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Scopus Author ID: 7401746254

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Employment (1)

University of Rochester: Rochester, NY, US

1998-12-01 to present | Professor (Medicine)
Employment
Source: Self-asserted source
Chen Yan

Education and qualifications (1)

University of Washington: Seattle, WA, US

1991-09-01 to 1996-05-30 | PhD (Pharmacology)
Qualification
Source: Self-asserted source
Chen Yan

Funding (1)

Focusing on the Regulation of Intercellular Communication Mediated by Cardiomyocytes

2024-07-01 to 2027-06-30 | Grant
American Heart Association (Dallas, US)
DOI: 10.58275/AHA.24TPA1299958.pc.gr.198275
GRANT_NUMBER:

24TPA1299958
Source: check_circle
American Heart Association

Works (50 of 149)

Items per page:
Page 1 of 3

MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.

EMBO molecular medicine
2020-12-28 | Journal article
DOI: 10.15252/emmm.202012710
PMID: 33369227
PMC: PMC7863409
Source: Self-asserted source
Chen Yan

Role of IgE-FcεR1 in Pathological Cardiac Remodeling and Dysfunction.

Circulation
2020-12-11 | Journal article
DOI: 10.1161/circulationaha.120.047852
PMID: 33305586
Source: Self-asserted source
Chen Yan

Vinpocetine protects against the development of experimental abdominal aortic aneurysms.

Clinical science (London, England : 1979)
2020-11-01 | Journal article
DOI: 10.1042/cs20201057
PMID: 33111936
Source: Self-asserted source
Chen Yan

An update of cyclic nucleotide phosphodiesterase as a target for cardiac diseases.

Expert opinion on drug discovery
2020-09-21 | Journal article
DOI: 10.1080/17460441.2020.1821643
PMID: 32957823
Source: Self-asserted source
Chen Yan

Response by Chen and Yan to Letter Regarding Article, "A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction".

Circulation
2020-07-20 | Journal article
DOI: 10.1161/circulationaha.120.048259
PMID: 32687445
Source: Self-asserted source
Chen Yan

Vinpocetine Suppresses <i>Streptococcus pneumoniae</i>-Induced Inflammation via Inhibition of ERK1 by CYLD.

Journal of immunology (Baltimore, Md. : 1950)
2020-01-03 | Journal article
DOI: 10.4049/jimmunol.1901299
PMID: 31900337
Source: Self-asserted source
Chen Yan

Updates of Recent Vinpocetine Research in Treating Cardiovascular Diseases.

Journal of cellular immunology
2020-01-01 | Journal article
DOI: 10.33696/immunology.2.045
PMID: 32832931
PMC: PMC7437952
Source: Self-asserted source
Chen Yan

The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla

American Journal of Pathology
2019 | Journal article
DOI: 10.1016/j.ajpath.2019.05.020
EID:

2-s2.0-85070778885
Contributors: Dugbartey, G.J.; Quinn, B.; Luo, L.; Mickelsen, D.M.; Ture, S.K.; Morrell, C.N.; Czyzyk, J.; Doyley, M.M.; Yan, C.; Berk, B.C. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.

Circulation
2019-12-05 | Journal article
DOI: 10.1161/circulationaha.119.042178
PMID: 31801360
PMC: PMC7147986
Source: Self-asserted source
Chen Yan

Patients with advanced chronic kidney disease and vascular calcification have a large hydrodynamic radius of secondary calciprotein particles.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
2019-06-01 | Journal article
DOI: 10.1093/ndt/gfy117
PMID: 29788425
PMC: PMC6545469
Source: Self-asserted source
Chen Yan

An update on vinpocetine: New discoveries and clinical implications

European Journal of Pharmacology
2018 | Journal article
DOI: 10.1016/j.ejphar.2017.11.041
EID:

2-s2.0-85035794409
Contributors: Zhang, Y.-S.; Li, J.-D.; Yan, C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Multiprotein complex with TRPC (transient receptor potential-canonical) channel, PDE1c (phosphodiesterase 1C), and A2R (adenosine A2 receptor) plays a critical role in regulating cardiomyocyte cAMP and survival

Circulation
2018 | Journal article
DOI: 10.1161/CIRCULATIONAHA.118.034189
EID:

2-s2.0-85055666962
Contributors: Zhang, Y.; Knight, W.; Chen, S.; Mohan, A.; Yan, C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling

Cardiovascular Research
2018 | Journal article
DOI: 10.1093/cvr/cvy035
EID:

2-s2.0-85044765711
Contributors: Zuo, C.; Li, X.; Huang, J.; Chen, D.; Ji, K.; Yang, Y.; Xu, T.; Zhu, D.; Yan, C.; Gao, P.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients

Translational Stroke Research
2018 | Journal article
DOI: 10.1007/s12975-017-0549-z
EID:

2-s2.0-85021965283
Contributors: Zhang, F.; Yan, C.; Wei, C.; Yao, Y.; Ma, X.; Gong, Z.; Liu, S.; Zang, D.; Chen, J.; Shi, F.-D. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Dexamethasone Inhibits Synergistic Induction of PDE4B Expression by Roflumilast and Bacterium NTHi

International Journal of Molecular Sciences
2018-11 | Journal article | Author
DOI: 10.3390/ijms19113511
Contributors: Byungcheol Lee; Seiko Susuki-Miyata; Chen Yan; Jian-Dong Li
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Roles of PDE1 in Pathological Cardiac Remodeling and Dysfunction

Journal of Cardiovascular Development and Disease
2018-04 | Journal article
DOI: 10.3390/jcdd5020022
Source: check_circle
Multidisciplinary Digital Publishing Institute

Glutaredoxin 1 mediates the protective efect of steady laminar fow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim

Scientific Reports
2017 | Journal article
DOI: 10.1038/s41598-017-15672-3
EID:

2-s2.0-85034101535
Contributors: Li, Y.; Ren, M.; Wang, X.; Cui, X.; Zhao, H.; Zhao, C.; Zhou, J.; Guo, Y.; Hu, Y.; Yan, C. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Loss of osteoglycin promotes angiogenesis in limb ischaemiamousemodels viamodulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway

Cardiovascular Research
2017 | Journal article
DOI: 10.1093/cvr/cvw220
EID:

2-s2.0-85016015338
Contributors: Wu, Q.-H.; Ma, Y.; Ruan, C.-C.; Yang, Y.; Liu, X.-H.; Ge, Q.; Kong, L.-R.; Zhang, J.-W.; Yan, C.; Gao, P.-J.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice

Scientific Reports
2017 | Journal article
DOI: 10.1038/s41598-017-12321-7
EID:

2-s2.0-85029866041
Contributors: Korshunov, V.A.; Wang, H.; Ahmed, R.; Mickelsen, D.M.; Zhou, Q.; Yan, C.; Doyley, M.M.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Phospholipase Cγ1 mediates intima formation through Akt-Notch1 signaling independent of the phospholipase activity

Journal of the American Heart Association
2017 | Journal article
DOI: 10.1161/JAHA.117.005537
EID:

2-s2.0-85025445762
Contributors: Jiang, D.; Zhuang, J.; Peng, W.; Lu, Y.; Liu, H.; Zhao, Q.; Chi, C.; Li, X.; Zhu, G.; Xu, X. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Vinpocetine Attenuates Pathological Cardiac Remodeling by Inhibiting Cardiac Hypertrophy and Fibrosis

Cardiovascular Drugs and Therapy
2017 | Journal article
DOI: 10.1007/s10557-017-6719-0
EID:

2-s2.0-85015667471
Contributors: Wu, M.-P.; Zhang, Y.-S.; Xu, X.; Zhou, Q.; Li, J.-D.; Yan, C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cell inflammation and dysfunction

Journal of Molecular and Cellular Cardiology
2016 | Journal article
DOI: 10.1016/j.yjmcc.2016.02.001
EID:

2-s2.0-84958549716
Contributors: Zhang, Z.-B.; Ruan, C.-C.; Chen, D.-R.; Zhang, K.; Yan, C.; Gao, P.-J.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β<inf>2</inf>-AR/PI3K/AKT signaling pathway

Pharmacological Research
2016 | Journal article
DOI: 10.1016/j.phrs.2015.12.032
EID:

2-s2.0-84953250455
Contributors: Wu, M.-P.; Zhang, Y.-S.; Zhou, Q.-M.; Xiong, J.; Dong, Y.-R.; Yan, C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

Proceedings of the National Academy of Sciences of the United States of America
2016 | Journal article
DOI: 10.1073/pnas.1607728113
EID:

2-s2.0-84994528953
Contributors: Knight, W.E.; Chen, S.; Zhang, Y.; Oikawa, M.; Wu, M.; Zhou, Q.; Miller, C.L.; Cai, Y.; Mickelsen, D.M.; Moravec, C. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury

Journal of Cardiovascular Pharmacology and Therapeutics
2016 | Journal article
DOI: 10.1177/1074248415591700
EID:

2-s2.0-84959232562
Contributors: Shi, X.; O'Neill, M.M.; Macdonnell, S.; Brookes, P.S.; Yan, C.; Berk, B.C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1α and transforming growth factor-β1 expression

Hypertension
2015 | Journal article
DOI: 10.1161/HYPERTENSIONAHA.115.05654
EID:

2-s2.0-84941215708
Contributors: Huang, C.-K.; Luo, J.; Lai, K.-P.; Wang, R.; Pang, H.; Chang, E.; Yan, C.; Sparks, J.; Lee, S.O.; Cho, J. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Complement-Mediated Macrophage Polarization in Perivascular Adipose Tissue Contributes to Vascular Injury in Deoxycorticosterone Acetate-Salt Mice

Arteriosclerosis, Thrombosis, and Vascular Biology
2015 | Journal article
DOI: 10.1161/ATVBAHA.114.304927
EID:

2-s2.0-84922235080
Contributors: Ruan, C.-C.; Ge, Q.; Li, Y.; Li, X.-D.; Chen, D.-R.; Ji, K.-D.; Wu, Y.-J.; Sheng, L.-J.; Yan, C.; Zhu, D.-L. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
DOI: 10.1073/pnas.1418716112
EID:

2-s2.0-84928807928
Contributors: Susuki-Miyata, S.; Miyata, M.; Lee, B.-C.; Xu, H.; Kai, H.; Yan, C.; Li, J.-D.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Cyclic nucleotide phosphodiesterase 1 and vascular aging

Clinical Science
2015 | Journal article
DOI: 10.1042/CS20150605
EID:

2-s2.0-84951985233
Contributors: Yan, C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Downregulation of Dynamin-Related Protein 1 Contributes to Impaired Autophagic Flux and Angiogenic Function in Senescent Endothelial Cells

Arteriosclerosis, Thrombosis, and Vascular Biology
2015 | Journal article
DOI: 10.1161/ATVBAHA.115.305706
EID:

2-s2.0-84933041134
Contributors: Lin, J.-R.; Shen, W.-L.; Yan, C.; Gao, P.-J.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia

Circulation Research
2015 | Journal article
DOI: 10.1161/CIRCRESAHA.116.304408
EID:

2-s2.0-84942981204
Contributors: Cai, Y.; Nagel, D.J.; Zhou, Q.; Cygnar, K.D.; Zhao, H.; Li, F.; Pi, X.; Knight, P.A.; Yan, C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media

Journal of Immunology
2015 | Journal article
DOI: 10.4049/jimmunol.1401489
EID:

2-s2.0-84931405251
Contributors: Lee, J.-Y.; Komatsu, K.; Lee, B.-C.; Miyata, M.; Bohn, A.O.; Xu, H.; Yan, C.; Li, J.-D.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Biological values of acupuncture and chinese herbal medicine: Impact on the life science

Evidence-based Complementary and Alternative Medicine
2014 | Journal article
DOI: 10.1155/2014/593921
EID:

2-s2.0-84893785303
Contributors: Yang, Y.-Q.; Yan, C.; Branford-White, C.J.; Hou, X.-Y.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Impaired angiogenesis during fracture healing in GPCR Kinase 2 interacting protein-1 (GIT1) knock out mice

PLoS ONE
2014 | Journal article
DOI: 10.1371/journal.pone.0089127
EID:

2-s2.0-84896801533
Contributors: Yin, G.; Sheu, T.-J.; Menon, P.; Pang, J.; Ho, H.-C.; Shi, S.; Xie, C.; Smolock, E.; Yan, C.; Zuscik, M.J. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Phosphodiesterase 3A1 protects the heart against angiotensin ii-induced cardiac remodeling through regulation of transforming growth factor-β expression

International Heart Journal
2014 | Journal article
DOI: 10.1536/ihj.13-268
EID:

2-s2.0-84897059273
Contributors: Iwaya, S.; Oikawa, M.; Chen, Y.; Takeishi, Y.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Thioredoxin-interacting protein is a biomechanical regulator of src activity: Key role in endothelial cell stress fiber formation

Circulation Research
2014 | Journal article
DOI: 10.1161/CIRCRESAHA.114.301315
EID:

2-s2.0-84897499180
Contributors: Spindel, O.N.; Burke, R.M.; Yan, C.; Berk, B.C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury

Journal of Molecular and Cellular Cardiology
2013 | Journal article
DOI: 10.1016/j.yjmcc.2013.08.003
EID:

2-s2.0-84883701893
Contributors: Oikawa, M.; Wu, M.; Lim, S.; Knight, W.E.; Miller, C.L.; Cai, Y.; Lu, Y.; Blaxall, B.C.; Takeishi, Y.; Abe, J.-I. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD

Nature Communications
2013 | Journal article
DOI: 10.1038/ncomms2674
EID:

2-s2.0-84877786775
Contributors: Komatsu, K.; Lee, J.-Y.; Miyata, M.; Hyang Lim, J.; Jono, H.; Koga, T.; Xu, H.; Yan, C.; Kai, H.; Li, J.-D.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Smooth muscle cell plasticity: fact or fiction?

Circulation research
2013 | Other
DOI: 10.1161/CIRCRESAHA.112.281048
EID:

2-s2.0-84874429367
Contributors: Nguyen, A.T.; Gomez, D.; Bell, R.D.; Campbell, J.H.; Clowes, A.W.; Gabbiani, G.; Giachelli, C.M.; Parmacek, M.S.; Raines, E.W.; Rusch, N.J. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Therapeutic potential of PDE modulation in treating heart disease

Future Medicinal Chemistry
2013 | Journal article
DOI: 10.4155/fmc.13.127
EID:

2-s2.0-84884559109
Contributors: Knight, W.; Yan, C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology
2013 | Journal article
DOI: 10.1161/ATVBAHA.112.300386
EID:

2-s2.0-84875370798
Contributors: Park, S.-Y.; Shi, X.; Pang, J.; Yan, C.; Berk, B.C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Vinpocetine attenuates lipid accumulation and atherosclerosis formation

Biochemical and Biophysical Research Communications
2013 | Journal article
DOI: 10.1016/j.bbrc.2013.03.092
EID:

2-s2.0-84880487718
Contributors: Cai, Y.; Li, J.-D.; Yan, C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Cardiac cyclic nucleotide phosphodiesterases: Function, regulation, and therapeutic prospects

Hormone and Metabolic Research
2012 | Journal article
DOI: 10.1055/s-0032-1321870
EID:

2-s2.0-84865662834
Contributors: Knight, W.E.; Yan, C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Corrigendum to p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: A pathogenic mechanism for ischemia-reperfusion injury [J. Mol. Cell. Cardiol. 51 (2011) 272-275]

Journal of Molecular and Cellular Cardiology
2012 | Journal article
DOI: 10.1016/j.yjmcc.2011.11.006
EID:

2-s2.0-84155194932
Contributors: Shi, X.; Yan, C.; Nadtochiy, S.M.; Abe, J.-I.; Brookes, P.S.; Berk, B.C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

Nature Communications
2012 | Journal article
DOI: 10.1038/ncomms1776
EID:

2-s2.0-84860284249
Contributors: Lim, J.H.; Jono, H.; Komatsu, K.; Woo, C.-H.; Lee, J.; Miyata, M.; Matsuno, T.; Xu, X.; Huang, Y.; Zhang, W. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation

Journal of Immunology
2012 | Journal article
DOI: 10.4049/jimmunol.1103527
EID:

2-s2.0-84862627867
Contributors: Xu, X.; Woo, C.-H.; Steere, R.R.; Lee, B.C.; Huang, Y.; Wu, J.; Pang, J.; Lim, J.H.; Xu, H.; Zhang, W. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

P90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction

Circulation Research
2012 | Journal article
DOI: 10.1161/CIRCRESAHA.111.254730
EID:

2-s2.0-84862785619
Contributors: Le, N.-T.; Takei, Y.; Shishido, T.; Woo, C.-H.; Chang, E.; Heo, K.-S.; Lee, H.; Lu, Y.; Morrell, C.; Oikawa, M. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway

Journal of Biological Chemistry
2012 | Journal article
DOI: 10.1074/jbc.M111.337378
EID:

2-s2.0-84863336938
Contributors: Lee, J.; Komatsu, K.; Lee, B.C.; Lim, J.H.; Jono, H.; Xu, H.; Kai, H.; Zhang, Z.J.; Yan, C.; Li, J.-D.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases

Circulation
2012 | Journal article
DOI: 10.1161/CIRCULATIONAHA.112.114074
EID:

2-s2.0-84867881959
Contributors: Ghigo, A.; Perino, A.; Mehel, H.; Zahradníková, A.; Morello, F.; Leroy, J.; Nikolaev, V.O.; Damilano, F.; Cimino, J.; De Luca, E. et al.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier

Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2

Circulation Research
2012 | Journal article
DOI: 10.1161/CIRCRESAHA.111.256362
EID:

2-s2.0-84862816264
Contributors: Wang, X.-Q.; Nigro, P.; World, C.; Fujiwara, K.; Yan, C.; Berk, B.C.
Source: Self-asserted source
Chen Yan via Scopus - Elsevier
Items per page:
Page 1 of 3

Peer review (3 reviews for 3 publications/grants)

Review activity for Nature communications (1)
Review activity for Redox biology. (1)
Review activity for Translational research. (1)
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