Personal information

Emails & domains

Verified email addresses

Other IDs

Scopus Author ID: 24367721900

Keywords

Spinal Muscular Atrophy, SMN, Cell Biology of the Nucleus, Nuclear Envelope , pre-mRNA splicing , Cajal body, Neuromuscular disorders, skeletal muscle cell biology

Countries

Spain

Activities

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Employment (6)

Universidad de La Laguna: San Cristobal de La Laguna, Tenerife, ES

2023-04-13 to present | Assistant Professor (Department of Basic Medical Sciences)
Employment
Source: Self-asserted source
Olga Tapia Martínez

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas: Santander, ES

2007-05-01 to present | CIBERNED Researcher (Lab. Neurology, Dr. Jon Infante)
Employment
Source: Self-asserted source
Olga Tapia Martínez

Universidad Europea del Atlántico: Santander, ES

2017-09-01 to 2023-02-05 | Profesor Agregado (Cell & Molecular Biology)
Employment
Source: Self-asserted source
Olga Tapia Martínez

Instituto de Investigación Sanitaria Valdecilla (IDIVAL): Santander, ES

2019-07-01 to 2021-08-31 | Senior Ph.D. Researcher (Neuroscience Area)
Employment
Source: Self-asserted source
Olga Tapia Martínez

University of Cantabria: Santander, ES

2015-11-15 to 2018-06-30 | Senior Ph.D. Researcher (Dept. Anatomy and Cell Biology)
Employment
Source: Self-asserted source
Olga Tapia Martínez

Scripps Research Institute: La Jolla, CA, US

2012-06-01 to 2015-10-16 | Research Associate (Dept. Cell and Molecular Biology)
Employment
Source: Self-asserted source
Olga Tapia Martínez

Education and qualifications (3)

University of Cantabria: Santander, ES

2006 to 2009-10-08 | PhD in Biomedicine (Dept. Anatomy and Cell Biology)
Education
Source: Self-asserted source
Olga Tapia Martínez

Universidad Nacional de Educación a Distancia: -, ES

2005 to 2006 | Ionizing Radiations in Medicine: Radioprotection (Faculty of Sciences)
Education
Source: Self-asserted source
Olga Tapia Martínez

Universidad Nacional de Educación a Distancia: -, ES

1998 to 2004 | B.Sc. Chemistry (Faculty of Sciences)
Education
Source: Self-asserted source
Olga Tapia Martínez

Professional activities (2)

Scripps Research Institute: La Jolla, CA, US

2015-10-16 to present | Professional Scientific Collaborator (Dept. Cell and Molecular Biology)
Invited position
Source: Self-asserted source
Olga Tapia Martínez

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas: Madrid, ES

2007 to present
Membership
Source: Self-asserted source
Olga Tapia Martínez

Funding (4)

Preclinical Analysis Of New Combinatorial Treatments For Spinal Muscular Atrophy (Sma): Effects On Motoneuron Survival, Synaptic Integrity, And Skeletal Muscle Preservation

2021-04 to 2024-04 | Grant
Fundació la Marató de TV3 (Barcelona, ES)
Source: Self-asserted source
Olga Tapia Martínez

Diseño de estructuras biopoliméricas funcionalizadas con grafeno para el desarrollo de cultivos neuronales en modelos celulares de patología de la motoneurona

2017-10 to 2020-10 | Grant
Instituto de Investigación Sanitaria Valdecilla (IDIVAL) (Santander, ES)
Source: Self-asserted source
Olga Tapia Martínez

Efecto del déficit del factor de supervivencia de las neuronas motoras (SMN) sobre la organización estructural y molecular de los compartimentos nucleares implicados en la biogénesis de RNPs espliceosomales y en el procesamiento de RNAs: Estudio experimental en motoneuronas del modelo murino "SMNΔ7" de Atrofia Muscular Espinal tipo I

2017-08 to 2019-08 | Grant
Instituto de Investigación Sanitaria Valdecilla (IDIVAL) (Santander, ES)
Source: Self-asserted source
Olga Tapia Martínez

Regulation of the Survival Motor Neuron (SMN) protein by acetylation and its importance in snRNP biogenesis and molecular assembly of Cajal bodies

2017-01 to 2017-12 | Grant
SMA-Europe (EU, ES)
Source: Self-asserted source
Olga Tapia Martínez

Works (44)

Conventional and microfluidic methods: Design and optimization of lipid-polymeric hybrid nanoparticles for gene therapy

Drug Delivery and Translational Research
2025-03 | Journal article
DOI: 10.1007/s13346-024-01644-4
Contributors: Daniel González-García; Olga Tapia; Carmen Évora; Patricia García-García; Araceli Delgado
Source: check_circle
Crossref

SMN Deficiency Induces an Early Non-Atrophic Myopathy with Alterations in the Contractile and Excitatory Coupling Machinery of Skeletal Myofibers in the SMN∆7 Mouse Model of Spinal Muscular Atrophy

International Journal of Molecular Sciences
2024-11-19 | Journal article
DOI: 10.3390/ijms252212415
Contributors: María T. Berciano; Alaó Gatius; Alba Puente-Bedia; Alexis Rufino-Gómez; Olga Tarabal; José C. Rodríguez-Rey; Jordi Calderó; Miguel Lafarga; Olga Tapia
Source: check_circle
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SMN deficiency induces an early non-atrophic myopathy with alterations in the contractile and excitatory coupling machinery of skeletal myofibers in the SMNΔ7 mouse model of spinal muscular atrophy

2024-09-15 | Preprint
DOI: 10.1101/2024.09.11.612470
Contributors: María T. Berciano; Alaó Gatius; Alba Puente-Bedia; Alexis Rufino-Gómez; Olga Tarabal; José C. Rodríguez-Rey; Jordi Calderó; Miguel Lafarga; Olga Tapia
Source: check_circle
Crossref

Lem2 is essential for cardiac development by maintaining nuclear integrity.

Cardiovascular research
2023-04-17 | Journal article
DOI: 10.1093/cvr/cvad061
PMID: 37067297
Contributors: Ross JA; Arcos-Villacis N; Battey E; Boogerd C; Avalos Orellana C; Marhuenda E; Swiatlowska P; Hodzic D; Prin F; Mohun T et al.
Source: Self-asserted source
Olga Tapia Martínez

Cytotoxicity and Antimicrobial Resistance of <i>Aeromonas</i> Strains Isolated from Fresh Produce and Irrigation Water.

Antibiotics (Basel, Switzerland)
2023-03-03 | Journal article
DOI: 10.3390/antibiotics12030511
PMID: 36978377
PMC: PMC10044025
Contributors: Alberto Pintor-Cora; Tapia O; Maria Elexpuru Zabaleta; Ruiz de Alegría C; Jose M. Rodríguez-Calleja; Jesus A. Santos; JOSE RAMOS VIVAS
Source: Self-asserted source
Olga Tapia Martínez

Coaxial electrospraying technology for the synthesis of PEI-based nanocarriers with encapsulated RNA-ASOs to target delivery in muscle cells

2023-01-31 | Conference paper
DOI: 10.48158/MeCCE-15.T1-O-03
Contributors: Raquel de la Hoz; Nazely Diban; Maria T. Berciano; Ane Urtiaga; Miguel Lafarga; José Rodríguez -Rey; Olga Tapia
Source: check_circle
Crossref

Non-homogeneous dispersion of graphene in polyacrylonitrile substrates induces a migrastatic response and epithelial-like differentiation in MCF7 breast cancer cells

Cancer Nanotechnology
2022-12 | Journal article
DOI: 10.1186/s12645-021-00107-6
Contributors: Nazely Diban; Marián Mantecón-Oria; María T. Berciano; Alba Puente-Bedia; María J. Rivero; Ane Urtiaga; Miguel Lafarga; Olga Tapia
Source: check_circle
Crossref

The Molecular Weaponry Produced by the Bacterium Hafnia alvei in Foods

Molecules
2022-08-30 | Journal article
DOI: 10.3390/molecules27175585
Contributors: José Ramos-Vivas; Olga Tapia; María Elexpuru-Zabaleta; Kilian Tutusaus Pifarre; Yasmany Armas Diaz; Maurizio Battino; Francesca Giampieri
Source: check_circle
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Coaxial Synthesis of PEI-Based Nanocarriers of Encapsulated RNA-Therapeutics to Specifically Target Muscle Cells

Biomolecules
2022-07-22 | Journal article
DOI: 10.3390/biom12081012
Contributors: Raquel de la Hoz; Nazely Diban; María T. Berciano; Carlos San Emeterio; Ane Urtiaga; Miguel Lafarga; José C. Rodríguez-Rey; Olga Tapia
Source: check_circle
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grade
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HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

Science
2021-02-05 | Journal article
DOI: 10.1126/science.abb4309
Contributors: Haiyang Yu; Shan Lu; Kelsey Gasior; Digvijay Singh; Sonia Vazquez-Sanchez; Olga Tapia; Divek Toprani; Melinda S. Beccari; John R. Yates, III; Sandrine Da Cruz et al.
Source: check_circle
Crossref

Nuclear Reorganization in Hippocampal Granule Cell Neurons from a Mouse Model of Down Syndrome: Changes in Chromatin Configuration, Nucleoli and Cajal Bodies

International Journal of Molecular Sciences
2021-01-27 | Journal article
DOI: 10.3390/ijms22031259
Contributors: Alba Puente-Bedia; María T. Berciano; Olga Tapia; Carmen Martínez-Cué; Miguel Lafarga; Noemí Rueda
Source: check_circle
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Mislocalization of SMN from the I-band and M-band in human skeletal myofibers in spinal muscular atrophy associates with primary structural alterations of the sarcomere

Cell and Tissue Research
2020-09 | Journal article
DOI: 10.1007/s00441-020-03236-3
Contributors: María T. Berciano; María S. Castillo-Iglesias; J. Fernando Val-Bernal; Vanesa Lafarga; José C. Rodriguez-Rey; Miguel Lafarga; Olga Tapia
Source: check_circle
Crossref

Hollow Fiber Membranes of PCL and PCL/Graphene as Scaffolds with Potential to Develop In Vitro Blood—Brain Barrier Models

Membranes
2020-07-22 | Journal article
DOI: 10.3390/membranes10080161
Contributors: Marián Mantecón-Oria; Nazely Diban; Maria T. Berciano; Maria J. Rivero; Oana David; Miguel Lafarga; Olga Tapia; Ane Urtiaga
Source: check_circle
Crossref
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Nusinersen ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model

Scientific Reports
2020-07-01 | Journal article
DOI: 10.1038/s41598-020-67569-3
Part of ISSN: 2045-2322
Source: Self-asserted source
Olga Tapia Martínez

GRK2-Dependent HuR Phosphorylation Regulates HIF1α Activation under Hypoxia or Adrenergic Stress.

Cancers
2020-05-13 | Journal article
DOI: 10.3390/cancers12051216
PMID: 32413989
PMC: PMC7281538
Source: Self-asserted source
Olga Tapia Martínez

TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli

2020-03-29 | Preprint
DOI: 10.1101/2020.03.28.985986
Contributors: Haiyang Yu; Shan Lu; Kelsey Gasior; Digvijay Singh; Olga Tapia; Sonia Vazquez-Sanchez; Divek Toprani; Melinda S. Beccari; John R. Yates, III; Sandrine Da Cruz et al.
Source: check_circle
Crossref

ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage.

Journal of neurology
2020-01-14 | Journal article
DOI: 10.1007/s00415-020-09704-8
PMID: 31938860
Source: Self-asserted source
Olga Tapia Martínez

Identification of new transmembrane proteins concentrated at the nuclear envelope using organellar proteomics of mesenchymal cells

Nucleus
2019 | Journal article
DOI: 10.1080/19491034.2019.1618175
EID:

2-s2.0-85067288079
Contributors: Cheng, L.-C.; Baboo, S.; Lindsay, C.; Brusman, L.; Martinez-Bartolomé, S.; Tapia, O.; Zhang, X.; Yates, J.R.; Gerace, L.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Nucleolin reorganization and nucleolar stress in Purkinje cells of mutant PCD mice

Neurobiology of Disease
2019-07 | Journal article
DOI: 10.1016/j.nbd.2019.03.017
Contributors: Fernando C. Baltanás; María T. Berciano; Olga Tapia; Josep Oriol Narcis; Vanesa Lafarga; David Díaz; Eduardo Weruaga; Eugenio Santos; Miguel Lafarga
Source: check_circle
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Reorganization of the nuclear compartments involved in transcription and RNA processing in myonuclei of type I spinal muscular atrophy.

Histochemistry and cell biology
2019-06-11 | Journal article
DOI: 10.1007/s00418-019-01792-6
PMID: 31183542
Source: Self-asserted source
Olga Tapia Martínez
grade
Preferred source (of 2)‎

Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA

Scientific Reports
2018 | Journal article
DOI: 10.1038/s41598-018-27821-3
EID:

2-s2.0-85049215852
Contributors: Narcís, J.O.; Tapia, O.; Tarabal, O.; Piedrafita, L.; Calderó, J.; Berciano, M.T.; Lafarga, M.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Messages from the voices within: regulation of signaling by proteins of the nuclear lamina

Current Opinion in Cell Biology
2018 | Journal article
DOI: 10.1016/j.ceb.2017.12.009
EID:

2-s2.0-85040002700
Contributors: Gerace, L.; Tapia, O.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Persistent accumulation of unrepaired DNA damage in rat cortical neurons: Nuclear organization and ChIP-seq analysis of damaged DNA

Acta Neuropathologica Communications
2018 | Journal article
DOI: 10.1186/s40478-018-0573-6
EID:

2-s2.0-85062009190
Contributors: Mata-Garrido, J.; Tapia, O.; Casafont, I.; Berciano, M.T.; Cuadrado, A.; Lafarga, M.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN

Cellular and Molecular Life Sciences
2018-02 | Journal article
DOI: 10.1007/s00018-017-2638-2
Contributors: Vanesa Lafarga; Olga Tapia; Sahil Sharma; Rocio Bengoechea; Georg Stoecklin; Miguel Lafarga; Maria T. Berciano
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Cajal bodies in neurons

RNA Biology
2017 | Journal article
DOI: 10.1080/15476286.2016.1231360
EID:

2-s2.0-84991031056
Contributors: Lafarga, M.; Tapia, O.; Romero, A.M.; Berciano, M.T.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

SUMO regulates p21<sup>Cip1</sup> intracellular distribution and with p21<sup>Cip1</sup> facilitates multiprotein complex formation in the nucleolus upon DNA damage

PLoS ONE
2017 | Journal article
DOI: 10.1371/journal.pone.0178925
EID:

2-s2.0-85020412353
Contributors: Brun, S.; Abella, N.; Berciano, M.T.; Tapia, O.; Jaumot, M.; Freire, R.; Lafarga, M.; Agell, N.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus

Neurobiology of Disease
2017-12 | Journal article
DOI: 10.1016/j.nbd.2017.08.004
Contributors: Olga Tapia; Josep Oriol Narcís; Javier Riancho; Olga Tarabal; Lídia Piedrafita; Jordi Calderó; Maria T. Berciano; Miguel Lafarga
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Analysis of nuclear lamina proteins in myoblast differentiation by functional complementation

Methods in Molecular Biology
2016 | Book chapter
DOI: 10.1007/978-1-4939-3530-7_11
EID:

2-s2.0-84971228898
Contributors: Tapia, O.; Gerace, L.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis

Oncotarget
2016 | Journal article
DOI: 10.18632/oncotarget.11766
EID:

2-s2.0-84994311323
Contributors: Lafita-Navarro, M.C.; Blanco, R.; Mata-Garrido, J.; Liaño-Pons, J.; Tapia, O.; García-Gutiérrez, L.; García-Alegría, E.; Berciano, M.T.; Lafarga, M.; León, J.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Neuronal accumulation of unrepaired DNA in a novel specific chromatin domain: structural, molecular and transcriptional characterization

Acta neuropathologica communications
2016 | Journal article
DOI: 10.1186/s40478-016-0312-9
EID:

2-s2.0-85020318776
Contributors: Mata-Garrido, J.; Casafont, I.; Tapia, O.; Berciano, M.T.; Lafarga, M.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Cystatin D locates in the nucleus at sites of active transcription and modulates gene and protein expression

Journal of Biological Chemistry
2015 | Journal article
DOI: 10.1074/jbc.M115.660175
EID:

2-s2.0-84946032984
Contributors: Ferrer-Mayorga, G.; Alvarez-Díaz, S.; Valle, N.; De Las Rivas, J.; Mendes, M.; Barderas, R.; Canals, F.; Tapia, O.; Casal, J.I.; Lafarga, M. et al.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer

Oncotarget
2015 | Journal article
DOI: 10.18632/oncotarget.3464
EID:

2-s2.0-84925669422
Contributors: Aguilera, O.; González-Sancho, J.M.; Zazo, S.; Rincón, R.; Fernández, A.F.; Tapia, O.; Canals, F.; Morte, B.; Calvanese, V.; Orgaz, J.L. et al.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases

PLoS ONE
2015 | Journal article
DOI: 10.1371/journal.pone.0116196
EID:

2-s2.0-84961290235
Contributors: Tapia, O.; Fong, L.G.; Huber, M.D.; Young, S.G.; Gerace, L.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to cajal body biogenesis

Journal of Cell Science
2014 | Journal article
DOI: 10.1242/jcs.138537
EID:

2-s2.0-84896883621
Contributors: Tapia, O.; Lafarga, V.; Bengoechea, R.; Palanca, A.; Lafarga, M.; Berciano, M.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

A novel GRK2/HDAC6 interaction modulates cell spreading and motility

EMBO Journal
2012 | Journal article
DOI: 10.1038/emboj.2011.466
EID:

2-s2.0-84857036295
Contributors: Lafarga, V.; Aymerich, I.; Tapia, O.; Mayor Jr., F.; Penela, P.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Nuclear speckles are involved in nuclear aggregation of PABPN1 and in the pathophysiology of oculopharyngeal muscular dystrophy

Neurobiology of Disease
2012 | Journal article
DOI: 10.1016/j.nbd.2011.12.052
EID:

2-s2.0-84858155192
Contributors: Bengoechea, R.; Tapia, O.; Casafont, I.; Berciano, J.; Lafarga, M.; Berciano, M.T.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Reorganization of Cajal bodies and nucleolar targeting of coilin in motor neurons of type i spinal muscular atrophy

Histochemistry and Cell Biology
2012 | Journal article
DOI: 10.1007/s00418-012-0921-8
EID:

2-s2.0-84862865734
Contributors: Tapia, O.; Bengoechea, R.; Palanca, A.; Arteaga, R.; Val-Bernal, J.F.; Tizzano, E.F.; Berciano, M.T.; Lafarga, M.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility

Science Signaling
2012 | Journal article
DOI: 10.1126/scisignal.2003098
EID:

2-s2.0-84861118861
Contributors: Penela, P.; Lafarga, V.; Tapia, O.; Rivas, V.; Nogués, L.; Lucas, E.; Vila-Bedmar, R.; Murga, C.; Mayor Jr., F.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Nucleolar Disruption Ensures Nuclear Accumulation of p21 upon DNA Damage

Traffic
2010 | Journal article
DOI: 10.1111/j.1600-0854.2010.01063.x
EID:

2-s2.0-77953410517
Contributors: Abella, N.; Brun, S.; Calvo, M.; Tapia, O.; Weber, J.D.; Berciano, M.T.; Lafarga, M.; Bachs, O.; Agell, N.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Nucleolar targeting of coilin is regulated by its hypomethylation state

Chromosoma
2010 | Journal article
DOI: 10.1007/s00412-010-0276-7
EID:

2-s2.0-77957682036
Contributors: Tapia, O.; Bengoechea, R.; Berciano, M.T.; Lafarga, M.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Cajal's contribution to the knowledge of the neuronal cell nucleus

Chromosoma
2009 | Journal article
DOI: 10.1007/s00412-009-0212-x
EID:

2-s2.0-67649503031
Contributors: Lafarga, M.; Casafont, I.; Bengoechea, R.; Tapia, O.; Berciano, M.T.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons

Journal of Structural Biology
2009 | Journal article
DOI: 10.1016/j.jsb.2009.06.006
EID:

2-s2.0-67650747230
Contributors: Casafont, I.; Bengoechea, R.; Tapia, O.; Berciano, M.T.; Lafarga, M.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

SUMO-1 transiently localizes to Cajal bodies in mammalian neurons

Journal of Structural Biology
2008 | Journal article
DOI: 10.1016/j.jsb.2008.04.013
EID:

2-s2.0-46749152929
Contributors: Navascues, J.; Bengoechea, R.; Tapia, O.; Casafont, I.; Berciano, M.T.; Lafarga, M.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier

Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells

Chromosoma
2007 | Journal article
DOI: 10.1007/s00412-007-0107-7
EID:

2-s2.0-34648823175
Contributors: Navascués, J.; Bengoechea, R.; Tapia, O.; Vaqué, J.P.; Lafarga, M.; Berciano, M.T.
Source: Self-asserted source
Olga Tapia Martínez via Scopus - Elsevier
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