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Employment (3)

Trinity College Dublin: Dublin, ireland, IE

2011-04-01 to present | Lecturer and Course Director (Biochemistry and Immunology)
Employment
Source: Self-asserted source
aisling dunne

University of Dublin Trinity College: Dublin, IE

2008 to 2011 | Senior Research Fellow (Biochemistry and Immunology)
Employment
Source: Self-asserted source
aisling dunne

Opsona Therapeutics Ltd: Dublin, Dublin, IE

2006 to 2008 | Head of Molecular Biology and Protein Chemistry
Employment
Source: Self-asserted source
aisling dunne

Education and qualifications (1)

Trinity College Dublin: Dublin, IE

1997-09-01 to 2001-09-01 | PhD (Biochemistry)
Education
Source: Self-asserted source
aisling dunne

Funding (11)

Trinity College Provost's PhD Award

2021 to 2025 | Award
Trinity College Dublin (Dublin, IE)
Source: Self-asserted source
aisling dunne

An improved solution for subunit vaccines

2020-05 to 2023-05 | Grant
Enterprise Ireland (Dublin, IE)
GRANT_NUMBER:

CF20201340
Source: Self-asserted source
aisling dunne

AMBER Centre for Advanced Materials and Bioengineering Research

2019-01 to 2024-03 | Grant
Science Foundation Ireland (Dublin, IE)
Source: Self-asserted source
aisling dunne

The heme oxygenase system as a therapeutic intervention for Inflammatory Bowel Disease.

2017-09 to 2021-09 | Grant
Health Research Board (Dublin, ireland, IE)
GRANT_NUMBER:

(ILP/POR/2017/041).
Source: Self-asserted source
aisling dunne

Validation of lipoproteins/lipopeptides as adjuvants and antigens for a new pertussis vaccine

2016-01-01 to 2016-12-31 | Grant
Science Foundation Ireland (Dublin, IE)
URL: https://app.dimensions.ai/details/grant/grant.7668452
GRANT_NUMBER:

15/TIDA/2918
Source: Self-asserted source
aisling dunne via DimensionsWizard

Assessment of marine derived linear tetrapyrroles as immunosuppressive agents for organ transplantation

2015-01-01 to 2016-04-30 | Grant
Science Foundation Ireland (Dublin, IE)
URL: https://app.dimensions.ai/details/grant/grant.7670655
GRANT_NUMBER:

14/TIDA/2267
Source: Self-asserted source
aisling dunne via DimensionsWizard

The heme oxygenase system as a therapeutic intervention for Psoriasis

2014-09 to 2017-09 | Grant
Health Research Board (Dublin, ireland, IE)
GRANT_NUMBER:

(HRA-POR-2014-582).
Source: Self-asserted source
aisling dunne

Assessment of marine derived linear tetrapyrroles for use in the functional/nutraceutical food industry

2014-01-01 to 2015-06-30 | Grant
Science Foundation Ireland (Dublin, IE)
URL: https://app.dimensions.ai/details/grant/grant.3983512
GRANT_NUMBER:

13/TIDA/I2591
Source: Self-asserted source
aisling dunne via DimensionsWizard

Identification of new targets for the treatment of Osteoarthritis

2012-09 to 2016-09 | Grant
Health Research Board (Dublin, ireland, IE)
GRANT_NUMBER:

(HRA-POR-2012-20).

Source: Self-asserted source
aisling dunne

HEA-PRTLI Cycle 5 Funded PhD Programme.

2012-09 to 2015-09 | Grant
Higher Education Authority (Dublin, ireland, IE)
Source: Self-asserted source
aisling dunne

Science Foundation Ireland Strategic Research Cluster.

2009-09 to 2011-09 | Grant
Science Foundation Ireland (Dublin, ireland, IE)
Source: Self-asserted source
aisling dunne

Works (50 of 58)

Items per page:
Page 1 of 2

Macrophage metabolic profile is altered by hydroxyapatite particle size

Acta Biomaterialia
2023-04 | Journal article
DOI: 10.1016/j.actbio.2023.01.058
Contributors: Lianne C. Shanley; Olwyn R. Mahon; Sinead A. O'Rourke; Nuno G.B. Neto; Michael G. Monaghan; Daniel J. Kelly; Aisling Dunne
Source: check_circle
Crossref

Endogenous drivers of altered immune cell metabolism

Experimental Biology and Medicine
2022-12 | Journal article
DOI: 10.1177/15353702221134093
Contributors: Lianne C Shanley; Hannah K Fitzgerald; Sinead A O’Rourke; Aisling Dunne
Source: check_circle
Crossref

Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages.

Atherosclerosis
2022-05 | Journal article
DOI: 10.1016/j.atherosclerosis.2022.05.015
PMID: 35667162
Contributors: O'Rourke SA; Neto NGB; Devilly E; Shanley LC; Fitzgerald HK; Monaghan MG; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning

2022-01 | Preprint
DOI: 10.1101/2022.01.22.477332
PPR: PPR445615
Contributors: Neto NG; O’Rourke SA; Zhang M; Fitzgerald HK; Dunne A; Monaghan MG
Source: Self-asserted source
aisling dunne via Europe PubMed Central

The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells.

Antioxidants (Basel, Switzerland)
2022-01 | Journal article
DOI: 10.3390/antiox11010164
PMID: 35052669
PMC: PMC8772738
Contributors: Fitzgerald HK; O'Rourke SA; Desmond E; Neto NGB; Monaghan MG; Tosetto M; Doherty J; Ryan EJ; Doherty GA; Nolan DP et al.
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Regulation of inflammation by the antioxidant haem oxygenase 1

Nature Reviews Immunology
2021-07 | Journal article
DOI: 10.1038/s41577-020-00491-x
Contributors: Nicole K. Campbell; Hannah K. Fitzgerald; Aisling Dunne
Source: check_circle
Crossref

Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages.

Acta biomaterialia
2021-02 | Journal article
DOI: 10.1016/j.actbio.2021.02.023
PMID: 33657453
Contributors: Shanley LC; Mahon OR; Kelly DJ; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner.

Biomaterials
2020-01 | Journal article
DOI: 10.1016/j.biomaterials.2020.119833
PMID: 32062479
Contributors: Mahon OR; Browe DC; Gonzalez-Fernandez T; Pitacco P; Whelan IT; Von Euw S; Hobbs C; Nicolosi V; Cunningham KT; Mills KHG et al.
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization.

Osteoarthritis and cartilage
2019-11-12 | Journal article
DOI: 10.1016/j.joca.2019.10.010
PMID: 31730805
Source: Self-asserted source
aisling dunne

Glyoxal cross‐linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro‐permissive scaffolds for orthopedic tissue engineering

Journal of Biomedical Materials Research Part A
2019-10 | Journal article
DOI: 10.1002/jbm.a.36731
Part of ISSN: 1549-3296
Part of ISSN: 1552-4965
Source: Self-asserted source
aisling dunne

Trypanosoma brucei Secreted Aromatic Ketoacids Activate the Nrf2/HO-1 Pathway and Suppress Pro-inflammatory Responses in Primary Murine Glia and Macrophages

Frontiers in Immunology
2019-09-11 | Journal article
DOI: 10.3389/fimmu.2019.02137
Part of ISSN: 1664-3224
Source: Self-asserted source
aisling dunne

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

Glia
2019-07 | Journal article
DOI: 10.1002/glia.23592
Part of ISSN: 0894-1491
Part of ISSN: 1098-1136
Source: Self-asserted source
aisling dunne

The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling

Frontiers in Cardiovascular Medicine
2019-07-31 | Journal article
DOI: 10.3389/fcvm.2019.00101
Part of ISSN: 2297-055X
Source: Self-asserted source
aisling dunne

Calcium crystals and auto-inflammation

Rheumatology
2019-07-19 | Journal article
DOI: 10.1093/rheumatology/kez296
Part of ISSN: 1462-0324
Part of ISSN: 1462-0332
Source: Self-asserted source
aisling dunne

S100A8 acts as an autocrine priming signal for heme‐induced human Mϕ pro‐inflammatory responses in hemolytic inflammation

Journal of Leukocyte Biology
2019-05-15 | Journal article
DOI: 10.1002/jlb.3mia1118-418rr
Part of ISSN: 0741-5400
Part of ISSN: 1938-3673
Source: Self-asserted source
aisling dunne

Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1

Frontiers in Immunology
2019-03-01 | Journal article
DOI: 10.3389/fimmu.2019.00345
Part of ISSN: 1664-3224
Source: Self-asserted source
aisling dunne

Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
2018-11 | Journal article
DOI: 10.1177/1073858418809941
PMID: 30451065
Contributors: Cunningham C; Dunne A; Lopez-Rodriguez AB
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Calcium crystal deposition diseases - beyond gout.

Nature reviews. Rheumatology
2018-10 | Journal article
DOI: 10.1038/s41584-018-0078-5
PMID: 30190520
Contributors: McCarthy GM; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues.

Biomaterials
2018-10 | Journal article
DOI: 10.1016/j.biomaterials.2018.09.044
PMID: 30321864
Contributors: Cunniffe GM; DĂ­az-Payno PJ; Sheehy EJ; Critchley SE; Almeida HV; Pitacco P; Carroll SF; Mahon OR; Dunne A; Levingstone TJ et al.
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment.

Scientific reports
2018-07 | Journal article
DOI: 10.1038/s41598-018-28488-6
PMID: 29980703
PMC: PMC6035209
Contributors: Campbell NK; Fitzgerald HK; Malara A; Hambly R; Sweeney CM; Kirby B; Fletcher JM; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets.

Frontiers in immunology
2018-05 | Journal article
DOI: 10.3389/fimmu.2018.01145
PMID: 29892292
PMC: PMC5985611
Contributors: Mahon OR; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner.

Acta biomaterialia
2017-11 | Journal article
DOI: 10.1016/j.actbio.2017.10.041
PMID: 29104084
Contributors: Mahon OR; O'Hanlon S; Cunningham CC; McCarthy GM; Hobbs C; Nicolosi V; Kelly DJ; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Growth plate extracellular matrix-derived scaffolds for large bone defect healing.

European cells & materials
2017-02 | Journal article
DOI: 10.22203/ecm.v033a10
PMID: 28197989
Contributors: Cunniffe GM; DĂ­az-Payno PJ; Ramey JS; Mahon OR; Dunne A; Thompson EM; O'Brien FJ; Kelly DJ
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.

Arthritis research & therapy
2017-02 | Journal article
DOI: 10.1186/s13075-017-1225-0
PMID: 28173838
PMC: PMC5296949
Contributors: Corr EM; Cunningham CC; Helbert L; McCarthy GM; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.

The Journal of biological chemistry
2016-12 | Journal article
DOI: 10.1074/jbc.A116.508892
PMID: 27941071
PMC: PMC5207091
Contributors: Gray P; Dunne A; Brikos C; Jefferies CA; Doyle SL; O Neill LA
Source: Self-asserted source
aisling dunne via Europe PubMed Central

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

The Journal of biological chemistry
2016-11 | Journal article
DOI: 10.1074/jbc.A109.098137
PMID: 27864528
PMC: PMC5114429
Contributors: Dunne A; Carpenter S; Brikos C; Gray P; Strelow A; Wesche H; Morrice N; O'Neill LA
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling.

Osteoarthritis and cartilage
2016-07 | Journal article
DOI: 10.1016/j.joca.2016.07.001
PMID: 27426968
Contributors: Cunningham CC; Corr EM; McCarthy GM; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation.

Translational research : the journal of laboratory and clinical medicine
2016-07 | Journal article
DOI: 10.1016/j.trsl.2016.07.011
PMID: 27497182
Contributors: Basdeo SA; Campbell NK; Sullivan LM; Flood B; Creagh EM; Mantle TJ; Fletcher JM; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells.

Atherosclerosis
2016-06 | Journal article
DOI: 10.1016/j.atherosclerosis.2016.06.035
PMID: 27356299
Contributors: Corr EM; Cunningham CC; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease.

Glia
2015-01 | Journal article
DOI: 10.1002/glia.22786
PMID: 25627810
PMC: PMC4657478
Contributors: Cox DJ; Field RH; Williams DG; Baran M; Bowie AG; Cunningham C; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Investigating inflammasome activation under conditions of cellular stress and injury.

Methods in molecular biology (Clifton, N.J.)
2015-01 | Journal article
DOI: 10.1007/978-1-4939-2522-3_8
PMID: 25804751
Contributors: Cunningham CC; Corr EM; Cox DJ; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.

Mucosal immunology
2014-10 | Journal article
DOI: 10.1038/mi.2014.93
PMID: 25315966
Contributors: Dunne A; Mielke LA; Allen AC; Sutton CE; Higgs R; Cunningham CC; Higgins SC; Mills KH
Source: Self-asserted source
aisling dunne via Europe PubMed Central

TRIL is involved in cytokine production in the brain following Escherichia coli infection.

Journal of immunology (Baltimore, Md. : 1950)
2014-07 | Journal article
DOI: 10.4049/jimmunol.1302392
PMID: 25015823
PMC: PMC5503690
Contributors: Wochal P; Rathinam VA; Dunne A; Carlson T; Kuang W; Seidl KJ; Hall JP; Lin LL; Collins M; Schattgen SA et al.
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Activation of human biliverdin-IXα reductase by urea: generation of kinetically distinct forms during the unfolding pathway.

Biochimica et biophysica acta
2013-09 | Journal article
DOI: 10.1016/j.bbapap.2013.09.009
PMID: 24060811
Contributors: Franklin E; Mantle T; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP.

Methods in molecular biology (Clifton, N.J.)
2013-01 | Journal article
DOI: 10.1007/978-1-62703-523-1_2
PMID: 23852593
Contributors: Westwell-Roper C; Dunne A; Kim ML; Verchere CB; Masters SL
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase.

Clinical immunology (Orlando, Fla.)
2012-07 | Journal article
DOI: 10.1016/j.clim.2012.06.007
PMID: 22854286
Contributors: Cunningham CC; Mills E; Mielke LA; O'Farrell LK; Lavelle E; Mori A; McCarthy GM; Mills KH; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).

The Journal of biological chemistry
2011-09 | Journal article
DOI: 10.1074/jbc.M111.255893
PMID: 21911501
PMC: PMC3207441
Contributors: Carpenter S; Wochal P; Dunne A; O'Neill LA
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Inflammasome activation: from inflammatory disease to infection.

Biochemical Society transactions
2011-04 | Journal article
DOI: 10.1042/bst0390669
PMID: 21428959
Contributors: Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

TLR based therapeutics.

Current opinion in pharmacology
2011-04 | Journal article
DOI: 10.1016/j.coph.2011.03.004
PMID: 21501972
Contributors: Dunne A; Marshall NA; Mills KH
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1ÎČ in type 2 diabetes.

Nature immunology
2010-09 | Journal article
DOI: 10.1038/ni.1935
PMID: 20835230
PMC: PMC3103663
Contributors: Masters SL; Dunne A; Subramanian SL; Hull RL; Tannahill GM; Sharp FA; Becker C; Franchi L; Yoshihara E; Chen Z et al.
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.

Journal of immunology (Baltimore, Md. : 1950)
2010-07 | Journal article
DOI: 10.4049/jimmunol.1000105
PMID: 20610650
Contributors: Dunne A; Ross PJ; Pospisilova E; Masin J; Meaney A; Sutton CE; Iwakura Y; Tschopp J; Sebo P; Mills KH
Source: Self-asserted source
aisling dunne via Europe PubMed Central

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

The Journal of biological chemistry
2010-04 | Journal article
DOI: 10.1074/jbc.M109.098137
PMID: 20400509
PMC: PMC2881752
Contributors: Dunne A; Carpenter S; Brikos C; Gray P; Strelow A; Wesche H; Morrice N; O'Neill LA
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Immune modulation: IL-1, master mediator or initiator of inflammation.

Nature medicine
2009-12 | Journal article
DOI: 10.1038/nm1209-1363
PMID: 19966773
Contributors: Mills KH; Dunne A
Source: Self-asserted source
aisling dunne via Europe PubMed Central

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.

Journal of immunology (Baltimore, Md. : 1950)
2009-08 | Journal article
DOI: 10.4049/jimmunol.0901518
PMID: 19710467
Contributors: Carpenter S; Carlson T; Dellacasagrande J; Garcia A; Gibbons S; Hertzog P; Lyons A; Lin LL; Lynch M; Monie T et al.
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions.

The Biochemical journal
2007-07 | Journal article
DOI: 10.1042/BJ20061651
PMID: 17402939
PMC: PMC1925240
Contributors: Franklin E; Browne S; Hayes J; Boland C; Dunne A; Elliot G; Mantle TJ
Source: Self-asserted source
aisling dunne via Europe PubMed Central

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

Nature genetics
2007-02 | Journal article
DOI: 10.1038/ng1976
PMID: 17322885
PMC: PMC2660299
Contributors: Khor CC; Chapman SJ; Vannberg FO; Dunne A; Murphy C; Ling EY; Frodsham AJ; Walley AJ; Kyrieleis O; Khan A et al.
Source: Self-asserted source
aisling dunne via Europe PubMed Central

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

Proceedings of the National Academy of Sciences of the United States of America
2007-02 | Journal article
DOI: 10.1073/pnas.0608100104
PMID: 17360653
PMC: PMC1805564
Contributors: Miggin SM; PĂ„lsson-McDermott E; Dunne A; Jefferies C; Pinteaux E; Banahan K; Murphy C; Moynagh P; Yamamoto M; Akira S et al.
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Polypeptides and use thereof

2006-04 | Patent
OTHER-ID:

CN101198622
Contributors: AISLING DUNNE
Source: Self-asserted source
aisling dunne via Europe PubMed Central

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.

The Journal of biological chemistry
2006-01 | Journal article
DOI: 10.1074/jbc.m508892200
PMID: 16439361
Contributors: Gray P; Dunne A; Brikos C; Jefferies CA; Doyle SL; O'Neill LA
Source: Self-asserted source
aisling dunne via Europe PubMed Central

Adaptor usage and Toll-like receptor signaling specificity.

FEBS letters
2005-04 | Journal article
DOI: 10.1016/j.febslet.2005.04.024
PMID: 15876435
Contributors: Dunne A; O'Neill LA
Source: Self-asserted source
aisling dunne via Europe PubMed Central
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