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Formation of Trideuteromethylated Artifacts of Pyrrole-Containing Natural Products.

Journal of natural products
2024-01-30 | Journal article
Contributors: Maria Orfanoudaki; Akee RK; Martínez-Fructuoso L; Dongdong Wang; Kelley JA; Smith EA; Henrich CJ; Martin Schnermann; Barry O'Keefe; Tanja Grkovic
Source: Self-asserted source
James Kelley

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I.

Journal of the American Chemical Society
2020-12-02 | Journal article
Source: Self-asserted source
James Kelley

Multiphase Assembly of Small Molecule Microcrystalline Peptide Hydrogel Allows Immunomodulatory Combination Therapy for Long-Term Heart Transplant Survival.

Small (Weinheim an der Bergstrasse, Germany)
2020-08-18 | Journal article
Source: Self-asserted source
James Kelley

Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box

Chem Sci
2018 | Journal article
Source: Self-asserted source
James Kelley

Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCalpha, PKCepsilon, and RasGRP

Bioorg Med Chem
2017 | Journal article
Source: Self-asserted source
James Kelley

Experimental and Chemoinformatics Study of Tautomerism in a Database of Commercially Available Screening Samples

J Chem Inf Model
2016 | Journal article
Source: Self-asserted source
James Kelley

Neighbor-directed histidine N (tau)-alkylation: A route to imidazolium- containing phosphopeptide macrocycles

Biopolymers
2015 | Journal article
Source: Self-asserted source
James Kelley

Reactive Species Involved in the Regioselective Photooxidation of Heptamethine Cyanines

Chem Sci
2015 | Journal article
Source: Self-asserted source
James Kelley

Design and synthesis of Fmoc-Thr[PO(OH)(OPOM)] for the preparation of peptide prodrugs containing phosphothreonine in fully protected form

Chem Biodivers
2014 | Journal article
Source: Self-asserted source
James Kelley

Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells

Biopolymers
2014 | Journal article
Source: Self-asserted source
James Kelley

Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP

Bioorg Med Chem
2014 | Journal article
Source: Self-asserted source
James Kelley

Enhanced stereoselectivity of a Cu(II) complex chiral auxiliary in the synthesis of Fmoc-L-gamma-carboxyglutamic acid

J Org Chem
2011 | Journal article
Source: Self-asserted source
James Kelley

Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids

Bioorg Med Chem Lett
2010 | Journal article
Source: Self-asserted source
James Kelley

Using conformationally locked nucleosides to calibrate the anomeric effect: Implications for glycosyl bond stability

Tetrahedron
2010 | Journal article
Source: Self-asserted source
James Kelley

A novel side-bridged hybrid phosphonate/acetate pendant cyclam: synthesis, characterization, and 64Cu small animal PET imaging

Bioorg Med Chem
2009 | Journal article
Source: Self-asserted source
James Kelley

North- and south-bicyclo[3.1.0]hexene nucleosides: the effect of ring planarity on anti-HIV activity

ChemMedChem
2009 | Journal article
Source: Self-asserted source
James Kelley

Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities

J Med Chem
2008 | Journal article
Source: Self-asserted source
James Kelley

Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling

Bioconjug Chem
2008 | Journal article
Source: Self-asserted source
James Kelley

What are the consequences of freezing the anomeric effect in nucleosides?

Nucleic Acids Symp Ser (Oxf)
2008 | Journal article
Source: Self-asserted source
James Kelley

Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups

J Med Chem
2007 | Journal article
Source: Self-asserted source
James Kelley

A practical synthesis of fully protected L-gamma-carboxyglutamic acid

Tetrahedron Letters
2006 | Journal article
Source: Self-asserted source
James Kelley

Design and concise synthesis of fully protected analogues of l-gamma- carboxyglutamic acid

J Org Chem
2006 | Journal article
Source: Self-asserted source
James Kelley

Mining the NCI antiviral compounds for HIV-1 integrase inhibitors

Bioorg Med Chem
2006 | Journal article
Source: Self-asserted source
James Kelley

Dynamics of the antiviral activity of N-methanocarbathymidine against herpes simplex virus type 1 in cell culture

Int J Antimicrob Agents
2005 | Journal article
Source: Self-asserted source
James Kelley

Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation

Cancer Res
2005 | Journal article
Source: Self-asserted source
James Kelley

Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells

Biochem Pharmacol
2005 | Journal article
Source: Self-asserted source
James Kelley

Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe

Bioorg Med Chem
2005 | Journal article
Source: Self-asserted source
James Kelley

Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy

Ann N Y Acad Sci
2005 | Journal article
Source: Self-asserted source
James Kelley

Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology

Nucleosides Nucleotides Nucleic Acids
2005 | Journal article
Source: Self-asserted source
James Kelley

Caulibugulones A-F, novel cytotoxic isoquinoline quinones and iminoquinones from the marine bryozoan Caulibugula intermis

J Nat Prod
2004 | Journal article
Source: Self-asserted source
James Kelley

Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands

J Med Chem
2004 | Journal article
Source: Self-asserted source
James Kelley

Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line

Cancer Res
2004 | Journal article
Source: Self-asserted source
James Kelley

Potent inhibition of HhaI DNA methylase by the aglycon of 2-(1H)-pyrimidinone riboside (zebularine) at the GCGC recognition domain

Ann N Y Acad Sci
2003 | Journal article
Source: Self-asserted source
James Kelley
grade
Preferred source (of 7)‎

Synthesis and conformational analysis of a locked analogue of carbovir built on a bicyclo[3.1.0]hex-2-enyl template

Nucleosides Nucleotides Nucleic Acids
2003 | Journal article
Source: Self-asserted source
James Kelley

Enantioselective synthesis of N(alpha)-Fmoc protected (2S,3R)-3-phenylpipecolic acid. A constrained phenylalanine analogue suitably protected for solid-phase peptide synthesis

J Org Chem
2002 | Journal article
Source: Self-asserted source
James Kelley

Evaluation of a fluorogenic derivatization method for the reversed-phase HPLC analysis of 2'-beta-fluoro-2',3'-dideoxyadenosine, a new anti-AIDS drug

J Pharm Biomed Anal
2001 | Journal article
Source: Self-asserted source
James Kelley

Fluorometric determination of 2'-beta-fluoro-2',3'-dideoxyadenosine 5'-triphosphate, the active metabolite of a new anti-human immunodeficiency virus drug, in human lymphocytes

Anal Biochem
2001 | Journal article
Source: Self-asserted source
James Kelley

Determination of lodenosine and its major metabolite in human plasma by liquid chromatography/electrospray ionization tandem mass spectrometry

Source: Self-asserted source
James Kelley

Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets

Bioorg Med Chem
2000 | Journal article
Source: Self-asserted source
James Kelley

Preparation of aryl isothiocyanates via protected phenylthiocarbamates and application to the synthesis of caffeic acid (4-isothiocyanato)phenyl ester

J Org Chem
2000 | Journal article
Source: Self-asserted source
James Kelley

The "beta-fluorine effect" in the non-metal hydride radical deoxygenation of fluorine-containing nucleoside xanthates

Nucleosides Nucleotides Nucleic Acids
2000 | Journal article
Source: Self-asserted source
James Kelley

2'-beta-fluoro-2',3'-dideoxyadenosine, lodenosine, in rhesus monkeys: plasma and cerebrospinal fluid pharmacokinetics and urinary disposition

Drug Metab Dispos
1999 | Journal article
Source: Self-asserted source
James Kelley

Determination of 2'-beta-fluoro-2',3'-dideoxyadenosine, an experimental anti-AIDS drug, in human plasma by high-performance liquid chromatography

J Chromatogr B Biomed Sci Appl
1998 | Journal article
Source: Self-asserted source
James Kelley

Antiproliferative effects of cyclopentenyl cytosine (NSC 375575) in human glioblastoma cells

Oncol Res
1997 | Journal article
Source: Self-asserted source
James Kelley

Reversed-phase high-performance liquid chromatographic determination of the new antitumor agent cyclopentenyl cytosine in biological fluids

J Chromatogr B Biomed Sci Appl
1997 | Journal article
Source: Self-asserted source
James Kelley

Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar

Biochem Biophys Res Commun
1996 | Journal article
Source: Self-asserted source
James Kelley

Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 3. 6-Amino prodrugs of 2'-beta- fluoro-2',3'-dideoxyinosine

J Med Chem
1996 | Journal article
Source: Self-asserted source
James Kelley

Acute cardiotoxicity of the Anti-HIV dideoxynucleoside, F-ddA, in the rat

Fundam Appl Toxicol
1995 | Journal article
Source: Self-asserted source
James Kelley

Comparative molecular field analysis of hydrophobicity descriptors of cytosine nucleosides

Quantitative Structure-Activity Relationships
1995 | Journal article
Source: Self-asserted source
James Kelley

DETERMINATION OF THE ANTI-HIV DRUG 2'-BETA-FLUORO-2',3'-DIDEOXYADENOSINE IN BIOLOGICAL-FLUIDS BY REVERSED-PHASE HPLC

Journal of Liquid Chromatography
1995 | Journal article
Source: Self-asserted source
James Kelley
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