Personal information

Emails & domains

Verified email domains

Other IDs

Scopus Author ID: 56585267600

Keywords

Structure Biology, Molecular Immunology

Countries

United States

Activities

Collapse all

Employment (2)

Lycia Therapeutics: South San Francisco, California, US

2024-11-13 to present | Scientist (Biology)
Employment
Source: Self-asserted source
Siyi Gu

University of California San Diego: La Jolla, CA, US

2018-08-13 to 2023-11-06 | Post-doctoral researcher (Skaggs School of Pharmacy and Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Siyi Gu

Education and qualifications (2)

University of Chicago: Chicago, IL, US

2012-09-16 to 2018-06-09 | Ph.D. (Biochemistry and Molecular Biophysics)
Education
Source: Self-asserted source
Siyi Gu

Nankai University: Tianjin, Tianjin, CN

2008-09-01 to 2012-06-30 | B.S. (Biological Sciences)
Education
Source: Self-asserted source
Siyi Gu

Works (12)

Traffic Control: Mechanisms of Ligand-Specific Internalization and Intracellular Distribution of CCR5

Molecular Pharmacology
2025-02 | Journal article
DOI: 10.1016/j.molpha.2025.100020
Contributors: Siyi Gu; Svetlana Maurya; Alexis Lona; Leire Borrega-Roman; Catherina Salanga; David J. Gonzalez; Irina Kufareva; Tracy M. Handel
Source: check_circle
Crossref

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

2023-11-17 | Preprint
DOI: 10.1101/2023.11.15.567150
Contributors: John R.D. Dawson; Grant M. Wadman; Penglie Zhang; Andrew Tebben; Percy H. Carter; Siyi Gu; Thomas Shroka; Leire Borrega-Roman; Catherina L. Salanga; Tracy M. Handel et al.
Source: check_circle
Crossref

Ligand-Dependent Mechanisms of C-C Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics

2023-11-03 | Preprint
DOI: 10.1101/2023.11.01.565224
Contributors: Siyi Gu; Svetlana Maurya; Alexis Lona; Leire Borrega-Roman; Catherina Salanga; David J. Gonzalez; Irina Kufareva; Tracy M. Handel
Source: Self-asserted source
Siyi Gu

On-bead purification and nanodisc reconstitution of human chemokine receptor complexes for structural and biophysical studies

STAR Protocols
2023-09 | Journal article
DOI: 10.1016/j.xpro.2023.102460
Contributors: Siyi Gu; Mian Huang; Tracy M. Handel
Source: check_circle
Crossref

Alpaca ( <i>Vicugna pacos</i> ), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset

Proceedings of the National Academy of Sciences
2020-03-05 | Journal article
DOI: 10.1073/pnas.1909474117
Part of ISSN: 0027-8424
Contributors: Alina S. Fichtner; Mohindar M. Karunakaran; Siyi Gu; Christopher T. Boughter; Marta T. Borowska; Lisa Starick; Anna Nöhren; Thomas W. Göbel; Erin J. Adams; Thomas Herrmann
Source: Self-asserted source
Siyi Gu via Crossref Metadata Search

Butyrophilin3A proteins and Vγ9Vδ2 T cell activation

Seminars in Cell and Developmental Biology
2018 | Journal article
DOI: 10.1016/j.semcdb.2018.02.007
EID:

2-s2.0-85043373095
Contributors: Gu, S.; Borowska, M.T.; Boughter, C.T.; Adams, E.J.
Source: Self-asserted source
Siyi Gu via Scopus - Elsevier

A Photo-Crosslinkable Biotin Derivative of the Phosphoantigen (E)-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate (HMBPP) Activates Vγ9Vδ2 T Cells and Binds to the HMBPP Site of BTN3A1

Chemistry - A European Journal
2017 | Journal article
DOI: 10.1002/chem.201702650
EID:

2-s2.0-85028623935
Contributors: Mattarei, A.; Enzinger, M.; Gu, S.; Karunakaran, M.M.; Kimmel, B.; Berner, N.; Adams, E.J.; Herrmann, T.; Amslinger, S.
Source: Self-asserted source
Siyi Gu via Scopus - Elsevier

Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
DOI: 10.1073/pnas.1707547114
EID:

2-s2.0-85028544604
Contributors: Gu, S.; Sachleben, J.R.; Boughter, C.T.; Nawrocka, W.I.; Borowska, M.T.; Tarrasch, J.T.; Skiniotis, G.; Roux, B.; Adams, E.J.
Source: Self-asserted source
Siyi Gu via Scopus - Elsevier

Vγ9Vδ2 T cell activation by strongly agonistic nucleotidic phosphoantigens

Cellular and Molecular Life Sciences
2017 | Journal article
DOI: 10.1007/s00018-017-2583-0
EID:

2-s2.0-85021727798
Contributors: Moulin, M.; Alguacil, J.; Gu, S.; Mehtougui, A.; Adams, E.J.; Peyrottes, S.; Champagne, E.
Source: Self-asserted source
Siyi Gu via Scopus - Elsevier

RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor

Cell Reports
2016 | Journal article
DOI: 10.1016/j.celrep.2016.04.081
EID:

2-s2.0-84971231480
Contributors: Sebestyen, Z.; Scheper, W.; Vyborova, A.; Gu, S.; Rychnavska, Z.; Schiffler, M.; Cleven, A.; Chéneau, C.; Van Noorden, M.; Peigné, C.-M. et al.
Source: Self-asserted source
Siyi Gu via Scopus - Elsevier

Human gamma delta T cells: Evolution and ligand recognition

Cellular Immunology
2015 | Journal article
DOI: 10.1016/j.cellimm.2015.04.008
EID:

2-s2.0-84930763992
Contributors: Adams, E.J.; Gu, S.; Luoma, A.M.
Source: Self-asserted source
Siyi Gu via Scopus - Elsevier

Sensing of pyrophosphate metabolites by Vγ9Vδ2 T cells

Frontiers in Immunology
2015 | Journal article
DOI: 10.3389/fimmu.2014.00688
EID:

2-s2.0-84926620608
Contributors: Gu, S.; Nawrocka, W.; Adams, E.J.
Source: Self-asserted source
Siyi Gu via Scopus - Elsevier
How many people are using ORCID?