Prashantha Kumar B R

B R Prashantha Kumar; Bommenahally Ravanappa Prashantha Kumar; Prashantha Kumar Bommenahally Ravanappa; BR Prashantha Kumar; BRP Kumar; Prashantha Kumar Bommenahalli Ravanappa; Prashantha Kumar BR; B. R. Prashantha Kumar; Prashantha Kumar B. R.; Kumar Br, P.; Kumar Br, P; Kumar B P; Kumar, B.R.P; Bommenahalli Ravanappa Prashantha Kumar; Kumar, B.R.P.; Kumar, B.R; Kumar B.R.P.; Kumar P.B.R; Kumar BRP; Kumar PBR; Kumar Prashantha, BR; Kumar, B.P.; Prashantha Kumar, B.R.; B.R. Prashantha Kumar

https://orcid.org/0000-0001-9503-741X

Personal information

Biography

Medicinal Chemist takes part in drug research for the past 22 years

Activities

Collapse all

JSS College of Pharmacy Mysore: Mysuru, Karnataka, IN

2003-03-01 to present | Associate Professor (Pharmaceutical Chemistry)

Employment

Prashantha Kumar B R

https://orcid.org/0000-0001-9503-741X

Personal information

Emails & domains

Verified email domains

Other IDs

Keywords

Countries

Biography

Activities

Employment (1)

JSS College of Pharmacy Mysore: Mysuru, Karnataka, IN

Education and qualifications (1)

JSS College of Pharmacy: Mysore, Karnataka, IN

Works (50 of 78)

Novel rhodanine–thiazole hybrids as potential antidiabetic agents: a structure-based drug design approach

Computational and experimental approach to develop novel Biginelli dihydropyrimidines as EGFR inhibitors against breast cancer

Unlocking the potential of Rosmarinic acid: A review on extraction, isolation, quantification, pharmacokinetics and pharmacology

Anticancer potential of novel symmetrical and asymmetrical dihydropyridines against breast cancer via EGFR inhibition: molecular design, synthesis, analysis and screening

Novel PPAR-γ agonists as potential neuroprotective agents against Alzheimer's disease: rational design, synthesis, in silico evaluation, PPAR-γ binding assay and transactivation and expression studies

Design, synthesis, molecular dynamic simulation, DFT analysis, computational pharmacology and decoding the antidiabetic molecular mechanism of sulphonamide-thiazolidin-4-one hybrids

Computational analysis of natural product B-Raf inhibitors

Development of novel thiazolidine-2,4-dione derivatives as PPAR-γ agonists through design, synthesis, computational docking, MD simulation, and comprehensive in vitro and in vivo evaluation

Molecular dynamics articulated multilevel virtual screening protocol to discover novel dual PPAR α/γ agonists for anti-diabetic and metabolic applications

Isolation, Identification, and Antibacterial Properties of Prodigiosin, a Bioactive Product Produced by a New <i>Serratia marcescens</i> JSSCPM1 Strain: Exploring the Biosynthetic Gene Clusters of <i>Serratia</i> Species for Biological Applications

Discovery of Novel Myristic Acid Derivatives as N-Myristoyltransferase Inhibitors: Design, Synthesis, Analysis, Computational Studies and Antifungal Activity

Computational studies, synthesis, in-vitro binding and transcription analysis of novel imidazolidine-2,4-dione and 2-thioxo thiazolidine-4-one based glitazones for central PPAR-γ agonism

Design, Synthesis, Analysis, Evaluation of Cytotoxicity Against MCF-7 Breast Cancer Cells, 3D QSAR Studies and EGFR, HER2 Inhibition Studies on Novel Biginelli 1,4-Dihydropyrimidines

Design and Development of Novel Glitazones for Activation of PGC-1α Signaling Via PPAR-γ Agonism: A Promising Therapeutic Approach against Parkinson’s Disease

A Novel Partial PPARγAgonist Has Weaker Lipogenic Effect in Adipocytes and Stimulates GLUT4 Translocation in Skeletal Muscle Cells via AMPK-Dependent Signaling

Biphenyl-based small molecule inhibitors: Novel cancer immunotherapeutic agents targeting PD-1/PD-L1 interaction

Discovery of Rhodanine and Thiazolidinediones as Novel Scaffolds for EGFR Inhibition: Design, Synthesis, Analysis and CoMSIA Studies

Evaluation of flavonoids from banana pseudostem and flower (quercetin and catechin) as potent inhibitors of α-glucosidase: An in silico perspective

Novel derivatives of eugenol as potent anti-inflammatory agents via PPARγ agonism: rational design, synthesis, analysis, PPARγ protein binding assay and computational studies

Novel dual PPARα/γ agonists protect against liver steatosis and improve insulin sensitivity while avoiding side effects

Rational design, molecular docking, dynamic simulation, synthesis, PPAR-γ competitive binding and transcription analysis of novel glitazones

Rational Design, Synthesis and Evaluation of Novel Rodanine Derivatives for Antihyperglycemic Activity

Phenyl glycine incorporated glitazones as promising novel antidiabetic agents through PPARγ agonism: Design, synthesis and preclinical studies

Novel Imidazole Phenoxyacetic Acids as Inhibitors of USP30 for Neuroprotection Implication via the Ubiquitin-Rho-110 Fluorometric Assay: Design, Synthesis, and In Silico and Biochemical Assays

Peroxisome Proliferator-activated Receptor-γ As A Novel and Promising Target For Treating Cancer Via Regulation of Inflammation: A Brief Review

Novel glitazone attenuates rotenone-induced toxicity in mouse model of Parkinson’s disease

A promising in silico protocol to develop novel PPARγ antagonists as potential anticancer agents: Design, synthesis and experimental validation via PPARγ protein activity and competitive binding assay.

Design, parallel synthesis of Biginelli 1,4-dihydropyrimidines using PTSA as a catalyst, evaluation of anticancer activity and structure activity relationships via 3D QSAR studies.

Identification of Benzothiazole‒Rhodanine Derivatives as α-Amylase and α-Glucosidase Inhibitors: Design, Synthesis, In-silico and In-Vitro Analysis

Glitazones Activate PGC-1α Signaling via PPAR-γ: A Promising Strategy for Antiparkinsonism Therapeutics

Glitazones, PPAR-γ and Neuroprotection

Development of Novel Rhodanine Analogs as Anticancer Agents: Design, Synthesis, Evaluation and CoMSIA Study.

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Decades-old renin inhibitors are still struggling to find a niche in antihypertensive therapy. A fleeting look at the old and the promising new molecules

Rational Design, Synthesis, and In Vitro Neuroprotective Evaluation of Novel Glitazones for PGC-1α Activation via PPAR-γ: a New Therapeutic Strategy for Neurodegenerative Disorders

Semisynthesis of Myristic Acid Derivatives and their Biological Activities: A Critical Insight

Semisynthetic Derivatives of Eugenol and their Biological Properties: A Fleeting Look at the Promising Molecules

Synthesis of 1,2,4-oxadiazole derivatives: anticancer and 3D QSAR studies

Minutes of PPAR-γ agonism and neuroprotection

Multi-conformational frame from molecular dynamics as a structure-based pharmacophore model for mapping, screening and identifying ligands against PPAR-γ: a new protocol to develop promising candidates.

Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model.

Development of Novel Glitazones as Antidiabetic Agents: Molecular Design, Synthesis, Evaluation of Glucose Uptake Activity and SAR Studies

Structure-based design and synthesis of new 4-methylcoumarin-based lignans as pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β)inhibitors

Novel glitazones as PPARγ agonists: molecular design, synthesis, glucose uptake activity and 3D QSAR studies

Thiazolidinediones as antidiabetic agents: A critical review

CoMFA, CoMSIA, kNN MFA and docking studies of 1,2,4-oxadiazole derivatives as potent caspase-3 activators

Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study

Dual drug conjugate loaded nanoparticles for the treatment of cancer

Design, synthesis and glucose uptake activity of some novel glitazones

Efficient conversion of N-terminal of L-tyrosine, DL-phenyl alanine, and glycine to substituted 2-thioxo-thiazolidine-4-ones: A stereospecific synthesis

Peer review (3 reviews for 3 publications/grants)