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Employment (1)

The Francis Crick Institute: London, GB

2021-05-01 to present | Head (Proteomics)
Employment
Source: Self-asserted source
Mark Skehel

Works (20)

Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening

Angewandte Chemie
2025-02-03 | Journal article
DOI: 10.1002/ange.202418314
Contributors: Harry Wilders; George Biggs; Sam M. Rowe; Emma E. Cawood; Ioannis G. Riziotis; Alan R. Rendina; Emma K. Grant; Jonathan Pettinger; David J. Fallon; Mark Skehel et al.
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Crossref

Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening

Angewandte Chemie International Edition
2025-02-03 | Journal article
DOI: 10.1002/anie.202418314
Contributors: Harry Wilders; George Biggs; Sam M. Rowe; Emma E. Cawood; Ioannis G. Riziotis; Alan R. Rendina; Emma K. Grant; Jonathan Pettinger; David J. Fallon; Mark Skehel et al.
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Crossref

Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation

Communications Chemistry
2025-01-15 | Journal article
DOI: 10.1038/s42004-025-01410-8
Contributors: Aini Vuorinen; Cassandra R. Kennedy; Katherine A. McPhie; William McCarthy; Jonathan Pettinger; J. Mark Skehel; David House; Jacob T. Bush; Katrin Rittinger
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Crossref

Mechanism of single-stranded DNA annealing by RAD52–RPA complex

Nature
2024-05-16 | Journal article
DOI: 10.1038/s41586-024-07347-7
Contributors: Chih-Chao Liang; Luke A. Greenhough; Laura Masino; Sarah Maslen; Ilirjana Bajrami; Marcel Tuppi; Mark Skehel; Ian A. Taylor; Stephen C. West
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Crossref

The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

2023-12-19 | Preprint
DOI: 10.1101/2023.12.19.572309
Contributors: Lewis Timimi; Antoni G. Wrobel; George N. Chiduza; Sarah L. Maslen; Antonio Torres-Méndez; Beatriz Montaner; Colin Davis; J. Mark Skehel; John L. Rubinstein; Anne Schreiber et al.
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Crossref

Multi-signal regulation of the GSK-3β homolog Rim11 governs meiosis entry in yeast

2023-09-22 | Preprint
DOI: 10.1101/2023.09.21.558844
Contributors: Johanna Kociemba; Andreas Christ Sølvsten Jørgensen; Nika Tadic; Anthony Harris; Theodora Sideri; Wei Yee Chan; Fairouz Ibrahim; Elcin Unal; Mark Skehel; Vahid Shahrezaei et al.
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Crossref

Checkpoint kinase interaction with DNA polymerase alpha regulates replication progression during stress [version 1; peer review: 3 approved]

2023-07-26 | Journal article
DOI: 10.12688/wellcomeopenres.19617.1
Part of ISSN: 2398-502X
Funded by GRANT_NUMBER:

107056

Funded by GRANT_NUMBER: AICR 10-0908
Funded by GRANT_NUMBER: BBS/E/B/000C0423
Funded by GRANT_NUMBER: C15873/A12700
Contributors: Andreas Hadjicharalambous; Alex J. Whale; Geylani Can; J. Mark Skehel; Jonathan M. Houseley; Philip Zegerman; Can Geylani; Can Geylani; Can Geylani; Hadjicharalambous Andreas et al.
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Wellcome Open Research
grade
Preferred source (of 2)‎

O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern

2022-09-15 | Preprint
DOI: 10.1101/2022.09.15.508093
Contributors: Edgar Gonzalez-Rodriguez; Mia Zol-Hanlon; Ganka Bineva-Todd; Andrea Marchesi; Mark Skehel; Keira E. Mahoney; Chloë Roustan; Annabel Borg; Lucia Di Vagno; Svend Kjaer et al.
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Crossref

Multidimensional Dynamics of the Proteome in the Neurodegenerative and Aging Mammalian Brain

Molecular & Cellular Proteomics
2022-02 | Journal article
DOI: 10.1016/j.mcpro.2021.100192
Contributors: Byron Andrews; Alan E. Murphy; Michele Stofella; Sarah Maslen; Leonardo Almeida-Souza; J. Mark Skehel; Nathan G. Skene; Frank Sobott; René A.W. Frank
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Crossref

Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins

Communications Biology
2021-11-09 | Journal article
DOI: 10.1038/s42003-021-02750-6
Contributors: Francesca Malvezzi; Christopher J. Stubbs; Thomas A. Jowitt; Ian L. Dale; Xieyang Guo; Jon P. DeGnore; Gianluca Degliesposti; J. Mark Skehel; Andrew J. Bannister; Mark S. McAlister
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Crossref

The bacterial actin-like cell division protein FtsA forms curved antiparallel double filaments upon binding of FtsN

2021-11-08 | Other
DOI: 10.1101/2021.11.08.467742
Contributors: Tim Nierhaus; Stephen H McLaughlin; Frank Bürmann; Danguole Kureisaite-Ciziene; Sarah Maslen; Mark J Skehel; Conny WH Yu; Stefan MV Freund; Louise FH Funke; Jason W Chin et al.
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Crossref

Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins

2021-05-14 | Other
DOI: 10.21203/rs.3.rs-519038/v1
Contributors: Mark Mcalister; Francesca Malvezzi; Christopher Stubbs; Thomas Jowitt; Ian Dale; Xieyang Guo; Jon DeGnore; Gianluca Degliesposti; John Skehel; Andrew Bannister
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Crossref

Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation

Angewandte Chemie
2021-05-03 | Journal article
DOI: 10.1002/ange.202015834
Contributors: George S. Biggs; Oskar James Klein; Sarah L. Maslen; J. Mark Skehel; Trevor J. Rutherford; Stefan M. V. Freund; Florian Hollfelder; Sally R. Boss; Paul D. Barker
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Crossref

Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation

Angewandte Chemie International Edition
2021-05-03 | Journal article
DOI: 10.1002/anie.202015834
Contributors: George S. Biggs; Oskar James Klein; Sarah L. Maslen; J. Mark Skehel; Trevor J. Rutherford; Stefan M. V. Freund; Florian Hollfelder; Sally R. Boss; Paul D. Barker
Source: check_circle
Crossref

Shulin packages axonemal outer dynein arms for ciliary targeting

Science
2021-02-26 | Journal article
DOI: 10.1126/science.abe0526
Contributors: Girish R. Mali; Ferdos Abid Ali; Clinton K. Lau; Farida Begum; Jérôme Boulanger; Jonathan D. Howe; Zhuo A. Chen; Juri Rappsilber; Mark Skehel; Andrew P. Carter
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Crossref

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

2020-11-09 | Preprint
DOI: 10.1101/2020.11.09.374355
Contributors: Mohinder Pal; Hugo Muñoz-Hernandez; Dennis Bjorklund; Lihong Zhou; Gianluca Degliesposti; J. Mark Skehel; Emma L. Hesketh; Rebecca F. Thompson; Laurence H. Pearl; Oscar Llorca et al.
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Crossref

Shulin packages axonemal outer dynein arms for ciliary targeting

2020-09-04 | Preprint
DOI: 10.1101/2020.09.04.282897
Contributors: Girish R. Mali; Ferdos Abid Ali; Clinton K. Lau; Farida Begum; Mark Skehel; Andrew P. Carter
Source: check_circle
Crossref

Structure of a human 48 S translational initiation complex

Science
2020-09-04 | Journal article
DOI: 10.1126/science.aba4904
Contributors: Jailson Brito Querido; Masaaki Sokabe; Sebastian Kraatz; Yuliya Gordiyenko; J. Mark Skehel; Christopher S. Fraser; V. Ramakrishnan
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Crossref

Human CNS barrier-forming organoids with cerebrospinal fluid production

Science
2020-07-10 | Journal article
DOI: 10.1126/science.aaz5626
Contributors: Laura Pellegrini; Claudia Bonfio; Jessica Chadwick; Farida Begum; Mark Skehel; Madeline A. Lancaster
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Crossref

Architecture of eukaryotic mRNA 3′-end processing machinery

Science
2017-11-24 | Journal article
DOI: 10.1126/science.aao6535
Contributors: Ana Casañal; Ananthanarayanan Kumar; Chris H. Hill; Ashley D. Easter; Paul Emsley; Gianluca Degliesposti; Yuliya Gordiyenko; Balaji Santhanam; Jana Wolf; Katrin Wiederhold et al.
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Crossref

Peer review (1 review for 1 publication/grant)

Review activity for Wellcome open research. (1)
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