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Scopus Author ID: 55704703800
Ciência ID: 6011-5B64-8904

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Employment (5)

Universidade de Coimbra: Coimbra, PT

2022-04-01 to present | Research assistance (Multidisciplinary Institute of Ageing)
Employment
Source: Self-asserted source
Neuza Domingues

Universidade de Coimbra Faculdade de Medicina: Coimbra, Coimbra, PT

2019-01-25 to 2022-01-25 | Doutorado contratado (Medicine - iCBR)
Employment
Source: Self-asserted source
Neuza Domingues

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra: Coimbra, PT

2013-01-01 to 2014-01-01 | Research grant - Studies of surfactants effects on the respiratory chain of mammalian and bacterial cells - analyzing of oxygen consumption and quantification of ATP, ADP and AMP levels
Employment
Source: Self-asserted source
Neuza Domingues

Universidade de Coimbra Faculdade de Ciencias e Tecnologia: Coimbra, Coimbra, PT

2011-02-01 to 2011-10-31 | Research grant - Kinetics studies of amphiphilic molecules interaction in the presence and absence of disaccharide, using membrane models. (Chemistry department)
Employment
Source: Self-asserted source
Neuza Domingues

Universidade de Coimbra Faculdade de Ciencias e Tecnologia: Coimbra, Coimbra, PT

2009-10 to 2010-09 | Researcher - Thymoquinone and β-cyclodextrin nanoencapsulation system. Activity - preparation of inclusion compounds of thymoquinone and β-cyclodextrin; characterization of the inclusion using NMR and differential scanning calorimetry (Physical-Chemistry Unity of Coimbra University)
Employment
Source: Self-asserted source
Neuza Domingues

Education and qualifications (3)

Universidade Nova de Lisboa: Lisboa, Lisboa, PT

2014-01-01 to 2018-04-09 | PhD (Nova Medical School)
Education
Source: Self-asserted source
Neuza Domingues

Universidade de Coimbra Faculdade de Ciencias e Tecnologia: Coimbra, Coimbra, PT

2010-09 to 2012-09 | Master (Biochemistry)
Education
Source: Self-asserted source
Neuza Domingues

Universidade de Coimbra Faculdade de Ciencias e Tecnologia: Coimbra, Coimbra, PT

2007-09 to 2010-07 | Bachelor (Biochemistry)
Education
Source: Self-asserted source
Neuza Domingues

Funding (4)

Re-Pair - A novel mechanism to re-pair HFpEF and endothelial damage

2019-01 to present | Contract
N/A (N/A, PT)
GRANT_NUMBER:

Re-Pair - A novel mechanism to re-pair HFpEF and endothelial damage
Source: check_circle
CIÊNCIAVITAE

The role of cholesteryl hemiesters in the etiology, development and instability of atheromata

2018-01 to 2018-12 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

UID/Multi/ 04462/2013
Source: check_circle
CIÊNCIAVITAE

Exocytosis of Dysfunctional Lysosomes as a New Paradigm Shift in the Pathogenesis of Atherosclerosis.

2017-01 to 2017-12 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

PTDC/MED-PAT/ 29395/2017
Source: check_circle
CIÊNCIAVITAE

New Targets in DIAstolic heart failure: from coMOrbidities to persoNalizeD medicine

2016-01 to 2019-12 | Contract
N/A (N/A, PT)
GRANT_NUMBER:

SAICTPAC/0047/2015
Source: check_circle
CIÊNCIAVITAE

Works (33)

Role of lipids in interorganelle communication

Trends in Cell Biology
2025-01 | Journal article
DOI: 10.1016/j.tcb.2024.04.008
SOURCE-WORK-ID:

cv-prod-id-4519128

Part of ISSN: 0962-8924
Contributors: Neuza Domingues; Joana Pires; Ira Milosevic; Nuno Raimundo
Source: check_circle
CIÊNCIAVITAE
grade
Preferred source (of 2)‎

Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged lysosomes to the cell periphery to potentiate exocytosis

Autophagy
2024-12 | Journal article
DOI: 10.1080/15548627.2024.2408711
SOURCE-WORK-ID:

cv-prod-id-4519127

Part of ISSN: 1554-8627
Part of ISSN: 1554-8635
Contributors: Neuza Domingues; Teresa Ribeiro-Rodrigues; Girao H
Source: check_circle
CIÊNCIAVITAE
grade
Preferred source (of 2)‎

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

The EMBO Journal
2024-07-23 | Journal article
DOI: 10.1038/s44318-024-00177-3
SOURCE-WORK-ID:

cv-prod-id-4519129

Part of ISSN: 1460-2075
Contributors: Neuza Domingues; S Catarino; Beatriz Cristóvão; Lisa Rodrigues; Filomena A. Carvalho; Maria J. Sarmento; Mónica Zuzarte; Jani Almeida; Teresa M Ribeiro-Rodrigues; Ânia Correia-Rodrigues et al.
Source: check_circle
CIÊNCIAVITAE
grade
Preferred source (of 2)‎

Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling

2024-06-01 | Preprint
DOI: 10.1101/2024.05.31.596474
SOURCE-WORK-ID:

cv-prod-id-4443191
Contributors: Neuza Domingues; Alessia Calcagni’; Joana Pires; Sofia Roque Freire; Niculin Joachim Herz; Tuong Huynh; Katarzyna Wieciorek; Maria João Moreno; Tiago Fleming Outeiro; Henrique Girão et al.
Source: check_circle
CIÊNCIAVITAE
grade
Preferred source (of 2)‎

Role of lipids in inter-organelle communication

Trends in Cell Biology
2024-04 | Journal article
SOURCE-WORK-ID:

cv-prod-id-4519125
Contributors: Domingues, Neuza; Joana F. Pires; Milosevic, Ira; Raimundo, Nuno
Source: check_circle
CIÊNCIAVITAE

Candida-Host Interactions in Opportunistic Infections, Dysbiosis and Aging

Frontiers in Cellular and Infection Microbiology
2023 | Journal issue or edition
SOURCE-WORK-ID:

cv-prod-id-4519123
Contributors: Rolo, Joana; Rodrigues, Lisa ; Domingues, Neuza
Source: check_circle
CIÊNCIAVITAE

Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection

Microbiology Spectrum
2023-10-17 | Journal article
DOI: 10.1128/spectrum.01238-23
Part of ISSN: 2165-0497
Contributors: Beatriz Cristovao; Lisa Rodrigues; Steve Catarino; Monica Abreu; Teresa Gonçalves; Neuza Domingues; Girao H
Source: Self-asserted source
Neuza Domingues
grade
Preferred source (of 2)‎

Cholesteryl hemiazelate identified in CVD patients causes in vitro and in vivo inflammation

Journal of Lipid Research
2023-09 | Journal article
DOI: 10.1016/j.jlr.2023.100419
Contributors: Neuza Domingues; Joana Gaifem; Rune Matthiesen; Diana P. Saraiva; Luís Bento; André R.A. Marques; Maria I.L. Soares; Julio Sampaio; Christian Klose; Michal A. Surma et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages

Traffic
2023-07 | Journal article
DOI: 10.1111/tra.12888
Part of ISSN: 1398-9219
Part of ISSN: 1600-0854
Contributors: Neuza Domingues; André R. A. Marques; Rita Diogo Almeida Calado; Inês Ferreira; Cristiano Ramos; José Ramalho; Maria I. L. Soares; Telmo Pereira; Luís Oliveira; José R. Vicente et al.
Source: Self-asserted source
Neuza Domingues
grade
Preferred source (of 3)‎

Reply to the Comment on “1,8-Cineole ameliorates right ventricle dysfunction associated with pulmonary arterial hypertension by restoring connexin43 and mitochondrial homeostasis”

Pharmacological Research
2023-05 | Journal article
DOI: 10.1016/j.phrs.2022.106623
SOURCE-WORK-ID:

cv-prod-id-4519121

Part of ISSN: 1043-6618
Contributors: Alves-Silva, Jorge M.; Zuzarte, Mónica; Marques, Carla; Viana, Sofia; Preguiça, Inês; Baptista, Rui; Ferreira, Cátia; et al.
Source: check_circle
CIÊNCIAVITAE

Unveiling the molecular mechanisms of Batten disease in the absence of CLN3

Gordon Research Conference Lysosomal Diseases
2023-05-16 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4519126
Contributors: Domingues, Neuza; Joana F. Pires; Raimundo, Nuno; Corresponding author: Raimundo, Nuno.
Source: check_circle
CIÊNCIAVITAE

Cx43 promotes exocytosis of damaged lysosomes through actin remodelling

2022-12 | Preprint
DOI: 10.21203/rs.3.rs-2277227/v1
PPR: PPR587647
Contributors: Domingues N; Catarino S; Cristovao B; Rodrigues L; Filomena C; Sarmento MJ; Zuzarte M; Almeida J; Fernandes F; Rodrigues-Santos P et al.
Source: Self-asserted source
Neuza Domingues via Europe PubMed Central
grade
Preferred source (of 2)‎

Phagolysosomal remodeling to confine Candida albicans in the macrophage

Trends in Microbiology
2022-06-30 | Journal article
DOI: 10.1016/j.tim.2022.03.004
SOURCE-WORK-ID:

cv-prod-id-4519122

ISSN: 0966-842X
Contributors: Domingues, Neuza; Gonçalves, Teresa; Girao, Henrique; Corresponding author: Girao, Henrique.
Source: check_circle
CIÊNCIAVITAE

1,8-cineole Ameliorates Right Ventricle Dysfunction Associated With Pulmonary Arterial Hypertension by Restoring Connexin 43 and Mitochondrial Homeostasis

Pharmacological Research
2022-03 | Journal article
DOI: 10.1016/j.phrs.2022.106151
Part of ISSN: 1043-6618
Source: Self-asserted source
Neuza Domingues
grade
Preferred source (of 2)‎

Phagolysosomal remodeling to confine C. albicans in macrophage

Trends in microbiology
2022-03-03 | Journal article
SOURCE-WORK-ID:

cv-prod-id-3050724

OTHER-ID:

Cell press
Contributors: Domingues, Neuza; Gonçalves, Teresa; Girao, Henrique; Corresponding author: Girao, Henrique.
Source: check_circle
CIÊNCIAVITAE

Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages

bioRxiv
2021 | Journal article
SOURCE-WORK-ID:

cv-prod-id-1976609
Source: Self-asserted source
Neuza Domingues
grade
Preferred source (of 2)‎

Insulin resistance as a predictor of cardiovascular diseases

Revista Portuguesa de Cardiologia
2021-08 | Journal article
DOI: 10.1016/j.repc.2021.06.004
Part of ISSN: 0870-2551
Source: Self-asserted source
Neuza Domingues
grade
Preferred source (of 2)‎

Shotgun mass spectrometry-based lipid profiling identifies and distinguishes between chronic inflammatory diseases

EBioMedicine
2021-08 | Journal article
DOI: 10.1016/j.ebiom.2021.103504
Part of ISSN: 2352-3964
Source: Self-asserted source
Neuza Domingues
grade
Preferred source (of 3)‎

Unveiling the role of Cx43 in damaged lysosome secretion

EMBO Workshop 2019 - Proteostasis: From organelles to organisms
2019 | Conference poster
SOURCE-WORK-ID:

cv-prod-id-4519124
Contributors: Domingues, Neuza; Cristóvão, Beatriz; Zuzarte, Mónica; Ribeiro-Rodrigues, Teresa M; Catarino, Steve; Girao, Henrique
Source: check_circle
CIÊNCIAVITAE

Molecular crowding effects on the distribution of amphiphiles in biological media

Colloids and Surfaces B: Biointerfaces
2019-08 | Journal article
DOI: 10.1016/j.colsurfb.2019.04.065
Part of ISSN: 0927-7765
Source: Self-asserted source
Neuza Domingues
grade
Preferred source (of 2)‎

In vitro and in vivo studies of proatherogenic effects induced by end-products of cholesteryl esters oxidation

2018 | Dissertation or Thesis
SOURCE-WORK-ID:

cv-prod-id-1548016

OTHER-ID:

101497997

HANDLE: http://hdl.handle.net/10362/34210
Contributors: Domingues, Neuza Luisa da Silva
Source: check_circle
CIÊNCIAVITAE

Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients

Scientific Reports
2018-12 | Journal article
DOI: 10.1038/s41598-018-33116-4
Part of ISSN: 2045-2322
Source: Self-asserted source
Neuza Domingues
grade
Preferred source (of 2)‎

Lipid and Non-lipid Factors Affecting Macrophage Dysfunction and Inflammation in Atherosclerosis

Frontiers in Physiology
2018-06-26 | Journal article
DOI: 10.3389/fphys.2018.00654
SOURCE-WORK-ID:

cv-prod-id-1548019

ISSN: 1664-042X
Contributors: Gibson, Mark S.; Domingues, Neuza; Vieira, Otilia V.
Source: check_circle
CIÊNCIAVITAE

Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
2017 | Journal article
DOI: 10.1016/j.bbalip.2016.10.009
EID:

2-s2.0-84999089924
Contributors: Domingues, N.; Estronca, L.M.B.B.; Silva, J.; Encarnação, M.R.; Mateus, R.; Silva, D.; Santarino, I.B.; Saraiva, M.; Soares, M.I.L.; Pinho e Melo, T.M.V.D. et al.
Source: Self-asserted source
Neuza Domingues via Scopus - Elsevier
grade
Preferred source (of 2)‎

Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis

Scientific Reports
2017 | Journal article
DOI: 10.1038/s41598-017-05687-1
EID:

2-s2.0-85025474729
Contributors: Santarino, I.B.; Viegas, M.S.; Domingues, N.S.; Ribeiro, A.M.; Soares, M.P.; Vieira, O.V.
Source: Self-asserted source
Neuza Domingues via Scopus - Elsevier
grade
Preferred source (of 2)‎

In vitro effects of bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV), or VO(dmpp)<inf>2,</inf> on insulin secretion in pancreatic islets of type 2 diabetic Goto-Kakizaki rats

Journal of Inorganic Biochemistry
2016 | Journal article
DOI: 10.1016/j.jinorgbio.2015.11.004
EID:

2-s2.0-84946761475
Contributors: Pelletier, J.; Domingues, N.; Castro, M.M.C.A.; Östenson, C.-G.
Source: Self-asserted source
Neuza Domingues via Scopus - Elsevier
grade
Preferred source (of 2)‎

Quaternary ammonium surfactant structure determines selective toxicity towards bacteria: Mechanisms of action and clinical implications in antibacterial prophylaxis

Journal of Antimicrobial Chemotherapy
2016 | Journal article
DOI: 10.1093/jac/dkv405
EID:

2-s2.0-84960839711
Contributors: Inácio, Â.S.; Domingues, N.S.; Nunes, A.; Martins, P.T.; Moreno, M.J.; Estronca, L.M.; Fernandes, R.; Moreno, A.J.M.; Borrego, M.J.; Gomes, J.P. et al.
Source: Self-asserted source
Neuza Domingues via Scopus - Elsevier
grade
Preferred source (of 2)‎

The therapeutic properties of VO (dmpp)(2) as demonstrated by in vivo studies in type 2 diabetic GK rats

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
2014 | Conference poster
Part of DOI: 10.1007/s00775-014-1150-5
SOURCE-WORK-ID:

cv-prod-id-1552776
Contributors: Domingues, Neuza
Source: check_circle
CIÊNCIAVITAE

Therapeutic properties of VO(dmpp)2 as assessed by in vitro and in vivo studies in type 2 diabetic GK rats

Journal of Inorganic Biochemistry
2014 | Journal article
DOI: 10.1016/j.jinorgbio.2013.11.005
EID:

2-s2.0-84890462956
Contributors: Domingues, N.; Pelletier, J.; Ostenson, C.-G.; Castro, M.M.C.A.
Source: Self-asserted source
Neuza Domingues via Scopus - Elsevier
grade
Preferred source (of 2)‎

Mitochondrial dysfunction is the focus of quaternary ammonium surfactant toxicity to mammalian epithelial cells

Antimicrobial Agents and Chemotherapy
2013 | Journal article
DOI: 10.1128/AAC.02437-12
EID:

2-s2.0-84877862108
Contributors: Inácio, A.S.; Costa, G.N.; Domingues, N.S.; Santos, M.S.; Moreno, A.J.M.; Vaz, W.L.C.; Vieiraa, O.V.
Source: Self-asserted source
Neuza Domingues via Scopus - Elsevier

Therapeutic properties of the vanadium compound, VO(dmpp)2, by ex vivo and in vivo studies in diabetic GK rats

49th EASD Annual Meeting
2013 | Conference abstract
SOURCE-WORK-ID:

cv-prod-id-1552873

CTX:

Revista Portuguesa de Diabetes. 2013; 8 (3): 141-148
Contributors: Domingues, Neuza
Source: check_circle
CIÊNCIAVITAE

Unveiling the interaction of vanadium compounds with human serum albumin by using 1H STD NMR and computational docking studies

European Journal of Inorganic Chemistry
2013 | Journal article
DOI: 10.1002/ejic.201300419
EID:

2-s2.0-84883525535
Contributors: Dias, D.M.; Rodrigues, J.P.G.L.M.; Domingues, N.S.; Bonvin, A.M.J.J.; Castro, M.M.C.A.
Source: Self-asserted source
Neuza Domingues via Scopus - Elsevier
grade
Preferred source (of 2)‎

Ex vivo and in vivo studies with VO (dmpp) : validation of its anti-diabetic properties

2012 | Dissertation or Thesis
SOURCE-WORK-ID:

cv-prod-id-1548018

HANDLE: http://hdl.handle.net/10316/25151
Contributors: Domingues, Neuza Luísa da Silva
Source: check_circle
CIÊNCIAVITAE

Peer review (4 reviews for 2 publications/grants)

Review activity for iScience. (2)
Review activity for STAR protocols. (2)
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