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ResearcherID: B-3543-2015
Scopus Author ID: 6602440788

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Western University: London, ON, CA

2005-07-01 to present | Professor (Chemistry)
Employment
Source: Self-asserted source
Leonard Luyt

Works (50 of 79)

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Page 1 of 2

A survey of stapling methods to increase affinity, activity, and stability of ghrelin analogues

RSC Medicinal Chemistry
2024 | Journal article
DOI: 10.1039/D3MD00441D
Contributors: Juan J. Esteban; Julia R. Mason; Jakob Kaminski; Rithwik Ramachandran; Leonard G. Luyt
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Crossref

Tailored peptide nanomaterials for receptor targeted prostate cancer imaging

Nanoscale
2024 | Journal article
DOI: 10.1039/D4NR03273J
Contributors: Fátima Santillán; Carlie L. Charron; Betty C. Galarreta; Leonard G. Luyt
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Crossref

Discovery of Ghrelin(1–8) Analogues with Improved Stability and Functional Activity for PET Imaging

ACS Pharmacology & Translational Science
2023-07-14 | Journal article
DOI: 10.1021/acsptsci.3c00088
Contributors: Marina D. Childs; Arundhasa Chandrabalan; Derian Hodgson; Rithwik Ramachandran; Leonard G. Luyt
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Crossref

Protease-activated receptor 2 (PAR2)-targeting peptide derivatives for positron emission tomography (PET) imaging

European Journal of Medicinal Chemistry
2023-01 | Journal article
DOI: 10.1016/j.ejmech.2022.114989
Contributors: Jordan C. LeSarge; Pierre Thibeault; Lihai Yu; Marina D. Childs; Victor M. Mirka; Qi Qi; Matthew S. Fox; Michael S. Kovacs; Rithwik Ramachandran; Leonard G. Luyt
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Radiofluorination of non-activated aromatic prosthetic groups for synthesis and evaluation of fluorine-18 labelled ghrelin(1–8) analogues

Organic & Biomolecular Chemistry
2021 | Journal article
DOI: 10.1039/D1OB01023A
Contributors: Marina D. Childs; Lihai Yu; Michael S. Kovacs; Leonard G. Luyt
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Crossref

Targeting Glioblastoma Using a Novel Peptide Specific to a Deglycosylated Isoform of Brevican

Advanced Therapeutics
2021-04 | Journal article
DOI: 10.1002/adtp.202000244
Part of ISSN: 2366-3987
Contributors: Leonard Luyt
Source: Self-asserted source
Leonard Luyt

The development of peptide–boron difluoride formazanate conjugates as fluorescence imaging agents

RSC Advances
2020 | Journal article
DOI: 10.1039/D0RA02104K
Contributors: Neha Sharma; Stephanie M. Barbon; Tyler Lalonde; Ryan R. Maar; Mark Milne; Joe B. Gilroy; Leonard G. Luyt
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Incorporation of Fluorine into an OBOC Peptide Library by Copper-Free Click Chemistry toward the Discovery of PET Imaging Agents

ACS Combinatorial Science
2020-03-09 | Journal article
DOI: 10.1021/acscombsci.9b00146
Contributors: Emily Murrell; Leonard G. Luyt
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Crossref

A Hyaluronan-binding Peptide (P15-1) Reduces Inflammatory and Catabolic Events in IL-1β-treated Human Articular Chondrocytes

Scientific Reports
2020-01-29 | Journal article
DOI: 10.1038/s41598-020-57586-7
Contributors: Claire Shortt; Leonard G. Luyt; Eva A. Turley; Mary K. Cowman; Thorsten Kirsch
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Crossref

A Decade’s Progress in the Development of Molecular Imaging Agents Targeting the Growth Hormone Secretagogue Receptor

Molecular Imaging
2020-01-01 | Journal article
DOI: 10.1177/1536012120952623
Contributors: Marina D. Childs; Leonard G. Luyt
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Crossref

A dual modality 99mTc/Re(i)-labelled T140 analogue for imaging of CXCR4 expression

Organic & Biomolecular Chemistry
2019 | Journal article
DOI: 10.1039/C8OB01947A
Contributors: William L. Turnbull; Lihai Yu; Emily Murrell; Mark Milne; Carlie L. Charron; Leonard G. Luyt
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Crossref

A study of 99mTc/Re-tricarbonyl complexes of 4-amino-1,8-naphthalimides

Dalton Transactions
2019 | Journal article
DOI: 10.1039/C9DT01752F
Contributors: William L. Turnbull; Emily Murrell; Mariel Bulcan-Gnirss; Maryam Majeed; Mark Milne; Leonard G. Luyt
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Crossref

Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as 18F-Labeled Positron Emission Tomography Probes via I-SPANC

ACS Omega
2019-11-19 | Journal article
DOI: 10.1021/acsomega.9b02322
Contributors: Sara Ghiassian; Lihai Yu; Pierangelo Gobbo; Ali Nazemi; Tommaso Romagnoli; Wilson Luo; Leonard G. Luyt; Mark S. Workentin
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Crossref

Front Cover: Single Amino Acid Replacement in G‐7039 Leads to a 70‐fold Increase in Binding toward GHS‐R1a (ChemMedChem 20/2019)

ChemMedChem
2019-10-17 | Journal article
DOI: 10.1002/cmdc.201900563
Contributors: Tyler Lalonde; Milan M. Fowkes; Jinqiang Hou; Pierre E. Thibeault; Mark Milne; Savita Dhanvantari; Rithwik Ramachandran; Leonard G. Luyt
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Crossref

Single Amino Acid Replacement in G‐7039 Leads to a 70‐fold Increase in Binding toward GHS‐R1a

ChemMedChem
2019-10-17 | Journal article
DOI: 10.1002/cmdc.201900466
Contributors: Tyler Lalonde; Milan M. Fowkes; Jinqiang Hou; Pierre E. Thibeault; Mark Milne; Savita Dhanvantari; Rithwik Ramachandran; Leonard G. Luyt
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Crossref

High Affinity Fluorescent Probe for Proteinase-Activated Receptor 2 (PAR2)

ACS Medicinal Chemistry Letters
2019-07-11 | Journal article
DOI: 10.1021/acsmedchemlett.9b00094
Contributors: Jordan C. LeSarge; Pierre Thibeault; Mark Milne; Rithwik Ramachandran; Leonard G. Luyt
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Crossref

Dynamics of the Ghrelin/Growth Hormone Secretagogue Receptor System in the Human Heart Before and After Cardiac Transplantation

Journal of the Endocrine Society
2019-04-01 | Journal article
DOI: 10.1210/js.2018-00393
Contributors: Rebecca Sullivan; Varinder K Randhawa; Anne Stokes; Derek Wu; Tyler Lalonde; Bob Kiaii; Leonard Luyt; Gerald Wisenberg; Savita Dhanvantari
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18F-Labeled PET Probe Targeting Enhancer of Zeste Homologue 2 (EZH2) for Cancer Imaging

ACS Medicinal Chemistry Letters
2019-03-14 | Journal article
DOI: 10.1021/acsmedchemlett.8b00613
Contributors: Lihai Yu; Nikola Despotovic; Michael S. Kovacs; Christopher L. Pin; Leonard G. Luyt
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Crossref

The development of a near infrared inulin optical probe for measuring glomerular filtration rate

International Journal of Biological Macromolecules
2019-02 | Journal article
DOI: 10.1016/j.ijbiomac.2018.11.034
Contributors: A. Hauser-Kawaguchi; M. Milne; F. Li; T.Y. Lee; L.G. Luyt
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Crossref

Stapled ghrelin peptides as fluorescent imaging probes

Peptide Science
2019-01 | Journal article
DOI: 10.1002/pep2.24055
Contributors: Tyler Lalonde; Trevor G. Shepherd; Savita Dhanvantari; Leonard G. Luyt
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Crossref

Development of a [68Ga]-ghrelin analogue for PET imaging of the ghrelin receptor (GHS-R1a)

MedChemComm
2018 | Journal article
DOI: 10.1039/C8MD00210J
Contributors: C. L. Charron; M. S. McFarland; S. Dhanvantari; L. G. Luyt
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Crossref

Boosting the turn-on fluorescent signaling ability of thiazole orange dyes: The effectiveness of structural modification site and its unusual interaction behavior with nucleic acids

Dyes and Pigments
2018-12 | Journal article
DOI: 10.1016/j.dyepig.2018.07.008
Contributors: Wei Long; Yu-Jing Lu; Kun Zhang; Xuan-He Huang; Jin-Qiang Hou; Sen-Yuan Cai; Ying Li; Xian Du; Leonard G. Luyt; Wing-Leung Wong et al.
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Crossref

The Chimera That Curbs Appetite

Journal of Medicinal Chemistry
2018-12-27 | Journal article
DOI: 10.1021/acs.jmedchem.8b01809
Contributors: Leonard G. Luyt
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Crossref

A truncated RHAMM protein for discovering novel therapeutic peptides

Bioorganic & Medicinal Chemistry
2018-10 | Journal article
DOI: 10.1016/j.bmc.2018.09.018
Contributors: Alexandra Hauser-Kawaguchi; Cornelia Tolg; Teresa Peart; Mark Milne; Eva A. Turley; Leonard G. Luyt
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Crossref

Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography imaging of the ghrelin receptor

European Journal of Medicinal Chemistry
2018-09 | Journal article
DOI: 10.1016/j.ejmech.2018.08.062
Contributors: Milan M. Fowkes; Tyler Lalonde; Lihai Yu; Savita Dhanvantari; Michael S. Kovacs; Leonard G. Luyt
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Crossref

Amino‐Substituted 2,2′‐Bipyridine Ligands as Fluorescent Indicators for ZnII and Applications for Fluorescence Imaging of Prostate Cells

Chemistry – A European Journal
2018-09-25 | Journal article
DOI: 10.1002/chem.201803051
Contributors: William L. Turnbull; Leonard G. Luyt
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Crossref

A Compact and Synthetically Accessible Fluorine‐18 Labelled Cyclooctyne Prosthetic Group for Labelling of Biomolecules by Copper‐Free Click Chemistry

ChemMedChem
2018-08-20 | Journal article
DOI: 10.1002/cmdc.201800334
Contributors: Emily Murrell; Michael S. Kovacs; Leonard G. Luyt
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Crossref

Development of Candidates for Positron Emission Tomography (PET) Imaging of Ghrelin Receptor in Disease: Design, Synthesis, and Evaluation of Fluorine-Bearing Quinazolinone Derivatives

Journal of Medicinal Chemistry
2018-02-08 | Journal article
DOI: 10.1021/acs.jmedchem.7b01754
Contributors: Jinqiang Hou; Michael S. Kovacs; Savita Dhanvantari; Leonard G. Luyt
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Crossref

Copper-assisted azide-alkyne cycloaddition chemistry as a tool for the production of emissive boron difluoride 3-cyanoformazanates

Organic Chemistry Frontiers
2017 | Journal article
DOI: 10.1039/c6qo00640j
EID:

2-s2.0-85011371230
Contributors: Barbon, S.M.; Novoa, S.; Bender, D.; Groom, H.; Luyt, L.G.; Gilroy, J.B.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis

Integrative Biology
2017 | Journal article
DOI: 10.1039/C7IB00002B
Contributors: S. B. Bahrami; C. Tolg; T. Peart; C. Symonette; M. Veiseh; J. U. Umoh; D. W. Holdsworth; J. B. McCarthy; L. G. Luyt; M. J. Bissell et al.
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The interaction of a structural flexible small molecule with nucleic acid structures: Investigation of the origin of fluorescence signal discrimination in sensing and the utilization in live cell imaging

Sensors and Actuators, B: Chemical
2017 | Journal article
DOI: 10.1016/j.snb.2017.05.018
EID:

2-s2.0-85019146176
Contributors: Sun, N.; Wang, C.; Xu, M.-H.; Lu, Y.-J.; Zheng, Y.-Y.; Yan, Y.; Guo, X.-L.; Hou, J.; Zhang, K.; Luyt, L.G. et al.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature

Nanoscale
2017 | Journal article
DOI: 10.1039/C7NR02558K
Contributors: Choi-Fong Cho; Lihai Yu; Tienabe K. Nsiama; Alisha N. Kadam; Arun Raturi; Sourabh Shukla; Giulio A. Amadei; Nicole F. Steinmetz; Leonard G. Luyt; John D. Lewis
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Preferred source (of 2)‎

Bombesin‐functionalized water‐soluble gold nanoparticles for targeting prostate cancer

Journal of Interdisciplinary Nanomedicine
2017-12 | Journal article
DOI: 10.1002/jin2.33
Contributors: Emily J. Simpson; Pierangelo Gobbo; Fernanda C. Bononi; Emily Murrell; Mark S. Workentin; Leonard G. Luyt
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Crossref

Structure–Activity Study of Ghrelin(1–8) Resulting in High Affinity Fluorine-Bearing Ligands for the Ghrelin Receptor

Journal of Medicinal Chemistry
2017-09-14 | Journal article
DOI: 10.1021/acs.jmedchem.7b00164
Contributors: Carlie L. Charron; Jinqiang Hou; Mark S. McFarland; Savita Dhanvantari; Michael S. Kovacs; Leonard G. Luyt
Source: check_circle
Crossref

Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries

ACS Combinatorial Science
2016 | Journal article
DOI: 10.1021/acscombsci.5b00180
EID:

2-s2.0-84974578385
Contributors: Cho, C.-F.; Lee, K.; Speranza, M.-C.; Bononi, F.C.; Viapiano, M.S.; Luyt, L.G.; Weissleder, R.; Chiocca, E.A.; Lee, H.; Lawler, S.E.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Evaluation of 6-([<sup>18</sup>F] fluoroacetamido)-1-hexanoic-anilide (<sup>18</sup>F-FAHA) as imaging probe in tumor xenograft mice model

Progress in Biomedical Optics and Imaging - Proceedings of SPIE
2016 | Conference paper
DOI: 10.1117/12.2216905
EID:

2-s2.0-84978861766
Contributors: Li, F.; Cho, S.J.; Yu, L.; Hudson, R.H.E.; Luyt, L.G.; Pin, C.L.; Kovacs, M.S.; Koropatnick, J.; Lee, T.-Y.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Molecular Engineering of Thiazole Orange Dye: Change of Fluorescent Signaling from Universal to Specific upon Binding with Nucleic Acids in Bioassay

ACS Chemical Biology
2016 | Journal article
DOI: 10.1021/acschembio.5b00987
EID:

2-s2.0-84966263743
Contributors: Lu, Y.-J.; Deng, Q.; Hou, J.-Q.; Hu, D.-P.; Wang, Z.-Y.; Zhang, K.; Luyt, L.G.; Wong, W.-L.; Chow, C.-F.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Molecular imaging probes derived from natural peptides

Natural Product Reports
2016 | Journal article
DOI: 10.1039/c5np00083a
EID:

2-s2.0-84973650183
Contributors: Charron, C.L.; Hickey, J.L.; Nsiama, T.K.; Cruickshank, D.R.; Turnbull, W.L.; Luyt, L.G.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Novel Methods of Determining Urinary Calculi Composition: Petrographic Thin Sectioning of Calculi and Nanoscale Flow Cytometry Urinalysis

Scientific Reports
2016 | Journal article
DOI: 10.1038/srep19328
EID:

2-s2.0-84954513541
Contributors: Gavin, C.T.; Ali, S.N.; Tailly, T.; Olvera-Posada, D.; Alenezi, H.; Power, N.E.; Hou, J.; St. Amant, A.H.; Luyt, L.G.; Wood, S. et al.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Bridging computational modeling with amino acid replacements to investigate GHS-R1a-peptidomimetic recognition

European Journal of Medicinal Chemistry
2016-11 | Journal article
DOI: 10.1016/j.ejmech.2016.07.078
Contributors: Jinqiang Hou; Carlie L. Charron; Milan M. Fowkes; Leonard G. Luyt
Source: check_circle
Crossref

An integrated imaging probe design: The synthesis of 99mTc/Re-containing macrocyclic peptide scaffolds

Chemistry - A European Journal
2015 | Journal article
DOI: 10.1002/chem.201404774
EID:

2-s2.0-84920180988
Contributors: Hickey, J.L.; Simpson, E.J.; Hou, J.; Luyt, L.G.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Evaluation of Anisole-Substituted Boron Difluoride Formazanate Complexes for Fluorescence Cell Imaging

Chemistry - A European Journal
2015 | Journal article
DOI: 10.1002/chem.201502821
EID:

2-s2.0-84944910155
Contributors: Maar, R.R.; Barbon, S.M.; Sharma, N.; Groom, H.; Luyt, L.G.; Gilroy, J.B.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach

Chemical Communications
2015 | Journal article
DOI: 10.1039/c4cc06951j
EID:

2-s2.0-84915819840
Contributors: Hou, J.-Q.; Chen, S.-B.; Zan, L.-P.; Ou, T.-M.; Tan, J.-H.; Luyt, L.G.; Huang, Z.-S.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR)

Integrative Biology (United Kingdom)
2015 | Journal article
DOI: 10.1039/c5ib00222b
EID:

2-s2.0-84948742436
Contributors: Esguerra, K.V.N.; Tolg, C.; Akentieva, N.; Price, M.; Cho, C.-F.; Lewis, J.D.; McCarthy, J.B.; Turley, E.A.; Luyt, L.G.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Nanomedicine—nanoparticles in cancer imaging and therapy

Cancer Metastasis - Biology and Treatment
2015 | Book
DOI: 10.1007/978-3-319-12136-910
EID:

2-s2.0-84916232562
Contributors: Hauser-Kawaguchi, A.M.N.; Luyt, L.G.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Nanomedicine—nanoparticles in cancer imaging and therapy

Cancer Metastasis - Biology and Treatment
2015 | Book
DOI: 10.1007/978-3-319-12136-9_10
EID:

2-s2.0-84921520364
Contributors: Hauser-Kawaguchi, A.M.N.; Luyt, L.G.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Synthesis and cell-based screening of one-bead-one- compound peptide libraries

Methods in Molecular Biology
2015 | Book
DOI: 10.1007/978-1-4939-2020-4_15
EID:

2-s2.0-84922032563
Contributors: Bononi, F.C.; Luyt, L.G.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Synthesis and evaluation of optical and PET GLP-1 peptide analogues for GLP-1R imaging

Molecular Imaging
2015 | Journal article
DOI: 10.2310/7290.2014.00057
EID:

2-s2.0-84928997163
Contributors: Azad, B.B.; Rota, V.; Yu, L.; McGirr, R.; St. Amant, A.H.; Lee, T.-Y.; Dhanvantari, S.; Luyt, L.G.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

The development of organometallic OBOC peptide libraries and sequencing of N-terminal rhenium(I) tricarbonyl-containing peptides utilizing MALDI tandem mass spectrometry

Canadian Journal of Chemistry
2015 | Journal article
DOI: 10.1139/cjc-2014-0259
EID:

2-s2.0-84921763415
Contributors: Cruickshank, D.R.; Luyt, L.G.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier

Characterization of a far-red analog of ghrelin for imaging GHS-R in P19-derived cardiomyocytes

Peptides
2014 | Journal article
DOI: 10.1016/j.peptides.2014.01.011
EID:

2-s2.0-84893833093
Contributors: Douglas, G.A.F.; McGirr, R.; Charlton, C.L.; Kagan, D.B.; Hoffman, L.M.; Luyt, L.G.; Dhanvantari, S.
Source: Self-asserted source
Leonard Luyt via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (49 reviews for 10 publications/grants)

Review activity for ACS combinatorial science. (1)
Review activity for ACS medicinal chemistry letters. (2)
Review activity for ACS omega. (6)
Review activity for Bioconjugate chemistry. (4)
Review activity for ChemMedChem. (4)
Review activity for Inorganic chemistry. (2)
Review activity for Journal of medicinal chemistry. (21)
Review activity for Molecular imaging and biology (1)
Review activity for Molecular pharmaceutics. (7)
Review activity for Organic letters. (1)
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