Personal information

Emails & domains

Verified email addresses

Verified email domains

Keywords

neuropathology, neurooncology, multi-omics, DNA methylation profiling, next-generation sequencing, cell culture, brain tumours

Countries

Germany

Activities

Collapse all

Employment (3)

University Hospital Regensburg: Regensburg, DE

2024-08-19 to present | Senior physician, research group leader (Department of Neuropathology)
Employment
Source: Self-asserted source
Annika K. Wefers

University Hospital Hamburg-Eppendorf: Hamburg, DE

2020-09-01 to 2024-07-31 | Senior physician (board certified neuropathologist) and head of molecular neuropathology; research group leader (Neuropathology)
Employment
Source: Self-asserted source
Annika K. Wefers

University Hospital Heidelberg: Heidelberg, DE

2015-10-01 to 2020-08-31 | Resident physician and postdoc (Department of Neuropathology, Institute of Pathology)
Employment
Source: Self-asserted source
Annika K. Wefers

Works (45)

Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Nature Medicine
2024-01 | Journal article
DOI: 10.1038/s41591-023-02652-6
Contributors: Dominik Sturm; David Capper; Felipe Andreiuolo; Marco Gessi; Christian Kölsche; Annekathrin Reinhardt; Philipp Sievers; Annika K. Wefers; Azadeh Ebrahimi; Abigail K. Suwala et al.
Source: check_circle
Crossref

Atypical neurofibromas reveal distinct epigenetic features with proximity to benign peripheral nerve sheath tumor entities

Neuro-Oncology
2023-09-05 | Journal article
DOI: 10.1093/neuonc/noad053
Contributors: Catena Kresbach; Matthias Dottermusch; Alicia Eckhardt; Inka Ristow; Petros Paplomatas; Lea Altendorf; Annika K Wefers; Michael Bockmayr; Sarra Belakhoua; Ivy Tran et al.
Source: check_circle
Crossref

Classification of brain tumors by Nanopore sequencing of cell-free DNA from cerebrospinal fluid

2023-07-23 | Other
DOI: 10.1093/clinchem/hvad115
Contributors: Ann-Kristin Afflerbach; Christian Rohrandt; Björn Brändl; Marthe Sönksen; Jürgen Hench; Daniela Börnigen; Beate Winkler; Michael Synowitz; Lasse Dührsen; Annika Wefers et al.
Source: check_circle
Crossref

Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Nature Medicine
2023-04 | Journal article
DOI: 10.1038/s41591-023-02255-1
Contributors: Dominik Sturm; David Capper; Felipe Andreiuolo; Marco Gessi; Christian Kölsche; Annekathrin Reinhardt; Philipp Sievers; Annika K. Wefers; Azadeh Ebrahimi; Abigail K. Suwala et al.
Source: check_circle
Crossref

Anaplastic ganglioglioma—A diagnosis comprising several distinct tumour types

Neuropathology and Applied Neurobiology
2022-12 | Journal article
DOI: 10.1111/nan.12847
Contributors: Annekathrin Reinhardt; Kristin Pfister; Daniel Schrimpf; Damian Stichel; Felix Sahm; David E. Reuss; David Capper; Annika K. Wefers; Azadeh Ebrahimi; Martin Sill et al.
Source: check_circle
Crossref

An H3F3A K27M‐mutation in a sonic hedgehog medulloblastoma

Brain Pathology
2022-05 | Journal article
DOI: 10.1111/bpa.13024
Contributors: Matthias Dottermusch; Nesrin Uksul; Ulrich J. Knappe; Bernhard Erdlenbruch; Annika K. Wefers
Source: check_circle
Crossref

Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data

Neuropathol Appl Neurobiol
2021 | Journal article
DOI: 10.1111/nan.12683
Part of ISSN: 1365-2990 (Electronic) 0305-1846 (Linking)
Source: Self-asserted source
Annika K. Wefers

Neurofibromatosis type 2 predisposes to ependymomas of various localization, histology, and molecular subtype

Acta Neuropathol
2021 | Journal article
DOI: 10.1007/s00401-021-02304-4
Part of ISSN: 0001-6322
Source: Self-asserted source
Annika K. Wefers

68Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of adenoid cystic carcinomas – Imaging analysis and histological validation

Radiotherapy and Oncology
2021-07 | Journal article
DOI: 10.1016/j.radonc.2021.04.016
Contributors: Manuel Röhrich; Mustafa Syed; Dawn P. Liew; Frederik L. Giesel; Jakob Liermann; Peter L. Choyke; Annika K. Wefers; Thomas Ritz; Marina Szymbara; Lisa Schillings et al.
Source: check_circle
Crossref

An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data

Acta Neuropathol
2020 | Journal article
DOI: 10.1007/s00401-020-02167-1
Part of ISSN: 0001-6322
Source: Self-asserted source
Annika K. Wefers

Impact of (68)Ga-FAPI-PET/CT imaging on the therapeutic management of primary and recurrent pancreatic ductal adenocarcinomas

J Nucl Med
2020 | Journal article
DOI: 10.2967/jnumed.120.253062
Part of ISSN: 0161-5505
Source: Self-asserted source
Annika K. Wefers

Molecular characterization of CNS paragangliomas identifies cauda equina paragangliomas as a distinct tumor entity

Acta Neuropathologica
2020 | Journal article
DOI: 10.1007/s00401-020-02218-7
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

Acta Neuropathol
2020 | Journal article
DOI: 10.1007/s00401-020-02243-6
Part of ISSN: 0001-6322
Source: Self-asserted source
Annika K. Wefers

Sarcoma classification by DNA-methylation profiling

Acta Neuropathologica Communications
2020 | Journal article
Source: Self-asserted source
Annika K. Wefers

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course

Acta Neuropathologica
2020-01-28 | Journal article
DOI: 10.1007/s00401-019-02078-w
Contributors: Annika K. Wefers; Damian Stichel; Daniel Schrimpf; Roland Coras; Mélanie Pages; Arnault Tauziède-Espariat; Pascale Varlet; Daniel Schwarz; Figen Söylemezoglu; Ute Pohl et al.
Source: check_circle
Crossref

Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults

Acta Neuropathologica
2019 | Journal article
DOI: 10.1007/s00401-019-02094-w
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein–specific PET/CT

European Journal of Nuclear Medicine and Molecular Imaging
2019 | Journal article
DOI: 10.1007/s00259-019-04444-y
Part of ISSN: 1619-7089
Source: Self-asserted source
Annika K. Wefers

Molecular characterization of histopathological ependymoma variants

Acta Neuropathologica
2019 | Journal article
DOI: 10.1007/s00401-019-02090-0
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Mutational patterns and regulatory networks in epigenetic subgroups of meningioma

Acta Neuropathologica
2019 | Journal article
DOI: 10.1007/s00401-019-02008-w
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA

Acta Neuropathologica
2019 | Journal article
DOI: 10.1007/s00401-019-01969-2
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype-phenotype analysis

Neuropathol Appl Neurobiol
2019 | Journal article
DOI: 10.1111/nan.12522
Part of ISSN: 1365-2990 (Electronic) 0305-1846 (Linking)
Source: Self-asserted source
Annika K. Wefers

Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1

Acta Neuropathologica
2019 | Journal article
DOI: 10.1007/s00401-019-02038-4
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions

Acta Neuropathol
2019 | Journal article
DOI: 10.1007/s00401-019-02039-3
Part of ISSN: 1432-0533 (Electronic) 0001-6322 (Linking)
Source: Self-asserted source
Annika K. Wefers

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

Acta Neuropathologica Communications
2019 | Journal article
DOI: 10.1186/s40478-019-0801-8
Part of ISSN: 2051-5960
Source: Self-asserted source
Annika K. Wefers

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

Acta Neuropathologica
2018 | Journal article
DOI: 10.1007/s00401-018-1837-8
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p

Acta Neuropathologica
2018 | Journal article
DOI: 10.1007/s00401-018-1924-x
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

DNA methylation-based classification of central nervous system tumours

Nature
2018 | Journal article
DOI: 10.1038/nature26000
Source: Self-asserted source
Annika K. Wefers

DNA methylation-based reclassification of olfactory neuroblastoma

Acta Neuropathologica
2018 | Journal article
DOI: 10.1007/s00401-018-1854-7
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma

Acta Neuropathologica
2018 | Journal article
DOI: 10.1007/s00401-018-1882-3
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas

Acta Neuropathologica
2018 | Journal article
DOI: 10.1007/s00401-018-1849-4
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

Acta Neuropathologica
2018 | Journal article
DOI: 10.1007/s00401-018-1879-y
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry

Acta Neuropathologica Communications
2018 | Journal article
DOI: 10.1186/s40478-018-0523-3
Part of ISSN: 2051-5960
Source: Self-asserted source
Annika K. Wefers

The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma

Clinical Cancer Research
2018 | Journal article
DOI: 10.1158/1078-0432.CCR-18-1965
Source: Self-asserted source
Annika K. Wefers

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors
Source: Self-asserted source
Annika K. Wefers

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

The Lancet Oncology
2017 | Journal article
DOI: 10.1016/S1470-2045(17)30155-9
Part of ISSN: 1470-2045
Source: Self-asserted source
Annika K. Wefers

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

Acta Neuropathologica
2017 | Journal article
DOI: 10.1007/s00401-016-1657-7
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Migration of Interneuron Precursors in the Nascent Cerebellar Cortex

The Cerebellum
2017 | Journal article
DOI: 10.1007/s12311-017-0900-7
Part of ISSN: 1473-4230
Source: Self-asserted source
Annika K. Wefers

Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex

Scientific Reports
2017 | Journal article
DOI: 10.1038/s41598-017-06150-x
Part of ISSN: 2045-2322
Source: Self-asserted source
Annika K. Wefers

Synaptic input as a directional cue for migrating interneuron precursors

Development
2017 | Journal article
DOI: 10.1242/dev.154096
Source: Self-asserted source
Annika K. Wefers

Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium

PLOS ONE
2016 | Journal article
DOI: 10.1371/journal.pone.0166690
Source: Self-asserted source
Annika K. Wefers

Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum

The Cerebellum
2016 | Journal article
DOI: 10.1007/s12311-016-0774-0
Part of ISSN: 1473-4230
Source: Self-asserted source
Annika K. Wefers

Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis

Acta Neuropathologica
2016 | Journal article
DOI: 10.1007/s00401-016-1574-9
Part of ISSN: 1432-0533
Source: Self-asserted source
Annika K. Wefers

Consensus Paper: Cerebellar Development

The Cerebellum
2015 | Journal article
DOI: 10.1007/s12311-015-0724-2
Part of ISSN: 1473-4222
Source: Self-asserted source
Annika K. Wefers

MiR-34a deficiency accelerates medulloblastoma formation in vivo

International Journal of Cancer
2014 | Journal article
DOI: 10.1002/ijc.29294
Part of ISSN: 1097-0215
Source: Self-asserted source
Annika K. Wefers

Subgroup-specific localization of human medulloblastoma based on pre-operative MRI

Acta Neuropathologica
2014 | Journal article
DOI: 10.1007/s00401-014-1271-5
Part of ISSN: 0001-6322
Source: Self-asserted source
Annika K. Wefers

Peer review (1 review for 1 publication/grant)

Review activity for Neuro-oncology advances. (1)
How many people are using ORCID?