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Employment (2)

Centre for Genomic Regulation: Barcelona, ES

2018-10-01 to present | Postdoctoral researcher (Bioinformatics and Genomics)
Employment
Source: Self-asserted source
Sílvia Bonàs-Guarch

Institut d'Investigacions Biomèdiques August Pi i Sunyer: Barcelona, Catalunya, ES

2017-02-08 to 2018-09-30 | Postdoctoral Researcher (Programació Genòmica de Cèl·lules Beta i Diabetis)
Employment
Source: Self-asserted source
Sílvia Bonàs-Guarch

Education and qualifications (3)

Universitat de Barcelona: Barcelona, Catalunya, ES

2011-11 to 2017-02 | PhD in Biomedicine
Education
Source: Self-asserted source
Sílvia Bonàs-Guarch

Universitat Pompeu Fabra: Barcelona, Catalunya, ES

2010 to 2012 | Master of Bioinformatics for Health Sciences
Education
Source: Self-asserted source
Sílvia Bonàs-Guarch

Universitat Autònoma de Barcelona: Bellaterra, Catalunya, ES

2005 to 2010 | Biotecnologia
Education
Source: Self-asserted source
Sílvia Bonàs-Guarch

Funding (1)

Desenvolupament de noves eines computacionals i de biologia de sistemes per a l’anàlisi de polimorfismes genètics a gran escala (GWAS). Aplicació a diabetis de tipus 2 i tipus 1 i comorbiditats associades

2013-06 to 2016-06 | Grant
Generalitat de Catalunya (Barcelona, Catalonia, ES)
GRANT_NUMBER:

FI-DGR

Source: Self-asserted source
Sílvia Bonàs-Guarch

Works (34)

Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology

Nature Metabolism
2024-10-17 | Journal article
Contributors: A. L. Madsen; S. Bonàs-Guarch; S. Gheibi; R. Prasad; J. Vangipurapu; V. Ahuja; L. R. Cataldo; O. Dwivedi; G. Hatem; G. Atla et al.
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Multiple genetic variants at the SLC30A8 locus affect local super‐enhancer activity and influence pancreatic β‐cell survival and function

The FASEB Journal
2024-04-30 | Journal article
Contributors: Ming Hu; Innah Kim; Ignasi Morán; Weicong Peng; Orien Sun; Amélie Bonnefond; Amna Khamis; Sílvia Bonàs‐Guarch; Philippe Froguel; Guy A. Rutter
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Crossref

Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function

bioRxiv
2023 | Other
EID:

2-s2.0-85178906595

Part of ISSN: 26928205
Contributors: Hu, M.; Kim, I.; Morán, I.; Peng, W.; Sun, O.; Bonnefond, A.; Khamis, A.; Bonas-Guarch, S.; Froguel, P.; Rutter, G.A.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Pancreatic microexons regulate islet function and glucose homeostasis

Nature Metabolism
2023-02-09 | Journal article
Contributors: Jonàs Juan-Mateu; Simon Bajew; Marta Miret-Cuesta; Luis P. Íñiguez; Amaya Lopez-Pascual; Sophie Bonnal; Goutham Atla; Sílvia Bonàs-Guarch; Jorge Ferrer; Juan Valcárcel et al.
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Control of pancreatic islet function and glucose homeostasis by a novel microexon program misregulated in type 2 diabetes

bioRxiv
2022 | Other
EID:

2-s2.0-85142919146

Part of ISSN: 26928205
Contributors: Juan-Mateu, J.; Bajew, S.; Miret-Cuesta, M.; Íñiguez, L.P.; López-Pascual, A.; Bonnal, S.; Atla, G.; Bonàs-Guarch, S.; Ferrer, J.; Valcárcel, J. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Genetic regulation of RNA splicing in human pancreatic islets

Genome Biology
2022 | Journal article
EID:

2-s2.0-85137930726

Part of ISSN: 1474760X 14747596
Contributors: Atla, G.; Bonàs-Guarch, S.; Cuenca-Ardura, M.; Beucher, A.; Crouch, D.J.M.; Garcia-Hurtado, J.; Moran, I.; Cnop, M.; Eliasson, L.; Esguerra, J.L.S. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

Diabetes
2022 | Journal article
EID:

2-s2.0-85125212528

Part of ISSN: 1939327X 00121797
Contributors: O’Connor, M.J.; Schroeder, P.; Huerta-Chagoya, A.; Cortes-Sanchez, P.; Bonas-Guarch, S.; Guindo-Martınez, M.; Cole, J.B.; Kaur, V.; Torrents, D.; Veerapen, K. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Genetic regulation of RNA splicing in human pancreatic islets

bioRxiv
2021 | Other
EID:

2-s2.0-85121550460

Part of ISSN: 26928205
Contributors: Atla, G.; Bonas-Guarch, S.; Beucher, A.; Cuenca-Ardura, M.; Garcia-Hurtado, J.; Moran, I.; Irimia, M.; Prasad, R.B.; Gloyn, A.L.; Marselli, L. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Genome-wide association meta-analysis using a recessive model illuminates genetic architecture of type 2 diabetes

medRxiv
2021 | Other
EID:

2-s2.0-85113824323

Contributors: O'Connor, M.J.; Huerta-Chagoya, A.; Cortés-Sánchez, P.; Bonàs-Guarch, S.; Guindo-Martínez, M.; Cole, J.B.; Torrents, D.; Veerapen, K.; Grarup, N.; Kurki, M. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

bioRxiv
2021 | Other
EID:

2-s2.0-85108814806

Part of ISSN: 26928205
Contributors: Alonso, L.; Piron, A.; Morán, I.; Guindo-Martínez, M.; Bonàs-Guarch, S.; Atla, G.; Miguel-Escalada, I.; Royo, R.; Puiggròs, M.; Garcia-Hurtado, X. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

Cell Reports
2021 | Journal article
EID:

2-s2.0-85118520914

Part of ISSN: 22111247
Contributors: Alonso, L.; Piron, A.; Morán, I.; Guindo-Martínez, M.; Bonàs-Guarch, S.; Atla, G.; Miguel-Escalada, I.; Royo, R.; Puiggròs, M.; Garcia-Hurtado, X. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

CRISPR-based genome editing in primary human pancreatic islet cells

Nature Communications
2021-04-23 | Journal article
Contributors: Romina J. Bevacqua; Xiaoqing Dai; Jonathan Y. Lam; Xueying Gu; Mollie S. H. Friedlander; Krissie Tellez; Irene Miguel-Escalada; Silvia Bonàs-Guarch; Goutham Atla; Weichen Zhao et al.
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The impact of non-additive genetic associations on age-related complex diseases

Nature Communications
2021-04-23 | Journal article
Contributors: Marta Guindo-Martínez; Ramon Amela; Silvia Bonàs-Guarch; Montserrat Puiggròs; Cecilia Salvoro; Irene Miguel-Escalada; Caitlin E. Carey; Joanne B. Cole; Sina Rüeger; Elizabeth Atkinson et al.
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Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes

medRxiv
2020 | Other
EID:

2-s2.0-85163238970

Contributors: Wessel, J.; Majarian, T.D.; Highland, H.M.; Raghavan, S.; Szeto, M.D.; Hasbani, N.R.; de Vries, P.S.; Brody, J.A.; Sarnowski, C.; DiCorpo, D. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

The impact of non-additive genetic associations on age-related complex diseases

2020-05-14 | Preprint
Contributors: Marta Guindo-Martínez; Ramon Amela; Silvia Bonàs-Guarch; Montserrat Puiggròs; Cecilia Salvoro; Irene Miguel-Escalada; Caitlin E Carey; Joanne B. Cole; Sina Rüeger; Elizabeth Atkinson et al.
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Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis

Annals of the rheumatic diseases
2019 | Journal article
EID:

2-s2.0-85058700955

Contributors: Aterido, A.; Cañete, J.D.; Tornero, J.; Ferrándiz, C.; Pinto, J.A.; Gratacós, J.; Queiró, R.; Montilla, C.; Torre-Alonso, J.C.; Pérez-Venegas, J.J. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis

Annals of the Rheumatic Diseases
2019 | Journal article
EID:

2-s2.0-85062111703

Contributors: Aterido, A.; Cañete, J.D.; Tornero, J.; Ferrándiz, C.; Pinto, J.A.; Gratacós, J.; Queiró, R.; Montilla, C.; Torre-Alonso, J.C.; Pérez-Venegas, J.J. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Nature Genetics
2019 | Journal article
EID:

2-s2.0-85065213720

Contributors: Warrington, N.M.; Beaumont, R.N.; Horikoshi, M.; Day, F.R.; Helgeland, Ø.; Laurin, C.; Bacelis, J.; Peng, S.; Hao, K.; Feenstra, B. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

Nature Genetics
2019-07 | Journal article
Part of ISSN: 1061-4036
Part of ISSN: 1546-1718
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Sílvia Bonàs-Guarch
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Clustering of Type 2 diabetes genetic loci by multi-trait associations identifies disease mechanisms and subtypes

bioRxiv
2018 | Other
EID:

2-s2.0-85094300143

Part of ISSN: 26928205
Contributors: Udler, M.S.; Kim, J.; von Grotthuss, M.; Bonàs-Guarch, S.; Mercader, J.M.; Cole, J.B.; Chiou, J.; Anderson, C.D.; Boehnke, M.; Laakso, M. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Erratum to: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis (Nature Genetics, (2018), 50, 8, (1072-1080), 10.1038/s41588-018-0157-1)

Nature Genetics
2018 | Journal article
EID:

2-s2.0-85052333167

Contributors: Waage, J.; Standl, M.; Curtin, J.A.; Jessen, L.E.; Thorsen, J.; Tian, C.; Schoettler, N.; Flores, C.; Abdellaoui, A.; Ahluwalia, T.S. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Nature Genetics
2018 | Journal article
EID:

2-s2.0-85049975477

Contributors: Waage, J.; Standl, M.; Curtin, J.A.; Jessen, L.E.; Thorsen, J.; Tian, C.; Schoettler, N.; Flores, C.; Abdellaoui, A.; Ahluwalia, T.S. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus

Arthritis Research and Therapy
2018 | Journal article
EID:

2-s2.0-85047900718

Contributors: Julià, A.; López-Longo, F.J.; Pérez Venegas, J.J.; Bonàs-Guarch, S.; Olivé; Andreu, J.L.; Aguirre-Zamorano, M.; Vela, P.; Nolla, J.M.; de la Fuente, J.L.M. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes

bioRxiv
2018 | Other
EID:

2-s2.0-85095657413

Part of ISSN: 26928205
Contributors: Miguel-Escalada, I.; Bonàs-Guarch, S.; Cebola, I.; Joan, P.-C.; Mendieta-Esteban, J.; Rolando, D.M.Y.; Javierre, B.M.; Atla, G.; Farabella, I.; Morgan, C.C. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

bioRxiv
2018 | Other
EID:

2-s2.0-85095279871

Part of ISSN: 26928205
Contributors: Warrington, N.M.; Beaumont, R.N.; Horikoshi, M.; Day, F.R.; Helgeland, Ø.; Laurin, C.; Bacelis, J.; Peng, S.; Hao, K.; Feenstra, B. et al.
Source: Self-asserted source
Sílvia Bonàs-Guarch via Scopus - Elsevier

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

PLoS Medicine
2018 | Journal article
EID:

2-s2.0-85054638667

Contributors: Udler, M.S.; Kim, J.; von Grotthuss, M.; Bonàs-Guarch, S.; Cole, J.B.; Chiou, J.; Boehnke, M.; Laakso, M.; Atzmon, G.; Glaser, B. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Nature Communications
2018-05-30 | Journal article
Contributors: Sílvia Bonàs-Guarch; Marta Guindo-Martínez; Irene Miguel-Escalada; Niels Grarup; David Sebastian; Elias Rodriguez-Fos; Friman Sánchez; Mercè Planas-Fèlix; Paula Cortes-Sánchez; Santi González et al.
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Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Nature Communications
2018-01-22 | Journal article
Contributors: Sílvia Bonàs-Guarch; Marta Guindo-Martínez; Irene Miguel-Escalada; Niels Grarup; David Sebastian; Elias Rodriguez-Fos; Friman Sánchez; Mercè Planas-Fèlix; Paula Cortes-Sánchez; Santi González et al.
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A comprehensive reanalysis of publicly available GWAS datasets reveals an X chromosome rare regulatory variant associated with high risk for type 2 diabetes

bioRxiv
2017 | Other
EID:

2-s2.0-85095650935

Part of ISSN: 26928205
Contributors: Bonás-Guarch, S.; Guindo-Martínez, M.; Miguel-Escalada, I.; Grarup, N.; Sebastian, D.; Rodriguez-Fos, E.; Sánchez, F.; Planas-Félix, M.; Cortes-Sánchez, P.; González, S. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

A loss-of-function splice acceptor variant in igf2 is protective for type 2 diabetes

Diabetes
2017 | Journal article
EID:

2-s2.0-85037582424

Part of ISSN: 1939327X 00121797
Contributors: Mercader, J.M.; Liao, R.G.; Bell, A.D.; Dymek, Z.; Estrada, K.; Tukiainen, T.; Huerta-Chagoya, A.; Moreno-Macías, H.; Jablonski, K.A.; Hanson, R.L. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Genome-wide associations for birth weight and correlations with adult disease

Nature
2016 | Journal article
EID:

2-s2.0-84991665514

Contributors: Horikoshi, M.; Beaumont, R.N.; Day, F.R.; Warrington, N.M.; Kooijman, M.N.; Fernandez-Tajes, J.; Feenstra, B.; Van Zuydam, N.R.; Gaulton, K.J.; Grarup, N. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

Nature Genetics
2014 | Journal article
EID:

2-s2.0-84891372721

Contributors: Bønnelykke, K.; Sleiman, P.; Nielsen, K.; Kreiner-Møller, E.; Mercader, J.M.; Belgrave, D.; Den Dekker, H.T.; Husby, A.; Sevelsted, A.; Faura-Tellez, G. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Common Genetic Variants of Surfactant Protein-D (SP-D) Are Associated with Type 2 Diabetes

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84875946684

Part of ISSN: 19326203
Contributors: Pueyo, N.; Ortega, F.J.; Mercader, J.M.; Moreno-Navarrete, J.M.; Sabater, M.; Bonàs, S.; Botas, P.; Delgado, E.; Ricart, W.; Martinez-Larrad, M.T. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier

Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems

PLoS Genetics
2012 | Journal article
EID:

2-s2.0-84872014037

Contributors: Mercader, J.M.; Puiggros, M.; Segrè, A.V.; Planet, E.; Sorianello, E.; Sebastian, D.; Rodriguez-Cuenca, S.; Ribas, V.; Bonàs-Guarch, S.; Draghici, S. et al.
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Sílvia Bonàs-Guarch via Scopus - Elsevier