Personal information

Activities

Employment (1)

Universidad de La Frontera: Temuco, La Araucania, CL

2024-03-15 to present | Associate professor (Center of Excellence in Translational Medicine (CETM))
Employment
Source: Self-asserted source
Brian Effer

Education and qualifications (1)

Universidade de Sao Paulo : Sao Paulo, Sao Paulo, BR

2016-02-01 to 2019-02-01 | PhD (Biochemical and Pharmaceutical Technology)
Education
Source: Self-asserted source
Brian Effer

Funding (3)

A versatile platform to produce monoclonal antibodies (mAbs) against biomarkers overexpressed in the most lethal cancers: Towards the national sustainable production of proteins with biopharmaceutical and biotechnological purpose

2024-04 to 2027-04 | Grant
Agencia Nacional de Investigación y Desarrollo (Temuco, Araucanía, CL)
Source: Self-asserted source
Brian Effer

Librerías génicas: Una plataforma versátil para obtener anticuerpos contra la tuberculosis en humanos

2024-02 to 2025-02 | Grant
Agencia Nacional de Investigación y Desarrollo (Temuco, La Araucania, CL)
Source: Self-asserted source
Brian Effer

Setting up de una plataforma de Phage – ribosome display para la obtención de anticuerpos monoclonales para cáncer de vesícula biliar: nueva fuente de aplicación diagnóstica y de terapia

Grant
Agencia Nacional de Investigación y Desarrollo (Temuco, La Araucania, CL)
GRANT_NUMBER:

3210142

Source: Self-asserted source
Brian Effer

Works (20)

Construction of a Human Immune Library from Gallbladder Cancer Patients for the Single-Chain Fragment Variable (scFv) Antibody Selection against Claudin 18.2 via Phage Display

Antibodies
2024-03-12 | Journal article
Contributors: Brian Effer; Daniel Ulloa; Camila Dappolonnio; Francisca Muñoz; Isabel Iturrieta-González; Loraine Cotes; Claudio Rojas; Pamela Leal
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Downstream process and evaluation of the concomitant impact of a recombinant glycosylated L-asparaginase on leukemic cancer cells and the bone marrow tumor microenvironment

Process Biochemistry
2023-08 | Journal article
Contributors: Eduardo Krebs Kleingesinds; Letícia de Almeida Parizotto; Brian Effer; Gisele Monteiro; Paul F. Long; Yoana Arroyo-Berdugo; Volker Behrends; Maria Teresa Esposito; Yolanda Calle; Adalberto Pessoa-Jr
Source: check_circle
Crossref

Therapeutic Targets of Monoclonal Antibodies Used in the Treatment of Cancer: Current and Emerging

Biomedicines
2023-07-24 | Journal article
Contributors: Brian Effer; Isabela Perez; Daniel Ulloa; Carolyn Mayer; Francisca Muñoz; Diego Bustos; Claudio Rojas; Carlos Manterola; Luis Vergara-Gómez; Camila Dappolonnio et al.
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Crossref
grade
Preferred source (of 2)‎

Cathepsin B Is Not an Intrinsic Factor Related to Asparaginase Resistance of the Acute Lymphoblastic Leukemia REH Cell Line

International Journal of Molecular Sciences
2023-07-07 | Journal article
Contributors: Iris Munhoz Costa; Brian Effer; Tales Alexandre Costa-Silva; Chen Chen; Michael F. Ciccone; Adalberto Pessoa; Camila O. dos Santos; Gisele Monteiro
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Crossref
grade
Preferred source (of 2)‎

Current state of molecular and metabolic strategies for the improvement of L-asparaginase expression in heterologous systems

Frontiers in Pharmacology
2023-06-22 | Journal article
Part of ISSN: 1663-9812
Contributors: Nicolás Lefin; Javiera Miranda; Jorge F. Beltrán; Lisandra Herrera Belén; Brian Effer; Adalberto Pessoa; Jorge G. Farias; Mauricio Zamorano
Source: Self-asserted source
Brian Effer

A low-cost system for the study of proteins used in salmonid diets, use of proteolysis to determine the quality

LWT
2022-08 | Journal article
Part of ISSN: 0023-6438
Contributors: Brian Effer
Source: Self-asserted source
Brian Effer

Structure of the Mycobacterium tuberculosis cPknF and conformational changes induced in Forkhead-Associated regulatory domains

Current Research in Structural Biology
2021-07 | Journal article
Part of ISSN: 2665-928X
Source: Self-asserted source
Brian Effer

Increased glycosylated L-asparaginase production through selection of Pichia pastoris platform and oxygen-methanol control in fed-batches

Biochemical Engineering Journal
2021-05 | Journal article
Part of ISSN: 1369-703X
Source: Self-asserted source
Brian Effer

Glycosylation of Erwinase results in active protein less recognized by antibodies

Biochemical Engineering Journal
2020-11 | Journal article
Contributors: Brian Effer; Eduardo Krebs Kleingesinds; Guilherme Meira Lima; Iris Munhoz Costa; Ignacio Sánchez-Moguel; Adalberto Pessoa; Verônica Feijoli Santiago; Giuseppe Palmisano; Jorge G. Farías; Gisele Monteiro
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Glycosylation of L-asparaginase from E. coli through yeast expression and site-directed mutagenesis

Biochemical Engineering Journal
2020-04 | Journal article
Part of ISSN: 1369-703X
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 3)‎

From Synthesis to Characterization of Site-Selective PEGylated Proteins

Frontiers in Pharmacology
2019-12-18 | Journal article
Part of ISSN: 1663-9812
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

A structural in silico analysis of the immunogenicity of l-asparaginase from Escherichia coli and Erwinia carotovora

Biologicals
2019-05 | Journal article
Part of ISSN: 1045-1056
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

L-Asparaginase from E. chrysanthemi expressed in glycoswitch®: effect of His-Tag fusion on the extracellular expression

Preparative Biochemistry and Biotechnology
2019-04-16 | Journal article
Part of ISSN: 1082-6068
Part of ISSN: 1532-2297
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

Gamete quality in fish: evaluation parameters and determining factors

Zygote
2015-04 | Journal article
Part of ISSN: 0967-1994
Part of ISSN: 1469-8730
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

Short-term cold storage of the semen of rainbow troutOncorhynchus mykiss(Walbaum, 1792) incorporating DMSO in the sperm diluent. Effects on motility and fertilizing capacity

Aquaculture Research
2015-03 | Journal article
Part of ISSN: 1355-557X
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

Morphometric of blastomeres in Salmo salar

Zygote
2014-11 | Journal article
Part of ISSN: 0967-1994
Part of ISSN: 1469-8730
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

Effect of seminal plasma on Atlantic salmon (Salmo salar) sperm vitrification.

Theriogenology
2014-09-19 | Journal article
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

Sperm biology of Merluccius australis: Sperm structure, semen characteristics and effects of pH, temperature and osmolality on sperm motility

Aquaculture
2013-09 | Journal article
Part of ISSN: 0044-8486
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

Morphometric characterization of the first blastomeres of rainbow trout (Oncorhynchus mykiss)

Zygote
2012-11 | Journal article
Part of ISSN: 0967-1994
Part of ISSN: 1469-8730
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

Study of the first blastomeres in Coho salmon (Oncorhynchus kisutch).

Zygote (Cambridge, England)
2012-07-11 | Journal article
Source: Self-asserted source
Brian Effer
grade
Preferred source (of 2)‎

Peer review (1 review for 1 publication/grant)

Review activity for Brazilian journal of microbiology. (1)