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A foldon-free prefusion F trimer vaccine for respiratory syncytial virus to reduce off-target immune responses

Nature Microbiology
2024-11-20 | Journal article
DOI: 10.1038/s41564-024-01860-1
Contributors: Mark J. G. Bakkers; Freek Cox; Annemart Koornneef; Xiaodi Yu; Daan van Overveld; Lam Le; Ward van den Hoogen; Joost Vaneman; Anne Thoma; Richard Voorzaat et al.
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Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer

Nature Communications
2024-07-25 | Journal article
DOI: 10.1038/s41467-024-50659-5
Contributors: Mark J. G. Bakkers; Tina Ritschel; Machteld Tiemessen; Jacobus Dijkman; Angelo A. Zuffianò; Xiaodi Yu; Daan van Overveld; Lam Le; Richard Voorzaat; Marlies M. van Haaren et al.
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Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein

Nature Communications
2024-05-31 | Journal article
DOI: 10.1038/s41467-024-48059-w
Contributors: Johannes P. M. Langedijk; Freek Cox; Nicole V. Johnson; Daan van Overveld; Lam Le; Ward van den Hoogen; Richard Voorzaat; Roland Zahn; Leslie van der Fits; Jarek Juraszek et al.
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Design and Preclinical Evaluation of a Nanoparticle Vaccine against Respiratory Syncytial Virus Based on the Attachment Protein G

Vaccines
2024-03-12 | Journal article
DOI: 10.3390/vaccines12030294
Contributors: Richard Voorzaat; Freek Cox; Daan van Overveld; Lam Le; Lisanne Tettero; Joost Vaneman; Mark J. G. Bakkers; Johannes P. M. Langedijk
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Stabilizing the closed SARS-CoV-2 spike trimer

Nature Communications
2021-01-11 | Journal article
DOI: 10.1038/s41467-020-20321-x
Contributors: Jarek Juraszek; Lucy Rutten; Sven Blokland; Pascale Bouchier; Richard Voorzaat; Tina Ritschel; Mark J. G. Bakkers; Ludovic L. R. Renault; Johannes P. M. Langedijk
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