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Ocular Immune Privilege, Neuroimmunomodulation, Melanocortins, Innate Immune Memory, Immune Tolerance
United States

Biography

Immunology
Vision Science
Autoimmune disease models
Immune cell activation and culturing
animal models
neuropeptides
gene therapy
Antibodies
Flow Cytometry
ELISA
Immunoblotting
Intraocular Injections
Ocular Fluid Collection

Activities

Employment (1)

Boston University School of Medicine: Boston, MA, US

2010-04-01 to present | Assoc. Dean of Research, Professor (ophthalmology)
Employment
Source: Self-asserted source
Andrew W Taylor

Education and qualifications (1)

Ohio State University: Columbus, OH, US

1985 to 1989 | PhD (Microbiology)
Education
Source: Self-asserted source
Andrew W Taylor

Funding (3)

Manipulation of Immunity to Treat Uveitis

2016-03-01 to 2020-02-29 | Grant
National Eye Institute (Bethesda, US)
GRANT_NUMBER: R01EY025961
Source: Self-asserted source
Andrew W Taylor via DimensionsWizard

Neuroimmunomodulation within the eye

1995-04-01 to 2013-03-31 | Grant
National Eye Institute (Bethesda, US)
GRANT_NUMBER: R01EY010752
Source: Self-asserted source
Andrew W Taylor via DimensionsWizard

NEUROIMMUNOMODULATION WITHIN THE EYE

1995-04-01 to 2001-03-31 | Grant
National Eye Institute (Bethesda, US)
GRANT_NUMBER: R29EY010752
Source: Self-asserted source
Andrew W Taylor via DimensionsWizard

Works (50 of 83)

Items per page:
Page 1 of 2

Alpha-Melanocyte-Stimulating Hormone Maintains Retinal Homeostasis after Ischemia/Reperfusion

Biomolecules
2024-04 | Journal article | Author
Contributors: Tat Fong Ng; Jenna Y. Cho; John Zhao; John R. Gardiner; Eric S. Wang; Elman Leung; Ziqian Xu; Samantha L Fineman; Melinda Lituchy; Amy Cheuk Yin Lo et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Identification of an APOE ε4-specific blood-based molecular pathway for Alzheimer's disease risk.

Alzheimer's & dementia (Amsterdam, Netherlands)
2023-10-16 | Journal article
Contributors: Qiushan Tao; Zhang C; Mercier G; Lunetta K; Ang TFA; Akhter-Khan S; Zhang Z; Taylor A; Killiany RJ; Alosco M et al.
Source: Self-asserted source
Andrew W Taylor

Stimulating the Melanocortin System in Uveitis and Diabetes Preserves the Structure and Anti-Inflammatory Activity of the Retina

International Journal of Molecular Sciences
2023-04-08 | Journal article
Contributors: Tat Fong Ng; Andrew W. Taylor
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The central melanocortin system as a treatment target for obesity and diabetes: A brief overview

European Journal of Pharmacology
2022-06 | Journal article
Contributors: Rajesh Kumar Goit; Andrew W. Taylor; Amy Cheuk Yin Lo
Source: check_circle
Crossref

Melanocortin receptor agonists suppress experimental autoimmune uveitis

Experimental Eye Research
2022-05 | Journal article
Contributors: Tat Fong Ng; Kaleb Dawit; Andrew W. Taylor
Source: check_circle
Crossref

Melanocortin 5 Receptor Expression and Recovery of Ocular Immune Privilege after Uveitis

Ocular Immunology and Inflammation
2022-05-19 | Journal article
Contributors: Tat Fong Ng; Ambika Manhapra; David Cluckey; Yoona Choe; Srujan Vajram; Andrew W. Taylor
Source: check_circle
Crossref

Neuropeptide α-Melanocyte-Stimulating Hormone Promotes Neurological Recovery and Repairs Cerebral Ischemia/Reperfusion Injury in Type 1 Diabetes

Neurochemical Research
2022-02 | Journal article
Contributors: Rajesh Kumar Goit; Tsz Chung Ng; Ka Cheung Tam; Jessica K. W. Tsang; Andrew W. Taylor; Amy C. Y. Lo
Source: check_circle
Crossref

The Neuropeptide Alpha-Melanocyte–Stimulating Hormone Is Critical for Corneal Endothelial Cell Protection and Graft Survival after Transplantation

The American Journal of Pathology
2022-02 | Journal article
Contributors: Zala Lužnik Marzidovšek; Tomas Blanco; Zhongmou Sun; Hamid Alemi; Gustavo Ortiz; Hayate Nakagawa; Sunil K. Chauhan; Andrew W. Taylor; Ula V. Jurkunas; Jia Yin et al.
Source: check_circle
Crossref

Tailoring immune cell behavior to stop autoimmune disease

EBioMedicine
2021-08 | Journal article
Contributors: Andrew W. Taylor
Source: check_circle
Crossref

Extracellular Soluble Membranes from Retinal Pigment Epithelial Cells Mediate Apoptosis in Macrophages

Cells
2021-05-13 | Journal article
Contributors: Nayan Sanjiv; Pawarissara Osathanugrah; Emma Fraser; Tat Fong Ng; Andrew W. Taylor
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The Neuropeptides of Ocular Immune Privilege, α-MSH and NPY, Suppress Phagosome Maturation in Macrophages

ImmunoHorizons
2018-11-01 | Journal article
Contributors: Isaac J Benque; Pu Xia; Robert Shannon; Tat Fong Ng; Andrew W Taylor
Source: check_circle
Crossref

Negative regulators that mediate ocular immune privilege.

2018-02-12 | Journal article
Source: check_circle
Boston University

The Role of Alpha-MSH as a Modulator of Ocular Immunobiology Exemplifies Mechanistic Differences between Melanocortins and Steroids

Ocular Immunology and Inflammation
2017-03-04 | Journal article
Contributors: Christine M. Clemson; John Yost; Andrew W. Taylor
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Retinal Pigment Epithelial Cells Suppress Phagolysosome Activation in Macrophages.

2017-02-01 | Journal article
Source: check_circle
Boston University

MC5r and A2Ar Deficiencies During Experimental Autoimmune Uveitis Identifies Distinct T cell Polarization Programs and a Biphasic Regulatory Response.

2016-11-25 | Journal article
Source: check_circle
Boston University

Ocular Immune Privilege and Transplantation.

2016-02-08 | Journal article
Source: check_circle
Boston University

Recovery from experimental autoimmune uveitis promotes induction of antiuveitic inducible Tregs.

2015-04-15 | Journal article
Source: check_circle
Boston University

Retinal Pigment Epithelial Cell Line Suppression of Phagolysosome Activation.

2015-01-29 | Journal article
Source: check_circle
Boston University

Re-evaluating the treatment of acute optic neuritis.

2014-10-29 | Journal article
Source: check_circle
Boston University

Influence of subretinal fluid in advanced stage retinopathy of prematurity on proangiogenic response and cell proliferation.

2014-06-21 | Journal article
Source: check_circle
Boston University

Ex-vivo tolerogenic F4/80? antigen-presenting cells (APC) induce efferent CD8? regulatory T cell-dependent suppression of experimental autoimmune uveitis.

2014-04-01 | Journal article
Source: check_circle
Boston University

Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice.

2013-09-16 | Journal article
Source: check_circle
Boston University

Alpha-melanocyte stimulating hormone (a-MSH) is a post-caspase suppressor of apoptosis in RAW 264.7 macrophages.

2013-08-29 | Journal article
Source: check_circle
Boston University

The neuropeptides a-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells.

2013-05-17 | Standards or policy
DOI:

10.1016/j.jneuroim.2013.04.019

PMID:

23689030

Source: check_circle
Boston University

Primary Open-Angle Glaucoma: A Transforming Growth Factor-ß Pathway-Mediated Disease.

2012-04-21 | Standards or policy
DOI:

10.1016/j.ajpath.2012.03.011

PMID:

22525463

Source: check_circle
Boston University

Following EAU recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen.

2011-11-17 | Standards or policy
DOI:

10.1167/iovs.11-8153

PMID:

21989727

Source: check_circle
Boston University

The alpha-melanocyte stimulating hormone induces conversion of effector T cells into treg cells.

2011-09-15 | Standards or policy
DOI:

10.1155/2011/246856

PMID:

21941624

Source: check_circle
Boston University
grade
Preferred source (of 2)‎

Ocular immune privilege in the year 2010: ocular immune privilege and uveitis.

2010-12-01 | Standards or policy
DOI:

10.3109/09273948.2010.525730

PMID:

21091058

Source: check_circle
Boston University

Localized retinal neuropeptide regulation of macrophage and microglial cell functionality.

2010-10-20 | Standards or policy
DOI:

10.1016/j.jneuroim.2010.09.025

PMID:

20965575

Source: check_circle
Boston University

Inflammatory cytokines in eyes with uveal melanoma and relation with macrophage infiltration.

2010-06-10 | Standards or policy
DOI:

10.1167/iovs.10-5526

PMID:

20538984

Source: check_circle
Boston University

Applications of the Role of a-MSH in Ocular Immune Privilege.

2010-01-01 | Standards or policy
PMID:

21222267

Source: check_circle
Boston University

The immune privileged retina mediates an alternative activation of J774A.1 cells.

2009-11-01 | Standards or policy
DOI:

10.3109/09273940903118642

PMID:

20001256

Source: check_circle
Boston University

Local treatment with alpha-melanocyte stimulating hormone reduces corneal allorejection.

2009-07-27 | Standards or policy
DOI:

10.1097/TP.0b013e3181ac11ea

PMID:

19623012

Source: check_circle
Boston University

Injection of an alpha-melanocyte stimulating hormone expression plasmid is effective in suppressing experimental autoimmune uveitis.

2009-05-06 | Standards or policy
DOI:

10.1016/j.intimp.2009.05.001

PMID:

19426838

Source: check_circle
Boston University

Ocular immune privilege.

2009-01-09 | Standards or policy
DOI:

10.1038/eye.2008.382

PMID:

19136922

Source: check_circle
Boston University

Review of the activation of TGF-beta in immunity.

2008-09-25 | Standards or policy
DOI:

10.1189/jlb.0708415

PMID:

18818372

Source: check_circle
Boston University

Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264.7 macrophages.

2008-04-03 | Standards or policy
DOI:

10.1189/jlb.0707463

PMID:

18388300

Source: check_circle
Boston University

The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) therapy.

2008-01-02 | Standards or policy
DOI:

10.1016/j.bbi.2007.11.001

PMID:

18171609

Source: check_circle
Boston University

In vitro generated autoimmune regulatory T cells enhance intravitreous allogeneic retinal graft survival.

2007-11-01 | Standards or policy
DOI:

10.1167/iovs.07-0175

PMID:

17962463

Source: check_circle
Boston University

Effect of the ocular microenvironment in regulating corneal dendritic cell maturation.

2007-07-01 | Standards or policy
DOI:

10.1001/archopht.125.7.908

PMID:

17620569

Source: check_circle
Boston University

Creating an immune-privileged site using retinal progenitor cells and biodegradable polymers.

2007-06-01 | Standards or policy
DOI:

10.1634/stemcells.2006-0780

PMID:

17548532

Source: check_circle
Boston University

Aqueous humor induces transforming growth factor-beta (TGF-beta)-producing regulatory T-cells. 1997.

2007-05-01 | Journal article
Source: check_circle
Boston University

Thrombospondin plays a vital role in the immune privilege of the eye. 2005.

2007-05-01 | Journal article
Source: check_circle
Boston University

Ocular immunosuppressive microenvironment.

2007-01-01 | Standards or policy
DOI:

10.1159/000099255

PMID:

17264484

Source: check_circle
Boston University

An eye's view of T regulatory cells.

2006-12-28 | Standards or policy
DOI:

10.1189/jlb.0606383

PMID:

17194735

Source: check_circle
Boston University

Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation.

2006-09-01 | Standards or policy
DOI:

10.1167/iovs.05-1267

PMID:

16936104

Source: check_circle
Boston University

Alpha-MSH regulates protein ubiquitination in T cells.

2006-05-30 | Standards or policy
PMID:

16914084

Source: check_circle
Boston University

Melanocortin 5 receptor and ocular immunity.

2006-05-30 | Standards or policy
PMID:

16914087

Source: check_circle
Boston University

The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages.

2005-05-01 | Standards or policy
DOI:

10.1016/j.jneuroim.2005.01.008

PMID:

15833358

Source: check_circle
Boston University

Thrombospondin plays a vital role in the immune privilege of the eye.

2005-03-01 | Standards or policy
DOI:

10.1167/iovs.04-0362

PMID:

15728547

Source: check_circle
Boston University
Items per page:
Page 1 of 2

Peer review (4 reviews for 4 publications/grants)

Review activity for Cellular and molecular life sciences (1)
Review activity for Journal of autoimmunity. (1)
Review activity for Journal of neuroinflammation (1)
Review activity for Neuropharmacology. (1)