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https://www.mskcc.org/research-areas/labs/danwei-huangfu

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Scopus Author ID: 6602142501

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Employment (2)

Memorial Sloan Kettering Cancer Center: New York, New York, US

2010-09-01 to present | Member and Professor (Developmental Biology)
Employment
Source: Self-asserted source
Danwei Huangfu

Cornell University, Weill Cornell Graduate School of Medical Sciences: New York, NY, US

2010-09-01 to present | Professor (Cell and Developmental Biology)
Employment
Source: Self-asserted source
Danwei Huangfu

Works (50 of 52)

Items per page:
Page 1 of 2

Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions.

Nature genetics
2023-07-24 | Journal article | Author
DOI: 10.1038/s41588-023-01450-7
PMID: 37488417
Contributors: Luo R; Yan J; Jin Woo Oh; Xi W; Shigaki D; Wong W; Hyein S. Cho; Murphy D; Cutler R; Rosen BP et al.
Source: Self-asserted source
Danwei Huangfu

Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project.

Molecular cell
2023-07-06 | Journal article
DOI: 10.1016/j.molcel.2023.06.018
PMID: 37419111
Contributors: Job Dekker; Alber F; Aufmkolk S; Beliveau BJ; Bruneau BG; Belmont AS; Bintu L; Boettiger A; Calandrelli R; Disteche CM et al.
Source: Self-asserted source
Danwei Huangfu

MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state.

Nature cell biology
2023-01-05 | Journal article | Author
DOI: 10.1038/s41556-022-01045-0
PMID: 36604594
PMC: PMC10003829
Contributors: jihong cui; Zhang C; Ji-Eun Lee; Bartholdy BA; Dapeng Yang; Liu Y; Erler P; Galbo PM Jr; Dayle Hodge; Danwei Huangfu et al.
Source: Self-asserted source
Danwei Huangfu

Genetic Engineering of Immune Evasive Stem Cell-Derived Islets.

Transplant international : official journal of the European Society for Organ Transplantation
2022-12-05 | Journal article
DOI: 10.3389/ti.2022.10817
PMID: 36545154
PMC: PMC9762357
Contributors: Sackett SD; Kaplan SJ; Mitchell SA; Brown ME; Burrack AL; Grey S; Huangfu D; Odorico J
Source: Self-asserted source
Danwei Huangfu

A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation.

Biology open
2022-08-08 | Journal article | Author
DOI: 10.1242/bio.059307
PMID: 35876795
PMC: PMC9382117
Contributors: Tingxu Chen; Alcorn H; Devbhandari S; Dirk Remus; Elizabeth Lacy; Danwei Huangfu; Kathryn Anderson
Source: Self-asserted source
Danwei Huangfu

CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction.

Nature cell biology
2022-07-04 | Journal article
DOI: 10.1038/s41556-022-00946-4
PMID: 35787684
Source: Self-asserted source
Danwei Huangfu

Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8.

Nature metabolism
2022-01-20 | Journal article
DOI: 10.1038/s42255-021-00516-2
PMID: 35058633
Source: Self-asserted source
Danwei Huangfu
grade
Preferred source (of 2)‎

Epigenome rewiring in human pluripotent stem cells.

Trends in cell biology
2021-12-23 | Journal article
DOI: 10.1016/j.tcb.2021.12.001
PMID: 34955367
Source: Self-asserted source
Danwei Huangfu

209.7: An Inducible Genome Engineering Approach for Preventing Immune Rejection of hESC-derived Beta Cells.

Transplantation
2021-12-01 | Journal article
DOI: 10.1097/01.tp.0000804364.20737.4c
PMID: 34908318
Source: Self-asserted source
Danwei Huangfu

Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.

Cell reports
2021-12-01 | Journal article
DOI: 10.1016/j.celrep.2021.110095
PMID: 34879277
Source: Self-asserted source
Danwei Huangfu

Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors.

Oncogene
2021-06-30 | Journal article
DOI: 10.1038/s41388-021-01843-0
PMID: 34193943
Source: Self-asserted source
Danwei Huangfu

QSER1 protects DNA methylation valleys from de novo methylation.

Science (New York, N.Y.)
2021-04-01 | Journal article
DOI: 10.1126/science.abd0875
PMID: 33833093
Source: Self-asserted source
Danwei Huangfu

Kathryn Anderson (1952-2020).

Cell
2021-03-01 | Journal article
DOI: 10.1016/j.cell.2021.01.054
PMID: 33667364
Source: Self-asserted source
Danwei Huangfu

Kathryn Anderson (1952-2020).

Developmental cell
2021-02-01 | Journal article
DOI: 10.1016/j.devcel.2021.01.009
PMID: 33561421
Source: Self-asserted source
Danwei Huangfu

Enhancer Predictions and Genome-Wide Regulatory Circuits.

Annual review of genomics and human genetics
2020-05-22 | Journal article
DOI: 10.1146/annurev-genom-121719-010946
PMID: 32443951
Source: Self-asserted source
Danwei Huangfu

Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency.

Wiley interdisciplinary reviews. Systems biology and medicine
2019-08 | Journal article
DOI: 10.1002/wsbm.1464
PMID: 31407519
Contributors: Li QV; Rosen BP; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation.

Cell reports
2019-07 | Journal article
DOI: 10.1016/j.celrep.2019.06.034
PMID: 31291575
PMC: PMC6636862
Contributors: Lee K; Cho H; Rickert RW; Li QV; Pulecio J; Leslie CS; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Glutamine independence is a selectable feature of pluripotent stem cells.

Nature metabolism
2019-07-08 | Journal article
DOI: 10.1038/s42255-019-0082-3
PMID: 31511848
PMC: PMC6737941
Source: Self-asserted source
Danwei Huangfu

Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation.

Nature genetics
2019-05 | Journal article
DOI: 10.1038/s41588-019-0408-9
PMID: 31110351
Contributors: Li QV; Dixon G; Verma N; Rosen BP; Gordillo M; Luo R; Xu C; Wang Q; Soh CL; Yang D et al.
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells.

Stem cell reports
2018-08 | Journal article
DOI: 10.1016/j.stemcr.2018.07.013
PMID: 30146489
PMC: PMC6135725
Contributors: Teijeiro V; Yang D; Majumdar S; González F; Rickert RW; Xu C; Koche R; Verma N; Lai EC; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

Transplantation
2018-08 | Journal article
DOI: 10.1097/tp.0000000000002217
PMID: 29781950
Contributors: Odorico J; Markmann J; Melton D; Greenstein J; Hwa A; Nostro C; Rezania A; Oberholzer J; Pipeleers D; Yang L et al.
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Discovery of a drug candidate for GLIS3-associated diabetes.

Nature communications
2018-07 | Journal article
DOI: 10.1038/s41467-018-04918-x
PMID: 29992946
PMC: PMC6041295
Contributors: Amin S; Cook B; Zhou T; Ghazizadeh Z; Lis R; Zhang T; Khalaj M; Crespo M; Perera M; Xiang JZ et al.
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Decoding the noncoding genome via large-scale CRISPR screens.

Current opinion in genetics & development
2018-06 | Journal article
DOI: 10.1016/j.gde.2018.06.001
PMID: 29913329
Contributors: Shukla A; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Genome-Wide Identification of HES1 Target Genes Uncover Novel Roles for HES1 in Pancreatic Development

2018-05 | Other
DOI: 10.1101/335869
OTHER-ID:

PPR10671
Contributors: de Lichtenberg KH; Funa N; Nakic N; Ferrer J; Zhu Z; Huangfu D; Serup P
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.

Nature genetics
2018-01 | Journal article
DOI: 10.1038/s41588-017-0002-y
PMID: 29203910
Contributors: Verma N; Pan H; Doré LC; Shukla A; Li QV; Pelham-Webb B; Teijeiro V; González F; Krivtsov A; Chang CJ et al.
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

CRISPR/Cas-mediated knockin in human pluripotent stem cells

Methods in Molecular Biology
2017 | Book
DOI: 10.1007/978-1-4939-6539-7_9
EID:

2-s2.0-84994311202
Contributors: Verma, N.; Zhu, Z.; Huangfu, D.
Source: Self-asserted source
Danwei Huangfu via Scopus - Elsevier

CRISPR/Cas9-Based Engineering of the Epigenome

Cell Stem Cell
2017 | Journal article
DOI: 10.1016/j.stem.2017.09.006
EID:

2-s2.0-85032478389
Contributors: Pulecio, J.; Verma, N.; Mejía-Ramírez, E.; Huangfu, D.; Raya, A.
Source: Self-asserted source
Danwei Huangfu via Scopus - Elsevier

CRISPR/Cas9-mediated mutagenesis of human pluripotent stem cells in defined xeno-free E8 medium

Methods in Molecular Biology
2017 | Book
DOI: 10.1007/978-1-4939-6472-7_5
EID:

2-s2.0-84990932227
Contributors: Soh, C.-L.; Huangfu, D.
Source: Self-asserted source
Danwei Huangfu via Scopus - Elsevier

Genome editing and directed differentiation of hPSCs for interrogating lineage determinants in human pancreatic development

Journal of Visualized Experiments
2017 | Journal article
DOI: 10.3791/55267
EID:

2-s2.0-85017125158
Contributors: Shi, Z.-D.; Soh, C.-L.; Zhu, Z.; Huangfu, D.
Source: Self-asserted source
Danwei Huangfu via Scopus - Elsevier

Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development

Cell Stem Cell
2017 | Journal article
DOI: 10.1016/j.stem.2017.01.001
EID:

2-s2.0-85012873249
Contributors: Shi, Z.-D.; Lee, K.; Yang, D.; Amin, S.; Verma, N.; Li, Q.V.; Zhu, Z.; Soh, C.-L.; Kumar, R.; Evans, T. et al.
Source: Self-asserted source
Danwei Huangfu via Scopus - Elsevier

The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells

Cell Stem Cell
2017 | Journal article
DOI: 10.1016/j.stem.2016.10.002
EID:

2-s2.0-85007227714
Contributors: Wang, Q.; Zou, Y.; Nowotschin, S.; Kim, S.Y.; Li, Q.V.; Soh, C.-L.; Su, J.; Zhang, C.; Shu, W.; Xi, Q. et al.
Source: Self-asserted source
Danwei Huangfu via Scopus - Elsevier

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

Cell Stem Cell
2016 | Journal article
DOI: 10.1016/j.stem.2016.03.015
EID:

2-s2.0-84964576014
Contributors: Zhu, Z.; Li, Q.V.; Lee, K.; Rosen, B.P.; González, F.; Soh, C.-L.; Huangfu, D.
Source: Self-asserted source
Danwei Huangfu via Scopus - Elsevier

Mechanisms underlying the formation of induced pluripotent stem cells.

2016-01 | Journal article
DOI: 10.1002/wdev.206
PMID: 26383234
Contributors: González F; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

A CRISPR/Cas-Mediated Selection-free Knockin Strategy in Human Embryonic Stem Cells.

2015-06 | Journal article
DOI: 10.1016/j.stemcr.2015.04.016
PMID: 26028531
PMC: PMC4471821
Contributors: Zhu Z; Verma N; González F; Shi ZD; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells.

2015-06 | Journal article
DOI: 10.1038/nbt.3178
PMID: 25798938
PMC: PMC4464949
Contributors: Kotini AG; Chang CJ; Boussaad I; Delrow JJ; Dolezal EK; Nagulapally AB; Perna F; Fishbein GA; Klimek VM; Hawkins RD et al.
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Chemicals Facilitating Reprogramming

Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies
2014 | Book
DOI: 10.1002/9781118695746.ch9
EID:

2-s2.0-85016083051
Contributors: Shi, Z.; González, F.; Huangfu, D.
Source: Self-asserted source
Danwei Huangfu via Scopus - Elsevier

The iCRISPR platform for rapid genome editing in human pluripotent stem cells.

2014 | Journal article
DOI: 10.1016/B978-0-12-801185-0.00011-8
PMID: 25398343
PMC: PMC4418970
Contributors: Zhu Z; González F; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells.

2014-08 | Journal article
DOI: 10.1016/j.stem.2014.05.018
PMID: 24931489
PMC: PMC4127112
Contributors: González F; Zhu Z; Shi ZD; Lelli K; Verma N; Li QV; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Stem cell epigenetics: looking forward.

2014-06 | Journal article
DOI: 10.1016/j.stem.2014.05.011
PMID: 25032261
Contributors: Benitah SA; Bracken A; Dou Y; Huangfu D; Ivanova N; Koseki H; Laurent L; Lim DA; Meshorer E; Pombo A et al.
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state.

2013-03 | Journal article
DOI: 10.1016/j.celrep.2013.02.005
PMID: 23478019
PMC: PMC4315363
Contributors: González F; Georgieva D; Vanoli F; Shi ZD; Stadtfeld M; Ludwig T; Jasin M; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Human pluripotent stem cells: an emerging model in developmental biology.

2013-02 | Journal article
DOI: 10.1242/dev.086165
PMID: 23362344
PMC: PMC3557771
Contributors: Zhu Z; Huangfu D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Glucose and aging control the quiescence period that follows pancreatic beta cell replication.

2010-10 | Journal article
DOI: 10.1242/dev.054304
PMID: 20823063
PMC: PMC2934733
Contributors: Salpeter SJ; Klein AM; Huangfu D; Grimsby J; Dor Y
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

2009-11 | Journal article
DOI: 10.1016/j.stem.2009.09.012
PMID: 19818703
PMC: PMC3335195
Contributors: Ichida JK; Blanchard J; Lam K; Son EY; Chung JE; Egli D; Loh KM; Carter AC; Di Giorgio FP; Koszka K et al.
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

2008-11 | Journal article
DOI: 10.1038/nbt.1502
PMID: 18849973
Contributors: Huangfu D; Osafune K; Maehr R; Guo W; Eijkelenboom A; Chen S; Muhlestein W; Melton DA
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.

2008-07 | Journal article
DOI: 10.1038/nbt1418
PMID: 18568017
Contributors: Huangfu D; Maehr R; Guo W; Eijkelenboom A; Snitow M; Chen AE; Melton DA
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Correction: All ß Cells Contribute Equally to Islet Growth and Maintenance.

2007-09 | Journal article
PMC: PMC1994270
Contributors: Brennand K; Huangfu D; Melton D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

All beta cells contribute equally to islet growth and maintenance.

2007-07 | Journal article
DOI: 10.1371/journal.pbio.0050163
PMID: 17535113
PMC: PMC1877817
Contributors: Brennand K; Huangfu D; Melton D
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates.

2006-01 | Journal article
DOI: 10.1242/dev.02169
PMID: 16339192
Contributors: Huangfu D; Anderson KV
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Cilia and Hedgehog responsiveness in the mouse.

2005-08 | Journal article
DOI: 10.1073/pnas.0505328102
PMID: 16061793
PMC: PMC1183606
Contributors: Huangfu D; Anderson KV
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

2005-04 | Journal article
DOI: 10.1073/pnas.0501071102
PMID: 15755804
PMC: PMC1087930
Contributors: García-García MJ; Eggenschwiler JT; Caspary T; Alcorn HL; Wyler MR; Huangfu D; Rakeman AS; Lee JD; Feinberg EH; Timmer JR et al.
Source: Self-asserted source
Danwei Huangfu via Europe PubMed Central
Items per page:
Page 1 of 2

Peer review (26 reviews for 13 publications/grants)

Review activity for British journal of cancer. (1)
Review activity for Cell genomics. (3)
Review activity for Cell reports. (2)
Review activity for Communications biology. (1)
Review activity for Nature (1)
Review activity for Nature communications (9)
Review activity for Nature genetics. (1)
Review activity for Nature metabolism. (1)
Review activity for Nature neuroscience. (1)
Review activity for Nature reviews. (1)
Review activity for Science. (1)
Review activity for Stem cell reports. (2)
Review activity for Trends in endocrinology and metabolism (2)
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