Personal information

Websites & social links

College of Medicine, Qatar Univeristy

Other IDs

Scopus Author ID: 22948560100

Keywords

Calcium, Fertilization, Heart disease, Phospholipase C, Male infertility, Calmodulin, Ryanodine rece

Countries

Qatar

Activities

Collapse all

Employment (5)

Qatar University: Doha, Ad Dawhah, QA

2016-09-01 to present | Assistant Professor (College of Medicine)
Employment
Source: Self-asserted source
Michail Nomikos

Cardiff University: Cardiff, Cardiff, GB

2014-09-10 to 2016-09-09 | Marie Curie Intra-European Fellow (School of Medicine (Institute of Molecular and Experimental Medicine))
Employment
Source: Self-asserted source
Michail Nomikos

Cardiff University: Cardiff, Cardiff, GB

2012-09-09 to 2014-09-10 | Senior Research Associate (School of Medicine (Institute of Molecular and Experimental Medicine))
Employment
Source: Self-asserted source
Michail Nomikos

National Centre for Scientific Research-Demokritos: Athens, GR

2008-09-10 to 2012-09-09 | 4-year Institutional Research Fellow (Researcher D) (INRASTES)
Employment
Source: Self-asserted source
Michail Nomikos

National Centre for Scientific Research-Demokritos: Athens, GR

2007-09-09 to 2008-09-08 | Postdoctoral scholar (IRRP-Protein Chemistry Laboratory)
Employment
Source: Self-asserted source
Michail Nomikos

Education and qualifications (3)

Cardiff University: Cardiff, Cardiff, GB

2002-01-01 to 2006-07-05 | PhD (College of Medicine)
Education
Source: Self-asserted source
Michail Nomikos

Brunel University: Uxbridge, Middlesex, GB

2000-10-01 to 2002-01-01 | MSc in Medical Genetics with Immunology (Biological Sciences)
Education
Source: Self-asserted source
Michail Nomikos

University of Liverpool: Liverpool, Liverpool, GB

1997-09-28 to 2000-07-04 | BSc (Biochemistry)
Education
Source: Self-asserted source
Michail Nomikos

Funding (1)

The molecular basis for the ability of PLC-zeta to stimulate mammalian embryo development

2014-09 to 2016-09 | Award
European Commission (Brussels, BE)
GRANT_NUMBER:

628634
Source: Self-asserted source
Michail Nomikos

Works (41)

Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model

International Journal of Molecular Sciences
2022-08 | Journal article | Author
DOI: 10.3390/ijms23168840
Contributors: Sahar Da'as; Waseem Hasan; Rola Salem; Nadin Younes; Doua Abdelrahman; Iman Abdelaziz Mohamed; Arwa Aldaalis; Mohamed Ramzi TEMANNI; Lisa Mathew; Stephan Lorenz et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Expression of sperm PLCζ and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion

Reproductive BioMedicine Online
2018 | Journal article
DOI: 10.1016/j.rbmo.2017.12.013
EID:

2-s2.0-85040449970
Contributors: Tavalaee, M.; Nomikos, M.; Lai, F.A.; Nasr-Esfahani, M.H.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction

Biochemical Journal
2018 | Journal article
DOI: 10.1042/BCJ20180685
EID:

2-s2.0-85058958997
Contributors: Da’as, S.I.; Fakhro, K.; Thanassoulas, A.; Krishnamoorthy, N.; Saleh, A.; Calver, B.L.; Safieh-Garabedian, B.; Toft, E.; Nounesis, G.; Anthony Lai, F. et al.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions

Advances in Biological Regulation
2018 | Book
DOI: 10.1016/j.jbior.2017.10.012
EID:

2-s2.0-85032993065
Contributors: Kashir, J.; Nomikos, M.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Targeting inflammatory components in neuropathic pain: The analgesic effect of thymulin related peptide

Neuroscience Letters
2018 | Journal article
DOI: 10.1016/j.neulet.2018.11.041
EID:

2-s2.0-85057881970
Contributors: Safieh-Garabedian, B.; Nomikos, M.; Saadé, N.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Antigen unmasking enhances visualization efficacy of the oocyte activation factor, phospholipase C zeta, in mammalian sperm

Molecular human reproduction
2017 | Journal article
DOI: 10.1093/molehr/gaw073
EID:

2-s2.0-85019377068
Contributors: Kashir, J.; Buntwal, L.; Nomikos, M.; Calver, B.L.; Stamatiadis, P.; Ashley, P.; Vassilakopoulou, V.; Sanders, D.; Knaggs, P.; Livaniou, E. et al.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Fundamental role for sperm phospholipase C? In mammalian fertilization

The Sperm Cell: Production, Maturation, Fertilization, Regeneration
2017 | Book
Part of DOI: 10.1017/9781316411124.014
EID:

2-s2.0-85048474191
Contributors: Nomikos, M.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ

Biochemical Journal
2017 | Journal article
DOI: 10.1042/BCJ20161057
EID:

2-s2.0-85016161508
Contributors: Nomikos, M.; Stamatiadis, P.; Sanders, J.R.; Beck, K.; Calver, B.L.; Buntwal, L.; Lofty, M.; Sideratou, Z.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation

Biochemical Journal
2017 | Journal article
DOI: 10.1042/BCJ20160521
EID:

2-s2.0-85032153435
Contributors: Nomikos, M.; Kashir, J.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Ca<sup>2+</sup>dynamics in oocytes from naturally-aged mice

Scientific Reports
2016 | Journal article
DOI: 10.1038/srep19357
EID:

2-s2.0-84955137314
Contributors: Haverfield, J.; Nakagawa, S.; Love, D.; Tsichlaki, E.; Nomikos, M.; Lai, F.A.; Swann, K.; Fitzharris, G.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function

FEBS Journal
2016 | Journal article
DOI: 10.1111/febs.13939
EID:

2-s2.0-85002524189
Contributors: Nomikos, M.; Thanassoulas, A.; Beck, K.; Theodoridou, M.; Kew, J.; Kashir, J.; Calver, B.L.; Matthews, E.; Rizkallah, P.; Sideratou, Z. et al.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease

Biochimica et Biophysica Acta - General Subjects
2015 | Journal article
DOI: 10.1016/j.bbagen.2015.07.001
EID:

2-s2.0-84940562260
Contributors: Vassilakopoulou, V.; Calver, B.L.; Thanassoulas, A.; Beck, K.; Hu, H.; Buntwal, L.; Smith, A.; Theodoridou, M.; Kashir, J.; Blayney, L. et al.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Essential role of the EF-hand domain in targeting sperm phospholipase Cζ to membrane phosphatidylinositol 4,5-bisphosphate (PIP<inf>2</inf>)

Journal of Biological Chemistry
2015 | Journal article
DOI: 10.1074/jbc.M115.658443
EID:

2-s2.0-84949033253
Contributors: Nomikos, M.; Sanders, J.R.; Parthimos, D.; Buntwal, L.; Calver, B.L.; Stamatiadis, P.; Smith, A.; Clue, M.; Sideratou, Z.; Swann, K. et al.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Functional disparity between human pawpand plcζ in the generation of Ca&lt;sup&gt;2+&lt;/sup&gt; oscillations for oocyte activation

Molecular Human Reproduction
2015 | Journal article
DOI: 10.1093/molehr/gav034
EID:

2-s2.0-84940831886
Contributors: Nomikos, M.; Sanders, J.R.; Kashir, J.; Sanusi, R.; Buntwal, L.; Love, D.; Ashley, P.; Sanders, D.; Knaggs, P.; Bunkheila, A. et al.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Is PAWP the "real" sperm factor?

Asian Journal of Andrology
2015 | Journal article
DOI: 10.4103/1008-682X.142145
EID:

2-s2.0-84928987207
Contributors: Nomikos, M.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Novel signalling mechanism and clinical applications of sperm-specific PLCζ

Biochemical Society Transactions
2015 | Journal article
DOI: 10.1042/BST20140291
EID:

2-s2.0-84934980815
Contributors: Nomikos, M.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ

Molecular Human Reproduction
2015 | Journal article
DOI: 10.1093/molehr/gav042
EID:

2-s2.0-84943797179
Contributors: Sanusi, R.; Yu, Y.; Nomikos, M.; Lai, F.A.; Swann, K.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death

FEBS Letters
2014 | Journal article
DOI: 10.1016/j.febslet.2014.07.007
EID:

2-s2.0-84906216370
Contributors: Nomikos, M.; Thanassoulas, A.; Beck, K.; Vassilakopoulou, V.; Hu, H.; Calver, B.L.; Theodoridou, M.; Kashir, J.; Blayney, L.; Livaniou, E. et al.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca<sup>2+</sup> oscillations required for mammalian oocyte activation

Molecular Human Reproduction
2014 | Journal article
DOI: 10.1093/molehr/gau011
EID:

2-s2.0-84900527603
Contributors: Nomikos, M.; Theodoridou, M.; Elgmati, K.; Parthimos, D.; Calver, B.L.; Buntwal, L.; Nounesis, G.; Swann, K.; Anthony Lai, F.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

PLCζ or PAWP: Revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis

Molecular Human Reproduction
2014 | Journal article
DOI: 10.1093/molehr/gav009
EID:

2-s2.0-84929749560
Contributors: Kashir, J.; Nomikos, M.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Sperm-induced Ca<sup>2+</sup> release during egg activation in mammals

Biochemical and Biophysical Research Communications
2014 | Journal article
DOI: 10.1016/j.bbrc.2014.04.078
EID:

2-s2.0-84905905762
Contributors: Kashir, J.; Nomikos, M.; Lai, F.A.; Swann, K.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca&lt;sup&gt;2+&lt;/sup&gt; release in mouse oocytes

Molecular Human Reproduction
2014 | Journal article
DOI: 10.1093/molehr/gau056
EID:

2-s2.0-84917671765
Contributors: Nomikos, M.; Sanders, J.R.; Theodoridou, M.; Kashir, J.; Matthews, E.; Nounesis, G.; Lai, F.A.; Swann, K.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

The dynamics of MAPK inactivation at fertilization in mouse eggs

Journal of Cell Science
2014 | Journal article
DOI: 10.1242/jcs.145045
EID:

2-s2.0-84902436577
Contributors: Gonzalez-Garcia, J.R.; Bradley, J.; Nomikos, M.; Paul, L.; Machaty, Z.; Anthony Lai, F.; Swann, K.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Where life begins: Sperm PLC in mammalian egg activation and implications in male infertility

Phospholipases in Health and Disease
2014 | Book
Part of DOI: 10.1007/978-1-4939-0464-8_15
EID:

2-s2.0-85028608288
Contributors: Nomikos, M.; Theodoridou, M.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

ATP interacts with the CPVT mutation-associated central domain of the cardiac ryanodine receptor

Biochimica et Biophysica Acta - General Subjects
2013 | Journal article
DOI: 10.1016/j.bbagen.2013.05.038
EID:

2-s2.0-84879471620
Contributors: Blayney, L.; Beck, K.; Macdonald, E.; D'Cruz, L.; Nomikos, M.; Griffiths, J.; Thanassoulas, A.; Nounesis, G.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca<sup>2+</sup> oscillations in mammalian eggs at fertilization

Molecular Human Reproduction
2013 | Journal article
DOI: 10.1093/molehr/gat070
EID:

2-s2.0-84889025626
Contributors: Theodoridou, M.; Nomikos, M.; Parthimos, D.; Gonzalez-Garcia, J.R.; Elgmati, K.; Calver, B.L.; Sideratou, Z.; Nounesis, G.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility

Fertility and Sterility
2013 | Journal article
DOI: 10.1016/j.fertnstert.2012.08.035
EID:

2-s2.0-84871920566
Contributors: Nomikos, M.; Yu, Y.; Elgmati, K.; Theodoridou, M.; Campbell, K.; Vassilakopoulou, V.; Zikos, C.; Livaniou, E.; Amso, N.; Nounesis, G. et al.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Sperm PLCζ: From structure to Ca2+ oscillations, egg activation and therapeutic potential

FEBS Letters
2013 | Journal article
DOI: 10.1016/j.febslet.2013.10.008
EID:

2-s2.0-84887406850
Contributors: Nomikos, M.; Kashir, J.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Studies on the essential intramolecular interaction between the A1 and A2 domains of von willebrand factor

Protein and Peptide Letters
2013 | Journal article
EID:

2-s2.0-84877988749
Contributors: Karoulia, Z.; Papadopoulos, G.; Nomikos, M.; Thanassoulas, A.; Papadopoulou, T.C.; Nounesis, G.; Kontou, M.; Stathopoulos, C.; Leonidas, D.D.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Phospholipase C-ζ-induced Ca <sup>2+</sup> oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injection

Fertility and Sterility
2012 | Journal article
DOI: 10.1016/j.fertnstert.2011.12.013
EID:

2-s2.0-84857794091
Contributors: Swann, K.; Windsor, S.; Campbell, K.; Elgmati, K.; Nomikos, M.; Zernicka-Goetz, M.; Amso, N.; Lai, F.A.; Thomas, A.; Graham, C.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

PLCζ causes Ca <sup>2+</sup> oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P <inf>2</inf>

Molecular Biology of the Cell
2012 | Journal article
DOI: 10.1091/mbc.E11-08-0687
EID:

2-s2.0-84855888455
Contributors: Yu, A.; Nomikos, M.; Theodoridou, M.; Nounesis, G.; Lai, F.A.; Swann, K.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Starting a new life: Sperm PLC-zeta mobilizes the Ca <sup>2+</sup> signal that induces egg activation and embryo development: An essential phospholipase C with implications for male infertility

BioEssays
2012 | Journal article
DOI: 10.1002/bies.201100127
EID:

2-s2.0-84855808340
Contributors: Nomikos, M.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Divergent effect of mammalian PLCζ in generating Ca <sup>2+</sup> oscillations in somatic cells compared with eggs

Biochemical Journal
2011 | Journal article
DOI: 10.1042/BJ20101581
EID:

2-s2.0-80052162953
Contributors: Phillips, S.V.; Yu, Y.; Rossbach, A.; Nomikos, M.; Vassilakopoulou, V.; Livaniou, E.; Cumbes, B.; Lai, F.A.; George, C.H.; Swann, K.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Male infertility-linked point mutation disrupts the Ca<sup>2+</sup> oscillation-inducing and PIP<inf>2</inf> hydrolysis activity of sperm PLCζ

Biochemical Journal
2011 | Journal article
DOI: 10.1042/BJ20101772
EID:

2-s2.0-79951548080
Contributors: Nomikos, M.; Elgmati, K.; Theodoridou, M.; Calver, B.L.; Cumbes, B.; Nounesis, G.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Male infertility-linked point mutation disrupts the Ca<sup>2+</sup>oscillation-inducing and PIP<inf>2</inf>hydrolysis activity of sperm PLC (Biochemical Journal (2011) 434, (211-217))

Biochemical Journal
2011 | Journal article
EID:

2-s2.0-79954459277
Contributors: Nomikos, M.; Elgmati, K.; Theodoridou, M.; Calver, B.L.; Cumbes, B.; Nounesis, G.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Novel regulation of PLCζ activity via its XY-linker

Biochemical Journal
2011 | Journal article
DOI: 10.1042/BJ20110953
EID:

2-s2.0-80052164183
Contributors: Nomikos, M.; Elgmati, K.; Theodoridou, M.; Georgilis, A.; Gonzalez-Garcia, J.R.; Nounesis, G.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Phospholipase Cζ binding to PtdIns(4,5)P <inf>2</inf> requires the XY-linker region

Journal of Cell Science
2011 | Journal article
DOI: 10.1242/jcs.083485
EID:

2-s2.0-79961164207
Contributors: Nomikos, M.; Elgmati, K.; Theodoridou, M.; Calver, B.L.; Nounesis, G.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Thermal and chemical denaturation of the BRCT functional module of human 53BP1

International Journal of Biological Macromolecules
2011 | Journal article
DOI: 10.1016/j.ijbiomac.2011.05.001
EID:

2-s2.0-79959608330
Contributors: Thanassoulas, A.; Nomikos, M.; Theodoridou, M.; Stavros, P.; Mastellos, D.; Nounesis, G.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Thermodynamic study of the BRCT domain of BARD1 and its interaction with the -pSER-X-X-Phe- motif-containing BRIP1 peptide

Biochimica et Biophysica Acta - Proteins and Proteomics
2010 | Journal article
DOI: 10.1016/j.bbapap.2010.04.012
EID:

2-s2.0-77955097286
Contributors: Thanassoulas, A.; Nomikos, M.; Theodoridou, M.; Yannoukakos, D.; Mastellos, D.; Nounesis, G.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Binding of phosphoinositide-specific phospholipase C-ζ (PLC-ζ) to phospholipid membranes: Potential role of an unstructured cluster of basic residues

Journal of Biological Chemistry
2007 | Journal article
DOI: 10.1074/jbc.M701072200
EID:

2-s2.0-34447521411
Contributors: Nomikos, M.; Mulgrew-Nesbitt, A.; Pallavi, P.; Mihalyne, G.; Zaitseva, I.; Swann, K.; Lai, F.A.; Murray, D.; McLaughlin, S.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Role of phospholipase C-ζ domains in Ca<sup>2+</sup>-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca<sup>2+</sup> oscillations

Journal of Biological Chemistry
2005 | Journal article
DOI: 10.1074/jbc.M500629200
EID:

2-s2.0-24744436941
Contributors: Nomikos, M.; Blayney, L.M.; Larman, M.G.; Campbell, K.; Rossbach, A.; Saunders, C.M.; Swann, K.; Lai, F.A.
Source: Self-asserted source
Michail Nomikos via Scopus - Elsevier

Peer review (1 review for 1 publication/grant)

Review activity for Nature communications (1)
How many people are using ORCID?