Personal information

Other IDs

Scopus Author ID: 51161454500
ResearcherID: A-5472-2019
Scopus Author ID: 57203168282

Keywords

Mitochondria, optic neuropathy, neurodegeneration, metabolism

Countries

Australia

Activities

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Employment (6)

Centre for Eye Research Australia Ltd: East Melbourne, VIC, AU

2020-02 to present | Principal Investigator (Mitochondrial Biology and Disease)
Employment
Source: Self-asserted source
Isabel Lopez Sanchez

Karolinska Institute: Stockholm, SE

2019-06 to 2020-01 | Research Fellow (Department of Medical Biochemistry and Biophysics)
Employment
Source: Self-asserted source
Isabel Lopez Sanchez

University of Melbourne: Melbourne, AU

2014 to 2019 | Research Fellow (Mitochondria and Neurodegeneration)
Employment
Source: Self-asserted source
Isabel Lopez Sanchez

Margarita Salas Center for Biological Research: Madrid, ES

2016-09-01 to 2016-11-01 | Visiting Postdoctoral Researcher (Autophagy in Health and Disease Group)
Employment
Source: Self-asserted source
Isabel Lopez Sanchez

Kennedy Krieger Institute: Baltimore, US

2015-06-01 to 2015-07-01 | Visiting Postdoctoral Researcher (Department of Neuroscience)
Employment
Source: Self-asserted source
Isabel Lopez Sanchez

University of Western Australia: Crawley, WA, AU

2013-08 to 2013-09 | Research Assistant (Mitochondrial Medicine and Biology)
Employment
Source: Self-asserted source
Isabel Lopez Sanchez

Education and qualifications (2)

University of Western Australia: Crawley, WA, AU

2010 to 2014 | PhD (Mitochondrial Medicine and Biology)
Education
Source: Self-asserted source
Isabel Lopez Sanchez

Université Pierre et Marie Curie: Paris, Île-de-France, FR

2006 to 2009 | Bachelor of Science (Life Sciences)
Education
Source: Self-asserted source
Isabel Lopez Sanchez

Works (26)

Family and genetic counseling in Leber hereditary optic neuropathy

Ophthalmic Genetics
2025-01-20 | Journal article
DOI: 10.1080/13816810.2025.2451175
Contributors: David A. Mackey; Sandra E. Staffieri; M. Isabel G. Lopez Sanchez; Lisa S. Kearns
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Crossref

Is the disease risk and penetrance in Leber hereditary optic neuropathy actually low?

American Journal of Human Genetics
2023 | Journal article
DOI: 10.1016/j.ajhg.2022.11.014
EID:

2-s2.0-85144923459

Part of ISSN: 15376605 00029297
Contributors: Mackey, D.A.; Ong, J.-S.; MacGregor, S.; Whiteman, D.C.; Craig, J.E.; Lopez Sanchez, M.I.G.; Kearns, L.S.; Staffieri, S.E.; Clarke, L.; McGuinness, M.B. et al.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

MicroRNA-101-3p Modulates Mitochondrial Metabolism via the Regulation of Complex II Assembly

Journal of Molecular Biology
2022 | Journal article
DOI: 10.1016/j.jmb.2021.167361
EID:

2-s2.0-85119853945

Part of ISSN: 10898638 00222836
Contributors: Ziemann, M.; Lim, S.C.; Kang, Y.; Samuel, S.; Sanchez, I.L.; Gantier, M.; Stojanovski, D.; McKenzie, M.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

Nature Communications
2022 | Journal article
DOI: 10.1038/s41467-022-31707-4
EID:

2-s2.0-85134852710

Part of ISSN: 20411723
Contributors: Senabouth, A.; Daniszewski, M.; Lidgerwood, G.E.; Liang, H.H.; Hernández, D.; Mirzaei, M.; Keenan, S.N.; Zhang, R.; Han, X.; Neavin, D. et al.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

Stimulating Mitochondrial Biogenesis with Deoxyribonucleosides Increases Functional Capacity in ECHS1-Deficient Cells

International Journal of Molecular Sciences
2022-10-20 | Journal article
DOI: 10.3390/ijms232012610
Contributors: Harrison James Burgin; Jordan James Crameri; Diana Stojanovski; M. Isabel G. Lopez Sanchez; Mark Ziemann; Matthew McKenzie
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Establishing risk of vision loss in Leber hereditary optic neuropathy

American Journal of Human Genetics
2021 | Journal article
DOI: 10.1016/j.ajhg.2021.09.015
EID:

2-s2.0-85118347675

Part of ISSN: 15376605 00029297
Contributors: Lopez Sanchez, M.I.G.; Kearns, L.S.; Staffieri, S.E.; Clarke, L.; McGuinness, M.B.; Meteoukki, W.; Samuel, S.; Ruddle, J.B.; Chen, C.; Fraser, C.L. et al.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly

Nucleic Acids Research
2021 | Journal article
DOI: 10.1093/nar/gkaa1131
EID:

2-s2.0-85099721478

Part of ISSN: 13624962 03051048
Contributors: Cipullo, M.; Pearce, S.F.; Lopez Sanchez, I.G.; Gopalakrishna, S.; Krüger, A.; Schober, F.; Busch, J.D.; Li, X.; Wredenberg, A.; Atanassov, I. et al.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

MitoScape: A big-data, machine-learning platform for obtaining mitochondrial DNA from next-generation sequencing data

PLOS Computational Biology
2021-11-11 | Journal article
DOI: 10.1371/journal.pcbi.1009594
Contributors: Larry N. Singh; Manja Marz; Brian Ennis; Bryn Loneragan; Noah L. Tsao; M. Isabel G. Lopez Sanchez; Jianping Li; Patrick Acheampong; Oanh Tran; Ian A. Trounce et al.
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Human Mitoribosome Biogenesis and Its Emerging Links to Disease

International Journal of Molecular Sciences
2021-04-07 | Journal article
DOI: 10.3390/ijms22083827
Contributors: Maria Isabel G. Lopez Sanchez; Annika Krüger; Dmitrii I. Shiriaev; Yong Liu; Joanna Rorbach
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Methylation of Ribosomal RNA: A Mitochondrial Perspective

Frontiers in Genetics
2020 | Journal article
DOI: 10.3389/fgene.2020.00761
EID:

2-s2.0-85088507133

Part of ISBN:

16648021
Contributors: Lopez Sanchez, M.I.G.; Cipullo, M.; Gopalakrishna, S.; Khawaja, A.; Rorbach, J.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

OXPHOS bioenergetic compensation does not explain disease penetrance in Leber hereditary optic neuropathy

Mitochondrion
2020 | Journal article
DOI: 10.1016/j.mito.2020.07.003
EID:

2-s2.0-85089659743

Part of ISSN: 18728278 15677249
Contributors: Lopez Sanchez, M.I.G.; Van Bergen, N.J.; Kearns, L.S.; Ziemann, M.; Liang, H.; Hewitt, A.W.; Mackey, D.A.; Trounce, I.A.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response

PLOS ONE
2020-10-08 | Journal article
DOI: 10.1371/journal.pone.0239804
Contributors: M. Isabel G. Lopez Sanchez; Deepak Shukla; Mark Ziemann; Annabell Bachem; Rahul Makam; Jonathan G. Crowston; Carl A. Pinkert; Matthew McKenzie; Sammy Bedoui; Ian A. Trounce
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Pioglitazone and Deoxyribonucleoside Combination Treatment Increases Mitochondrial Respiratory Capacity in m.3243A>G MELAS Cybrid Cells

International Journal of Molecular Sciences
2020-03-20 | Journal article
DOI: 10.3390/ijms21062139
Contributors: Harrison J. Burgin; M. Isabel G. Lopez Sanchez; Craig M. Smith; Ian A. Trounce; Matthew McKenzie
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Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity

Molecular Neurobiology
2019 | Journal article
DOI: 10.1007/s12035-018-1460-7
EID:

2-s2.0-85059512930
Contributors: Cimdins, K.; Waugh, H.S.; Chrysostomou, V.; Lopez Sanchez, M.I.G.; Johannsen, V.A.; Cook, M.J.; Crowston, J.G.; Hill, A.F.; Duce, J.A.; Bush, A.I. et al.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

Correction to: Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (Molecular Neurobiology, (2019), 56, 8, (5471-5482), 10.1007/s12035-018-1460-7)

Molecular Neurobiology
2019 | Journal article
DOI: 10.1007/s12035-019-01726-2
EID:

2-s2.0-85070675941

Part of ISBN:

15591182 08937648
Contributors: Cimdins, K.; Waugh, H.S.; Chrysostomou, V.; Lopez Sanchez, M.I.G.; Johanssen, V.A.; Cook, M.J.; Crowston, J.G.; Hill, A.F.; Duce, J.A.; Bush, A.I. et al.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

Visual recovery as the target for glaucoma,Visuelle Regeneration als Ziel für das Glaukom

Ophthalmologe
2019 | Journal article
DOI: 10.1007/s00347-018-0649-5
EID:

2-s2.0-85041172544
Contributors: Chrysostomou, V.; Hatch, R.J.; Colgan, T.; Paul, J.P.; van Wijngaarden, P.; Trounce, I.; Lopez Sanchez, M.I.G.; Bell, K.; Grus, F.; Crowston, J.G.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

Amyloid precursor protein‐mediated mitochondrial regulation and Alzheimer's disease

British Journal of Pharmacology
2019-09 | Journal article
DOI: 10.1111/bph.14554
Contributors: M Isabel G Lopez Sanchez; Peter van Wijngaarden; Ian A Trounce
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Crossref
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Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma.

Investigative ophthalmology & visual science
2018-09 | Journal article
DOI: 10.1167/iovs.18-25085
PMID: 30242360
PMC: PMC6138263
Contributors: Singh LN; Crowston JG; Lopez Sanchez MIG; Van Bergen NJ; Kearns LS; Hewitt AW; Yazar S; Mackey DA; Wallace DC; Trounce IA
Source: Self-asserted source
Isabel Lopez Sanchez via Europe PubMed Central
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Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis.

BMC medical genomics
2018-07 | Journal article
DOI: 10.1186/s12920-018-0376-4
PMID: 30037347
PMC: PMC6057030
Contributors: De Smit E; Lukowski SW; Anderson L; Senabouth A; Dauyey K; Song S; Wyse B; Wheeler L; Chen CY; Cao K et al.
Source: Self-asserted source
Isabel Lopez Sanchez via Europe PubMed Central
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Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

Scientific Reports
2017-08 | Journal article
DOI: 10.1038/s41598-017-10233-0
Part of ISSN: 2045-2322
Contributors: M. Isabel G. Lopez Sanchez; Hayley S. Waugh; Andrew Tsatsanis; Bruce X. Wong; Jonathan G. Crowston; James A. Duce; Ian A. Trounce
Source: Self-asserted source
Isabel Lopez Sanchez via Crossref Metadata Search
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Emerging Mitochondrial Therapeutic Targets in Optic Neuropathies

Pharmacology & Therapeutics
2016-09 | Journal article
DOI: 10.1016/j.pharmthera.2016.06.004
Part of ISSN: 0163-7258
Contributors: M.I.G. Lopez Sanchez; J.G. Crowston; D.A. Mackey; I.A. Trounce
Source: Self-asserted source
Isabel Lopez Sanchez via Crossref Metadata Search
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Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly

The FASEB Journal
2016-02 | Journal article
DOI: 10.1096/fj.201500137r
Part of ISSN: 0892-6638
Contributors: S. C. Lim; J. Hroudova; N. J. Van Bergen; M. I. G. Lopez Sanchez; I. A. Trounce; M. McKenzie
Source: Self-asserted source
Isabel Lopez Sanchez via Crossref Metadata Search
grade
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Estrogen-mediated regulation of mitochondrial gene expression

Molecular Endocrinology
2015 | Journal article
DOI: 10.1210/me.2014-1077
EID:

2-s2.0-84922270948
Contributors: Lopez Sanchez, M.I.G.; Shearwood, A.-M.J.; Chia, T.; Davies, S.M.K.; Rackham, O.; Filipovska, A.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

Capture of somatic mtDNA point mutations with severe effects on oxidative phosphorylation in synaptosome cybrid clones from human brain

Human Mutation
2014 | Journal article
DOI: 10.1002/humu.22694
EID:

2-s2.0-84911419426
Contributors: Mckenzie, M.; Chiotis, M.; Hroudová, J.; Lopez Sanchez, M.I.G.; Lim, S.C.; Cook, M.J.; Mckelvie, P.; Cotton, R.G.H.; Murphy, M.; St John, J.C. et al.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins

FEBS Letters
2012 | Journal article
DOI: 10.1016/j.febslet.2012.07.043
EID:

2-s2.0-84867580040
Contributors: Davies, S.M.K.; Lopez Sanchez, M.I.G.; Narsai, R.; Shearwood, A.-M.J.; Razif, M.F.M.; Small, I.D.; Whelan, J.; Rackham, O.; Filipovska, A.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier

RNA processing in human mitochondria

Cell Cycle
2011 | Journal article
DOI: 10.4161/cc.10.17.17060
EID:

2-s2.0-80052395499
Contributors: Lopez Sanchez, M.I.G.; Mercer, T.R.; Davies, S.M.K.; Shearwood, A.-M.J.; Nygård, K.K.A.; Richman, T.R.; Mattick, J.S.; Rackham, O.; Filipovska, A.
Source: Self-asserted source
Isabel Lopez Sanchez via Scopus - Elsevier
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