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Innate immunity, Virus, RIG-I, RLR

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Japan

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Employment (1)

Kyoto University: Kyoto, JP

Professor (Department of Biosystems Science)
Employment
Source: Self-asserted source
Takashi Fujita

Works (46)

Physiological functions of RIG-I-like receptors

Immunity
2024-04 | Journal article
DOI: 10.1016/j.immuni.2024.03.003
Contributors: Mitsutoshi Yoneyama; Hiroki Kato; Takashi Fujita
Source: check_circle
Crossref

Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity

Science Advances
2024-03 | Journal article
DOI: 10.1126/sciadv.adk0820
Part of ISSN: 2375-2548
Contributors: Domnica Luca; Sumin Lee; Keiji Hirota; Yasutaka Okabe; Junji Uehori; Kazushi Izawa; Anna-Lisa Lanz; Verena Schütte; Burcu Sivri; Yuta TSUKAMOTO et al.
Source: Self-asserted source
Takashi Fujita

Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I

Scientific Reports
2023-04-18 | Journal article
DOI: 10.1038/s41598-023-33208-w
Part of ISSN: 2045-2322
Contributors: Jung Hyun Im; Ivana Duic; Shige H. Yoshimura; Koji Onomoto; Mitsutoshi Yoneyama; Hiroki Kato; Takashi Fujita
Source: Self-asserted source
Takashi Fujita

Double-Stranded RNA Induces Mortality in an MDA5-Mediated Type I Interferonopathy Model

The Journal of Immunology
2022-12-01 | Journal article
DOI: 10.4049/jimmunol.2200367
Part of ISSN: 0022-1767
Part of ISSN: 1550-6606
Contributors: Francine Lianne Emralino; Saya Satoh; Nobuhiro Sakai; Masamichi Takami; Fumihiko Takeuchi; Nan Yan; Frank Rutsch; Takashi Fujita; Hiroki Kato
Source: Self-asserted source
Takashi Fujita

Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model

Biochemical and Biophysical Research Communications
2022-11 | Journal article
DOI: 10.1016/j.bbrc.2022.09.017
Part of ISSN: 0006-291X
Contributors: Sumin Lee; Keiji Hirota; Verena Schuette; Takashi Fujita; Hiroki Kato
Source: Self-asserted source
Takashi Fujita

The Amino Acid at Position 95 in the Matrix Protein of Rabies Virus Is Involved in Antiviral Stress Granule Formation in Infected Cells

Journal of Virology
2022-09-28 | Journal article | Author
DOI: 10.1128/jvi.00810-22
Part of ISSN: 0022-538X
Part of ISSN: 1098-5514
Contributors: Isshu Kojima; Koji Onomoto; Wenjie Zuo; Makoto Ozawa; Kosuke Okuya; Kiyotada Naitou; Fumiki Izumi; Misuzu Okajima; Takuro Fujiwara; Naoto Ito et al.
Source: Self-asserted source
Takashi Fujita

Correction: PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis

Cell Death & Disease
2022-09-19 | Journal article
DOI: 10.1038/s41419-022-05227-4
Contributors: Wenjie Zuo; Mai Wakimoto; Noriyasu Kozaiwa; Yutaro Shirasaka; Seong-Wook Oh; Shiori Fujiwara; Hitoshi Miyachi; Amane Kogure; Hiroki Kato; Takashi Fujita
Source: check_circle
Crossref

PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis

Cell Death & Disease
2022-08-15 | Journal article
DOI: 10.1038/s41419-022-05101-3
Contributors: Wenjie Zuo; Mai Wakimoto; Noriyasu Kozaiwa; Yutaro Shirasaka; Seong-Wook Oh; Shiori Fujiwara; Hitoshi Miyachi; Amane Kogure; Hiroki Kato; Takashi Fujita
Source: check_circle
Crossref

The RNA helicase DDX3 promotes IFNB transcription via enhancing IRF-3/p300 holocomplex binding to the IFNB promoter

Scientific Reports
2022-03-10 | Journal article
DOI: 10.1038/s41598-022-07876-z
Part of ISSN: 2045-2322
Contributors: Wilaiporn Saikruang; Lena Ang Yan Ping; Hiroto Abe; Dacquin M. Kasumba; Hiroki Kato; Takashi Fujita
Source: Self-asserted source
Takashi Fujita

Virus-infection in cochlear supporting cells induces audiosensory receptor hair cell death by TRAIL-induced necroptosis

PLOS ONE
2021-11-29 | Journal article
DOI: 10.1371/journal.pone.0260443
Part of ISSN: 1932-6203
Contributors: Yushi Hayashi; Hidenori Suzuki; Wataru Nakajima; Ikuno Uehara; Atsuko Tanimura; Toshiki Himeda; Satoshi Koike; Tatsuya Katsuno; Shin-ichiro Kitajiri; Naoto Koyanagi et al.
Source: Self-asserted source
Takashi Fujita

The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome

Viruses
2021-05-11 | Journal article
DOI: 10.3390/v13050876
Part of ISSN: 1999-4915
Contributors: Jumana Khalil; Hiroki Kato; Takashi Fujita
Source: Self-asserted source
Takashi Fujita

Aicardi–Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5

International Immunology
2021-03-31 | Journal article
DOI: 10.1093/intimm/dxaa073
Part of ISSN: 1460-2377
Contributors: Hideo Onizawa; Hiroki Kato; Hiroyuki Kimura; Tomoo Kudo; Nobumasa Soda; Shota Shimizu; Masahide Funabiki; Yusuke Yagi; Yuji Nakamoto; Josef Priller et al.
Source: Self-asserted source
Takashi Fujita

Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton–Merten syndrome variant

International Immunology
2021-03-31 | Journal article
DOI: 10.1093/intimm/dxaa071
Part of ISSN: 1460-2377
Contributors: Ahmed Abu Tayeh; Masahide Funabiki; Shota Shimizu; Saya Satoh; Lee Sumin; Yoichiro Iwakura; Hiroki Kato; Takashi Fujita
Source: Self-asserted source
Takashi Fujita

The Nonstructural Protein NSs of Severe Fever with Thrombocytopenia Syndrome Virus Causes a Cytokine Storm through the Hyperactivation of NF-κB

Molecular and Cellular Biology
2021-03-01 | Journal article
DOI: 10.1128/MCB.00542-20
Contributors: Jumana Khalil; Shintaro Yamada; Yuta Tsukamoto; Hiroto Abe; Masayuki Shimojima; Hiroki Kato; Takashi Fujita
Source: check_circle
Crossref

Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation

JCI Insight
2021-02-08 | Journal article
DOI: 10.1172/jci.insight.145761
Contributors: Keigo Kawashima; Masanori Isogawa; Masaya Onishi; Ian Baudi; Satoru Saito; Atsushi Nakajima; Takashi Fujita; Yasuhito Tanaka
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Crossref

Influenza A virus NS1 optimises virus infectivity by enhancing genome packaging in a dsRNA-binding dependent manner

Virology Journal
2020-12 | Journal article
DOI: 10.1186/s12985-020-01357-3
Contributors: Tim Wai Sha; Michaela Weber; Dacquin M. Kasumba; Takeshi Noda; Masahiro Nakano; Hiroki Kato; Takashi Fujita
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Crossref

Establishment of a novel hepatitis B virus culture system using immortalized human hepatocytes

Scientific Reports
2020-12-10 | Journal article
DOI: 10.1038/s41598-020-78655-x
Part of ISSN: 2045-2322
Contributors: Yuichi Akahori; Hiroki Kato; Takashi Fujita; Kohji Moriishi; Yasuhito Tanaka; Koichi Watashi; Michio Imamura; Kazuaki Chayama; Takaji Wakita; Makoto Hijikata
Source: Self-asserted source
Takashi Fujita

Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization

Nucleic Acids Research
2020-11-18 | Journal article
DOI: 10.1093/nar/gkaa873
Contributors: Louise Dalskov; Ryo Narita; Line L Andersen; Nanna Jensen; Sonia Assil; Kennith H Kristensen; Jacob G Mikkelsen; Takashi Fujita; Trine H Mogensen; Søren R Paludan et al.
Source: check_circle
Crossref

Viral RNA recognition by LGP2 and MDA5, and activation of signaling through step-by-step conformational changes

Nucleic Acids Research
2020-11-18 | Journal article
DOI: 10.1093/nar/gkaa935
Contributors: Ivana Duic; Hisashi Tadakuma; Yoshie Harada; Ryo Yamaue; Katashi Deguchi; Yuki Suzuki; Shige H Yoshimura; Hiroki Kato; Kunio Takeyasu; Takashi Fujita
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Crossref

Spatio-temporal characterization of the antiviral activity of the XRN1-DCP1/2 aggregation against cytoplasmic RNA viruses to prevent cell death

Cell Death & Differentiation
2020-08 | Journal article
DOI: 10.1038/s41418-020-0509-0
Part of ISSN: 1350-9047
Part of ISSN: 1476-5403
Contributors: Chen Seng Ng; Dacquin M. Kasumba; Takashi Fujita; Honglin Luo
Source: Self-asserted source
Takashi Fujita

Cochlear supporting cells function as macrophage-like cells and protect audiosensory receptor hair cells from pathogens

Scientific Reports
2020-04-21 | Journal article
DOI: 10.1038/s41598-020-63654-9
Part of ISSN: 2045-2322
Contributors: Yushi Hayashi; Hidenori Suzuki; Wataru Nakajima; Ikuno Uehara; Atsuko Tanimura; Toshiki Himeda; Satoshi Koike; Tatsuya Katsuno; Shin-ichiro Kitajiri; Naoto Koyanagi et al.
Source: Self-asserted source
Takashi Fujita

Priming Phosphorylation of TANK-Binding Kinase 1 by I<i>κ</i>B Kinase<i>β</i>Is Essential in Toll-Like Receptor 3/4 Signaling

Molecular and Cellular Biology
2020-02-12 | Journal article
DOI: 10.1128/mcb.00509-19
Part of ISSN: 1098-5549
Contributors: Hiroto Abe; Junko Satoh; Yutaro Shirasaka; Amane Kogure; Hiroki Kato; Shinji Ito; Takashi Fujita
Source: Self-asserted source
Takashi Fujita

RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to Yellow fever virus

2020-02-05 | Preprint
DOI: 10.1101/2020.02.05.935486
Contributors: Guillaume Beauclair; Felix Streicher; Daniela Bruni; Ségolène Gracias; Salomé Bourgeau; Laura Sinigaglia; Takashi Fujita; Eliane F. Meurs; Frédéric Tangy; Nolwenn Jouvenet
Source: check_circle
Crossref

Broad and systemic immune-modulating capacity of plant-derived dsRNA

International Immunology
2019-11-08 | Journal article
DOI: 10.1093/intimm/dxz054
Part of ISSN: 0953-8178
Part of ISSN: 1460-2377
Contributors: Takara Hajake; Keita Matsuno; Dacquin M Kasumba; Haruka Oda; Moe Kobayashi; Nao Miyata; Madoka Shinji; Amane Kogure; Nodoka Kasajima; Masatoshi Okamatsu et al.
Source: Self-asserted source
Takashi Fujita

Singleton-Merten Syndrome–like Skeletal Abnormalities in Mice with Constitutively Activated MDA5

The Journal of Immunology
2019-09-01 | Journal article
DOI: 10.4049/jimmunol.1900354
Contributors: Nobumasa Soda; Nobuhiro Sakai; Hiroki Kato; Masamichi Takami; Takashi Fujita
Source: check_circle
Crossref

Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity

Cell
2019-05 | Journal article
DOI: 10.1016/j.cell.2019.03.017
Part of ISSN: 0092-8674
Contributors: Cristhian Cadena; Sadeem Ahmad; Audrey Xavier; Joschka Willemsen; Sehoon Park; Ji Woo Park; Seong-Wook Oh; Takashi Fujita; Fajian Hou; Marco Binder et al.
Source: Self-asserted source
Takashi Fujita

A Plant-Derived Nucleic Acid Reconciles Type I IFN and a Pyroptotic-like Event in Immunity against Respiratory Viruses

The Journal of Immunology
2017-10-01 | Journal article
DOI: 10.4049/jimmunol.1700523
Part of ISSN: 0022-1767
Part of ISSN: 1550-6606
Contributors: Dacquin M. Kasumba; Takara Hajake; Seong-Wook Oh; Sergei V. Kotenko; Hiroki Kato; Takashi Fujita
Source: Self-asserted source
Takashi Fujita

Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor

Immunity
2014-06 | Journal article
DOI: 10.1016/j.immuni.2014.05.007
Part of ISSN: 1074-7613
Contributors: Jianzhong Zhu; Yugen Zhang; Arundhati Ghosh; Rolando A. Cuevas; Adriana Forero; Jayeeta Dhar; Mikkel Søes Ibsen; Jonathan Leo Schmid-Burgk; Tobias Schmidt; Madhavi K. Ganapathiraju et al.
Source: Self-asserted source
Takashi Fujita

Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5

Immunity
2014-02 | Journal article
DOI: 10.1016/j.immuni.2013.12.014
Part of ISSN: 1074-7613
Contributors: Masahide Funabiki; Hiroki Kato; Yoshiki Miyachi; Hideaki Toki; Hiromi Motegi; Maki Inoue; Osamu Minowa; Aiko Yoshida; Katashi Deguchi; Hiroshi Sato et al.
Source: Self-asserted source
Takashi Fujita

Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

PLoS ONE
2012-08-13 | Journal article
DOI: 10.1371/journal.pone.0043031
Part of ISSN: 1932-6203
Contributors: Koji Onomoto; Michihiko Jogi; Ji-Seung Yoo; Ryo Narita; Shiho Morimoto; Azumi Takemura; Suryaprakash Sambhara; Atushi Kawaguchi; Suguru Osari; Kyosuke Nagata et al.
Source: Self-asserted source
Takashi Fujita

LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses

Proceedings of the National Academy of Sciences
2010-01-26 | Journal article
DOI: 10.1073/pnas.0912986107
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Takashi Satoh; Hiroki Kato; Yutaro Kumagai; Mitsutoshi Yoneyama; Shintaro Sato; Kazufumi Matsushita; Tohru Tsujimura; Takashi Fujita; Shizuo Akira; Osamu Takeuchi
Source: Self-asserted source
Takashi Fujita

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

The Journal of Experimental Medicine
2008-07-07 | Journal article
DOI: 10.1084/jem.20080091
Part of ISSN: 1540-9538
Part of ISSN: 0022-1007
Contributors: Hiroki Kato; Osamu Takeuchi; Eriko Mikamo-Satoh; Reiko Hirai; Tomoji Kawai; Kazufumi Matsushita; Akane Hiiragi; Terence S. Dermody; Takashi Fujita; Shizuo Akira
Source: Self-asserted source
Takashi Fujita

Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

Molecular Cell
2008-02 | Journal article
DOI: 10.1016/j.molcel.2007.11.028
Part of ISSN: 1097-2765
Contributors: Kiyohiro Takahasi; Mitsutoshi Yoneyama; Tatsuya Nishihori; Reiko Hirai; Hiroyuki Kumeta; Ryo Narita; Michael Gale; Fuyuhiko Inagaki; Takashi Fujita
Source: Self-asserted source
Takashi Fujita

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

Proceedings of the National Academy of Sciences
2007-01-09 | Journal article
DOI: 10.1073/pnas.0606699104
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Takeshi Saito; Reiko Hirai; Yueh-Ming Loo; David Owen; Cynthia L. Johnson; Sangita C. Sinha; Shizuo Akira; Takashi Fujita; Michael Gale
Source: Self-asserted source
Takashi Fujita

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Nature
2006-05 | Journal article
DOI: 10.1038/nature04734
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Hiroki Kato; Osamu Takeuchi; Shintaro Sato; Mitsutoshi Yoneyama; Masahiro Yamamoto; Kosuke Matsui; Satoshi Uematsu; Andreas Jung; Taro Kawai; Ken J. Ishii et al.
Source: Self-asserted source
Takashi Fujita

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

The Journal of Immunology
2005-09-01 | Journal article
DOI: 10.4049/jimmunol.175.5.2851
Part of ISSN: 0022-1767
Part of ISSN: 1550-6606
Contributors: Mitsutoshi Yoneyama; Mika Kikuchi; Kanae Matsumoto; Tadaatsu Imaizumi; Makoto Miyagishi; Kazunari Taira; Eileen Foy; Yueh-Ming Loo; Michael Gale; Shizuo Akira et al.
Source: Self-asserted source
Takashi Fujita

Cell Type-Specific Involvement of RIG-I in Antiviral Response

Immunity
2005-07 | Journal article
DOI: 10.1016/j.immuni.2005.04.010
Part of ISSN: 1074-7613
Contributors: Hiroki Kato; Shintaro Sato; Mitsutoshi Yoneyama; Masahiro Yamamoto; Satoshi Uematsu; Kosuke Matsui; Tohru Tsujimura; Kiyoshi Takeda; Takashi Fujita; Osamu Takeuchi et al.
Source: Self-asserted source
Takashi Fujita

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Nature Immunology
2004-07 | Journal article
DOI: 10.1038/ni1087
Part of ISSN: 1529-2908
Part of ISSN: 1529-2916
Contributors: Mitsutoshi Yoneyama; Mika Kikuchi; Takashi Natsukawa; Noriaki Shinobu; Tadaatsu Imaizumi; Makoto Miyagishi; Kazunari Taira; Shizuo Akira; Takashi Fujita
Source: Self-asserted source
Takashi Fujita

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

Nature
2002-11 | Journal article
DOI: 10.1038/nature01182
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Hideki Sanjo; Satoshi Uematsu; Tsuneyasu Kaisho; Katsuaki Hoshino; Osamu Takeuchi; Masaya Kobayashi; Takashi Fujita et al.
Source: Self-asserted source
Takashi Fujita

A new protein containing an SH2 domain that inhibits JAK kinases

Nature
1997-06-26 | Journal article
DOI: 10.1038/43213
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Takaho A. Endo; Masaaki Masuhara; Masahiro Yokouchi; Ritsu Suzuki; Hiroshi Sakamoto; Kaoru Mitsui; Akira Matsumoto; Shyu Tanimura; Motoaki Ohtsubo; Hiroyuki Misawa et al.
Source: Self-asserted source
Takashi Fujita

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

Cell
1990-10 | Journal article
DOI: 10.1016/0092-8674(90)90163-9
Part of ISSN: 0092-8674
Contributors: Hisashi Harada; Keith Willison; Jun Sakakibara; Masaaki Miyamoto; Takashi Fujita; Tadatsugu Taniguchi
Source: Self-asserted source
Takashi Fujita

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

Cell
1989-08 | Journal article
DOI: 10.1016/0092-8674(89)90107-4
Part of ISSN: 0092-8674
Contributors: Hisashi Harada; Takashi Fujita; Masaaki Miyamoto; Yoko Kimura; Mitsuo Maruyama; Adriana Furia; Takashi Miyata; Tadatsugu Taniguchi
Source: Self-asserted source
Takashi Fujita

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

Nature
1989-01 | Journal article
DOI: 10.1038/337270a0
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Takashi Fujita; Yoko Kimura; Masaaki Miyamoto; Edward L. Barsoumian; Tadatsugu Taniguchi
Source: Self-asserted source
Takashi Fujita

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

Cell
1988-09 | Journal article
DOI: 10.1016/s0092-8674(88)91307-4
Part of ISSN: 0092-8674
Contributors: Masaaki Miyamoto; Takashi Fujita; Yoko Kimura; Mitsuo Maruyama; Hisashi Harada; Yoshiaki Sudo; Takashi Miyata; Tadatsugu Taniguchi
Source: Self-asserted source
Takashi Fujita

Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer

Cell
1987-05 | Journal article
DOI: 10.1016/0092-8674(87)90288-1
Part of ISSN: 0092-8674
Contributors: Takashi Fujita; Hiroshi Shibuyà; Haku Hotta; Kiyofumi Yamanishi; Tadatsugu Taniguchi
Source: Self-asserted source
Takashi Fujita

Regulation of human interleukin-2 gene: Functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes

Cell
1986-08 | Journal article
DOI: 10.1016/0092-8674(86)90660-4
Part of ISSN: 0092-8674
Contributors: Takashi Fujita; Hiroshi Shibuya; Tetsuo Ohashi; Kiyofumi Yamanishi; Tadatsugu Taniguchi
Source: Self-asserted source
Takashi Fujita
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