientific reports
2013 | Journal article
Contributors: Arimura Y; Kimura H; Oda T; Sato K; Osakabe A; Tachiwana H; Sato Y; Kinugasa Y; Ikura T; Sugiyama M et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2.

Acta crystallographica. Section D, Biological crystallography
2013-12 | Journal article
Contributors: Horikoshi N; Sato K; Shimada K; Arimura Y; Osakabe A; Tachiwana H; Hayashi-Takanaka Y; Iwasaki W; Kagawa W; Harata M et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Gas-phase structure of the histone multimers characterized by ion mobility mass spectrometry and molecular dynamics simulation.

Analytical chemistry
2013-04 | Journal article
Contributors: Saikusa K; Fuchigami S; Takahashi K; Asano Y; Nagadoi A; Tachiwana H; Kurumizaka H; Ikeguchi M; Nishimura Y; Akashi S
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Nap1 regulates proper CENP-B binding to nucleosomes.

Nucleic acids research
2013-03 | Journal article
Contributors: Tachiwana H; Miya Y; Shono N; Ohzeki J; Osakabe A; Otake K; Larionov V; Earnshaw WC; Kimura H; Masumoto H et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription.

Journal of cell science
2013-03 | Journal article
Contributors: Osakabe A; Tachiwana H; Takaku M; Hori T; Obuse C; Kimura H; Fukagawa T; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Current progress on structural studies of nucleosomes containing histone H3 variants.

Current opinion in structural biology
2013-02 | Journal article
Contributors: Kurumizaka H; Horikoshi N; Tachiwana H; Kagawa W
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Comparison between the CENP-A and histone H3 structures in nucleosomes.

Nucleus (Austin, Tex.)
2012 | Journal article
Contributors: Tachiwana H; Kagawa W; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair.

The EMBO journal
2012-08 | Journal article
Contributors: Sato K; Ishiai M; Toda K; Furukoshi S; Osakabe A; Tachiwana H; Takizawa Y; Kagawa W; Kitao H; Dohmae N et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Structural analysis of the hexasome, lacking one histone H2A/H2B dimer from the conventional nucleosome.

Biochemistry
2012-04 | Journal article
Contributors: Arimura Y; Tachiwana H; Oda T; Sato M; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Structure of the CENP-A nucleosome and its implications for centromeric chromatin architecture.

Genes & genetic systems
2011 | Journal article
Contributors: Tachiwana H; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Comprehensive structural analysis of mutant nucleosomes containing lysine to glutamine (KQ) substitutions in the H3 and H4 histone-fold domains.

Biochemistry
2011-09 | Journal article
Contributors: Iwasaki W; Tachiwana H; Kawaguchi K; Shibata T; Kagawa W; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Crystal structure of the human centromeric nucleosome containing CENP-A.

Nature
2011-08 | Journal article
Contributors: Tachiwana H; Kagawa W; Shiga T; Osakabe A; Miya Y; Saito K; Hayashi-Takanaka Y; Oda T; Sato M; Park SY et al.
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Structures of human nucleosomes containing major histone H3 variants.

Acta crystallographica. Section D, Biological crystallography
2011-06 | Journal article
Contributors: Tachiwana H; Osakabe A; Shiga T; Miya Y; Kimura H; Kagawa W; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene.

Acta crystallographica. Section D, Biological crystallography
2011-02 | Journal article
Contributors: Horikoshi N; Tachiwana H; Saito K; Osakabe A; Sato M; Yamada M; Akashi S; Nishimura Y; Kagawa W; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Deimination stabilizes histone H2A/H2B dimers as revealed by electrospray ionization mass spectrometry.

Journal of mass spectrometry : JMS
2010-08 | Journal article
Contributors: Shimoyama S; Nagadoi A; Tachiwana H; Yamada M; Sato M; Kurumizaka H; Nishimura Y; Akashi S
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T.

Proceedings of the National Academy of Sciences of the United States of America
2010-06 | Journal article
Contributors: Tachiwana H; Kagawa W; Osakabe A; Kawaguchi K; Shiga T; Hayashi-Takanaka Y; Kimura H; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Nucleosome formation activity of human somatic nuclear autoantigenic sperm protein (sNASP).

The Journal of biological chemistry
2010-04 | Journal article
Contributors: Osakabe A; Tachiwana H; Matsunaga T; Shiga T; Nozawa RS; Obuse C; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Nucleosome formation with the testis-specific histone H3 variant, H3t, by human nucleosome assembly proteins in vitro.

Nucleic acids research
2008-04 | Journal article
Contributors: Tachiwana H; Osakabe A; Kimura H; Kurumizaka H
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

In vivo and in vitro footprinting of nucleosomes and transcriptional activators using an infrared-fluorescence DNA sequencer.

Biological & pharmaceutical bulletin
2008-02 | Journal article
Contributors: Morohashi N; Nakajima K; Kuwana S; Tachiwana H; Kurumizaka H; Shimizu M
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

HIV-1 Vpr induces DNA double-strand breaks.

Cancer research
2006-01 | Journal article
Contributors: Tachiwana H; Shimura M; Nakai-Murakami C; Tokunaga K; Takizawa Y; Sata T; Kurumizaka H; Ishizaka Y
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences.

The Journal of biological chemistry
2005-12 | Journal article
Contributors: Tanaka Y; Tachiwana H; Yoda K; Masumoto H; Okazaki T; Kurumizaka H; Yokoyama S
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central

Location of tyrosine 315, a target for phosphorylation by cAbl tyrosine kinase, at the edge of the subunit-subunit interface of the human Rad51 filament.

Journal of molecular biology
2004-06 | Journal article
Contributors: Conilleau S; Takizawa Y; Tachiwana H; Fleury F; Kurumizaka H; Takahashi M
Source: Self-asserted source
Hiroaki Tachiwana via Europe PubMed Central