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Baker Lab

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Employment (2)

Howard Hughes Medical Institute: Cambridge, MA, US

2002 to present | Investigator
Employment
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

1992-10-02 to present | Professor (Biology)
Employment
Source: Self-asserted source
Tania A. Baker

Education and qualifications (4)

National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda, MD, US

1989 to 1992 | Postdoctoral Fellow
Education
Source: Self-asserted source
Tania A. Baker

Stanford University School of Medicine: Stanford, CA, US

1988 to 1989 | Postdoctoral Fellow (Biochemistry)
Education
Source: Self-asserted source
Tania A. Baker

Stanford University: Stanford, CA, US

1983 to 1988 | PhD (Biochemistry)
Education
Source: Self-asserted source
Tania A. Baker

University of Wisconsin Madison: Madison, WI, US

1979-09 to 1983-05 | B.S. (Biochemistry)
Education
Source: Self-asserted source
Tania A. Baker

Professional activities (43)

NRC/Ford Foundation: NY, NY, US

2017 to present | Reviewer (Fellowship Programs)
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2014 to present | Chair (Biology Department Committee on Digital Learning)
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2013 to present | Director of MIT BioX (Education group & office of Digital Learning)
Service
Source: Self-asserted source
Tania A. Baker

Cold Spring Harbor Laboratory: Cold Spring Harbor, NY, US

2011 to present | Board of Trustees
Service
Source: Self-asserted source
Tania A. Baker

University of Massachusetts: MA, MA, US

2017 to 2017 | External Reviewer (Biochemistry & Molecular Biology)
Service
Source: Self-asserted source
Tania A. Baker

National Academy of Sciences: Washington, DC, US

2007 to 2017 | Section 21 Canvassing Panel
Service
Source: Self-asserted source
Tania A. Baker

American Society for Microbiology: Washington, DC, US

2007 to 2016 | Promega Biotechnology Research Award Panel
Service
Source: Self-asserted source
Tania A. Baker

Stanford Medical Center Alumni Association: Stanford, CA, US

2014 to 2014 | Lifetime Achievement Award
Distinction
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2012 to 2014 | Department Head (Biology)
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2008 to 2012 | Co-Director (Biology Graduate Program)
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2008 to 2012 | Gender Equity Chairs Committee
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2008 to 2012 | Steering Committee for the Chemistry/Biology Interface Training Program
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2007 to 2012 | Gender Equity Committee
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2006 to 2012 | Chair (“Target of Opportunity” Faculty Search Committee)
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

1994 to 2012 | Graduate Program Steering Committee
Service
Source: Self-asserted source
Tania A. Baker

Johns Hopkins University: Baltimore, MD, US

2011 to 2011 | External Reviewer (Biochemistry)
Service
Source: Self-asserted source
Tania A. Baker

National Institute of General Medical Sciences: Md., Md., US

2010-05 to 2010-05 | Ad Hoc Council Member
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2009 to 2009 | Institute-wide Planning Task Force
Service
Source: Self-asserted source
Tania A. Baker

Protein Society: Baltimore, Maryland, US

2006 to 2009 | Nominating Committee
Service
Source: Self-asserted source
Tania A. Baker

National Institutes of Health: Bethesda, MD, US

2006 to 2009 | Study Section Member (PCMB)
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2008 to 2008 | MacVicar Faculty Fellow for Innovation & Dedication to Undergraduate Education
Distinction
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2004 to 2008 | Co-chair/Chair (School of Science Committee Overseeing Institute Communications Requirement)
Service
Source: Self-asserted source
Tania A. Baker

National Academy of Sciences: Washington, DC, US

2007 to 2007 | Elected Member
Invited position
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2007 to 2007 | Dean of Science Search Committee
Service
Source: Self-asserted source
Tania A. Baker

Keck School of Medicine of USC: CA, CA, US

2007 to 2007 | Chair of Review Committee (Biochemistry & Molecular Biology)
Service
Source: Self-asserted source
Tania A. Baker

Keystone Symposia On Molecular and Cellular Biology: Silverthorne, Colorado, US

2002 to 2006 | Scientific Advisory Board for Molecular Biology
Service
Source: Self-asserted source
Tania A. Baker

American Association for the Advancement of Science: DC, DC, US

2005 to 2005 | Elected Fellow
Invited position
Source: Self-asserted source
Tania A. Baker

American Academy of Arts and Sciences: Cambridge, MA, US

2004 to 2004 | Elected Fellow
Invited position
Source: Self-asserted source
Tania A. Baker

Nat L. Sternberg Thesis Prize Committee: Madison, Wisconsin, US

2002 to 2004 | Member
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

1999 to 2004 | Associate Department Head (Biology)
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

1997 to 2004 | Biochemistry/Molecular Mechanism Faculty Search Committee
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2003 to 2003 | Provost’s Committee for Design of the Faculty Housing Benefit
Service
Source: Self-asserted source
Tania A. Baker

Keystone Symposium on Transposition and Other Genome Rearrangements: Santa Fe, New Mexico, US

2000 to 2003 | Co-organizer
Service
Source: Self-asserted source
Tania A. Baker

American Society for Microbiology: Washington, DC, US

2002 to 2002 | Elected Fellow
Invited position
Source: Self-asserted source
Tania A. Baker

American Society for Microbiology: Washington, DC, US

2001 to 2001 | Eli Lilly and Co. Research Award
Distinction
Source: Self-asserted source
Tania A. Baker

Molecular Genetics of Bacteria and Phages Annual Meeting: Madison, Wisconsin, US

1999 to 2001 | Co-organizer
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

2000 to 2000 | Teaching Prize for Excellence in Undergraduate Education (School of Science)
Distinction
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

1999 to 1999 | Harold E. Edgerton Award for Distinction in Teaching, Research, and Service to MIT
Distinction
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

1998 to 1998 | Dean’s Committee to recommend Biology Department Head
Service
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

1998 to 1998 | Co-organizer of the MIT Scientific Retreat for Junior Faculty in the School of Science
Service
Source: Self-asserted source
Tania A. Baker

American Society for Biochemistry and Molecular Biology: Rockville, MD, US

1998 to 1998 | Schering-Plough Research Institute Award
Distinction
Source: Self-asserted source
Tania A. Baker

Massachusetts Institute of Technology: Cambridge, MA, US

1997 to 1997 | Subcommittee to Design Biology Graduate Lab Rotations
Service
Source: Self-asserted source
Tania A. Baker

National Science Foundation: Arlington, VA, US

1993 to 1993 | Young Investigator Award
Distinction
Source: Self-asserted source
Tania A. Baker

Funding (1)

Mechaninistic studies of protein machines

1994-06 to present | Award
HHMI (Chevy Chase, US)
Source: Self-asserted source
Tania A. Baker

Works (20)

How the double-ring ClpAP protease motor grips the substrate to unfold and degrade stable proteins

Journal of Biological Chemistry
2024-11 | Journal article
DOI: 10.1016/j.jbc.2024.107861
Contributors: Tsai-Ting Shih; Robert T. Sauer; Tania A. Baker
Source: check_circle
Crossref

An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins

2024-08-10 | Preprint
DOI: 10.1101/2024.08.09.604662
Contributors: Alireza Ghanbarpour; Bertina Telusma; Barrett M. Powell; Jia Jia Zhang; Isabella Bolstad; Carolyn Vargas; Sandro Keller; Tania Baker; Robert T. Sauer; Joseph H. Davis
Source: check_circle
Crossref

A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation

Nature Communications
2023-11-10 | Journal article
DOI: 10.1038/s41467-023-43145-x
Contributors: Alireza Ghanbarpour; Steven E. Cohen; Xue Fei; Laurel F. Kinman; Tristan A. Bell; Jia Jia Zhang; Tania A. Baker; Joseph H. Davis; Robert T. Sauer
Source: check_circle
Crossref

Lon degrades stable substrates slowly but with enhanced processivity, redefining the attributes of a successful AAA+ protease

Cell Reports
2023-09 | Journal article
DOI: 10.1016/j.celrep.2023.113061
Contributors: Meghann R. Kasal; Hema Chandra Kotamarthi; Madeline M. Johnson; Hannah M. Stephens; Matthew J. Lang; Robert T. Sauer; Tania A. Baker
Source: check_circle
Crossref

The membrane-cytoplasmic linker defines activity of FtsH proteases inPseudomonas aeruginosaclone C

2023-06-20 | Preprint
DOI: 10.1101/2023.06.19.545564
Contributors: Gina D Mawla; Shady Mansour Kamal; Lianying Cao; Pasi Purhonen; Hans Hebert; Robert T Sauer; Tania A Baker; Ute Römling
Source: check_circle
Crossref

The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery

Proceedings of the National Academy of Sciences
2023-02-07 | Journal article
DOI: 10.1073/pnas.2219044120
Contributors: Alireza Ghanbarpour; Xue Fei; Tania A. Baker; Joseph H. Davis; Robert T. Sauer
Source: check_circle
Crossref

FtsH degrades kinetically stable dimers of cyclopropane fatty acid synthase via an internal degron

Molecular Microbiology
2023-01 | Journal article
DOI: 10.1111/mmi.15009
Contributors: Sanjay B. Hari; Juhee P. Morehouse; Tania A. Baker; Robert T. Sauer
Source: check_circle
Crossref

AAA+ protease-adaptor structures reveal altered conformations and ring specialization

Nature Structural & Molecular Biology
2022-11 | Journal article
DOI: 10.1038/s41594-022-00850-3
Contributors: Sora Kim; Xue Fei; Robert T. Sauer; Tania A. Baker
Source: check_circle
Crossref

The SspB adaptor drives structural changes in the AAA+ClpXP protease during ssrA-tagged substrate delivery

2022-11-06 | Preprint
DOI: 10.1101/2022.11.06.515074
Contributors: Alireza Ghanbarpour; Xue Fei; Tania A. Baker; Joseph H. Davis; Robert T. Sauer
Source: check_circle
Crossref

A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation

2022-08-27 | Preprint
DOI: 10.1101/2022.08.27.505532
Contributors: Alireza Ghanbarpour; Steven E. Cohen; Xue Fei; Tristan A. Bell; Tania A. Baker; Joseph H. Davis; Robert T. Sauer
Source: check_circle
Crossref

AAA+ protease-adaptor structures reveal altered conformations and ring specialization

2022-02-04 | Preprint
DOI: 10.1101/2022.02.04.479121
Contributors: Sora Kim; Xue Fei; Robert T. Sauer; Tania A. Baker
Source: check_circle
Crossref

Division of labor between the pore-1 loops of the D1 and D2 AAA+ rings coordinates substrate selectivity of the ClpAP protease

Journal of Biological Chemistry
2021-12 | Journal article
DOI: 10.1016/j.jbc.2021.101407
Contributors: Kristin L. Zuromski; Sora Kim; Robert T. Sauer; Tania A. Baker
Source: check_circle
Crossref

ClpP1P2 peptidase activity promotes biofilm formation in Pseudomonas aeruginosa

Molecular Microbiology
2021-06 | Journal article
DOI: 10.1111/mmi.14649
Contributors: Gina D. Mawla; Branwen M. Hall; Gerardo Cárcamo‐Oyarce; Robert A. Grant; Jia Jia Zhang; Julia R. Kardon; Katharina Ribbeck; Robert T. Sauer; Tania A. Baker
Source: check_circle
Crossref

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

eLife
2020-12-01 | Journal article
DOI: 10.7554/eLife.61451
Contributors: Sora Kim; Kristin L Zuromski; Tristan A Bell; Robert T Sauer; Tania A Baker
Source: check_circle
Crossref

Multistep substrate binding and engagement by the AAA+ ClpXP protease

Proceedings of the National Academy of Sciences
2020-11-10 | Journal article
DOI: 10.1073/pnas.2010804117
Contributors: Reuben A. Saunders; Benjamin M. Stinson; Tania A. Baker; Robert T. Sauer
Source: check_circle
Crossref

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

eLife
2020-10-22 | Journal article
DOI: 10.7554/eLife.61496
Contributors: Xue Fei; Tristan A Bell; Sarah R Barkow; Tania A Baker; Robert T Sauer
Source: check_circle
Crossref

Modular and coordinated activity of AAA+ active sites in the double-ring ClpA unfoldase of the ClpAP protease

Proceedings of the National Academy of Sciences
2020-10-13 | Journal article
DOI: 10.1073/pnas.2014407117
Contributors: Kristin L. Zuromski; Robert T. Sauer; Tania A. Baker
Source: check_circle
Crossref

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

eLife
2020-02-28 | Journal article
DOI: 10.7554/eLife.52774
Contributors: Xue Fei; Tristan A Bell; Simon Jenni; Benjamin M Stinson; Tania A Baker; Stephen C Harrison; Robert T Sauer
Source: check_circle
Crossref

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

eLife
2020-02-24 | Journal article
DOI: 10.7554/eLife.54387
Contributors: Julia R Kardon; Jamie A Moroco; John R Engen; Tania A Baker
Source: check_circle
Crossref

Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding

eLife
2019-06-28 | Journal article
DOI: 10.7554/eLife.46808
Contributors: Tristan A Bell; Tania A Baker; Robert T Sauer
Source: check_circle
Crossref
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