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A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues

Journal of the American Chemical Society

2025-01-29 | Journal article

DOI: 10.1021/jacs.4c10991

Contributors: Naoki Zenmyo; Yuya Matsumoto; Akihiro Yasuda; Shohei Uchinomiya; Naoya Shindo; Kaori Sasaki-Tabata; Emi Mishiro-Sato; Tomonori Tamura; Itaru Hamachi; Akio Ojida

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A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues

2024-05-02 | Preprint

DOI: 10.26434/chemrxiv-2024-cnt58

Contributors: Naoki Zenmyo; Yuya Matsumoto; Akihiro Yasuda; Shohei Uchinomiya; Naoya Shindo; Kaori Sasaki-Tabata; Tomonori Tamura; Itaru Hamachi; Akio Ojida

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Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

Chemical Communications

2023 | Journal article

DOI: 10.1039/D3CC03069E

Contributors: Izumi Kato; Yudai Ogawa; Fumika Yakushiji; Jiro Ogura; Masaki Kobayashi; Naoya Shindo; Satoshi Ichikawa; Katsumi Maenaka; Masahiro Sakaitani

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Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines

Journal of Medicinal Chemistry

2023-07-13 | Journal article

DOI: 10.1021/acs.jmedchem.3c00737

Contributors: Daiki Yamane; Ryo Tetsukawa; Naoki Zenmyo; Kaori Tabata; Yuya Yoshida; Naoya Matsunaga; Naoya Shindo; Akio Ojida

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Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide

Chemical Science

2022 | Journal article

DOI: 10.1039/D1SC06596C

Contributors: Daiki Yamane; Satsuki Onitsuka; Suyong Re; Hikaru Isogai; Rui Hamada; Tadanari Hiramoto; Eiji Kawanishi; Kenji Mizuguchi; Naoya Shindo; Akio Ojida

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Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease

Journal of Medicinal Chemistry

2022-10-27 | Journal article

DOI: 10.1021/acs.jmedchem.2c01081

Contributors: Yuya Hirose; Naoya Shindo; Makiko Mori; Satsuki Onitsuka; Hikaru Isogai; Rui Hamada; Tadanari Hiramoto; Jinta Ochi; Daisuke Takahashi; Tadashi Ueda et al.

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Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

2022-06-06 | Preprint

DOI: 10.1101/2022.06.05.494897

Contributors: Yuya Hirose; Naoya Shindo; Makiko Mori; Satsuki Onitsuka; Hikaru Isogai; Rui Hamada; Tadanari Hiramoto; Jinta Ochi; Daisuke Takahashi; Tadashi Ueda et al.

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Selective Covalent Targeting of SARS-CoV-2 Main Protease by Enantiopure Chlorofluoroacetamide

2021-09-28 | Preprint

DOI: 10.26434/chemrxiv-2021-xn1wc

Contributors: Daiki Yamane; Satsuki Onitsuka; Suyong Re; Hikaru Isogai; Rui Hamada; Tadanari Hiramoto; Eiji Kawanishi; Kenji Mizuguchi; Naoya Shindo; Akio Ojida

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Selective Covalent Targeting of SARS-CoV-2 Main Protease by Enantiopure Chlorofluoroacetamide

2021-09-28 | Other

DOI: 10.33774/chemrxiv-2021-xn1wc

Contributors: Daiki Yamane; Satsuki Onitsuka; Suyong Re; Hikaru Isogai; Rui Hamada; Tadanari Hiramoto; Eiji Kawanishi; Kenji Mizuguchi; Naoya Shindo; Akio Ojida

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Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins

Journal of the American Chemical Society

2020-10-28 | Journal article

DOI: 10.1021/jacs.0c07490

Contributors: Keisuke Tokunaga; Mami Sato; Keiko Kuwata; Chizuru Miura; Hirokazu Fuchida; Naoya Matsunaga; Satoru Koyanagi; Shigehiro Ohdo; Naoya Shindo; Akio Ojida

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Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

ACS Medicinal Chemistry Letters

2020-06-11 | Journal article

DOI: 10.1021/acsmedchemlett.9b00574

Contributors: Mami Sato; Hirokazu Fuchida; Naoya Shindo; Keiko Kuwata; Keisuke Tokunaga; Guo Xiao-Lin; Ryo Inamori; Keitaro Hosokawa; Kosuke Watari; Tomohiro Shibata et al.

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Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Nature Chemical Biology

2019-03-14 | Journal article

DOI: 10.1038/s41589-018-0204-3

Contributors: Naoya Shindo; Hirokazu Fuchida; Mami Sato; Kosuke Watari; Tomohiro Shibata; Keiko Kuwata; Chizuru Miura; Kei Okamoto; Yuji Hatsuyama; Keisuke Tokunaga et al.

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Synthesis of Azaheterocycles and Related Molecules by Tf2NH-Catalyzed Cycloadditions

HETEROCYCLES

2018 | Journal article

DOI: 10.3987/rev-17-875

Part of ISSN: 0385-5414

Contributors: Kiyosei Takasu; Naoya Shindo

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Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence

Science Signaling

2018-11 | Journal article

DOI: 10.1126/scisignal.aat5185

Part of ISSN: 1945-0877

Contributors: Akiyuki Nishimura; Tsukasa Shimauchi; Tomohiro Tanaka; Kakeru Shimoda; Takashi Toyama; Naoyuki Kitajima; Tatsuya Ishikawa; Naoya Shindo; Takuro Numaga-Tomita; Satoshi Yasuda et al.

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Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

EBioMedicine

2016-11 | Journal article

DOI: 10.1016/j.ebiom.2016.10.008

Part of ISSN: 2352-3964

Contributors: Naoya Matsunaga; Eriko Ikeda; Keisuke Kakimoto; Miyako Watanabe; Naoya Shindo; Akito Tsuruta; Hisako Ikeyama; Kengo Hamamura; Kazuhiro Higashi; Tomohiro Yamashita et al.

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Design of Coordination Interaction of Zn(II) Complex with Oligo-Aspartate Peptide to Afford a High-Affinity Tag–Probe Pair

Bulletin of the Chemical Society of Japan

2015-06 | Journal article

DOI: 10.1246/bcsj.20150037

Part of ISSN: 0009-2673

Contributors: Hirokazu Fuchida; Shigekazu Tabata; Naoya Shindo; Ippei Takashima; Qiao Leng; Yuji Hatsuyama; Itaru Hamachi; Akio Ojida

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Design of a binuclear Ni(II)–iminodiacetic acid (IDA) complex for selective recognition and covalent labeling of His-tag fused proteins

Bioorganic & Medicinal Chemistry Letters

2014-07 | Journal article

DOI: 10.1016/j.bmcl.2014.04.096

Part of ISSN: 0960-894X

Contributors: Ikuko Takahira; Hirokazu Fuchida; Shigekazu Tabata; Naoya Shindo; Shohei Uchinomiya; Itaru Hamachi; Akio Ojida

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Selective Synthesis of Polysubstituted Dihydroquinolines and α,β-Unsaturated Amidines by a Catalytic Reaction of Ynamides with Ketimines

Synthesis

2013-06 | Journal article

DOI: 10.1055/s-0033-1339191

Part of ISSN: 0039-7881

Contributors: Kiyosei Takasu; Yuusuke Kuroda; Naoya Shindoh; Yoshiji Takemoto

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Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines

Journal of the American Chemical Society

2011-06-08 | Journal article

DOI: 10.1021/ja202576e

Part of ISSN: 0002-7863

Contributors: Naoya Shindoh; Kazuo Kitaura; Yoshiji Takemoto; Kiyosei Takasu

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Unprecedented Synthesis of N,N-Divinylamines by Tf2NH-Catalyzed Reaction of Ynamide with Ketimine

HETEROCYCLES

2010 | Journal article

DOI: 10.3987/com-10-s(e)87

Part of ISSN: 0385-5414

Contributors: Kiyosei Takasu; Yoshiji Takemoto; Naoya Shindoh

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Triflic Imide Catalyzed [3+2] Cycloaddition of Aldimines with α,α-Dimethylallylsilane

HETEROCYCLES

2009 | Journal article

DOI: 10.3987/com-08-s(f)17

Part of ISSN: 0385-5414

Contributors: Kiyosei Takasu; Yoshiji Takemoto; Naoya Shindoh; Hidetoshi Tokuyama

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Auto-Tandem Catalysis: A Single Catalyst Activating Mechanistically Distinct Reactions in a Single Reactor

Chemistry - A European Journal

2009-11 | Journal article

DOI: 10.1002/chem.200901486

Part of ISSN: 0947-6539

Contributors: Naoya Shindoh; Yoshiji Takemoto; Kiyosei Takasu

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Atropisomerism of α,β-Unsaturated Amidines: Stereoselective Synthesis by Catalytic Cascade Reaction and Optical Resolution

Chemistry - A European Journal

2009-06 | Journal article

DOI: 10.1002/chem.200901103

Part of ISSN: 0947-6539

Contributors: Naoya Shindoh; Yoshiji Takemoto; Kiyosei Takasu

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Auto-Tandem Catalysis in the Synthesis of Substituted Quinolines from Aldimines and Electron-Rich Olefins: Cascade Povarov−Hydrogen-Transfer Reaction

The Journal of Organic Chemistry

2008-10-03 | Journal article

DOI: 10.1021/jo8009243

Part of ISSN: 0022-3263

Contributors: Naoya Shindoh; Hidetoshi Tokuyama; Yoshiji Takemoto; Kiyosei Takasu

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Cascade and one-pot processes providing substituted quinolines from aldimines and allylsilanes: auto-tandem catalysis of triflic imide

Tetrahedron Letters

2007-07 | Journal article

DOI: 10.1016/j.tetlet.2007.05.032

Part of ISSN: 0040-4039

Contributors: Naoya Shindoh; Hidetoshi Tokuyama; Kiyosei Takasu

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Catalytic imino Diels–Alder reaction by triflic imide and its application to one-pot synthesis from three components

Tetrahedron

2006 | Journal article

DOI: 10.1016/j.tet.2006.09.092

Part of ISSN: 0040-4020

Contributors: Kiyosei Takasu; Naoya Shindoh; Hidetoshi Tokuyama; Masataka Ihara

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Review activity for ACS omega. (1)

Review activity for Chemistry. (1)

How many people are using ORCID?

https://orcid.org/0000-0002-2374-9896

Activities

Works (26)

A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues

A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues

Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines

Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

Selective Covalent Targeting of SARS-CoV-2 Main Protease by Enantiopure Chlorofluoroacetamide

Selective Covalent Targeting of SARS-CoV-2 Main Protease by Enantiopure Chlorofluoroacetamide

Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins

Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Synthesis of Azaheterocycles and Related Molecules by Tf2NH-Catalyzed Cycloadditions

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Design of Coordination Interaction of Zn(II) Complex with Oligo-Aspartate Peptide to Afford a High-Affinity Tag–Probe Pair

Design of a binuclear Ni(II)–iminodiacetic acid (IDA) complex for selective recognition and covalent labeling of His-tag fused proteins

Selective Synthesis of Polysubstituted Dihydroquinolines and α,β-Unsaturated Amidines by a Catalytic Reaction of Ynamides with Ketimines

Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines

Unprecedented Synthesis of N,N-Divinylamines by Tf2NH-Catalyzed Reaction of Ynamide with Ketimine

Triflic Imide Catalyzed [3+2] Cycloaddition of Aldimines with α,α-Dimethylallylsilane

Auto-Tandem Catalysis: A Single Catalyst Activating Mechanistically Distinct Reactions in a Single Reactor

Atropisomerism of α,β-Unsaturated Amidines: Stereoselective Synthesis by Catalytic Cascade Reaction and Optical Resolution

Auto-Tandem Catalysis in the Synthesis of Substituted Quinolines from Aldimines and Electron-Rich Olefins: Cascade Povarov−Hydrogen-Transfer Reaction

Cascade and one-pot processes providing substituted quinolines from aldimines and allylsilanes: auto-tandem catalysis of triflic imide

Catalytic imino Diels–Alder reaction by triflic imide and its application to one-pot synthesis from three components

Peer review (2 reviews for 2 publications/grants)

https://orcid.org/0000-0002-2374-9896

Personal information

Activities

Works (26)

A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues

A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues

Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines

Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

Selective Covalent Targeting of SARS-CoV-2 Main Protease by Enantiopure Chlorofluoroacetamide

Selective Covalent Targeting of SARS-CoV-2 Main Protease by Enantiopure Chlorofluoroacetamide

Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins

Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Synthesis of Azaheterocycles and Related Molecules by Tf2NH-Catalyzed Cycloadditions

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Design of Coordination Interaction of Zn(II) Complex with Oligo-Aspartate Peptide to Afford a High-Affinity Tag–Probe Pair

Design of a binuclear Ni(II)–iminodiacetic acid (IDA) complex for selective recognition and covalent labeling of His-tag fused proteins

Selective Synthesis of Polysubstituted Dihydroquinolines and α,β-Unsaturated Amidines by a Catalytic Reaction of Ynamides with Ketimines

Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines

Unprecedented Synthesis of N,N-Divinylamines by Tf2NH-Catalyzed Reaction of Ynamide with Ketimine

Triflic Imide Catalyzed [3+2] Cycloaddition of Aldimines with α,α-Dimethylallylsilane

Auto-Tandem Catalysis: A Single Catalyst Activating Mechanistically Distinct Reactions in a Single Reactor

Atropisomerism of α,β-Unsaturated Amidines: Stereoselective Synthesis by Catalytic Cascade Reaction and Optical Resolution

Auto-Tandem Catalysis in the Synthesis of Substituted Quinolines from Aldimines and Electron-Rich Olefins: Cascade Povarov−Hydrogen-Transfer Reaction

Cascade and one-pot processes providing substituted quinolines from aldimines and allylsilanes: auto-tandem catalysis of triflic imide

Catalytic imino Diels–Alder reaction by triflic imide and its application to one-pot synthesis from three components

Peer review (2 reviews for 2 publications/grants)