Dr Brain graduated with a PhD in Physiology in 1998 and in Medicine in 1999 from the University of Sydney, Australia. After working as a medical officer at the Royal Prince Alfred Hospital in Sydney he joined the Department of Pharmacology, Oxford, in 2001.
While in Oxford, Dr Brain held a series of research fellowships, including a Nuffield Medical Fellowship, Wellcome Trust Career Development Research Fellowship (both based in the Department of Pharmacology), Staines Medical Research Fellowship (Exeter College) and the post of Research Fellow and Tutor (Keble College). In 2009 he moved to the post of Senior Lecturer (Neuropharmacology) at the University of Birmingham. He is also the lecturer in Pharmacology at Christ Church College, Oxford.