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Activities

Employment (2)

University of Hull: Hull, GB

2023-11 to present | Senior Lecturer (Hull York Medical School)
Employment
Source: Self-asserted source
Amin Ardestani

University of Bremen: Bremen, DE

2014 to 2022 | Group leader/senior scientist
Employment
Source: Self-asserted source
Amin Ardestani

Education and qualifications (3)

Universität Bremen: Bremen, Bremen, DE

2008 to 2013 | PhD
Education
Source: Self-asserted source
Amin Ardestani

University of Tehran: Tehran, Tehran, IR

2005 to 2007 | MSc Degree of Science in Biochemistry (Institute of biochemistry and biophysics (IBB))
Education
Source: Self-asserted source
Amin Ardestani

University of Tarbeiat moalem: Tehran, Tehran, IR

2000 to 2004 | Bachelors of Science in Biology (Biology)
Education
Source: Self-asserted source
Amin Ardestani

Works (45)

A small molecule MST1/2 inhibitor accelerates murine liver regeneration with improved survival in models of steatohepatitis.

PNAS nexus
2024-03-01 | Journal article | Author
Contributors: Ryan Watkins; Gamo A; Seung Hyuk Choi; Kumar M; EeeLN Buckarma; Chantal McCabe; Jennifer Tomlinson; Pereya D; Blaž Lupše; Shirin Geravandi et al.
Source: Self-asserted source
Amin Ardestani

Abnormal acinar–β-cell crosstalk in type 2 diabetes

Trends in Endocrinology & Metabolism
2023-11 | Journal article
Contributors: Shirin Geravandi; Amin Ardestani
Source: check_circle
Crossref

The liver-derived exosomes stimulate insulin gene expression in pancreatic beta cells under condition of insulin resistance.

Frontiers in endocrinology
2023-11-07 | Journal article
Contributors: Mahmoudi-Aznaveh A; Tavoosidana G; Najmabadi H; Zahra Azizi; Ardestani A
Source: Self-asserted source
Amin Ardestani

Case Report: Neratinib Therapy Improves Glycemic Control in a Patient With Type 2 Diabetes and Breast Cancer.

Frontiers in endocrinology
2022-03-17 | Journal article
Contributors: Angelis V; Johnston SRD; Ardestani A; Kathrin Maedler
Source: Self-asserted source
Amin Ardestani

MST1 deletion protects β-cells in a mouse model of diabetes

Nutrition & Diabetes
2022-02-08 | Journal article
Contributors: Amin Ardestani; Kathrin Maedler
Source: check_circle
Crossref

PHLPP1 deletion restores pancreatic β-cell survival and normoglycemia in the db/db mouse model of obesity-associated diabetes

Cell Death Discovery
2022-02-08 | Journal article
Contributors: Blaz Lupse; Nick Heise; Kathrin Maedler; Amin Ardestani
Source: check_circle
Crossref

How β cells can smell insulin fragments.

Cell metabolism
2022-02-01 | Journal article
Contributors: Ardestani A; Kathrin Maedler
Source: Self-asserted source
Amin Ardestani

Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy

Autophagy
2021-12-02 | Journal article
Contributors: Amin Ardestani; Kathrin Maedler
Source: check_circle
Crossref

SARS-CoV-2 and pancreas: a potential pathological interaction?

Trends in Endocrinology & Metabolism
2021-11 | Journal article
Contributors: Shirin Geravandi; Azam Mahmoudi-aznaveh; Zahra Azizi; Kathrin Maedler; Amin Ardestani
Source: check_circle
Crossref

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis.

Nature communications
2021-08-13 | Journal article
Source: Self-asserted source
Amin Ardestani

Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.

Cell reports
2021-08-01 | Journal article
Source: Self-asserted source
Amin Ardestani

LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes.

Biochemical and biophysical research communications
2021-07-01 | Journal article
Source: Self-asserted source
Amin Ardestani

Hippo STK kinases drive metabolic derangement

Nature Metabolism
2021-03-23 | Journal article
Contributors: Kathrin Maedler; Amin Ardestani
Source: check_circle
Crossref

Targeting glucose metabolism for treatment of COVID-19.

Signal transduction and targeted therapy
2021-03-06 | Journal article
Source: Self-asserted source
Amin Ardestani
grade
Preferred source (of 2)‎

Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.

Frontiers in endocrinology
2020-10-14 | Journal article
Source: Self-asserted source
Amin Ardestani

STRIPAK Is a Regulatory Hub Initiating Hippo Signaling.

Trends in biochemical sciences
2020-02-15 | Journal article
Source: Self-asserted source
Amin Ardestani

Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance.

Cell metabolism
2020-01-01 | Journal article
Source: Self-asserted source
Amin Ardestani

Neratinib is an MST1 inhibitor and restores pancreatic β-cells in diabetes.

Cell death discovery
2019-12-05 | Journal article
Source: Self-asserted source
Amin Ardestani

Neratinib protects pancreatic beta cells in diabetes.

Nature communications
2019-11-01 | Journal article
Source: Self-asserted source
Amin Ardestani

mTORC1 and IRS1: Another Deadly Kiss.

Trends in endocrinology and metabolism: TEM
2018-08-03 | Journal article
Source: Self-asserted source
Amin Ardestani

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism.

Trends in endocrinology and metabolism: TEM
2018-05-05 | Journal article
Source: Self-asserted source
Amin Ardestani

An SCF<sup>FBXO28</sup> E3 Ligase Protects Pancreatic β-Cells from Apoptosis.

International journal of molecular sciences
2018-03-24 | Journal article
Source: Self-asserted source
Amin Ardestani

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response.

iScience
2018-03-23 | Journal article
Source: Self-asserted source
Amin Ardestani

mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function.

Journal of molecular biology
2018-02-23 | Journal article
Source: Self-asserted source
Amin Ardestani

The Hippo Signaling Pathway in Pancreatic β-Cells: Functions and Regulations.

Endocrine reviews
2018-02-01 | Journal article
Source: Self-asserted source
Amin Ardestani

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells.

Cell metabolism
2017-12-21 | Journal article
Source: Self-asserted source
Amin Ardestani

mTORC in β cells: more Than Only Recognizing Comestibles.

The Journal of cell biology
2017-06-12 | Journal article
Source: Self-asserted source
Amin Ardestani

Pancreatic β-cell rescue in diabetes by targeting Merlin.

Expert review of endocrinology & metabolism
2017-02-16 | Journal article
Source: Self-asserted source
Amin Ardestani

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes.

Diabetologia
2016-12-21 | Journal article
Source: Self-asserted source
Amin Ardestani

Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic <b>β</b> cells.

JCI insight
2016-11-03 | Journal article
Source: Self-asserted source
Amin Ardestani

Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes.

PloS one
2016-09-12 | Journal article
Source: Self-asserted source
Amin Ardestani

β-MSCs: successful fusion of MSCs with β-cells results in a β-cell like phenotype.

Oncotarget
2016-08-01 | Journal article
Source: Self-asserted source
Amin Ardestani

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes.

Diabetologia
2016-04-06 | Journal article
Source: Self-asserted source
Amin Ardestani

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.

Nature medicine
2014-03-16 | Journal article
Source: Self-asserted source
Amin Ardestani

The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization.

The Journal of clinical endocrinology and metabolism
2013-04-30 | Journal article
Source: Self-asserted source
Amin Ardestani

Protective effects of four Iranian medicinal plants against free radical-mediated protein oxidation

Food Chemistry
2009-07 | Journal article
Part of ISSN: 0308-8146
Source: Self-asserted source
Amin Ardestani

Suppressive effect of ethyl acetate extract of Teucrium polium on cellular oxidative damages and apoptosis induced by 2-deoxy-d-ribose: Role of de novo synthesis of glutathione

Food Chemistry
2009-06 | Journal article
Part of ISSN: 0308-8146
Source: Self-asserted source
Amin Ardestani

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass.

PloS one
2009-02-06 | Journal article
Source: Self-asserted source
Amin Ardestani

2-Deoxy-D-ribose-induced oxidative stress causes apoptosis in human monocytic cells: prevention by pyridoxal-5'-phosphate.

Toxicology in vitro : an international journal published in association with BIBRA
2008-02-21 | Journal article
Source: Self-asserted source
Amin Ardestani

Nasturtium officinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats.

Chemico-biological interactions
2008-01-26 | Journal article
Source: Self-asserted source
Amin Ardestani

Cyperus rotundus suppresses AGE formation and protein oxidation in a model of fructose-mediated protein glycoxidation.

International journal of biological macromolecules
2007-07-27 | Journal article
Source: Self-asserted source
Amin Ardestani

Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
2007-06-23 | Journal article
Source: Self-asserted source
Amin Ardestani

Flavonoids as potential therapeutic agents for type 1 diabetes.

Medical hypotheses
2007-04-12 | Journal article
Source: Self-asserted source
Amin Ardestani

Antioxidant and free radical scavenging potential of Achillea santolina extracts

Food Chemistry
2007-01 | Journal article
Part of ISSN: 0308-8146
Source: Self-asserted source
Amin Ardestani

Experimental diabetes treated with Achillea santolina: effect on pancreatic oxidative parameters.

Journal of ethnopharmacology
2007-01-31 | Journal article
Source: Self-asserted source
Amin Ardestani

Peer review (7 reviews for 4 publications/grants)

Review activity for iScience. (2)
Review activity for Molecular metabolism. (2)
Review activity for Nature communications (1)
Review activity for Signal transduction and targeted therapy. (2)