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Keywords

molecular biology, genetics, high-throughput, data analysis, bioinformatics

Biography

PhD in Cell and Molecular Biology (focus Bioinformatics) with experience in molecular biology, genomics, transcriptomics, CRISPR genome and epigenome editing.

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Education and qualifications (5)

University of California, Berkeley: Berkeley, US

2023-02-15 to 2025-05-31 | Postdoctoral Fellow (Innovative Genomics Institute)
Education
Source: Self-asserted source
Thyago Leal Calvo

Oswaldo Cruz Foundation: Rio de Janeiro, BR

2022-06-01 to 2022-12-15 | Postdoctoral researcher
Education
Source: Self-asserted source
Thyago Leal Calvo

Fundação Oswaldo Cruz: Rio de Janeiro, RJ, BR

2018-08-20 to 2022-05-22 | PhD Cell and Molecular Biology (Bioinformatics)
Education
Source: Self-asserted source
Thyago Leal Calvo

Fundação Oswaldo Cruz: Rio de Janeiro, RJ, BR

2016-07-12 to 2018-08-06 | MSc Cell and Molecular Biology (Bioinformatics)
Education
Source: Self-asserted source
Thyago Leal Calvo

Universidade Federal de Goiás: Catalão, Goiás, BR

2012-02 to 2016-04 | BSc Biological Sciences
Education
Source: Self-asserted source
Thyago Leal Calvo

Funding (1)

Genetic and functional validation of genes involved in leprosy immunopathogenesis

2016-07 to 2018-07 | Grant
Fundação Oswaldo Cruz (Rio de Janeiro, BR)
Source: Self-asserted source
Thyago Leal Calvo

Works (16)

Putative pathogen-selected polymorphisms in the PKLR gene are associated with mycobacterial susceptibility in Brazilian and African populations.

PLoS neglected tropical diseases
2021-08 | Journal article
DOI: 10.1371/journal.pntd.0009434
PMID: 34449765
PMC: PMC8396769
Contributors: Bezerra OCL; Alvarado-Arnez LE; Mabunda N; Salomé G; de Sousa A; Kehdy FSG; Sales-Marques C; Manta FSN; Andrade RM; Ferreira LP et al.
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

The miR-125a-3p is Associated With Leprosy Phenotypes and Correlated With Bacillary Index

2021-08 | Preprint
DOI: 10.21203/rs.3.rs-763395/v1
PPR: PPR379136
Contributors: Santana NdL; Lago TSd; Vieira TS; Leal-Calvo T; Machado PRL; Castellucci LC
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

Two-Step In Vitro Model to Evaluate the Cellular Immune Response to SARS-CoV-2

Cells
2021-08 | Journal article | Author
DOI: 10.3390/cells10092206
Contributors: Juliana Melgaço; Tamiris Azamor; Andréa Marques Vieira da Silva; José Henrique Linhares; Tiago P. dos Santos; Ygara Mendes; Sheila M. B. de Lima; Camilla Bayma Fernandes; Jane da Silva; Alessandro F. de Souza et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Autophagy-Associated IL-15 Production Is Involved in the Pathogenesis of Leprosy Type 1 Reaction

Cells
2021-08-27 | Journal article
DOI: 10.3390/cells10092215
Contributors: Bruno Jorge de Andrade Silva; Tamiris Lameira Bittencourt; Thyago Leal-Calvo; Mayara Abud Mendes; Rhana Berto da Silva Prata; Mayara Garcia de Mattos Barbosa; Priscila Ribeiro Andrade; Suzana Côrte-Real; Gilberto Marcelo Sperandio da Silva; Milton Ozório Moraes et al.
Source: check_circle
Crossref
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Preferred source (of 2)‎

Interferon-lambda 3 and 4 Polymorphisms Increase Sustained Virological Responses and Regulate Innate Immunity in Antiviral Therapy With Pegylated Interferon-Alpha.

Frontiers in cellular and infection microbiology
2021-07 | Journal article
DOI: 10.3389/fcimb.2021.656393
PMID: 34307188
PMC: PMC8294038
Contributors: da Silva AMV; Alvarado-Arnez LE; Azamor T; Batista-Silva LR; Leal-Calvo T; Bezerra OCL; Ribeiro-Alves M; Kehdy FSG; Neves PCDC; Bayma C et al.
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

A new paradigm for leprosy diagnosis based on host gene expression Insights from leprosy lesions transcriptomics

2021-07-30 | Other
DOI: 10.1101/2021.07.30.454441
Contributors: Thyago Leal-Calvo; Charlotte Avanzi; Mayara Abud Mendes; Andrej Benjak; Philippe Busso; Roberta Olmo Pinheiro; Euzenir Nunes Sarno; Stewart T. Cole; Milton O. Moraes
Source: check_circle
Crossref

Large-Scale Gene Expression Signatures Reveal a Microbicidal Pattern of Activation in <i>Mycobacterium leprae</i>-Infected Monocyte-Derived Macrophages With Low Multiplicity of Infection.

Frontiers in immunology
2021-04 | Journal article
DOI: 10.3389/fimmu.2021.647832
PMID: 33936067
PMC: PMC8085500
Contributors: Leal-Calvo T; Martins BL; Bertoluci DF; Rosa PS; de Camargo RM; Germano GV; Brito de Souza VN; Pereira Latini AC; Moraes MO
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

Reduction of host cell mitochondrial activity as Mycobacterium leprae's strategy to evade host innate immunity.

Immunological reviews
2021-04 | Journal article
DOI: 10.1111/imr.12962
PMID: 33913182
Contributors: Oliveira MF; Medeiros RCA; Mietto BS; Calvo TL; Mendonça APM; Rosa TLSA; Silva DSD; Vasconcelos KGDC; Pereira AMR; de Macedo CS et al.
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

Increased oxidative stress in elderly leprosy patients is related to age but not to bacillary load.

PLoS neglected tropical diseases
2021-03 | Journal article
DOI: 10.1371/journal.pntd.0009214
PMID: 33690671
PMC: PMC7978340
Contributors: da Silva PHL; de Castro KKG; Mendes MA; Calvo TL; Leal JMP; Hacker MAV; Nery JADC; Sarno EN; Lourenço RA; Moraes MO et al.
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

Presence of Senescent and Memory CD8+ Leukocytes as Immunocenescence Markers in Skin Lesions of Elderly Leprosy Patients.

Frontiers in immunology
2021-03 | Journal article
DOI: 10.3389/fimmu.2021.647385
PMID: 33777045
PMC: PMC7991105
Contributors: da Silva PHL; de Castro KKG; Mendes MA; Leal-Calvo T; Leal JMP; Nery JADC; Sarno EN; Lourenço RA; Moraes MO; Lara FA et al.
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

Reanalysis and integration of public microarray datasets reveals novel host genes modulated in leprosy

Molecular Genetics and Genomics
2020-11-13 | Journal article
DOI: 10.1007/s00438-020-01705-6
Contributors: Thyago Leal-Calvo; Milton Ozório Moraes
Source: check_circle
Crossref

Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros.

Frontiers in microbiology
2020-05 | Journal article
DOI: 10.3389/fmicb.2020.00711
PMID: 32477280
PMC: PMC7233131
Contributors: Avanzi C; Lécorché E; Rakotomalala FA; Benjak A; Rapelanoro Rabenja F; Ramarozatovo LS; Cauchoix B; Rakoto-Andrianarivelo M; Tió-Coma M; Cole ST
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

Ultra-sensitive detection of Mycobacterium leprae: DNA extraction and PCR assays.

PLoS neglected tropical diseases
2020-05 | Journal article
DOI: 10.1371/journal.pntd.0008325
PMID: 32453754
PMC: PMC7274454
Contributors: Manta FSN; Leal-Calvo T; Moreira SJM; Marques BLC; Ribeiro-Alves M; Rosa PS; Nery JAC; Rampazzo RCP; Costa ADT; Krieger MA et al.
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

Reprogramming of Small Noncoding RNA Populations in Peripheral Blood Reveals Host Biomarkers for Latent and Active Mycobacterium tuberculosis Infection.

mBio
2019-12 | Journal article
DOI: 10.1128/mbio.01037-19
PMID: 31796535
PMC: PMC6890987
Contributors: de Araujo LS; Ribeiro-Alves M; Leal-Calvo T; Leung J; Durán V; Samir M; Talbot S; Tallam A; Mello FCQ; Geffers R et al.
Source: Self-asserted source
Thyago Leal Calvo via Europe PubMed Central

Reanalysis And Integration Of Public Microarray Datasets Reveals Novel Host Genes Modulated In Leprosy

2019-10-30 | Other
DOI: 10.1101/824805
Contributors: Thyago Leal-Calvo; Milton Ozório Moraes
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Congenital Zika Syndrome is associated with interferon alfa receptor 1

2019-07-26 | Other
DOI: 10.1101/715862
Contributors: Tamiris Azamor; Daniela Prado Cunha; Andréa Marques Vieira da Silva; Ohanna Cavalcanti de Lima Bezerra; Marcelo Ribeiro-Alves; Thyago Leal Calvo; Fernanda de Souza Gomes Kehdy; Fernanda Saloum de Neves Manta; Thyago Gomes Pinto; Laís Pereira Ferreira et al.
Source: check_circle
Crossref
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