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Works (23)

Targeting EZH2 in Cancer: Mechanisms, Pathways, and Therapeutic Potential

Molecules
2024-12-10 | Journal article
Contributors: Maria Saveria Gilardini Montani; Rossella Benedetti; Mara Cirone
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Post-Translational Modifications (PTMs) of mutp53 and Epigenetic Changes Induced by mutp53

Biology
2024-07-08 | Journal article
Contributors: Rossella Benedetti; Michele Di Crosta; Gabriella D’Orazi; Mara Cirone
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SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21 and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells

International Journal of Molecular Sciences
2024-06-27 | Journal article
Contributors: Michele Di Crosta; Francesca Chiara Ragone; Rossella Benedetti; Gabriella D’Orazi; Maria Saveria Gilardini Montani; Mara Cirone
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Recent Advances on Mutant p53: Unveiling Novel Oncogenic Roles, Degradation Pathways, and Therapeutic Interventions

Biomolecules
2024-05-31 | Journal article
Contributors: Marco Cordani; Alessia Garufi; Rossella Benedetti; Marco Tafani; Michele Aventaggiato; Gabriella D’Orazi; Mara Cirone
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5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells

Current Issues in Molecular Biology
2024-03-14 | Journal article
Contributors: Michele Di Crosta; Andrea Arena; Rossella Benedetti; Maria Saveria Gilardini Montani; Mara Cirone
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HSP110 Inhibition in Primary Effusion Lymphoma Cells: One Molecule, Many Pro-Survival Targets

Cancers
2023-11-29 | Journal article
Contributors: Roberta Gonnella; Roberta Zarrella; Michele Di Crosta; Rossella Benedetti; Andrea Arena; Roberta Santarelli; Maria Saveria Gilardini Montani; Gabriella D’Orazi; Mara Cirone
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NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma Cells

International Journal of Molecular Sciences
2023-07-18 | Journal article
Contributors: Andrea Arena; Michele Di Crosta; Roberta Gonnella; Roberta Zarrella; Maria Anele Romeo; Rossella Benedetti; Maria Saveria Gilardini Montani; Roberta Santarelli; Gabriella D’Orazi; Mara Cirone
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DNA damage triggers an interplay between wtp53 and c-Myc affecting lymphoma cell proliferation and Kaposi sarcoma herpesvirus replication

Biochimica et Biophysica Acta - Molecular Cell Research
2022 | Journal article
EID:

2-s2.0-85118539605

Part of ISSN: 18792596 01674889
Contributors: Arena, A.; Gilardini Montani, M.S.; Romeo, M.A.; Benedetti, R.; Gaeta, A.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells

Virus Research
2022 | Journal article
EID:

2-s2.0-85125851175

Part of ISSN: 18727492 01681702
Contributors: Romeo, M.A.; Gilardini Montani, M.S.; Benedetti, R.; Arena, A.; Gaeta, A.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway

Biomedicines
2022-10-05 | Journal article
Contributors: Maria Anele Romeo; Maria Saveria Gilardini Montani; Andrea Arena; Rossella Benedetti; Gabriella D’Orazi; Mara Cirone
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Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas

International Journal of Molecular Sciences
2022-08-14 | Journal article
Contributors: Rossella Benedetti; Andrea Arena; Maria Anele Romeo; Maria Saveria Gilardini Montani; Roberta Gonnella; Roberta Santarelli; Pankaj Trivedi; Mara Cirone
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The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells

Biochemical and Biophysical Research Communications
2022-07 | Journal article
Contributors: Andrea Arena; Maria Anele Romeo; Rossella Benedetti; Maria Saveria Gilardini Montani; Mara Cirone
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Targeting c-Myc Unbalances UPR towards Cell Death and Impairs DDR in Lymphoma and Multiple Myeloma Cells

Biomedicines
2022-03 | Journal article | Author
Contributors: Andrea Arena; Maria Anele Romeo; Rossella Benedetti; MARIA SAVERIA GILARDINI MONTANI; mara cirone
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Multidisciplinary Digital Publishing Institute
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VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor

International Journal of Molecular Sciences
2022-02 | Journal article | Author
Contributors: Maria Anele Romeo; MARIA SAVERIA GILARDINI MONTANI; Rossella Benedetti; Andrea Arena; Gabriella D'ORAZI; mara cirone
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Multidisciplinary Digital Publishing Institute
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Anticancer effect of AZD2461 PARP inhibitor against colon cancer cells carrying wt or dysfunctional p53

Experimental Cell Research
2021 | Journal article
EID:

2-s2.0-85116884973

Part of ISSN: 10902422 00144827
Contributors: Romeo, M.A.; Gilardini Montani, M.S.; Benedetti, R.; Arena, A.; Maretto, M.; Bassetti, E.; Caiazzo, R.; D'Orazi, G.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

New insights into curcumin-and resveratrol-mediated anti-cancer effects

Pharmaceuticals
2021 | Journal article
EID:

2-s2.0-85117921973

Part of ISSN: 14248247
Contributors: Arena, A.; Romeo, M.A.; Benedetti, R.; Masuelli, L.; Bei, R.; Gilardini Montani, M.S.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

P53‐r273h sustains ros, pro‐inflammatory cytokine release and mtor activation while reducing autophagy, mitophagy and ucp2 expression, effects prevented by wtp53

Biomolecules
2021 | Journal article
EID:

2-s2.0-85101254797

Part of ISSN: 2218273X
Contributors: Romeo, M.A.; Gilardini Montani, M.S.; Benedetti, R.; Arena, A.; D’orazi, G.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

PGE2 released by pancreatic cancer cells undergoing ER stress transfers the stress to DCs impairing their immune function

Molecular Cancer Therapeutics
2021 | Journal article
EID:

2-s2.0-85105258016

Part of ISSN: 15388514 15357163
Contributors: Gilardini Montani, M.S.; Benedetti, R.; Piconese, S.; Pulcinelli, F.M.; Timperio, A.M.; Romeo, M.A.; Masuelli, L.; Mattei, M.; Bei, R.; D'Orazi, G. et al.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

Role of upr sensor activation in cell death–survival decision of colon cancer cells stressed by dpe treatment

Biomedicines
2021 | Journal article
EID:

2-s2.0-85115785094

Part of ISSN: 22279059
Contributors: Benedetti, R.; Gilardini Montani, M.S.; Romeo, M.A.; Arena, A.; Santarelli, R.; D’orazi, G.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

The cross-talk between STAT1/STAT3 and ROS up-regulates PD-L1 and promotes the release of pro-inflammatory/immune suppressive cytokines in primary monocytes infected by HHV-6B

Virus Research
2021 | Journal article
EID:

2-s2.0-85097384111

Part of ISSN: 18727492 01681702
Contributors: Romeo, M.A.; Gilardini Montani, M.S.; Benedetti, R.; Giambelli, L.; D'Aprile, R.; Gaeta, A.; Faggioni, A.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

PBA preferentially impairs cell survival of glioblastomas carrying mutp53 by reducing its expression level, stabilizing wtp53, downregulating the mevalonate kinase and dysregulating UPR

Biomolecules
2020 | Journal article
EID:

2-s2.0-85083418218

Part of ISSN: 2218273X
Contributors: Romeo, M.A.; Gilardini Montani, M.S.; Benedetti, R.; Garufi, A.; D’Orazi, G.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway

Frontiers in Oncology
2020 | Journal article
EID:

2-s2.0-85088513415

Part of ISSN: 2234943X
Contributors: Romeo, M.A.; Gilardini Montani, M.S.; Benedetti, R.; Santarelli, R.; D'Orazi, G.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier

Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV

Cells
2020 | Journal article
EID:

2-s2.0-85097915798

Part of ISSN: 20734409
Contributors: Romeo, M.A.; Santarelli, R.; Gilardini Montani, M.S.; Gonnella, R.; Benedetti, R.; Faggioni, A.; Cirone, M.
Source: Self-asserted source
Rossella Benedetti via Scopus - Elsevier