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Works (5)

The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway

Nature Communications
2024-11-20 | Journal article
DOI: 10.1038/s41467-024-54212-2
Contributors: Dhiman Ghosh; Felix Torres; Matthias M. Schneider; Dzmitry Ashkinadze; Harindranath Kadavath; Yanick Fleischmann; Simon Mergenthal; Peter Güntert; Georg Krainer; Ewa A. Andrzejewska et al.
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Single-molecule digital sizing of proteins in solution

Nature Communications
2024-09-04 | Journal article
DOI: 10.1038/s41467-024-50825-9
Contributors: Georg Krainer; Raphael P. B. Jacquat; Matthias M. Schneider; Timothy J. Welsh; Jieyuan Fan; Quentin A. E. Peter; Ewa A. Andrzejewska; Greta Šneiderienė; Magdalena A. Czekalska; Hannes Ausserwoeger et al.
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Design of amyloidogenic peptide traps

Nature Chemical Biology
2024-08 | Journal article
DOI: 10.1038/s41589-024-01578-5
Contributors: Danny D. Sahtoe; Ewa A. Andrzejewska; Hannah L. Han; Enrico Rennella; Matthias M. Schneider; Georg Meisl; Maggie Ahlrichs; Justin Decarreau; Hannah Nguyen; Alex Kang et al.
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α-Synuclein oligomers form by secondary nucleation

Nature Communications
2024-08-17 | Journal article
DOI: 10.1038/s41467-024-50692-4
Contributors: Catherine K. Xu; Georg Meisl; Ewa A. Andrzejewska; Georg Krainer; Alexander J. Dear; Marta Castellana-Cruz; Soma Turi; Irina A. Edu; Giorgio Vivacqua; Raphaël P. B. Jacquat et al.
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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning

Nature Chemical Biology
2024-05 | Journal article
DOI: 10.1038/s41589-024-01580-x
Contributors: Robert I. Horne; Ewa A. Andrzejewska; Parvez Alam; Z. Faidon Brotzakis; Ankit Srivastava; Alice Aubert; Magdalena Nowinska; Rebecca C. Gregory; Roxine Staats; Andrea Possenti et al.
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