Personal information

Activities

Employment (2)

Stony Brook Medicine: Stony Brook, New York, US

2023-12 to present
Employment
Source: Self-asserted source
Ledong Wan

Cold Spring Harbor Laboratory: Cold Spring Harbor, New York, US

2018-05 to 2023-11
Employment
Source: Self-asserted source
Ledong Wan

Education and qualifications (1)

Zhejiang University: Hangzhou, Zhejiang, CN

2014 to 2018 | Ph.D. in Pathology and Pathophysiology
Education
Source: Self-asserted source
Ledong Wan

Professional activities (2)

RNA Society: Bethesda, Maryland, US

Membership
Source: Self-asserted source
Ledong Wan

American Association for Cancer Research: Philadelphia, PA, US

2019 to present
Membership
Source: Self-asserted source
Ledong Wan

Works (26)

Splicing Factor RBM10 Loss Fuels Thyroid Cancer Metastasis

2025-02-05 | Other
Contributors: Kevin Coughlin Jr.; Ledong Wan
Source: check_circle
Crossref

Data from Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

2024-09-16 | Preprint
Contributors: Ledong Wan; Kuang-Ting Lin; Mohammad Alinoor. Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Data from Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

2024-09-16 | Preprint
Contributors: Ledong Wan; Kuang-Ting Lin; Mohammad Alinoor. Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

2024-09-16 | Preprint
Contributors: Ledong Wan; Kuang-Ting Lin; Mohammad Alinoor. Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

2024-09-16 | Preprint
Contributors: Ledong Wan; Kuang-Ting Lin; Mohammad Alinoor. Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment.

Cancer cell
2024-02-22 | Journal article
Contributors: Xue-Yan He; Gao Y; Ng D; Michalopoulou E; George S; Adrover JM; Sun L; Albrengues J; Daßler-Plenker J; Xiao Han et al.
Source: Self-asserted source
Ledong Wan

Data from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS<sup>G12D</sup>-Mediated Pancreatic Cancer

2023-07-07 | Preprint
Contributors: Ledong Wan; Kuan-Ting Lin; Mohammad Alinoor Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

Cancer Discovery
2023-07-07 | Journal article
Contributors: Ledong Wan; Kuan-Ting Lin; Mohammad Alinoor Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS<sup>G12D</sup>-Mediated Pancreatic Cancer

2023-07-07 | Preprint
Contributors: Ledong Wan; Kuan-Ting Lin; Mohammad Alinoor Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS<sup>G12D</sup>-Mediated Pancreatic Cancer

2023-07-07 | Preprint
Contributors: Ledong Wan; Kuan-Ting Lin; Mohammad Alinoor Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Data from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS<sup>G12D</sup>-Mediated Pancreatic Cancer

2023-06-23 | Preprint
Contributors: Ledong Wan; Kuan-Ting Lin; Mohammad Alinoor Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS<sup>G12D</sup>-Mediated Pancreatic Cancer

2023-06-23 | Preprint
Contributors: Ledong Wan; Kuan-Ting Lin; Mohammad Alinoor Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Supplementary Figure S1-S11 and Table S1 from Splicing Factor SRSF1 Promotes Pancreatitis and KRAS<sup>G12D</sup>-Mediated Pancreatic Cancer

2023-06-23 | Preprint
Contributors: Ledong Wan; Kuan-Ting Lin; Mohammad Alinoor Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer
Source: check_circle
Crossref

Preclinical Screening of Splice-Switching Antisense Oligonucleotides in PDAC Organoids

2023-04-03 | Preprint
Contributors: Ledong Wan; Alexander J. Kral; Dillon Voss; Adrian R. Krainer
Source: Self-asserted source
Ledong Wan

SR Splicing Factors Promote Cancer via Multiple Regulatory Mechanisms

Genes
2022-09-16 | Journal article
Part of ISSN: 2073-4425
Contributors: Ledong Wan; Min Deng; Honghe Zhang
Source: Self-asserted source
Ledong Wan

SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer

Gut
2019-01 | Journal article
Part of ISSN: 0017-5749
Part of ISSN: 1468-3288
Contributors: Ledong Wan; Wenying Yu; Enhui Shen; Wenjie Sun; Yuan Liu; Jianlu Kong; Yihua Wu; Fengyan Han; Lei Zhang; Tianze Yu et al.
Source: Self-asserted source
Ledong Wan

Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer

Clinical Epigenetics
2018-12 | Journal article
Part of ISSN: 1868-7075
Part of ISSN: 1868-7083
Contributors: Yimin Zhu; Hanlin Lu; Dandan Zhang; Meiyan Li; Xiaohui Sun; Ledong Wan; Dan Yu; Yiping Tian; Hongchuan Jin; Aifen Lin et al.
Source: Self-asserted source
Ledong Wan

HOTAIRM1 as a potential biomarker for diagnosis of colorectal cancer functions the role in the tumour suppressor

Journal of Cellular and Molecular Medicine
2016-11 | Journal article
Part of ISSN: 1582-1838
Part of ISSN: 1582-4934
Contributors: Ledong Wan; Jianlu Kong; Jinlong Tang; Yihua Wu; Enping Xu; Maode Lai; Honghe Zhang
Source: Self-asserted source
Ledong Wan

Long non-coding RNA LINC01133 inhibits epithelial–mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6

Cancer Letters
2016-10 | Journal article
Part of ISSN: 0304-3835
Contributors: Jianlu Kong; Wenjie Sun; Chen Li; Ledong Wan; Shuo Wang; Yihua Wu; Enping Xu; Honghe Zhang; Maode Lai
Source: Self-asserted source
Ledong Wan

IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells

Oncotarget
2016-09-20 | Journal article
Part of ISSN: 1949-2553
Contributors: Hui Cao; Jing Zhang; Hong Liu; Ledong Wan; Honghe Zhang; Qiong Huang; Enping Xu; Maode Lai
Source: Self-asserted source
Ledong Wan

Decreased expression of dual specificity phosphatase 22 in colorectal cancer and its potential prognostic relevance for stage IV CRC patients

Tumor Biology
2015-11 | Journal article
Part of ISSN: 1010-4283
Part of ISSN: 1423-0380
Contributors: Dan Yu; Zhenli Li; Meifu Gan; Hanyun Zhang; Xiaoyang Yin; Shunli Tang; Ledong Wan; Yiping Tian; Shuai Zhang; Yimin Zhu et al.
Source: Self-asserted source
Ledong Wan

Polymorphisms involving gain or loss of CpG sites are significantly enriched in trait-associated SNPs

Oncotarget
2015-11-24 | Journal article
Part of ISSN: 1949-2553
Contributors: Dan Zhou; Zhenli Li; Dan Yu; Ledong Wan; Yimin Zhu; Maode Lai; Dandan Zhang
Source: Self-asserted source
Ledong Wan

Epithelial–mesenchymal transition in colorectal cancer metastasis: A system review

Pathology - Research and Practice
2015-08 | Journal article
Part of ISSN: 0344-0338
Contributors: Hui Cao; Enping Xu; Hong Liu; Ledong Wan; Maode Lai
Source: Self-asserted source
Ledong Wan

Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors

European Journal of Medicinal Chemistry
2014-04 | Journal article
Part of ISSN: 0223-5234
Contributors: Chun Han; Ledong Wan; Hongbin Ji; Ke Ding; Zhangjian Huang; Yisheng Lai; Sixun Peng; Yihua Zhang
Source: Self-asserted source
Ledong Wan

Novel Hybrids of (Phenylsulfonyl)furoxan and Anilinopyrimidine as Potent and Selective Epidermal Growth Factor Receptor Inhibitors for Intervention of Non-Small-Cell Lung Cancer

Journal of Medicinal Chemistry
2013-06-13 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Chun Han; Zhangjian Huang; Chao Zheng; Ledong Wan; Lianwen Zhang; Sixun Peng; Ke Ding; Hongbin Ji; Jide Tian; Yihua Zhang
Source: Self-asserted source
Ledong Wan

Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors.

European journal of medicinal chemistry
2013-05-29 | Journal article
Contributors: Han C; Huang Z; Zheng C; Wan L; Lai Y; Peng S; ke ding; Ke Ding; Ji H; Zhang Y
Source: Self-asserted source
Ledong Wan